Trigonella, Fenugreek, Hu Lu Ba 葫芦巴

Foenum Graecum
Hu Lu Ba (TCM)
Hulba (Unani)
Methi (Ayurveda)
Venthayam (Siddha)
Picture Picture
Picture Ortus Sanitatis, Meydenbach, 1491

Picture Picture
Dioscorides Materia Medica, Mathias, 1563

Medical Botany, Woodville, Hooker, Vol. 3, 1832


Botanical name:


Trigonella foenum-graecum

Parts used:


Seed

Temperature & Taste:


Warm, dry. Bitter, Pungent
“Hot in the last phase of the First degree and Dry in the First degree”. (Avicenna)

Classifications:


2B ATTENUATER.    2G. CLEANSING.    2J. RAREFYING.    2L. EMOLLIENT.    2Q. ANODYNE.    2U. SUPPURATIVE.    2V. EXPEL PUS
2W. SARCOTIC
3L. ANTI-TUSSIVE
4d. PECTORAL.    4f. SPLENETIC.    4j. NERVINE
Laxative, Purgatives and Cathartics

Uses:


1. Warms and Strengthens the Kidneys: (TCM, West, Ayurveda, Tibetan)
-Cold and Weak Kidneys with Lower Back Pain
-Edema, Fluid Retention
-Aphrodisiac; Impotence, male Infertility, cold Testicular pain
-Lumbago, Arthritis, Rheumatism, Sciatica
-Diabetes

2. Strengthens the Lungs, clears Phlegm, stops Cough: (West, Ayurveda)
-Cold-Phlegm type Cough and Wheezing, either acute, or chronic with Deficiency
-acute sore Throat, Tonsillitis
-Cough, Bronchitis, Asthma, Emphysema, Tuberculosis
-Scrofula
-Pus in the Lungs (Tibetan Medicine)
-“Fenugreek clears Voice, nourishes the Lungs, softens the Chest and Throat, soothes the Cough and Asthma”. (Avicenna)

3. Strengthens the Spleen, Increases Qi: (West, Ayurveda, Tibetan)
-increases appetite and digestion
-increases strength and body weight
-convalescence, chronic illness, debility, anemia

4. Moistens the Intestines: (West, Ayurveda)
-gentle, soothing laxative
-inflammation of the Stomach or Bowels; Gastritis, Dysentery
-decoction can be given for Ulcers of the Intestines (Pliny)
-“decoction is also a good remedy for Dysentery and Diarrhea”. (Avicenna)
-“
decoction of Fenugreek with honey expels the thick fluids from intestines”. (Avicenna)

5. Moves the Blood, Promotes Menstruation: (West)
-Amenorrhea and Dysmenorrhea associated with Cold
-used for hardness, swellings and tumors of the Uterus (mostly topically)
-traditionally to increase Breast size and give a more shapely body to women
-stimulates Labor (Pliny); “Fenugreek facilitates delivery”. (Avicenna)
-“Fenugreek dissolves Phlegmatic and Hard Swellings”. (Avicenna)

6. Promotes and Enriches Breast Milk: (West, Ayurveda)
-nourishes Breast Milk, increases quality and quantity

7. Externally:
-commonly used in Enemas and Douches
-douche, wash, sitz-bath or suppository is good for Abscesses, Ulcers, Hardness, Swellings, Inflammations and Obstructions of the Uterus and to soften all hard Tumors of it.
-“Used as a pessary with duck fat to cure hardness of Uterus”. (Avicenna)
-externally for Cold type skin eruptions, Wounds, Tumors, Abscesses, Boils, Swollen Glands, Scrofula, Sores
-“It softens and matures Abscesses” (Avicenna)
-topically for Pain and Inflammation in plasters and fomentations
-decoction as a wash for strong underarm odor (Pliny)
-decoction is used as a wash for Dandruff
-“used in Freckles, [and for] improvement of Complexion”. (Avicenna)
-“The oil of Fenugreek, obtained with Myrtle, is useful for the Hair and also for removing the Scars.” (Avicenna)
-“Its mucilage is usefuI in (skin) Ruptures attributed to Cold exposure, particularly when used with rose oil”. (Avicenna)



Dose:


1. Pliny noted that prolonged boiling reduces its bitterness.
2. “It makes the feces less foul smelling while the urine and perspiration become stinking”. (Avicenna)
Decoction: 4½–9 grams
Powder: 1–4 grams
Commonly used in Enemas and Douches.
Used topically in plasters, oils and as a mucilage.

