Zizyphus, Jujube, Da Zao 大枣

Da Zao, Hong Zao (Red) (TCM)
Unnab (Unani, Arabic)
Picture Ortus Sanitatis, Meydenbach, 1491

Picture Picture
Krauterbuch, Lonitzer, 1578

A Complete History of Drugs, Pomet, London, 1748
Picture Red Jujube Da Zao (Adam, 2017)

Botanical name:


Ziziphus jujuba (syn. Z. vulgaris)
There are a number of varieties: Sweet and Sour; Black and Red; Wild and Cultivated, as well as Jujubes harvested in different seasons.
Three varieties were known in the West: J. major, J. minor, J. agrestis. (Pomet)

Parts used:


Fruit; Black and Red varieties are used in TCM (mostly the Red); a White kind was known in the West.
The larger red coloured variety is considered better”. (Avicenna)

Temperature & Taste:


Neutral, moist. Sweet
Jujubes are cold in first degree, moderately dry and slightly moist in temperament” (Avicenna)

Classifications:


2E LENITIVE.    2F. PURIFYING.    2S. STRENGTHENING
3K. EXPECTORANT.    3L. ANTI-TUSSIVE
4d. PECTORAL
Preparers and Purgers of Bile

Uses:


1. Strengthen the Lungs, Stops Cough (West):
-‘expectorates tough Phlegm’ (Pomet, 1748)
-Hoarseness, Cough, Pleurisy, Spiting of Blood
-roughness of the Throat and Chest
-Wheezing, shortness of Breath
-“Useful for the Chest and Lungs”. (Avicenna)

2. Benefits the Spleen and Qi (West, TCM):
-Indigestion, poor appetite, fatigue
Pliny said it prevented diseases of the Stomach
-Heartburn (Unani)
-moderates a formula, makes other herbs more agreeable to the Stomach (similar to Licorice) (TCM)

3. Nourish the Blood, Benefits the Heart, Calms the Mind and Nerves:
-Palpitation, Irritability, emotional debility, Shock (TCM, Unani)

4. Promotes Urine, Clears Stones:
-sharp Urine, corrosion of the Bladder or Kidney
-‘Exulceration [Ulcers], or Excoriation of the Kidneys and Bladder’. (Pomet, 1748)
-Kidney and Bladder pain (Unani)
-for Stones since Dioscorides. (Seed can be used)

5. Clears Heat and Bile, Resists Poison:
-‘tempers the sharpness of Blood and Humors’. (Pomet, 1748)
-biliousness
-Eczema, Syphilis, Erysipelas
-Scrofula, Plague Buboes
-for Blood Heat and to cleanse the Blood
-Bites, Stings and Poison (Dioscorides)


Dose:


Decoctions or Soups: 3–9 dates (typically 4–5), or 10–30 grams in Decoction.
Often added to Soups in China

Main Combinations:


1. Pectoral Fruits: Jujubes with Dates, Figs, Raisins (Pharmacopoeia Gallica, 1818)
2. Cough:
i. Jujube with Licorice, Pearl Barley, Maidenhair
ii. Jujube with Licorice, Maidenhair, Violet, Poppy seed
iii. Jujube with Figs, Raisins, Licorice (Pharmacopoeia Sardoa, 1773)
iv. Jujube with Calf Lung, Chicken, Pearl Barley (Nouveau Formulaire Medicale et Pharmaceutique, 1820)
3. Pneumonia, Jujube, Barley, Sebesten (Persian Medicine)
4. Digestive weakness and to harmonise the Stomach, Jujube with fresh Ginger, Orange peel, Licorice (TCM)
5. Deficiency of Blood and Qi, combine Jujube (Da Zao) with Dang Gui (TCM)
6. Restlessness, combine Jujube (Da Zao) with Licorice and Wheat (TCM)
7. Cosmetic, Jujube, Prune, Rose, Sumac, Barberry (Persian: see research below)

Major Formulas:


