Sesamum, Sesame, Hei Zhi Ma 黑芝麻

Til, Tila (Ayurveda)
Hei Zhi Ma (TCM)
Kunjad Siyah (Unani)
Til snum 
ཏིལ་སྣུམ་ (Tibet)
Picture
Picture Ortus Sanitatis, Meydenbach, 1491

Picture Koehler, Medizinal Pflanzen, 1897

Picture (Photo by Vengolis) (Wikimedia)


Botanical name:


Sesamum indicum

Parts used:


Seed (Black are stronger)

Temperature & Taste:


Slightly Warm, moist. Sweet
It is Hot in the middle and Moist in the last phase of the first degree.” (Avicenna)

Classifications:


2K. RESOLVENT.    2L. EMOLLIENT.    2P. HEMOSTATIC.    2Q. ANODYNE.    2U. SUPPURATIVE
3H. LACTAGOGUE.    3I. APHRODISIAC.    3J. INCREASE SEMEN
TCM:
N. Yin Tonic

Uses:


1. Nourishes and Tonifies the Liver and Kidneys: (West, TCM, Ayurveda, Tibet)
-weakness of the Kidney and Liver Yin (Body moisture), with failing Eyesight, blurred Vision, Tinnitus and Dizziness. (TCM)
-for old weak patients, and for those recovering from severe and chronic disease; used for Paralysis, Rheumatism (TCM)
-strengthens Bones, Teeth; beneficial in Osteoporosis and chronic lower back pain
-‘It is a remedy against … pains of the Joints… It is a remedy against Sounding and Ringing of the Ears’. (Gerard)
-good hair tonic and is used for premature Greying of the Hair;
-listed by Dioscorides for Fractures, and griefs of the Eyes.
-‘It is a fattening drug’. (Avicenna)
-‘reinforces Qi, moistens and nourishes the Five Viscera [Heart, Lungs, Liver, Spleen Kidneys]’ (Da Ming Ri Hua Ben Cao)
-‘long term use makes one Happy and vigorous and able to enjoy a long life’. (Shen Nong Ben Cao)
-‘It has the function of dispersing the old and keeping the new’. (Ben Cao Gang Mu)
    
2. Nourishes the Blood, Calms Wind, Stops Spasm: (West, TCM, Ayurveda, Tibet)
-Headaches, Numbness and Dizziness from Wind, deficient Blood or Yin (TCM, Tibet)
-Itching from Phlegm or Blood Humors (Avicenna)
Gerard used it for Headaches from Heat.
-more recently recommended for Parkinson’s disease.
-Said in Ayurveda to be the best tonic and rejuvenating agent for Vata/Wind Dosas.
-‘it makes one resistant to both Cold and Hot weather’. (Da Ming Ri Hua Ben Cao)

3. Moisten the Intestines: (West, TCM, Ayurveda, Tibet)
-promotes passage of stool; used for Constipation from dryness, weakness, or deficient blood.
-Piles, including bleeding Piles in Ayurveda, for which it may be applied topically and taken internally.
    
4. Moves the Blood, Clears Stasis:
-Amenorrhea and Dysmenorrhea; irregular menstruation and spasmodic menstrual pain.
-“Its infusion is a potent emmenagogue and consequently it expels the Fetus”. (Ayurveda)
-‘dissolves hot swellings’ (Avicenna)
-promotes Delivery and expulsion of the placenta. (Da Ming Ri Hua Ben Cao)

5. Nourish Lung Yin, Stops Cough:
-dry Cough, Asthma, Breathlessness (Avicenna)
-Lung Yin deficiency; a good Lung tonic

6. Yogavaha:
-enhances or strengthens the other medicines it is used with. (Ayurveda)
    
7. Externally:
-seeds have been used both internally and externally for skin conditions including Eczema, Leprosy and Psoriasis.
-A decoction of the seeds is used as a hip-bath to promote Menstruation.
-In India, a Decoction of the leaves and roots is used as a hair wash to promote hair growth, and to blacken the hair
Sesame oil decocted with myrtle, preserves and strengthens the hair. (Avicenna)
-Plaster for hardening of the nerves and sinews
(Avicenna)
-extract of the plant is used for Dandruff (Avicenna)