Correctives:


1. Vinegar
2. Lemon juice;
3. Aniseed;
4. Seeds and leaves of Chicory, Spinach and Purslane. (Unani)

Substitutes:


1. Linseed
2. Alfalfa seed (Unani).

Main Combinations:


Fenugreek & Linseed
  These two medicine form mucilage when combined with water. They therefore have a soothing, softening, emollient action. They are are often combined for use in Enemas, Douches, Baths and Sitz-baths, and in plasters and poultices.

Lungs:
1. Cold and Moist Cough, Fenugreek with Cinnamon, Hyssop, Licorice, Figs, Dates, Aniseed, Almonds (Wirtzung)
2. To clear Phlegm:
i. Fenugreek mucilage with Honey (Salmon)
ii. Fenugreek with Fennel seed and Plantain
3. Cough and Asthma from weakness:
i. Fenugreek with Honey and Figs and/or Dates. (Avicenna)
ii. Fenugreek with Raisins (equal parts) as a decoction.
iii. “It is better that the extract of Fenugreek and puIpy dates is put together and mixed with a large quantity of honey and then heated on the live coal moderately. This preparation is to be taken before meals for a long period”. (Avicenna)
4. Asthma, Difficulty Breathing, Fenugreek, Raisins (equal parts). Decoct and give often. ‘It gives relief immediately’ (Syrian ‘Book of Medicine‘, Budge, 1913)
5. Shortness of Breath, Fenugreek, Rhubarb, Madder, Myrrh, Saffron, Agrimony (asin Troches for Shortness of Breath)
(Syrian ‘Book of Medicine‘, Budge, 1913)
6. Lung Ulcers:
i. ‘A pottage too is made of this meal, which is taken for ulcerations of the chest and chronic coughs; it is kept boiling a considerable time, in order to remove the bitterness, after which honey is added’. (Pliny)
ii. Fenugreek with Comfrey root
iii. Fenugreek and Dates in Decoction


Poison:
7. Sore Throat, Tonsillitis, Fenugreek with Agrimony and Sage as a gargle
8. Scarlet Fever, Fenugreek with Yarrow, Calamus and Camomile
9. Leprosy, Fenugreek with one quarter part Nasturtium (Pliny)

Digestive System
10. Indigestion, loss of Appetite, Diarrhea, Fenugreek with Triphala (3 Myrobalans), Trikatu (3 Pungents), Cyperus rotundus, Cumin, Cinnamon, Cardamon, Rock Salt (equal parts), Fenugreek (equal to the rest). Mix with Ghee and Honey, Dose: 1–2 drams. (Ayurveda)
11. Indigestion, Bloating, Colic:
i. Fenugreek with Fennel, Cumin, Coriander seed
ii. Fenugreek, Ginger, Long Pepper, Cumin seed
12. Indigestion, Poor appetite, Fatigue from Spleen Qi deficiency:
i. Fenugreek, Withania, Triphala
ii. Fenugreek, Astragalus, Licorice
13. Cold-type Hernia:
i. Fenugreek with Fennel seed (TCM)
ii. Fenugreek with Comfrey root, Aniseed

Gynecology, Obstetrics:
14. Amenorrhea, Dysmenorrhea:
i. Fenugreek, Cyperus rotundus, Cinnamon
ii. Fenugreek with Shatavari (Asparagus racemosus), Saraca indica (Ayurveda)
15. To stimulate Labor, Fenugreek powder is taken with boiled must.
16. To increase Milk:
i. Fenugreek with Fennel, Aniseed
ii. Fenugreek with Fennel, Shatavari (Asparagus racemosus) (Ayurveda)
iii. Fenugreek, Hops, Blessed Thistle
17. Inflammation and pain of the Uterus or Bowels, boil Fenugreek with Mallow, then take with honied wine; ‘extolled’ (Pliny)
18. Polycystic Ovary Syndrome, Fenugreek with
Aloe, Sphaeranthus, Indian Spikenard and Symplocos racemosa
19. Hardness of the Uterus:
i. decoct Fenugreek in wine. (Salmon)
ii. Fenugreek, Zedoary, Cyperus rotundus