Syrup of Jujube Compound (Mesue)
Decoction of Fruit
Decoction of Fruit and Flowers
Pectoral Decoction (London, 1650)
Decoction of Hyssop (Zacharia)
Syrup Against Consumption

Ban Xia Bai Zhu Tian Ma Tang
Ban Xia Xie Xin Tang
Chai Hu Gui Zhi Tang
Chai Hu Jia Long Gu Mu Li Tang
Da Chai Hu Tang
Da Qing Long Tang
Gan Cao Xie Xin Tang
Gui Zhi Fu Zi Tang
Gui Zhi Jia Long Gu Mu Li Tang
Gui Zhi Tang
Huang Lian Tang
Huang Lian Wen Dan Tang
Huo Xiang Zheng Qi Shui
Juan Bi Tang
Ping Wei San
Ren Shen Yang Rong Tang
Shi Pi Yin
Si Shen Wan
Tong Qiao Huo Xue Tang
Wen Dan Tang
Wu Zhu Yu Tang
Xiao Chai Hu Tang
Xiao Jian Zhong Tang
Xuan Fu Dai Zhe Tang
Zai Zao San
Zhi Gan Cao Tang

Cautions:


Generally Safe.
1. Should not be used to excess or it may cause clumping and obstruction.
2. Not used in Heat conditions (unless corrected).

Main Preparations used:




This is the Jujube of Arabic and Persian works on Materia Medica, and is largely imported in a dry state both from the Persian Gulf and China. Mir Mohammad Husain describes it as ” the fruit of a well-known tree of nearly the same size as the kunar and olive, but having leaves a little thicker and longer than those of the kunar, with one side downy. The bark, wood and fruit of the tree are red. The best fruit comes from Jurjan, China and Nipal; it should be sweet and moderately astringent, about the size of a dried date and with a small stone.” He gives a long account of the medicinal virtues of the Jujube, from which we gather that he regards it as a suppurative, expectorant, and purifier of the blood ;its uses would appear to be in many respects similar to those of dried prunes or raisins with us. Pliny, 15, 14, mentions Zizyphus as an exotic fruit coming from Syria, more like a berry than an apple. Sibthorp informs us that it is called in modern Greek nakiovpi, and is probably the nakiovpos of Dioscorides. The French prepare a Pate de jujubes by extracting 5 parts of jujubes in sufficient water to obtain 35 parts of infusion, in which are dissolved gum Arabic 30 parts and sugar 20 parts; the solution is evaporated, two parts of orange flower water added, kept slowly boiling for twelve hours, and then poured into moulds. The bark of the tree is used
to clean wounds and sores, the gum in certain affections of the eyes, and the leaves when chewed are said to destroy the power of the tongue to appreciate the taste of disagreeable medicines. In Western India we have several cultivated varieties of Jujube, which afford edible fruit, as well as a wild variety ; their bark is powerfully astringent, and a kind of lac, known as Bhuri lak, is found upon the branches. The fruit of Zizyphns Jujuba is dried and powdered; this powder is called in Hindi Ber-chuni. The young leaves are pounded with those of Ficus glomerata, and applied to scorpion stings in the Coucan; they are also with acacia catechu leaves given as a cooling medicine in hot weather; dose 2 tolas. According to Ainslie, the root is prescribed in decoction by the Vytians in conjunction with sundry warm seeds, as a drink in certain cases of fever. The white pear-shaped fruit of Z. rugosa (Turun, Bomb.), is eaten by the natives. The fruit of Z. xylopyra (Guti, Bomb.), is used by shoemakers for blackening leather and for making blacking. The flowers of Z. rugosa, with an equal quantity of the petioles of the Betel leaf and half as much lime, are given in 4 grain pills twice a day for menorrhagia’. (Vegetable Materia Medica of Western India, Dymock, 1885)
GENERAL / REVIEW
Physicochemical and antioxidant activity of fruit harvested from eight jujube (Ziziphus jujuba Mill.) cultivars at different development stages.
Multiple biological effects of secondary metabolites of Ziziphus jujuba: isolation and mechanistic insights through in vitro and in silico studies.
Composition and content of phenolic acids and flavonoids among the different varieties, development stages, and tissues of Chinese Jujube (Ziziphus jujuba Mill.).
Research advances in bioactive components and health benefits of jujube (Ziziphus jujuba Mill.) fruit.
A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence.
Therapeutic Effects of Ziziphus jujuba Mill. Fruit in Traditional and Modern Medicine: A Review.
Comparison of volatile compositions of 15 different varieties of Chinese jujube (Ziziphus jujuba Mill.).
A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection.
Isolation, structures and bioactivities of the polysaccharides from jujube fruit (Ziziphus jujuba Mill.): A review.
Experimental and Clinical Pharmacology of Ziziphus jujuba Mills.