Dose:


1. Seeds may be used in Decoction or Powder; the paste of the seeds (Tahini) can also be used in compounds; the Oil is much used externally in Ayurveda and is occasionally added to internal compounds.
2. “Its oil and decoction is also similar in properties”. (Avicenna)
3. ‘Stew the drug with white honey, and use to treat 100 diseases’. (Da Ming Ri Hua Ben Cao)
Decoction: 5–30 grams
Powder: 2–6 grams
Paste (Tahini): 1–2 spoonfuls

Correctives:


“When taken with honey its harmful effects are removed”. (Avicenna)

Substitutes:


1. Linseed or Hemp seed
2. For Sesame oil, oils of Olive, Almond or Linseed can usually be used.

Preparation:


1. Stir-fried or Roasted Sesame Seed:
  The seeds are sometimes roasted or dry fried until browned. This makes them more warming, less moist and more grateful to the Stomach. Avicenna said Sesame ‘hampers digestion and softens the Viscera … The fried seeds are relatively less harmful”. Roasting corrects these qualities. They were used to promote Semen and Sexual Desire. (Avicenna)
2. Prepared Sesame Seed:
  Sometimes Sesame seed was steeped in Child’s Urine or Alcohol, but this is rarely practiced today.

Main Combinations:


1. Tonic for the aged:
i. Black Sesame seed powder with Honey and Ghee (Ayurveda)
ii. Black Sesame powder with Poria Fu Ling and Honey.
iii. Black Sesame powder with Triphala, Withania, mixed with Honey and Ghee
iv. Black Sesame seed (50 grams), Walnuts (100 grams), form a congee with Rice.
v. Black Sesame seed with Withania, mixed with Honey to a paste, take Milk afterwards. “By observeing it for 12 days, even an old man will become young” (The Bower Manuscript, Ayurveda)
2. As a tonic, increasing strength and Intellect:
i. Black Sesame seed with Triphala, Honey and Ghee.
ii. Black Sesame seed with Triphala, Long Pepper, Black Pepper, Ginger
iii. Black Sesame seed with Calamus and Withania, mixed with Honey
3. Aphrodisiac, to strengthen the Kidney and nourish Semen:
i. Black Sesame seed with Withania and Shilajit
ii. Roasted Sesame seed, Poppy seed, Linseed (Avicenna)
iii. Black Sesame seed with Triphala, Orchid, Parsnip seed, Long Pepper, Red and White Behen (as in Triphala Electuary Greater)
iv. Black Sesame seed with Pine nut, Sweet Almond, Walnut, Pistachio, Orchis, Galangal, Sea Holly root, Asparagus root, Aniseed, White Poppy seed, Parsnip seed, Onion seed, Rocket seed, Fennel seed (as in Antidote for Cold Lumbar, for Venery, and Defect of Semen of Nicholas)
4. Infertility from Kidney deficiency:
i. Sesame seed, Shatavari, Withania
ii. Sesame seed, Withania, Shilajit, Nutmeg
iii. Sesame seed, Ginseng, Dioscorea Shan Yao
5. Strengthen the Bones and lower Back:
i. Sesame seed, Withania, Bdellium, Long Pepper (Ayurveda)
ii. Sesame seed, Asparagus root, Shailjit
6. Wounds and Fractures, steep Sesame seed in Child’s Urine four times, then steeped in distilled spirit three times; dry, and mix with Frankincense, Myrrh, and Dragon’s Blood, and form pills. (Chinese Materia Medica, Stuauoft)
7. Premature Ejaculation, use Unripe Rue, Toasted Rue, Poppy seed, Sesame seed (as in Pills of Hindi Mumsik of Unani)
8, Chronic Constipation:
i. Sesame seed oil (5 grams), Honey (15 grams). Mix well and take before breakfast.
ii. Sesame seed, Chebulic Myrobalan, Hemp seed (Ayurveda)
iii. in the aged due to dryness and deficiency, Black Sesame seed with Dang Gui, Polygonum He Shou Wu
9. Dysentery, Blood in the Stool, combine Raw Sesame seed (30 grams), toasted Sesame seed (15 grams), fried Black Fungus (15 grams). Make a powder, using 5 grams each time to make a tea. (TCM)
10. Dry Cough from Lung deficiency, Sesame seed, Sida, Inula racemosus (Ayurveda)
11. Headache Sesame oil, Madder, Rose (Avicenna)
12. Dry, itchy Skin conditions:
i. Sesame seed, Asparagus racemosus, Licorice (Ayurveda)
ii. Sesame oil, Raisin Water, Infusion of Aloe, taken internally (Avicenna)
13. To promote Milk:
i. Black Sesame seed with Fennel, Fenugreek
ii. Black Sesame seed with Red Clover, Aniseed, Fennel, Poppy seed (as in Powder for Defect of Milk)
14. As a hair tonic, boil Eclipta (Bhringaraja, Han Lian Cao) in Sesame oil and apply daily.
15. Leprosy, Roast Sesame seeds, soak in milk then beat to a paste. Mix with Licorice powder to form a poultice and apply. (The Bower Manuscript, Ayurveda)