Other:
20. Diabetes:
i. Fenugreek, Nigella, Chicory seed (proven efficacy)
ii. Fenugreek with Gymnema, Turmeric, Neem, Long Pepper, Ginger (Ayurveda)
21. Impotence, Fenugreek with Nutmeg, Withania, Sida cordifolia, Mucuna (Ayurveda)
22. Arthritic conditions, Fenugreek with Bdellium, Trikatu (Long and Black Pepper, Ginger), Boerhaavia
23. High Cholesterol, Fenugreek with Bdellium, Turmeric (Ayurveda)

Externally:
24. Hard Swellings, Tumors, Scrofula:
i. topically Fenugreek with Marshmallow, Linseed and Turpentine (as in Ointment of Marshmallow of Nicholas)
ii. topically Fenugreek with Saltpeter and Vinegar
25. Pessary for violent Uterine pain, Fenugreek boiled with barley or linseed in hydromel, is formed into a pessary. (Dioclesre out of Pliny)
26. Leprous sores, Freckles, equal parts of Fenugreek meal and Sulphur are used topically (Pliny)

27. Dandruff or Ringworm, Fenugreek meal with wine and niter, ‘speedily cures’ (Pliny)
28. Decocted in Hydromel with grease added, it was long applied to inflamed tumours, swellings of the parotid glands, arthritis in the feet and hands, joint diseases, and to cover bare bones in Wounds. (Pliny)
29. Sprains, knead the meal in vinegar and apply (Pliny)
30. ‘Kneaded with wine, it acts as a detergent upon carcinomatous sores; after which, applied with honey, it effects a perfect cure’. (Pliny)
31. Burns, topically with Rose oil. (Avicenna)


Major Formulas:


Decoction for Asthma (Zacharia)
Decoction for Asthma and Difficulty Breathing
Water for Cancer
Tragacanth Warming Powder (Pulvis Diatragacanth Calidii) (Nicholas)
A Sound and Experienced Electuary (Mesue)
Confection for Cold Cough
Troches for Pleurisy when not from Vehement Heat
Troches for Shortness of Breath
Ointment of Marshmallow (Nicolas)
Diachilon Plaster (Emplastrum Diachilon)

Cautions:


1. Not used (alone) for Heat or Fever, especially Deficient Heat
2. Not used during Pregnancy

Toxicity:


A systematic literature review of fenugreek seed toxicity by using ToxRTool: evidence from preclinical and clinical studies

Main Preparations used:


Mucilage, Mucilaginous Oil

1. Mucilage of Fenugreek:
i. Fenugreek seed (1 part), Water (10 parts). Macerate 12 hours; boil, express. (Pharmacopoeia Sardoa, 1773)

2. Mucilaginous Oil:
i. Fenugreek seed bruised (8 oz.), Linseed oil (2 lbs.). Infuse 10 days, strain.

Pliny on Fenugreek:
Nor is fenugreek held in less esteem. By some it is known as  “telis,” by others as “carphos,” and by others again as “buceras,” or “segoceras,” the produce of it bearing some resemblance to horns. Among us it is known as “silicia.” The mode of sowing it we have already described on the appropriate occasion. Its properties are desiccative, emollient, and resolvent. A decoction of it is useful for many female maladies, indurations for instance, tumours, and contractions of the uterus; in all which cases it is employed as a fomentation or used for a sitting-bath: it is serviceable also as an injection. It removes cutaneous eruptions on the face; and a decoction of it, applied topically with nitre or vinegar, cures diseases of the spleen or liver. In cases of difficult labour, Dioclesre commends the seed pounded, in doses of one acetabulum, mixed with boiled must. After taking one third of the mixture, the patient must use a warm bath, and then, while in a perspiration, she must take another third, and, immediately after leaving the bath, the remainder— this, he says, will prove a most effectual means of obtaining relief.
 