COMBINATIONS
New insight into the joint significance of dietary jujube polysaccharides and 6-gingerol in antioxidant and antitumor activities.
Licorice (Glycyrrhiza spp.) and jujube (Ziziphus jujuba Mill.) formula for menopausal symptoms: Classical records, clinical evidence and experimental data.

ANTIBACTERIAL
Antioxidant, antimicrobial, and cytotoxic activities of extracts from the seed and pulp of Jujube (Ziziphus jujuba) grown in Iran.
In Vivo Anti-Inflammatory, Anti-Bacterial and Anti-Diarrhoeal Activity of Ziziphus Jujuba Fruit Extract.

ANTI-INFLAMMATORY
Anti-inflammatory and cytotoxic activities of constituents isolated from the fruits of Ziziphus jujuba var. inermis Rehder.
In Vivo Anti-Inflammatory, Anti-Bacterial and Anti-Diarrhoeal Activity of Ziziphus Jujuba Fruit Extract.

ANTIOXIDANT
New insight into the joint significance of dietary jujube polysaccharides and 6-gingerol in antioxidant and antitumor activities.
Structural characterization and antioxidant activities of one neutral polysaccharide and three acid polysaccharides from Ziziphus jujuba cv. Hamidazao: A comparison.
Antioxidant, antimicrobial, and cytotoxic activities of extracts from the seed and pulp of Jujube (Ziziphus jujuba) grown in Iran.
Comparison of structural characterization and antioxidant activity of polysaccharides from jujube (Ziziphus jujuba Mill.) fruit.
Systematic evaluation of antioxidant capacities of the ethanolic extract of different tissues of jujube (Ziziphus jujuba Mill.) from China.

ANEMIA
A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence.

HYPERTENSION
Effect of Aqueous and Ethyl Acetate Fractions of Ziziphus jujuba Mill Extract on Cardiovascular Responses in Hypertensive Rats.
Ethyl Acetate and Aqueous Fractions of Ziziphus jujuba Prevent Acute Hypertension Induced by Angiotensin II in Rats.
Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats.

HEPATOPROTECTIVE
Jujube (Ziziphus jujuba Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation.
Protective Effect of Flavonoids from Ziziphus jujuba cv. Jinsixiaozao against Acetaminophen-Induced Liver Injury by Inhibiting Oxidative Stress and Inflammation in Mice.
Protective Effect of Bioactivity Guided Fractions of Ziziphus jujuba Mill. Root Bark against Hepatic Injury and Chronic Inflammation via Inhibiting Inflammatory Markers and Oxidative Stress.
Characterization and hepatoprotective effect of polysaccharides from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou sarcocarp.

APPETITE REGULATION
Mechanism of Jujube (Ziziphus jujuba Mill.) Fruit in the Appetite Regulation Based on Network Pharmacology and Molecular Docking Method.

ANTI-DIARRHEA
In Vivo Anti-Inflammatory, Anti-Bacterial and Anti-Diarrhoeal Activity of Ziziphus Jujuba Fruit Extract.

CHRONIC CONSTIPATION
Ziziphus jujuba extract for the treatment of chronic idiopathic constipation: a controlled clinical trial.
INTESTINAL FLORA
Elucidation of the Reinforcing Spleen Effect of Jujube Fruits Based on Metabolomics and Intestinal Flora Analysis.
Metagenomic analysis of gut microbiota modulatory effects of jujube (Ziziphus jujuba Mill.) polysaccharides in a colorectal cancer mouse model.