Major Formulas:


Confection of Sesame and Triphala (Ayurveda)
Triphala Electuary Greater (Unani)
Triphera of the Saracens (Triphera Saracenica Magna)
Antidote for Cold Lumbar, for Venery, and Defect of Semen (Nicholas)
Powder of Sesame and Chebula (Ayurveda)
Powder for Defect of Milk
Pills for Premature Ejaculation (Unani)
Xiao Feng San

Cautions:


1. Not for chronic Diarrhea associated with Spleen deficiency.
2. Large doses are abortifacient

Main Preparations used:


Expressed Oil

Sesame is a plant which we find on the authority of the most ancient documents of Egyptian, Hebrew, Sanskrit, Greek, and Roman literature, has been used by mankind for the sake of its oily seeds from the earliest times. The Egyptian name Semsemt already occurring in the Papyrus Ebers, is still existing in the Coptic Semsem, the Arabic Simsim, and the modern Sesamum. The Indian languages have their own terms for it, the Hindustani Til, from the Sanskrit Tila, being one of the best known. Tila already occurs in the Vedic literature. In the days of Pliny the oil was an
export from Sind to Europe by way of the Red Sea,
precisely as the seeds are at the present day. During the middle ages the plant, then known as Suseman or Sempsen, was cultivated in Cyprus, Egypt and Sicily; the oil was an article of import from Alexandria to Venice. Joachim Camerarius gave a good figure of the plant in his “Hortus medicus et philosophicus” 1588. In modern times sesame oil gave way to that of olives, yet at present it is an article which, if not so renowned, is at least of far greater consumption’.
(Pharmacographia, Fluckiger & Hanbury, 1879)

The Chinese Classic Ben Cao Kang Mu said: ‘Taking black sesame seeds can heal all the chronic illness after 100 days, improve skin tone of body and face after 1 year, reverse gray hair after 2 years, and regrow teeth after 3 years’.

Daoists texts on Sesame (from A Soup for the Qan, Hu Sihui et al. 2010)
Food for Beneficent Immortals:
‘Sesame seeds: eaten they can eliminate all kinds of obstinate illnesses. If eaten for a long time they lengthen life, and make a person plump and strong. They lengthen the years and prevent one from getting old’.
GENERAL / REVIEW
An Insight into Sesamolin: Physicochemical Properties, Pharmacological Activities, and Future Research Prospects.
A comprehensive review on Sesamum indicum L.: Botanical, ethnopharmacological, phytochemical, and pharmacological aspects.
Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review.
An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review.
Comparison between the nutritional quality of flour obtained from raw, roasted and fermented sesame (Sesamum indicum L.) seed grown in Nigeria.
Lignans of sesame: purification methods, biological activities and biosynthesis–a review.
[Nutritional value of sesame seeds].

ANTIBACTERIAL
Mass Spectrometric Identification of Antimicrobial Peptides from Medicinal Seeds.

