Zedoaria, Zedoary, E Zhu 莪术

E Zhu (TCM)
Karchura (Ayurveda)
Kachuri, Zaranbad (Unani)
Picture Picture
Picture Medizinal-Pflanzen, Köhler, 1897

Picture Long and Round Zedoary
Museum Museorum, Valentini, 1704
Picture Long and Round Zedoary
Parkinson, Theatrum Botanicum, 1640

Picture ZEDOARY
1, Large transverse section of the rhizome. 2. Longitudinal section of the rhizome. 3. Top of the rhizome
showing concentric leaf scars. 4. Cross-section showing sunken tissue inside endodermis.
5. Projecting woody conducting strands. 6. Wrinkled outer surface of the rhizome.
(
Squibb’s Atlas of the Official Drugs, Mansfield, 1919)

Botanical name:


Curcuma spp.
  1. C. zedoaria
  2. C. aromatica is the Round Zedoary (syn. Kaempferia rotunda, Zedoaria rotunda)
  3. C. phaeocaulis

Parts used:


Root
Round and Long Zedoary have the same functions and uses: ‘Round Zedoary agrees exactly with the former [Long Zedoary] in Substance, Weight, Solidity, Taste, and Smell; differing from it only in Figure, which is bulbous or globular’. (A Treatise on Foreign Drugs, Geoffroy and Thicknesse, 1749)

Temperature & Taste:


Warm, dry. Bitter, pungent
“Hot and Dry in the Third degree”. (Avicenna)

Classifications:


2A APERIENT.    2D ATTENUATERS OF CONGEALED BLOOD
3C. ALEXIPHARMIC.    3D. CORDIALS & CARDIACS.    3G. EMMENAGOGUE
4c. CARDIAC.    4e. STOMACHIC

Uses:


1. Moves the Blood, Promotes Menstruation, Eases Pain:
-Dysmenorrhea, Amenorrhea.
-abdominal pain from masses associated with congealed or stagnant blood, and for Hysteria.
-paste made with Alum and Zedoary is applied to bruises and sprains.
-Vinegar-prepared root is preferred to move the blood in TCM.
-used for weakness following Childbirth

2. Moves the Qi, Opens Obstructions:
-chest and abdominal pain from food stagnation, or sluggish digestion
-colic, griping, dyspepsia, as well as vomiting and fluxes.
-good for stinking Breath.
-“Zedoary is an Exhilarant and a Cardiac tonic”. (Avicenna)
-a corrector of purgatives etc. (Unprepared Root)

3. Moves the Blood, Resolves Masses:
-recognised as an important medicine for Tumors and Cancer in TCM, including Cancers of the Uterus, Lung, and Liver
Gerard also lists it for ‘abscesses of the Womb’.
-Black Spots on the body (Ayurveda)
-in modern China, it is used to resolve Hematomas.

4. Resists Poison:
-bites of venomous beasts, as well as ‘the Plague and all Malignant Diseases’ (Salmon)
-Cholera in Ayurveda and for Dysentery from damp heat in TCM.
-regularly used in Antidotes

5. Clears Phlegm, Stops Cough:
-‘Cleanses the Lungs’ (Salmon)
-the Extract or Distilled Oil from the root was used as a Pectoral, and given for Coughs and Asthma

6. Externally:
-In India it is highly esteemed for application to fresh Wounds.
-mixed with Alum and made into a paste, it is applied to Bruises.


Dose:


1. The prepared root is given in the same doses as the unprepared.
2. To move the Blood, it is best Prepared with Wine, or Decocted in Wine, or prepared as a Tincture
DECOCTION: 3–9 grams, up to 20 grams daily in severe cases;
TINCTURE: 1–3, or 5 mls, 2–3 times daily;
POWDER: 300mg–2 grams, with wine

Preparation:


1. The Unprepared root is best for food stagnation, and to move the Qi.
2. Vinegar Stir-fried Zedoary: this is stronger to move the blood, clear blood stasis and ease pain. It is especially used for abdominal masses and amenorrhea.
3. ‘The drug is torrified for diseases of the Liver Channel, simmered for diseases of the Heart-Spleen Channel and roasted with Goat or Chicken Blood for regulating menstruation with Si Wu Tang’. (Origin of Canon, TCM)

Correctives:


Orange juice (as a vehicle) (Unani)

Substitute:


1. Tumeric
2. Some claimed Zedoary and Zerumbet came from the same plant, the former being the long part of the root, the latter, the round part. In any case, Zedoary may replace Zerumbet.
3. Doronicum (Avicenna)

Main Combinations:


