Uterine Fibroids

Uterine Myoma, Leioma, Fibroma, Fibromyoma, Hysteromyoma
‘The immediate cause, is a thick earthy humor, as natural melancholy, when a thick humor is gathered in the womb, there is scirrhus without inflammation
aforegoing; this is usual in melancholy women, and such as are not cleansed by their terms, or have the Pica or Green sickness, and are fifty years old’
(Culpeper’s Directory for Midwives)

Uterine Fibroids are benign Uterine growths. They can be smaller than a pea up to larger than a grapefruit. They can be singular, often having several (2–4), and occasionally, multiple.

Uterine Fibroids are common, affecting around 20% of all menstruating women, being most common between the age of 35 and menopause. Often there is aggravation in the years before cessation of menstruation, followed by decline in symptoms and growth after menopause.


Cause
Pathophysiology is usually Damp/Melancholy with Qi and Blood Stasis. It may be caused after infection or chronic inflammation, Trauma or irritation. Retention of Menstruation was traditionally regarded to be a contributing factor.

In modern understanding, Hormones are recognised to have a major role, and emotions also have a pivotal role, these being the origin of Qi stagnation.

Fibroid growths are stimulated by Estrogen, but are also very sensitive to Progesterone. Another important factor is a hormone-like growth factor called bFGF which interacts with Estrogen and Progesterone to allow fibroids to grow. It becomes most active just after ovulation. It has long been recognised that Scirrhus (fibroid) tumors can occur as a result of chronic inflammation.


Symptoms
Small Fibroids usually have no symptoms. The most common presenting symptom is heavy menstrual bleeding which is seen in medium-to-large growths (over 2–3cm).

In larger tumors, a hard, painless mass may be palpated. Some women, even in advanced cases, may have no symptoms.


Treatment
Treatment aims to resolve Damp or Melancholy, move Qi and Blood and resolve Tumors.

Herbal medicine may help resolve small to medium growths (less than 3cm), and may help stop growth or reduce the size of larger growths.

Purging is generally indicated unless weak, then Bloodletting is often used.

See also
Tumors
Polcystic Ovary Syndrome

Western Tradition

Chinese Classification
Simples
Simples
Rue
Dodder
Fenugreek
Bitter Almond
Rhubarb
Zedoary
Bdellium
Agaric
Black Nightshade
Agnus Castus
Fumitory
Pennyroyal
Saffron (Safflower)
Madder
Turmeric
Myrrh
Turpeth
Pill Millipedes

Citrus Qing Pi
Costus Mu Xiang
Paeonia Mu Dan Pi
Zedoary (E Zhu)
Turmeric (Jiang Huang)
Peach kernel (Tao Ren)
Tripterygium Lei Gong teng

Citrus Zhi Ke
Cyperus Xiang Fu
Poria Fu Ling
Sparganium San Leng
Scutellaria Ban Zhi Lian
Safflower Hong Hua
Eupolyphaga Tu Bie Chong
Strong Medicines to ‘Break’ Tumors:
Prepared Arum root
Cyclamen root
Pill Millipedes
Arisaema Tian Nan Xing
Tripterygium Lei Gong teng


1. Turmeric:  “The size, volume, and proliferative activity of UF were significantly reduced when patients took 1.2 g of curcumin orally every day for 6 months, with no adverse effects observed” (see here)

Sample Combinations

1. Broom with Rue
2. Figs and Fenugreek are boiled in Barley broth.
3. Rhubarb, Madder, Bitter Almond, Saffron
4. Decoct Paul’s Betony with Agrimony, Fumitory and Dodder, and take with Confectio Hamech
5. Madder with Round Birthwort, Agaric, Cinnamon (as in Pills of Madder)
6. Madder with Round Birthwort, Savin, Cretan Dittany, Myrrh (as in Powder of Myrrh)
7. Myrrh with Lacca, Saffron, Costus, Madder, Licorice, Black Pepper, Rhubarb
8. Bauhinia with Myrrh, Turmeric, Saraca (Ayurveda)
9. Frankincense, Asparagus racemosus, Rose, Safflower (Ayurveda)
10. Costus, Cyperus rotundus, Madder, Agaric, Saffron
11. Citrus Zhi Ke, Citrus Qing Pi, Costus, Cyperus rotundus, Fennel, Clove (as in Xiao Leng Wan from TCM)
12. Citrus Chen Pi, Costus, Zedoary, Cyperus rotundus, Pinellia Ban Xia, Poria Fu Ling, Ginger, Atractylodes Bai Zhu, Licorice (as in Kaiyu Erchen Tang)
13. Zedoary, Sparganium, Dang Gui, Persica Tao Ren, Cyperus rotundus, Prunella Xia Ku Cao, Dipsacus Xu Duan, Laminaria (as in Gong Zheng Tang from An Illustrated Guide to Antineoplastic Chinese Herbal Medicine, 1990)
14. Black Cohosh, Blue Cohosh, Agnus Castus, Dioscorea villosa, Dandelion
15. Fomentation, White Lily with Marshmallow, Violet, Mugwort, Linseed and Fenugreek
16. Boil Oregano in wine, strain and mix with Olive oil, apply linen cloths and apply warm over the Uterus.