‘The same authority recommends fenugreek boiled, with barley or linseed, in hydromel, as a pessary for violent pains in the uterus: he prescribes it also as an external application for the lower regions of the abdomen. He speaks also of treating leprous sores and freckles with a mixture composed of equal proportions of sulphur and meal of fenugreek, recommending it to be applied repeatedly in the course of the day, due care being taken not to rub the part affected.

‘For the cure of leprosy, Theodoras prescribes a mixture of fenugreek, and one fourth part of cleaned nasturtium, the whole to be steeped in the strongest vinegar. Damion used to give a potion by way of emmenagogue, consisting of half an acetabulum of fenugreek seed in nine cyathi of boiled must and water. There is no doubt too, that a decoction of it is remarkably useful for diseases of the uterus and for ulcerations of the intestines, and that the seed is beneficial for affections of the joints and chest. Boiled with mallows and then taken in honied wine, fenugreek is extolled in the highest terms, as serviceable for affections of the uterus and intestines. Indeed, the very steam that arises from the decoction may be productive of considerable benefit. A decoction too of fenugreek seed is a corrective of the rank odours of the armpits. Meal of fenugreek, with wine and nitre, speedily removes ring-worm and dandruff of the head; and a decoction of it in hydromel, with the addition of axle-grease, is used for the cure of diseases of the generative organs, inflamed tumours, imposthumes of the parotid glands, gout in the feet and hands, maladies of the joints, and denudations of the bones. Kneaded with vinegar, it effects the cure of sprains, and, boiled in oxymel only, it is used as a liniment for affections of the spleen. Kneaded with wine, it acts as a detergent upon carcinomatous sores; after which, applied with honey, it effects a perfect cure. A pottage too is made of this meal, which is taken for ulcerations of the chest and chronic coughs; it is kept boiling a considerable time, in order to remove the bitterness, after which honey is added. (The Natural History of Pliny, trans. by Bostock and Riley, Vol. 5, 1856)

Pharmacographia, Fluckiger & Hanbury, 1879
‘In the old Egyptian preparation Kyphi, an ingredient “Sebes or Sebtu ” is mentioned, which is thought by Ebers to mean fenugreek. This plant was well known to the Roman writers on husbandry, as Porcius Cato (B.C. 234-149) who calls it Foenum Graecum and directs it to be sown as fodder for oxen. It is the [?] of Dioscorides and other Greek writers. Its mucilaginous seeds, “siliquae” of the Roman peasants, were valued as an aliment and condiment for man,and as such
are still largely consumed in the East. They were likewise supposed to possess many medicinal virtues, and had a place in the pharmacopoeias of the last century.

The cultivation of fenugreek in Central Europe was encouraged by Charlemagne (A.D. 812), and the plant was grown in English gardens in the 16th century.’

Vegetable Materia Medica of Western India, Dymock, 1885
Fenugreek has a history of great antiquity; it was much valued by the ancients both as a food and medicine; in India it has long been extensively cultivated, its seeds being considered carminative, tonic, and aphrodisiac. Several confections made with them are described in Sanskrit works under the names of Methi modaka, Svalpa methi modaka, &c, and are recommended for use in dyspepsia with loss of appetite, in the diarrhoea of puerperal women, and in rheumatism. All these preparations consist of a number of aromatic substances, one part each, and fenugreek seeds equal in quantity to all the other ingredients. Under the Arabic name of Hulbah, Mahometan writers describe the plant and seeds as hot and dry, suppurative, aperient, diuretic, emmenagogue, useful in dropsy, chronic cough and enlargements of the spleen and liver. A poultice of the leaves is said to be of use in external and internal swellings and burns, and to prevent tho hair falling off. The flour of the seeds is used as a poultice, and is applied to the skin as a cosmetic. They also use the oil of the seeds for various purposes.
In Europe the history of the plant is equally ancient. Aretaeus prescribed it both internally and externally. The powder of the seeds was recommended by Dioscorides in the form of a poultice for inflammatory affections. Pliny mentions its various uses as a medicine. Ainslie notices its uses by native practitioners in Southern India for dysentery, the seeds being toasted and afterwards infused. At the present time, Fenugreek is extensively used in India both as an article of diet and as a medicine. The young plants are always to be found in the vegetable markets, and are most esteemed when only the two seed leaves are formed; they are boiled and afterwards fried in butter, the taste is strongly bitter, and disagreeable to those who have not become accustomed to it; in bilious states of the system the vegetable has an aperient action. The seeds form the basis of a medicinal confection extensively used by the natives. They also enter into the composition of an imitation of carmine. The yellow decoction used with sulphate of copper produces a fine permanent green. In the Concan the leaves are used both internally and externally on account of their cooling properties’.
LAST UPDATED MARCH 2022