1. To promote Sweat, Zedoary with Angelica, Calamus, Ginger, Cinnamon, Pepper, Sarsaparilla, Aloe, Mastic, Myrrh, Frankincense, Camphor (as in the Sweating Tincture of Paracelsus)
2. Preservative against infection during Epidemics:
i. Zedoary with Aloe, Rhubarb, Saffron, Myrrh, Gentian (as in Pills for Pestilence)
ii. Zedoary with Angelica, Burnet, Rue, Turbith, Juniper berry, Bay berry, infused in Vinegar and distilled.
3. Fever, Coughs and Colds, Zedoary with Black Pepper, Cinnamon and Honey (Ayurveda)
4. Nausea and Vomiting:
i. Zedoary with Ginger
ii. powdered Zedoary is made into pills with Rose water (Unani)
5. To strengthen the Head, Stomach and Heart when affected by Cold:
i. Zedoary with Calamus, Cinnamon
ii. Zedoary with Cinnamon, Clove Nutmeg, Ginger
6. Strengthen the Stomach, benefit Digestion, relieve Wind and pain:
i. Zedoary with Citrus Qing Pi (Green Tangerine Peel) and Areca Bing Lang (Betel Nut) (as in E Zhu Wan [Zedoary Pill] from Zheng Zhi Zhun Sheng [The Level-line of Patterns & Treatment]).
ii. Zedoary, Calamus, Galangal, Angelica, Cinnamon (1 dram each), Clove (½ scruple), mixed into Sugar of Roses (6 drams). (A Treatise on Foreign Drugs, Geoffroy and Thicknesse, 1749)
7. Loss of Appetite, Zedoary with Cinnamon, Aniseed, Cyperus, Mint, Calamint (as in Powder for Loss of Appetite Greater)
8. Obesity, Zedoary with Tartar, Fennel, Cumin, Garlic (as in Powder Against Obesity)
9. To benefit Memory, increase Circulation, Dizziness, diseases of the Heart and for all Swellings, Zedoary with Senna, Cumin, Parsley, Ginger, Clove, Nutmeg, Calamus, Galangal, Sage, Rue, Valerian (as in Special Powder for Memory)
10. Amenorrhea, Hysteria:
i. Zedoary with Valerian
ii. Zedoary with Dang Gui, Cyperus rotundus
11. Endometriosis, Zedoary with Salvia Dan Shen. This has been studied and found to have 95% effective rate (see research below)
12. Postpartum Fever, Zedoary with Ginger, Picrorhiza, Cyperus rotundus, Fumitory (Ayurveda)
13. Intestinal Polyps, Zedoary with White Dead Silkworm (Jiang Can). (Chen & Chen)
14. Abdominal masses, Zedoary with Sparganus San Leng, Dang Gui, Cyperus rotundus (Xiang Fu) (as in E Zhu San [Zedoary Powder] from Shou Shi Bao Yuan [Protection of Vital Energy for Longevity]).
15. Paralysis, Zedoary with Galangal, Scorzonera, Aloeswood, Clove, Juniper berry, Cinnamon, Sage, Rosemary (as in Elixir Against Palsy)
16. To promote Happiness and resist Melancholy, Zedoary with Clove Basil, Saffron, Galangal, Sandalwood, Clove, Storax, Aniseed, Thyme, Dodder, Pearl (as in Powder of Happiness)
17. Schizophrenia or Mania with excess Yang and Blood stagnation, Zedoary (10 parts), Paeonia rubra Chi Shao Yao, Rhubarb (Da Huang) (3 parts each). These were formed into pills and had a 59% success rate in a clinical trial. (Chen & Chen)
18. Cold Phlegm of the Lungs, Zedoary with Orris (A Treatise on Foreign Drugs, Geoffroy and Thicknesse, 1749)
19. Chronic Obstructive Pulmonary Disease (COPD), Zedoary, Stephania tetandra Fang Ji, Vervain (Ma Bian Cao). Other herbs were added for underlying deficiency. This was used in a clinical trial, with 16 of 37 patients having marked benefit, 16 having moderate effect, and 5 having no effect. (Chen & Chen)

Major Formulas:


Secret Potion for Heart Debility
New Rose Powder (Rosata Novella) (Nicolas)
Aromatic Clove Powder (Aromaticum Caryophyllatum) (Mesue)
Powder Against Obesity
Powder for Loss of Appetite Greater
Powder for Uterine Pain (Wirtzung)
Powder of Musk Sweet (Diamoschu Dulce) (Mesue)
Powder of Happiness (Letificans)
Special Powder for Memory
Triphera Greater (Nicholas)
Pills for Pestilence
Pestilential Pills of Basil
Elixir Vitae (Tincture of Life)