NEUROPROTECTIVE
Antiamnesic and Neuroprotective Effects of an Aqueous Extract of Ziziphus jujuba Mill. (Rhamnaceae) on Scopolamine-Induced Cognitive Impairments in Rats.
Ziziphus jujuba (Rhamnaceae) Alleviates Working Memory Impairment and Restores Neurochemical Alterations in the Prefrontal Cortex of D-Galactose-Treated Rats.
A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection.

COGNITIVE IMPAIRMENT
Antiamnesic and Neuroprotective Effects of an Aqueous Extract of Ziziphus jujuba Mill. (Rhamnaceae) on Scopolamine-Induced Cognitive Impairments in Rats.

ALZHEIMER’S DISEASE
Effects of the fermented Zizyphus jujuba in the amyloid β25-35-induced Alzheimer’s disease mouse model.
Antioxidant and cholinesterase inhibitory activity of a new peptide from Ziziphus jujuba fruits.

ANTIAMNESIA EFFECT
Ziziphus jujuba (Rhamnaceae) Alleviates Working Memory Impairment and Restores Neurochemical Alterations in the Prefrontal Cortex of D-Galactose-Treated Rats.

INSOMNIA
Traditional Herbal Medicine for Insomnia in Patients With Cancer: A Systematic Review and Meta-Analysis.

ANTI-AGEING
Jujube (Ziziphus Jujuba Mill.) fruit feeding extends lifespan and increases tolerance to environmental stresses by regulating aging-associated gene expression in Drosophila.

MENOPAUSE
Licorice (Glycyrrhiza spp.) and jujube (Ziziphus jujuba Mill.) formula for menopausal symptoms: Classical records, clinical evidence and experimental data.

DIABETES
Ethnobotanical Survey of Medicinal Plants Used by Traditional Healers to Treat Diabetes in the Taza Region of Morocco.

TUMOR
New insight into the joint significance of dietary jujube polysaccharides and 6-gingerol in antioxidant and antitumor activities.

CANCER
Ziziphus jujuba”: A red fruit with promising anticancer activities
Flavonoid Glycosides from Ziziphus jujuba var. inermis (Bunge) Rehder Seeds Inhibit α-Melanocyte-Stimulating Hormone-Mediated Melanogenesis.
Metagenomic analysis of gut microbiota modulatory effects of jujube (Ziziphus jujuba Mill.) polysaccharides in a colorectal cancer mouse model.
Dietary Ziziphus jujuba Fruit Attenuates Colitis-Associated Tumorigenesis: A Pivotal Role of the NF-κB/IL-6/JAK1/STAT3 Pathway.
Triterpenoids from Ziziphus jujuba induce apoptotic cell death in human cancer cells through mitochondrial reactive oxygen species production.
Dietary Ziziphus jujuba Fruit Influence on Aberrant Crypt Formation and Blood Cells in Colitis-Associated Colorectal Cancer in Mice

CHEMOTHERAPY TOXICITY
Antioxidant and Anti-Inflammatory Effects of 3-Dehydroxyceanothetric Acid 2-Methyl Ester Isolated from Ziziphus jujuba Mill. against Cisplatin-Induced Kidney Epithelial Cell Death.
A standardized extract of Ziziphus jujuba Mill protects against adriamycin-induced liver, heart, and brain toxicity: An oxidative stress and biochemical approach.
The testicular protective effects of standardised hydroalcoholic extract of Ziziphus jujuba Mill against adriamycin-induced toxicity.

COSMETIC
Brightening effect of Ziziphus jujuba (jujube) fruit extract on facial skin: A randomized, double-blind, clinical study.
Ethnobotanical Survey on Skin Whitening Prescriptions of Traditional Chinese Medicine in Taiwan.
Isolation and Purification of Glucans from an Italian Cultivar of Ziziphus jujuba Mill. and In Vitro Effect on Skin Repair.