1. GENERAL / REVIEW
Trigonella foenum-graecum L. Sprouted Seed Extract: Its Chemical HPLC Analysis, Abortive Effect, and Neurodevelopmental Toxicity on Mice
Determination of Steroidal Saponins and Fixed Oil Content in Fenugreek (Trigonella foenum-graecum) Genotypes

2. ANTI-BACTERIAL
Antimicrobial activity of a novel polyherbal combination for the treatment of vaginal infection
In vitro antibacterial activity of seven Indian spices against high level gentamicin resistant strains of enterococci
In vitro antimicrobial activity of ten medicinal plants against clinical isolates of oral cancer cases

3. ANTI-FUNGAL
Invitro Anti-mycotic Activity of Hydro Alcoholic Extracts of Some Indian Medicinal Plants against Fluconazole Resistant Candida albicans

4. ANTI-INFLAMMATORY
Chemical Fingerprinting, Antioxidant, and Anti-Inflammatory Potential of Hydroethanolic Extract of Trigonella foenum-graecum
Anti-inflammatory activity of fenugreek (Trigonella foenum-graecum Linn) seed petroleum ether extract

5. ANTIOXIDANT
The plant extracts of Momordica charantia and Trigonella foenum graecum have antioxidant and anti-hyperglycemic properties for cardiac tissue during diabetes mellitus
Chemical Fingerprinting, Antioxidant, and Anti-Inflammatory Potential of Hydroethanolic Extract of Trigonella foenum-graecum
Fenugreek (Trigonella foenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice

6. IMMUNOMODULATING
The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-Probiotics

7. ANTICOAGULANT
An in vitro anticoagulant effect of Fenugreek (Trigonella foenum-graecum) in blood samples of normal Sudanese individuals

8. CARDIOPROTECTIVE
Cardioprotective effects of Fenugreek (Trigonella foenum-graceum) seed extract in streptozotocin induced diabetic rats

9. HEPATOPROTECTIVE
Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats
Antidiabetic antihyperlipidemic and hepato-protective effect of Gluconorm-5: A polyherbal formulation in steptozotocin induced hyperglycemic rats
Fenugreek seeds, a hepatoprotector forage crop against chronic AlCl3 toxicity

10. PREBIOTIC / PROBIOTIC EFFECT
Characterisation and In Vitro Evaluation of Fenugreek (Trigonella foenum-graecum) Seed Gum as a Potential Prebiotic in Growing Rabbit Nutrition
Culture Dependent and Independent Analysis of Potential Probiotic Bacterial Genera and Species Present in the Phyllosphere of Raw Eaten Produce

11. ASTHMA
Investigating the effectiveness of the Trigonella foenum-graecum L. (fenugreek) seeds in mild asthma: a randomized controlled trial

12. EFFECTS ON FAT METABOLISM / OBESITY
Fenugreek supplementation during high-fat feeding improves specific markers of metabolic health
The Effects of Hydro-Alcoholic Extract of Fenugreek Seeds on the Lipid Profile and Oxidative Stress in Fructose-Fed Rats
Fenugreek Counters the Effects of High Fat Diet on Gut Microbiota in Mice: Links to Metabolic Benefit
Fenugreek Seed Extract Inhibit Fat Accumulation and Ameliorates Dyslipidemia in High Fat Diet-Induced Obese Rats
Fennel (Foeniculum vulgare) and Fenugreek (Trigonella foenum-graecum) Tea Drinking Suppresses Subjective Short-term Appetite in Overweight Women
Trigonella Foenum-Graecum Seeds Lowers Postprandial Blood Glucose in Overweight and Obese Individuals
Common medicinal plants with antiobesity potential: A special emphasis on fenugreek