Hu Po San (Amber Powder)
Mu Xiang Bing Lang Wan
Mu Xiang Liu Qi Yin

1. Compound Tincture of Zedoary:
i. Zedoary (1 oz.), Carline Thistle, Galangal (½ oz. each), Orange peel, Caraway, Camomile, Clove, Bay berry, Calamus (1 ½ drams each), Mace (1 dram), Spirit of Lemon peel (2 lbs.), Nitric acid (½ oz.) (Dispensatorium medico pharmaceuticum Palatinatus, 1764)
ii. Zedoary (4 oz.), Carline Thistle, Calamus, Galangal (2 oz. each), Camomile, Aniseed, Caraway seed (1 oz. each), Clove, Bay berry (6 drams each). Mace (½ oz.), Orange peel (1 oz.), Spirit of Lemon peel (4 ½ lbs.), Spirit of Nitric Ether (2 ½ oz.). Infuse 6 days, express, filter. (Dispensatorium Pharmaceuticum, 1777)

Cautions:


Not used during Pregnancy

Toxicity:


The LD50 orally in mice is 147 g/kg.

Drug Interaction:
Use with caution in patients taking anticoagulants (such as Warfarin) or antiplatelet medication (such as aspirin). There have been no reports of interaction but the possibility exists.

Main Preparations used:


Candied Zedoary (as Ginger), Confection of Zedoary, Extract, Distilled Oil

From Pharmacographia Indica, Dymock, 1893
This plant is the Sati and Krachura of Sanskrit writers, and the Zerumbad and Uruk-el-kdfur, “camphor root,” of the Arabians. It is noticed by the later Greek physicians under the name [?], a corruption of the Arabic name, which, in the Middle Ages, was variously written as Zeruban, Zerumber, and Zerumbet. It is not the [?] of Aetius (A. D. 540— 550) or the [?] of Myrepsus, or the Zedoar of Macer Floridus (A.D. 1140). Barbosa (1516) speaks of Zedoaria and Zeruban as distinct articles of trade at Cannanore, so that it must have been some time after this date that Zerumbet came into use in Europe as a cheap substitute for the Zedoar of the earlier physicians, which, we have no doubt, was the same drug as the Jadwar of the Arabians. This name, correctly written by Aetius, is the Zhedwar of the ancient Persians, and is described in the Burhan (A. D. 1046) as a drug used as an antidote to poisons, the same as the Jadwar of the Arabians, and also called Mahparvin. Ibn Sina of Bokhara, who lived about the same time (980— 1037), describes Jadwar shortly in the following words:– “it has the form of the root of Aristolochia, but is smaller.” Haji-Zein-el-attar, the well-known Persian physician and apothecary, and the author of the “Ikhtiarat” (A. D. 1368), describes Jadwar as a root about the size and shape of the Indian Cyperus root, but harder and heavier, and the same as the Indian drug Nirbisi, the best internally of a purplish tint. He states that there are, as far as his experience goes, four drugs sold as Jadwar, viz., a white kind, a purplish, a black and a yellow ; the people of Cathay call the yellow kind Kurti and the purplish Burbi, the other two kinds come from India. As to the locality in which the drug is collected, he states that there is a mountain called Farajal between India and Cathay, where the plant grows along with the aconite, and that the latter, whenever it grows near the Jadwar, loses its poisonous properties and is eaten with impunity by the inhabitants. Where the Jadwar does not grow, the aconite (Bish) is a deadly poison, and is called Halahal by the natives (Halahala, Sanskrit). In the Dict. Econ. Prod, of India (ii.,p. 656), the following interesting account of certain drugs collected in Nepal by Dr. Gimlette, the Residency Surgeon, substantially confirms Haji-Zein’s description of Jadwar or Nirbisi :— According to Dr. Gimlette, “the Kala bikh of the Nepalese (the Dulingi of the Bhoteas) is a very poisonous form of Aconitum ferox, so poisonous, indeed, that the Katmandu druggists will not admit they possess any. Pahlo (yellow) bikh is a less poisonous form of the same plant, known to the Bhoteas as Holingi, while Setho (white) bikh (the Nirbisi sen of the Bhoteas) is A. Napellus, and Atis is Aconitum heterophyllum. The aconite adulterants or plants used for similar purposes are, Cynanthm lobatus, the true Nirbisi of Nepal, the root of which is boiled in oil, thus forming a liniment which is employed in chronic rheumatism, Delphinium denudatum, the Nilo (blue or purplish) bikh of the Nepalese and the Nirbisi of the Bhoteas, Dr. Gimlette says, is used by the Baids of Nepal for the same purposes as the Setho and Pahlo bikh. Geranium collinum (var-Donianum) is the Ratho (red) bikh of the Nepalese, and the Nirbki-num of the Bhoteas, and, like the Setho bikh, is given as a tonic in dyspepsia, fevers, and asthma. Lastly,a plant never before recorded as used medicinally, namely, Caragana crassicaulis, is known as the Artiras of the Nepalese,
and the Kurti of the Bhoteas; it affords a root which is employed as a febrifuge.