Formulas

General Formulas
Tincture of Pill Millipedes
Syrup of Mugwort
Antimoron (Nicholas)
Troches of Myrrh (Rhasis)
Pills for Uterine Fibroids
Plaster for Hard Tumors of the Uterus
Plaster for Uterine Fibroids (Wirtzung)
Plaster for Uterine Tumors (Aristotle)

Antelope Horn 14 (Rgya ru bcu bzhi) (Tibetan)
Caragana 6 Decoction (Mdzo mo drug thang)
Costus 13 (Ru rta bcu gsum) (Tibetan)
Greater Universal Women’s Disease Conqueror (Tibet)
Podophyllum 25 (‘Ol se nyer lnga) (Tibetan)
Withania 3 Decoction (Ba spru gsum thang)
Blood Breaking 8 (Khrag bshig brgyad pa) (Tibetan)  


Qi Stagnation
Syrup of Mugwort
Costus 13 (Ru rta bcu gsum) (Tibetan)


Phlegm and Damp
Tincture of Pill Millipedes
Decoction of Dodder of Thyme (Rhasis)
Decoction of Dodder of Thyme (Mesue)
Pills of Rhubarb (Greater) (Pil. de Raved Sceni) (Mesue)
Pills for Uterine Fibroids
Plaster for Hard Tumors of the Uterus
Plaster for Uterine Tumors (Aristotle)

Caragana 6 Decoction (Mdzo mo drug thang)
Greater Universal Women’s Disease Conqueror (Mo nad spyi ‘joms chen mo) (Tibetan)
Podophyllum 25 (‘Ol se nyer lnga) (Tibetan)
Rolled Turquoise 13 (Gyu dril 13) (Tibetan)


Blood Stagnation
Tincture of Pill Millipedes
Emmenagogue Syrup
Powder of Gum Lacca Lesser (Dialacca Minor) (Rhasis)
Powder of Gum Lacca Lesser (Dialacca Minor) (Mesue)
Powder of Gum Lacca Greater (Dialacca Majores) (Mes)
Troches of Myrrh (Rhasis)
Plaster for Hard Tumors of the Uterus
Plaster for Uterine Tumors (Aristotle)

Antelope Horn 14 (Rgya ru bcu bzhi) (Tibetan) 
Podophyllum 25 (‘Ol se nyer lnga) (Tibetan)
Blood Breaking 8 (Khrag bshig brgyad pa) (Tibetan)  


To Purge Melancholy
Decoction of Dodder of Thyme (Rhasis)
Decoction of Dodder of Thyme (Mesue)
Syrup of Fumitory Lesser (Mesue)
Pills of Azurite (Mesue)
Pills of Lapis Lazuli-1 (Mesue)
Pills for Uterine Fibroids
Indian Pills
Arabian Confect Purging Melancholy (Confectio Hamech)
Triphera Persica (Mesue)


Topically
Plaster for Hard Tumors of the Uterus
Plaster for Uterine Fibroids (Wirtzung)
Plaster for Uterine Tumors (Aristotle)

Formulas

Qi Stagnation
Distention in the chest, epigastric and hypochondric regions; Hyper-emotional, depression; pulse is tight
Dan Zhi Xiao Yao San
Chai Hu Shu Gan San
Mu Xiang Shun Qi Wan


Phlegm and Damp
Abdominal pain, heavyness, poor appetite, thick tongue coating, slippery pulse
Liu Jun Zi Tang
Xiang Sha Liu Jun Zi Tang
Liu Me Tang


Blood Stagnation
Fixed pain, dark or cyanotic tongue, nail bed, dull complexion, tight or choppy pulse. Initial stages are less severe, pain may come and go and the fibroids are smaller and soft. Later stages the pain in constant, mass is hard with symptoms being more pronounced.
Gui Zhi Fu Ling Wan
Hu Po San
Tao Hong Si Wu Tang
Ge Xia Zhu Yu Tang
Shao Fu Zhu Yu Tang
Sheng Hua Tang
Huo Luo Xiao Ling Dan
Da Huang Zhe Chong Wan
Tao He Cheng Qi Tang
Di Dang Tang


Qi Deficiency with Blood Stagnation
Chronic cases have more severe blood stasis along with both Qi stagnation and Qi deficiency. There is fatigue, discomfort when overly active with a heavy, dragging sensation.
Liu Jun Zi Tang + Shao Fu Zhu Yu Tang
Or
Xiang Sha Liu Jun Zi Tang + Shao Fu Zhu Yu Tang