13. DIABETES
Antidiabetic Effect of Fenugreek Seed Powder Solution (Trigonella foenum-graecum L.) on Hyperlipidemia in Diabetic Patients
Trigonella foenum-graecum water extract improves insulin sensitivity and stimulates PPAR and γ gene expression in high fructose-fed insulin-resistant rats
4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity
A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes
Polyphenol Stilbenes from Fenugreek (Trigonella foenum-graecum L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3-L1 Adipocytes
Some Common Medicinal Plants with Antidiabetic Activity, Known and Available in Europe (A Mini-Review)
The plant extracts of Momordica charantia and Trigonella foenum graecum have antioxidant and anti-hyperglycemic properties for cardiac tissue during diabetes mellitus
Antihyperglycemic Effect of Trigonella Foenum-Graecum (Fenugreek) Seed Extract in Alloxan-Induced Diabetic Rats and Its Use in Diabetes Mellitus: A Brief Qualitative Phytochemical and Acute Toxicity Test on the Extract
The Role of Adrenergic and Angiotensinergic Systems in Vascular Effect of Alcoholic of Extract Trigonella foenum-graecum Seed in Diabetic Rats
Antidiabetic Effect of GII Compound Purified from Fenugreek (Trigonella foenum graecum Linn) Seeds in Diabetic Rabbits
Protective effect of aqueous extract of seed of Psoralea corylifolia (Somraji) and seed of Trigonella foenum-graecum L. (Methi) in streptozotocin-induced diabetic rat: A comparative evaluation
Indian Herbs and Herbal Drugs Used for the Treatment of Diabetes
Middle East Medicinal Plants in the Treatment of Diabetes: A Review
Exploring the Therapeutic Ability of Fenugreek against Type 2 Diabetes and Breast Cancer Employing Molecular Docking and Molecular Dynamics Simulations
Concomitant Use of Herbal and Conventional Medicines among Patients with Diabetes Mellitus in Public Hospitals of Addis Ababa, Ethiopia: A Cross-Sectional Study
A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes
An update on natural compounds in the remedy of diabetes mellitus: A systematic review

14. METABOLIC SYNDROME
Diosgenin, 4-Hydroxyisoleucine, and Fiber from Fenugreek: Mechanisms of Actions and Potential Effects on Metabolic Syndrome
Fenugreek (Trigonella Foenum-Graecum) Seed Flour and Diosgenin Preserve Endothelium-Dependent Arterial Relaxation in a Rat Model of Early-Stage Metabolic Syndrome
Plant-derived therapeutics for the treatment of metabolic syndrome
15. ANTI-AGING
Ethanolic Fenugreek Extract: Its Molecular Mechanisms against Skin Aging and the Enhanced Functions by Nanoencapsulation
Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity

16. INCREASES STRENGTH
The effects of a commercially available botanical supplement on strength, body composition, power output, and hormonal profiles in resistance-trained males

17. INCREASES TESTOSTERONE / SPERM
Efficacy and Safety of a Mixed Extract of Trigonella foenum-graecum Seed and Lespedeza cuneata in the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Efficacy of FurosapTM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers
Examining the Effects of Herbs on Testosterone Concentrations in Men: A Systematic Review
Trigonellae Semen Enhances Sperm Motility and the Expression of the Cation Sperm Channel Proteins in Mouse Testes
Non-testosterone management of male hypogonadism: an examination of the existing literature

18. ERECTILE DYSFUNCTION
Efficacy and Safety of Common Ingredients in Aphrodisiacs Used for Erectile Dysfunction: A Review

19. GYNECOLOGY
Herbal Medicine for Oligomenorrhea and Amenorrhea: A Systematic Review of Ancient and Conventional Medicine
Herbal Products Used in Menopause and for Gynecological Disorders
Botanicals and Their Bioactive Phytochemicals for Women’s Health