The Jadwar or Nirbisi myth appears to have been invented in the East to account for the curious occurrence on the Himalayas of poisonous and non-poisonous aconites growing side by side (see Vol. I., pp. 1, 15, 18, 20).

It would appear also that the Curcumas have no claim to the name of zedoary, which was probably first given to them about the middle of the 16th century, as Clusius’s figure of Gedwar is certainly meant for the pendulous tuber of a Curcuma. The substitution of the cheaper for the more expensive article is rendered highly probable by the fact that Zerumbet was considered by the Arabians to be very little inferior to Jadwar as an antidote to poisons. Ibn Sina, Ibn Baitar, and Ibu Jazla in the Minhaj use almost the same words in speaking of these drugs; of Jadwar they say :— “it is an antidote for all poisons, even those of aconite and the viper”; and of Zerumbet —”it is most useful against the bites of venomous animals, and is almost equal to Jadwar.” Both drugs were considered to have properties similar to Darunaj (see Vol.II., p. 292). Ainslie (Mat. Ind., i, 492) remarks that C. Zedoaria is the Lampooyang of the Javanese, and the Lampuium of Rumphius (Herb. Amb, V., p. 148), and that it is a native of the East Indies, Cochin-Chiua, and Otaheite. He quotes Geoffrey’s description of the drug, which leaves no doubt as to its identity with the modern Kachora—”Foris cinerca, intus Candida; sapore acri-amaricante aromatico; odoro tenui fragrante, ac valde aromaticum suavitatem, cum tunditur aut manducatur, spirante et ad camphoram aliquatenus accedente.” Guibourt states that C. Zedoaria is the Zerumbet of Serapion, Pomet, and Lomery. The following is his description of it:— “The round zedoary is greyish-white externally heavy, compact, grey and often horny internally, having a bitter and strongly camphoraceous taste, like that of the long zedoary, which it also resembles in odour. The odour of both drugs is analogous with that of ginger, but weaker unless the rhizome be powdered, when it develops a powerful aromatic odour, similar to that of cardamoms.” (Hist. Nat.
6me-Ed., Vol. II., p.213.) In our opinion there is no doubt that G. Zedoaria is the source of the round and long zedoary of commerce. The plant is common in Bombay gardens, and was probably introduced by the Portuguese, whoso descendants and converts at the present day use the leaves in cookery, especially with fish. From Dr. Hove’s account of Bombay in 1787 it appears that Kachura and Turmeric were cultivated at that time in the cocoanut woods at Malum. The natives chew the root to correct a sticky taste in the mouth; it is also an ingredient in some of the strengthening conserves which are taken by women to remove weakness after child-birth. In colds it is given in decoction with long-pepper, cinnamon and honey, and the pounded root is applied as a paste to the body. Bheede says that the starch of the zedoary is much esteemed, and that the fresh root is considered to be cooling and diuretic, it checks leucorrheal and gonorrheal discharges and purifies the blood. The juice of the leaves is given in dropsy. One of us has had the plant in cultivation for some years; it blossoms in the hot weather just before the ruins, when the first leaves begin to appear.
GENERAL / REVIEW
Chemical Composition and Biological Activities of Essential Oils of Curcuma Species
Curcuma zedoaria Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties.

ANTIBACTERIAL
Antimicrobial activity and cytotoxicity of the essential oil of Curcuma zedoaria.
Antimicrobial activity of Curcuma zedoaria and Curcuma malabarica tubers.

ANTI-FUNGAL
Inhibition of human pathogenic fungi by members of Zingiberaceae used by the Kenyah (Indonesian Borneo).

ANTI-INFLAMMATORY
Evaluation of antinociceptive, in-vivo & in-vitro anti-inflammatory activity of ethanolic extract of Curcuma zedoaria rhizome
The Genus Curcuma and Inflammation: Overview of the Pharmacological Perspectives
Anti-inflammatory sesquiterpenes from Curcuma zedoaria.

ANTI-ALLERGY
Anti-allergic principles from Thai zedoary: structural requirements of curcuminoids for inhibition of degranulation and effect on the release of TNF-alpha and IL-4 in RBL-2H3 cells.