ANTI-INFLAMMATORY
Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions.
Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.-A Review.
A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking.
Identification and evaluation of anti-inflammatory properties of aqueous components extracted from sesame (Sesamum indicum) oil.

ANTIALLERGY
Ethanol Extract of Sesamum indicum Linn. Inhibits FcεRI-Mediated Allergic Reaction via Regulation of Lyn/Syk and Fyn Signaling Pathways in Rat Basophilic Leukemic RBL-2H3 Mast Cells.
Changes in the Anti-Allergic Activities of Sesame by Bioconversion.

ANTIOXIDANT
Phytochemical Profile and Antioxidant Activity of Sesame Seed (Sesamum indicum) By-Products for Stability and Shelf Life Improvement of Refined Olive Oil.
Widely targeted metabolome profiling of different colored sesame (Sesamum indicum L.) seeds provides new insight into their antioxidant activities.
A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking.
Phytochemical Contents and Antioxidant and Antiproliferative Activities of Selected Black and White Sesame Seeds.

ANALGESIC
Investigation of the analgesic and antioxidant activity from an ethanol extract of seeds of Sesamum indicum.

CARDIOVASCULAR EFFECT
Health benefits of sesamin on cardiovascular disease and its associated risk factors.
Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction.

CARDIOPROTECTIVE
Cardioprotective and Antioxidant Influence of Aqueous Extracts from Sesamum indicum Seeds on Oxidative Stress Induced by Cadmium in Wistar Rats.

ANTI-HYPERTENSIVE
Tahini consumption affects blood pressure and endothelial function in healthy males.

CHOLESTEROL
Sesamum indicum diet prevents hyperlipidemia in experimental rats.
Effects of sesamin on fatty acid and cholesterol metabolism, macrophage cholesterol homeostasis and serum lipid profile: A comprehensive review.
Antihyperlipidemic effects of Sesamum indicum L. in rabbits fed a high-fat diet.
Sesamol treatment reduces plasma cholesterol and triacylglycerol levels in mouse models of acute and chronic hyperlipidemia.

ATHEROSCLEROSIS
Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats.

ANTI-THROMBOTIC
Medicinal plants with antithrombotic property in Persian medicine: a mechanistic review.

PREVENTS AORTIC ANEURYSM
Sesame Extract Attenuates the Degradation of Collagen and Elastin Fibers in the Vascular Walls of Nicotine-administered Mice.

IMPROVES ENDOTHELIAL FUNCTION
Tahini consumption affects blood pressure and endothelial function in healthy males.

IMMUNOMODULATORY
Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions.

PULMONARY PROTECTIVE
Autophagy and apoptosis induction by sesamin in MOLT-4 and NB4 leukemia cells.

ASTHMA
Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice.

HEPATOPROTECTIVE
Protective effects of Sesamum indicum extract against oxidative stress induced by vanadium on isolated rat hepatocytes.
Prophylactic effect of aqueous extract of Sesamum indicum seeds on ethanol-induced toxicity in male rats.
Investigation of the hepatoprotective effects of Sesame (Sesamum indicum L.) in carbon tetrachloride-induced liver toxicity.

RENOPROTECTIVE
Synergistic renoprotective effects of sesame oil and erythropoietin on ischemic kidney injury after renal transplantation.

GASTROPROTECTIVE
Gastro-protective effect of crude hexane leaf extract of Sesamum indicum in rabbits.

INFLAMMATORY BOWEL DISEASE
Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats.

AGE-RELATED KIDNEY DISORDERS
Sesame lignans suppress age-related disorders of the kidney in mice.
CHRONIC KIDNEY DISEASE
(+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis.

DIABETES
Investigation of total zinc contents and zinc-protein profile in medicinal plants traditionally used for diabetes treatment.
Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction.
Prophylactic effect of aqueous extract of Sesamum indicum seeds on ethanol-induced toxicity in male rats.
Hypoglycemic effect of a hot-water extract from defatted sesame (Sesamum indicum L.) seed on the blood glucose level in genetically diabetic KK-Ay mice.

