Scutellaria barbata, Ban Zhi Lian 半枝莲

Barbat Skullcap
Ban Zhi Lian (TCM)
Picture Scutellaria barbata
(Photo by 阿橋) (Wikimedia)

Picture Dried Herb of Scutellaria Ban Zhi Lian (Adam, 2023)

Botanical name:


Scutellaria barbata (syn. S. rivularis)

Parts used:


Herb

Temperature & Taste:


Cold, dry. Pungent, slightly Bitter

Classification:


B. Clear Heat and Toxin

Uses:


1. Clears Heat and Toxins, Resolves Swellings:
-Sores, Boils, Abscesses, Furuncles (topically and internally)
-Cold, Flu, Fever from Wind-Heat and Toxin
-Snake Bite (topically and internally)

2. Clears Toxin, Resolves Masses:
-Hepatitis
-recently used for various types of Cancer

3. Clears Damp-Heat, Promotes Urine:
-Edema from Damp-Heat
-Jaundice
-Ascites related to Cirrhosis

4. Moves the Blood, Stops Bleeding:
-Trauma, Bruising
-Vomiting Blood, painful Bloody and dribbling urine


Dose:


Decoction: 15–30 grams (30–60 grams of the fresh herb).
Fresh herb is beaten to a paste for topically application.

Comment:


This, along with Hedyotis Bai Hua She She Cao have become commonly used anti-cancer medicines in modern China. They are often combined for various Cancers.

Substitute:


1. Andrographis Chuan Xin Lian is similar in effect and can be used in place (not for Cancer). Andrographis is stronger to clear Heat, but Scutellaria Ban Zhi Lian is better to remove stagnation, clear masses and is specifically used for Cancer.

Main Combinations:


In modern Cancer treatment, it is regularly combined with Hedyotis Bai Hua She She Cao

1. Furuncles, Boils and Toxic Sores, Scutellaria barbata Ban Zhi Lian with Chrysanthemum indicum Ye Ju hua, Violet (Zi Hua Di Ding)
2. Cancer:
i. general for Cancer, Scutellaria barbata Ban Zhi Lian with Hedyotis Bai Hua She She Cao, Black Nightshade (Long Kui), Agrimony (Xian He Cao)
ii. of the Liver, Scutellaria barbata Ban Zhi Lian with Salvia Dan Shen, Paeonia Bai Shao
iii. of the Liver, Scutellaria barbata Ban Zhi Lian with Agrimony (Xian He Cao), Black Nightshade (Long Kui)
iv. of the Liver, Scutellaria barbata Ban Zhi Lian with Paris root, Bezoar (Niu Huang), Cremastra Shan Ci Gu, Pseudoginseng San Qi, Centipede (Wu Gong), Zedoaria (E Zhu).
v. Gastric Cancer, Scutellaria barbata Ban Zhi Lian with Hedyotis Bai Hua She She Cao. Clinical trials using these 2 medicines showed a cure rate of approximately 25% in intermediate to advanced cases, taken on a long-term basis.
vi. Gastric or Esophageal Cancer from Phlegm and Heat with Qi and Blood stagnation, Scutellaria barbata Ban Zhi Lian with Dandelion (Pu Gong Ying), Hedyotis Bai Hua She She Cao, Sophora Ku Shen, Black Nightshade (Long Kui), Rhubarb (Da Huang), Frankincense (Ru Xiang), Astragalus Huang Qi (as in Jin Pu Jiao Nong)
vii. of the Digestive tract, Scutellaria barbata Ban Zhi Lian with Hedyotis Bai Hua She She Cao, Akebia Ba Yue Sha
viii. of the Lungs, Scutellaria barbata Ban Zhi Lian with Dandelion (Pu Gong Ying), Dioscorea Bulbifera Huang Yao Zi, Coptis Huang Lian, Pinellia Ban Xia, Trichosanthes Gua Lou. Clinical trials showed an effective rate of 60%
ix. Liver, Breast and Lymphatic Cancers, Scutellaria barbata Ban Zhi Lian with Hedyotis Bai Hua She She Cao. Semiaquilegia Tian Kui Zi, Paris root (Chong Lu)
3. Edema, Scutellaria barbata Ban Zhi Lian with Water Plantain root (Ze Xie), Corn Silk (Yu Mi Xu)
4. Common Cold and Flu from Wind-Heat and Toxin, Fever, acute Sore Throat or Tonsillitis and Cough with yellow Phlegm, Scutellaria barbata Ban Zhi Lian with Dandelion (Pu Gong Ying), Polygonum cuspidatum Hu Zhang, Sow Thistle (Sonchus arvensis) (Re Yan Ning Keli)
5. Snake Bite, Scutellaria barbata Ban Zhi Lian with Hedyotis Bai Hua She She Cao. Paris root (Chong Lu)

Cautions:


Use with caution during pregnancy

Main Preparations used:



Nother at the moment.
GENERAL / REVIEW:
–Phytochemical Profiling and Bio-Potentiality of Genus Scutellaria: Biomedical Approach

ANTIBACTERIAL
–Using the Chinese herb Scutellaria barbata against extensively drug-resistant Acinetobacter baumannii infections: in vitro and in vivo studies

ANTI-INFLAMMATORY:
–Functional components in Scutellaria barbata D. Don with anti-inflammatory activity on RAW 264.7 cells

ANTI-VIRAL
–Identification of Flavonoids from Scutellaria barbata D. Don as Inhibitors of HIV-1 and Cathepsin L Proteases and Their Structure–Activity Relationships