Special Formula

1. GUI ZHI FU LING WAN
    Cinnamon twig Gui Zhi
    Poria Fu Ling
    Peach kernel (Tao Ren)
    Paeonia Bai Shao
    Paeonia Mu Dan Pi
This formula was sown to relieve excess Bleeding and Dysmenorrhea in 90% of patients, and reduced Uterine Fibroid size in approximately 60% of cases. (see here)

2. SAN LENG E ZHU TANG
    Sparganium San Leng       9 grams
    Curcuma E Zhu                   9 grams
When both of these herbs are used together in the treatment of UF, the uterine mass was found to be decreased significantly with a significantly lowered progesterone and estradiol level”. (see here)

3. LI CHONG TANG
    Astragalus Huang Qi         9 grams
    Codonopsis Dang Shen    6 grams
    Atractylodes Bai Zhu        6 grams
    Dioscorea Shan Yao          15 grams
    Trichosanthes root             12 grams
    Anemarrhena Zhi Mu        12 grams
    Sparganium San Leng       9 grams
    Curcuma E Zhu                   9 grams
    Chicken Gizzard Ji Nei Jin 9 grams

4. A FORMULA OF DR. SHEN:
    Dang Gui                              6 grams
    Salvia Dan Shen                 6 grams
    Corydalis Yan Hu Suo       9 grams
    Rehmannia Shu Di             6 grams
    Mugwort (Ai Ye)                  3 grams
    Zedoary (E Zhu)                 2.4 grams
    Paeonia Bai Shao               6 grams
    Dodder seed (Tu Si Zi)       9 grams
    Ligustrum Nu Zhen Zi       9 grams
Decoct. (The Formulas of Dr. John H.F. Shen)

5. PILLS FOR UTERINE FIBROID
    Soft-Shelled Turtle
      Shell (Bie Jia)                    30 grams
    Vinegar-fried Rhubarb      15 grams
    Amber                                   5 grams

6. DECOCTION
    Hedyotis Bai Hua She She Cao
    Scutellaria Ban Zhi Lian
    Cremastra Shan Ci Gu
    Curcuma Yu Jin
    Salvia Dan Shen
    Angelica Dang Gui
    Ligusticum Chuan Xiong
    Paeonia Bai Shao
    Licorice (Gan Cao)


Many practitioners treat the condition with different formulas during different times of the cycle: Here is one example:
a. During Menstruation:
    Codonopsis Dang Shen
    Atractylodes Bai Zhu
    Astragalus Huang Qi
    Polygonum He Shou Wu
    Oyster shell (Mu Li)
    Leonurus Yi Mu Cao
    Litchi seed Li Zhi He
    Madder (Qian Cao)
b. During the non-menstruation period:
    Atractylodes Bai Zhu
    Oyster shell (Mu Li)
    Turtle shell (Bie Jia)
    Litchi seed Li Zhi He
    Fritillaria Zhe Bei Mu
    Sparganium San Leng
    Zedoary (E Zhu)
    Citrus Qing Pi

AYURVEDIC TREATMENT
A combination of Three formulas has been successfully used to treat Uterine Fibroids in Ayurveda: (see here)

KANCHANAR GUGGULU
    Bdellium (Guggulu)
    Bauhinia (Kanchanar)
    Triphala (3 Fruits)
    Trikatu (3 pungents)
    Crataeva (Varuna)
    Cardamon (Ela)
    Cinnamon (Tvak)
    Indian leaf (Tamalpatra)
500mg twice daily.

SHIGRU GUGGULU
    Bdellium (Guggulu)
    Moringa (Shigru)
    Salvadora (Pilu)
    Cinnabar (Ras Sindur)
500mg twice daily.

HARIDRA KAND
    Turmeric (Haridra)
    Triphala (3 Fruits)
    Trikatu (3 Pungents)
    Turbith (Nishoth)
    Cyperus (Nagarmotha)
    Picrorrhiza (Kutki)
    Plumbago (Chitraka)
    Cardamon (Ela)
    Cinnamon (Tvak)
    Cumin (Jirak)
    Coriander (Dhanyaka)
    Trachyospermum (Ajamoda)
    Sugar
    Iron Bhasma
    Mica Bhasma (Abhrak)
3 grams twice daily.
   



Research:

1. Herbal preparations for uterine fibroids (Review)
2. Chinese herbal medicine Guizhi Fuling Formula for treatment of uterine fibroids: a systematic review of randomised clinical trials.
3. Pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas.
4. Effect of Unani treatment in Sala’ al-Rahim (Leiomyomata): A case report
5. Evidence-Based Management of Uterine Fibroids With Botanical Drugs-A Review
6. Prescription patterns of Chinese herbal products for patients with uterine fibroid in Taiwan: A nationwide population-based study.
7. Ayurvedic intervention in the management of uterine fibroids: A Case series
8. Acupuncture for uterine fibroids.