MEMORY
Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer’s disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways.
Sesame indicum, a nutritional supplement, elicits antiamnesic effect via cholinergic pathway in scopolamine intoxicated mice.

NEUROPROTECTIVE
Sesamol, a lipid lowering agent, ameliorates aluminium chloride induced behavioral and biochemical alterations in rats.
Neuroprotective effect of defatted sesame seeds extract against in vitro and in vivo ischemic neuronal damage.

COGNITIVE DECLINE
Sesaminol glucosides protect beta-amyloid peptide-induced cognitive deficits in mice.

ALZHEIMER’S DISEASE / NEURODEGENERATION
Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer’s disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways.
An exploration of the potential mechanisms and translational potential of five medicinal plants for applications in Alzheimer’s disease.

HEARING LOSS
Sesamum indicum L. Oil and Sesamin Induce Auditory-Protective Effects Through Changes in Hearing Loss-Related Gene Expression.

OSTEOPOROSIS
DANCR Mediates the Rescuing Effects of Sesamin on Postmenopausal Osteoporosis Treatment via Orchestrating Osteogenesis and Osteoclastogenesis.
Screening for natural medicines effective for the treatment of osteoporosis.

OSTEOARTHRITIS
The efficacy of topical sesame oil in patients with knee osteoarthritis: A randomized double-blinded active-controlled non-inferiority clinical trial.
Effects of sesame seed supplementation on clinical signs and symptoms in patients with knee osteoarthritis.

RHEUMATOID ARTHRITIS
Anti-rheumatoid activity of ethanolic extract of Sesamum indicum seed extract in Freund’s complete adjuvant induced arthritis in Wistar albino rats.

SPERM ABNORMALITIES
An evidence-based approach to medicinal plants for the treatment of sperm abnormalities in traditional Persian medicine.

PROMOTE FERTILITY
Efficacy of vitamin C and ethanolic extract of Sesamum indicum in promoting fertility in male Wistar rats.

INCOMPLETE ABORTION
Efficacy of Sesame (Sesamum indicum L.) in the Management of Incomplete Abortion: An Open-Label Randomized Controlled Clinical Trial.

ANTIPROLIFERATIVE
Phytochemical Contents and Antioxidant and Antiproliferative Activities of Selected Black and White Sesame Seeds.

CANCER
Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.-A Review.
A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds (Sesamum indicum).
Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action.
[Antitumor effect of alcohol extract from Sesamum indicum flower on S180 and H22 experimental tumor].
BREAST
Pharmacological Properties to Pharmacological Insight of Sesamin in Breast Cancer Treatment: A Literature-Based Review Study.
COLORECTAL
Targeting UNC-51-like kinase 1 and 2 by lignans to modulate autophagy: possible implications in metastatic colorectal cancer.
In Vitro Antioxidant and Anti-Colon Cancer Activities of Sesamum indicum L. Leaf Extract and Its Major Component, Pedaliin.
LEUKEMIA
Autophagy and apoptosis induction by sesamin in MOLT-4 and NB4 leukemia cells.
LUNG
Suppression of cyclooxygenase 2 increases chemosensitivity to sesamin through the Akt‑PI3K signaling pathway in lung cancer cells.
Sesamol induced apoptotic effect in lung adenocarcinoma cells through both intrinsic and extrinsic pathways.
MELANOMA
Role of L-Type Amino Acid Transporter 1 (LAT1) for the Selective Cytotoxicity of Sesamol in Human Melanoma Cells.
ORAL
Sesamol induces cytotoxicity via mitochondrial apoptosis in SCC-25 cells.
SQUAMOUS CELL CARINOMA
Sesamol induces cytotoxicity via mitochondrial apoptosis in SCC-25 cells.

CHEMOTHERAPY-INDUCED PHLEBITIS
Effects of topical sesame (Sesamum indicum) oil on the pain severity of chemotherapy-induced phlebitis in patients with colorectal cancer: A randomized controlled trial.

WOUND HEALING
Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats.
Wound healing activity of Sesamum indicum L seed and oil in rats.