COVID:
–Scutellaria barbata D. Don Inhibits the Main Proteases (Mpro and TMPRSS2) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

ANTI-ANGIOGENIC:
–Anti-angiogenic effect of the total flavonoids in Scutellaria barbata D. Don

CANCER:
BLADDER:
–Hedyotis diffusa plus Scutellaria barbata Induce Bladder Cancer Cell Apoptosis by Inhibiting Akt Signaling Pathway through Downregulating miR-155 Expression
BREAST:
–Inhibition effects of total flavonoids from Scutellaria barbata D. Don on human breast carcinoma bone metastasis via downregulating PTHrP pathway
–Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Breast Cancer Effect via miR-200c-PDE7B/PD-L1-AKT/MAPK Axis
–Hedyotis diffusa Combined with Scutellaria barbata Are the Core Treatment of Chinese Herbal Medicine Used for Breast Cancer Patients: A Population-Based Study
CERVICAL:
–Scutellaria barbata D. Don inhibits cervical cancer cell proliferation, migration, and invasion via miR-195-5p/LOXL2 axis
COLORECTAL:
–Scutellaria barbata D. Don Inhibits Tumor Angiogenesis via Suppression of Hedgehog Pathway in a Mouse Model of Colorectal Cancer
–Scutellaria barbata D. Don inhibits migration and invasion of colorectal cancer cells via suppression of PI3K/AKT and TGF-β/Smad signaling pathways
–Hedyotis diffusa–Sculellaria barbata (HD–SB) suppresses the progression of colorectal cancer cells via the hsa_circ_0039933/hsa-miR-204-5p/wnt11 axis
–Scutellaria barbata D. Don inhibits growth and induces apoptosis by suppressing IL-6-inducible STAT3 pathway activation in human colorectal cancer cells
–Investigating the Mechanism of Scutellariae barbata Herba in the Treatment of Colorectal Cancer by Network Pharmacology and Molecular Docking
GASTRIC:
–Inductions of Caspase-, MAPK- and ROS-dependent Apoptosis and Chemotherapeutic Effects Caused by an Ethanol Extract of Scutellaria barbata D. Don in Human Gastric Adenocarcinom Cells
 LIVER CANCER:
–AURKB, CHEK1 and NEK2 as the Potential Target Proteins of Scutellaria barbata on Hepatocellular Carcinoma: An Integrated Bioinformatics Analysis
–Scutellaria barbata Inhibits Hepatocellular Carcinoma Tumorigenicity by Inducing Ferroptosis of Hepatocellular Carcinoma Cells
–Scutellaria barbata polysaccharides inhibit tumor growth and affect the serum proteomic profiling of hepatoma H22-bearing mice
–Study on the mechanism of action of Scutellaria barbata on hepatocellular carcinoma based on network pharmacology and bioinformatics
–Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro
–Extraction Optimization, Structural Characterization, and Anti-Hepatoma Activity of Acidic Polysaccharides From Scutellaria barbata D. Don
–Scutellaria barbata D. Don extract inhibits the tumor growth through down-regulating of Treg cells and manipulating Th1/Th17 immune response in hepatoma H22-bearing mice
–In Vitro and In Vivo Antitumor Activity of Scutellaria barbate Extract on Murine Liver Cancer
–Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3
LUNG CANCER:
–The anti-cancer effects and mechanisms of Scutellaria barbata D. Don on CL1-5 lung cancer cells
–Hedyotis diffusa plus Scutellaria barbata Suppress the Growth of Non-Small-Cell Lung Cancer via NLRP3/NF-κB/MAPK Signaling Pathways
–A Novel Systems Pharmacology Method to Investigate Molecular Mechanisms of Scutellaria barbata D. Don for Non-small Cell Lung Cancer
NASOPHARYNGEALER CANC:
–Molecular Assessment of Scutellaria barbata D. Don in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology and Experimental Verification
OVARIAN CANCER:
–Exploration of the effect and mechanism of Scutellaria barbata D. Don in the treatment of ovarian cancer based on network pharmacology and in vitro experimental verification.
PROSTATE CANCER:
–Scutellaria barbata D.Don (SBD) extracts suppressed tumor growth, metastasis and angiogenesis in Prostate cancer via PI3K/Akt pathway

SCUTELLARIA BARBATA PLUS HEDYOTIS IN CANCER TREATMENT:
–Hedyotis diffusa plus Scutellaria barbata Induce Bladder Cancer Cell Apoptosis by Inhibiting Akt Signaling Pathway through Downregulating miR-155 Expression
–Hedyotis diffusa plus Scutellaria barbata Suppress the Growth of Non-Small-Cell Lung Cancer via NLRP3/NF-κB/MAPK Signaling Pathways
–Hedyotis diffusa–Sculellaria barbata (HD–SB) suppresses the progression of colorectal cancer cells via the hsa_circ_0039933/hsa-miR-204-5p/wnt11 axis
–Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Suppresses Migration of Bone-Metastatic Breast Cancer Cells via OPN-FAK/ERK/NF-κB Axis
–Hedyotis diffusa Combined with Scutellaria barbata Are the Core Treatment of Chinese Herbal Medicine Used for Breast Cancer Patients: A Population-Based Study

UV PROTECTIVE:
–Anti-Photoaging Activity of Scutellaria barbata D. Don (Family Lamiaceae) on Ultraviolet B-Irradiated NIH-3T3 Skin Fibroblast and SKH-1 Hairless Mouse