ANTI-OXIDANT
Antioxidant effect of aqueous extract of four plants with therapeutic potential on gynecological diseases; Semen persicae, Leonurus cardiaca, Hedyotis diffusa, and Curcuma zedoaria

ANALGESIC
Phytochemical analysis and analgesic properties of Curcuma zedoaria grown in Brazil.
Seasonal variation and analgesic properties of different parts from Curcuma zedoaria Roscoe (Zingiberaceae) grown in Brazil.

ATHEROSCLEROSIS
Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice

ANTI-PLATELET AGGREGATION
New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria
A Review of Antiplatelet Activity of Traditional Medicinal Herbs on Integrative Medicine Studies

HIGH CHOLESTEROL
Phytopreventive antihypercholesterolmic and antilipidemic perspectives of zedoary (Curcuma Zedoaria Roscoe.) herbal tea

HYPERTENSION
Effect of curcuma herbs on vasomotion and hemorheology in spontaneously hypertensive rat.

ARTHRITIS
Effect of Curcuma zedoaria Rosc root extracts on behavioral and radiology changes in arthritic rats

HEPATOPROTECTIVE
Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae Rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury
Hepatoprotective constituents from zedoariae rhizoma: absolute stereostructures of three new carabrane-type sesquiterpenes, curcumenolactones A, B, and C.
Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha.

HEPATIC FIBROSIS
[Experimental study on Rhizoma sparganii and Radices zedoariae treating hepatic fibrosis].
Zedoariae rhizoma and curcumin inhibits platelet-derived growth factor-induced proliferation of human hepatic myofibroblasts.
The inhibitory effect of a Korean herbal medicine, Zedoariae rhizoma, on growth of cultured human hepatic myofibroblast cells.

IMMUNOMODULATORY / IMMUNOSTIMULANT
Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review
Effects of polysaccharides from rhizomes of Curcuma zedoaria on macrophage functions.
ENDOMETRIOSIS
[Clinical and experimental study on the treatment of endometriosis with dan’e mixture].

COGNITION / LEARNING / MEMORY
Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat

CYTOTOXIC
Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria
A Quantum Chemical and Statistical Study of Cytotoxic Activity of Compounds Isolated from Curcuma zedoaria

ANTIMUTAGENIC
Antimutagenic activity of extracts from anticancer drugs in Chinese medicine.
Pivotal role of curcuminoids on the antimutagenic activity of Curcuma zedoaria extracts.

ANTI-TUMOR
[The antitumor activity of elemene is associated with apoptosis].
Antitumor, genotoxicity and anticlastogenic activities of polysaccharide from Curcuma zedoaria.
Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells.

ANTI-ANGIOGENESIS
Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo.

CANCER
Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells
In Vitro Morphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes of Curcuma zedoaria
BRAIN
[Experimental study on apoptosis induced by elemene in glioma cells]
BREAST
Extracts from Curcuma zedoaria Inhibit Proliferation of Human Breast Cancer Cell MDA-MB-231 In Vitro
CERVICAL
Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells
LUNG
Preliminary evaluation of the potential role of β-elemene in reversing erlotinib-resistant human NSCLC A549/ER cells
β-elemene reverses the drug resistance of A549/DDP lung cancer cells by activating intracellular redox system, decreasing mitochondrial membrane potential and P-glycoprotein expression, and inducing apoptosis
β-Elemene Restrains PTEN mRNA Degradation to Restrain the Growth of Lung Cancer Cells via METTL3-Mediated N6 Methyladenosine Modification
Elemene for the treatment of lung cancer.
WITHDRAWN: Elemene for the treatment of lung cancer.
Chemical constituents and anticancer activity of Curcuma zedoaria roscoe essential oil against non-small cell lung carcinoma cells in vitro and in vivo.
MELANOMA
Suppressive effect of Zedoariae rhizoma on pulmonary metastasis of B16 melanoma cells.
OVARIAN
Cytotoxic Activity from Curcuma zedoaria Through Mitochondrial Activation on Ovarian Cancer Cells
Cytotoxicity of curcuminoids and some novel compounds from Curcuma zedoaria.
Enhancement of cisplatin-induced apoptosis by β-elemene in resistant human ovarian cancer cells.

ANTI-METASTASIS
Antimetastasis Effect of Astragalus membranaceusCurcuma zedoaria via β-Catenin Mediated CXCR4 and EMT Signaling Pathway in HCT116

USED WITH CHEMOTHERAPY
Curcuma zedoaria petroleum ether extract reverses the resistance of triple-negative breast cancer to docetaxel via pregnane X receptor