20. DYSMENORRHEA
Effects of Fenugreek Seed on the Severity and Systemic Symptoms of Dysmenorrhea

21. FEMALE INFERTILITY
Substantial Effect of Fenugreek Seeds Aqueous Extract on Serum Estradiol Level in Ovarian Hyperstimulation Syndrome Rat Model

22. LOW FEMALE SEX DRIVE
Effect of a multi-ingredient based food supplement on sexual function in women with low sexual desire

23. POLYCYSTIC OVARY SYNDROME
Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, FurocystTM) in Polycystic Ovary Syndrome (PCOS)
A comprehensive review of clinical studies with herbal medicine on polycystic ovary syndrome (PCOS)
Effect of “DXB-2030,” a Polyherbal Formulation, on Experimental Polycystic Ovary Syndrome Associated with Hyperandrogenism
The Effects of Traditional Chinese Medicine-Associated Complementary and Alternative Medicine on Women with Polycystic Ovary Syndrome

24. MENOPAUSE
Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause
Beneficial Role of Hydro-alcoholic Seed Extract of Trigonella foenum graecum on Bone Structure and Strength in Menopause Induced Osteopenia
Herbal Products Used in Menopause and for Gynecological Disorders
Effect of Fenugreek on vasomotor symptoms in menopausal women: A protocol for systematic review and meta-analysis

25. BREAST MILK
Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non‐hospitalised term infants
An ethnobotanical survey of galactogenic plants of the Berhoum District (M’sila, Algeria)
Ethnobotanical Survey of Natural Galactagogues Prescribed in Traditional Chinese Medicine Pharmacies in Taiwan

26. ARTHRITIS
Medicinal plants with potential anti-arthritic activity

27. NEUROLOGICAL DISEASE
Therapeutic Potential of Diosgenin and Its Major Derivatives against Neurological Diseases: Recent Advances

28. PERIPHERAL NEUROPATHY
Fenugreek seed extract treats peripheral neuropathy in pyridoxine induced neuropathic mice

29. MEMORY LOSS
Fenugreek Seed Powder Nullified Aluminium Chloride Induced Memory Loss, Biochemical Changes, Aβ Burden and Apoptosis via Regulating Akt/GSK3β Signaling Pathway

30. ANTI-DEPRESSANT
The Antidepressant-like Effect of Flavonoids from Trigonella Foenum-Graecum Seeds in Chronic Restraint Stress Mice via Modulation of Monoamine Regulatory Pathways
Effects of 4-hydroxyisoleucine from Fenugreek Seeds on Depression-like Behavior in Socially Isolated Olfactory Bulbectomized Rats

31. CANCER
Fenugreek: a naturally occurring edible spice as an anticancer agent
Antioxidant and anticancer activities of Trigonella foenum-graecum, Cassia acutifolia and Rhazya stricta
North African Medicinal Plants Traditionally Used in Cancer Therapy
Protein Hydrolysates from Fenugreek (Trigonella foenum graecum) as Nutraceutical Molecules in Colon Cancer Treatment
Cytotoxicity of Fenugreek Sprout and Seed Extracts and Their Bioactive Constituents on MCF-7 Breast Cancer Cells
Methanolic Fenugreek Seed Extract Induces p53-Dependent Mitotic Catastrophe in Breast Cancer Cells, Leading to Apoptosis
Exploring the Therapeutic Ability of Fenugreek against Type 2 Diabetes and Breast Cancer Employing Molecular Docking and Molecular Dynamics Simulations
Cytotoxic activity of standardized extracts, a fraction, and individual secondary metabolites from fenugreek seeds against SKOV-3, HeLa and MOLT-4 cell lines
Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review
The selective cytotoxic anti-cancer properties and proteomic analysis of Trigonella Foenum-Graecum
Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression
Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen
Diosgenin inhibits the expression of NEDD4 in prostate cancer cells
Nutraceutical use in late-stage cancer
Antineoplastic and Apoptotic Potential of Traditional Medicines Thymoquinone and Diosgenin in Squamous Cell Carcinoma

32. CATARACT
Inhibitory Effect of Trigonella Foenum-Graecum on Galactose Induced Cataracts in a Rat Model; in vitro and in vivo Studies