Scutellaria baicalensis, Huang Qin 黄芩 Huang Qin (TCM) Hong len ser po  ཧོང་ལེན་སེར་པོ་ (Tibetan)

Ben Cao Pin Hui Jing Yao, 1505 (Welcome)

Scutellaria baicalensis
Curtis’s Botanical Magazine, 1849

Scutellaria baicalensis
(Photo: National Institute of Ecology, Korea)

Botanical name:

Scutellaria baicalensis
Local varieties used include S. rehderiana (Gansu),  S. arnoena (Yunnan, Sichuan), S. hypericifolia (Sichuan)

Parts used:

Root

Temperature & Taste:

Cold, dry. Bitter

Classification:

B. Clears Heat & Damp

Uses:

1. Clears Heat and Damp:
-Diarrhea, Dysentery
-Fever, stifling sensation in Chest, Thirst
-Painful or Dribbling Urine
-Auxiliary for Jaundice

2. Clears Heat, Resists Toxin:
-Fever, Irritability, Thirst
-acute Cough with yellow sputum
-Heat-types Sores, Infections and Swellings
-important herb for acute bacterial infections

3. Clears Liver Heat:
-Headache, Red Eyes and Face, Restlessness, Anger, Bitter taste in the mouth
-Hypertension associated with Liver heat

4. Clears Heat, Stops Bleeding:
-Heat-type Blood in the Urine or Stool, Coughing or Vomiting Blood

5. Clears Heat, Calms the Fetus:
-Restless Fetus (excess movement or kicking)

Dose:

Decoction: 3–9 grams
Powder: 1–3 grams

Substitute:

1. This is similar in use to Barberry bark in the West which is probably a suitable substitute.
2. Picrorhiza is also a possible substitute

Main Combinations:

Fever, Acute Disease:
1. Acute Fever with Heat and Toxin, Scutellaria Huang Qin with Forsythia Lian Qiao, Saposhnikovia Fang Feng, Rhubarb Da Huang (as in Fang Feng Tong Shen San)
2. High Fever, Irritability, or Acute Swollen Sore Throat, Boils, Abscesses, Scutellaria Huang Qin with Coptis Huang Lian (as in Huang Lian Jie Du Tang)
3. Fever and irritability; damp heat diarrhea, Jaundice; red and swollen eyes; carbuncle, Scutellaria Huang Qin with Green tea (decoct the Scutellaria, then infuse the Green tea)
4. Alternating Fever and Chills, Scutellaria Huang Qin with Bupleurum Chai Hu.
5. Malarial disorders, Bupleurum Chai Hu with Chinese Pulsatilla Bai Tou Weng, Scutellaria Huang Qin, Areca Bing Lang (Betel nut)
6. Lesser Yang disorders with Chills and Fever, fullness in the chest and hyponchondria; and acute Phlegm-Heat disorders, Scutellaria Huang Qin with Bupleurum Chai Hu, Pinella Ban Xia.
7. Shao Yang disease, Scutellaria Huang Qin with Paeonia Bai Shao, Licorice and Jujubes (Shang Han Lun)

Heat and Toxin:
8. Acute Heat diseases affecting the Head, Scutellaria Huang Qin with Isatis Radix Ban Lan Gen, Coptis Huang Lian, Fosrythia Lian Qiao, Licorice, Peppermint
9. Childhood convulsions from Heart Fire, Scutellaria Huang Qin with Ginseng (Sheng Ji Zhong Lu)
10. Broad-spectrum antibacterial for Heat and Toxin, Scutellaria Huang Qin, Coptis Huang Lian is often combined and Phellodendron Huang Bai, known as ‘San Huang‘, the ‘Three Yellows’. To Make it stronger, add Gardenia Zhi Zi (as in Huang Lian Jie Du Tang). This again, can be made stronger with the addition of Rhubarb (Da Huang).
11. Dysentery with Blood, Scutellaria Huang Qin with, Paeonia Bai Shao, Dang Gui, Coptis Huang Lian, Areca Bing Lang (Betel Nut), Costus Mu Xiang, Licorice (Gan Cao), Rhubarb root (Da Huang), Cinnamon bark (Gui Pi) (as in Shao Yao Tang, from Su Wen Bing Ji Bao Ming Ji)
12. Herpes or Viral Hepatitis, Gynostemma Jiao Gu Lan with Gentian (Long Dan Cao), Scutellaria Huang Qin
13. Fever, swelling and pain in the Head, Mouth or Throat, Cimicifuga Sheng Ma with Scutellaria Huang Qin, Coptis Huang Lian, Figwort root (Xuan Shen), Isatis root (Ban Lan Gen)
14. Carbuncles and Internal or External Abscesses:
i. Scutellaria Huang Qin with Coptis Huang Lian and Dandelion root.
ii Scutellaria Huang Qin with, with Angelica Du Huo, Rhubarb (Da Huang), Dang Gui, Paeonia Chi Shao Yao (Red Peony root) (as in Du Huo San)
15. Eczema, Scutellaria Huang Qin with Sophora Ku Shen, Paeonia Chi Shao

Cough, Bronchitis:
16. Heat-type Cough:
i. acute Cough with yellow Sputum or Hot and dry Lungs, Scutellaria Huang Qin with Almond/Apricot kernel (Xing Ren) and Licorice.
ii. acute Heat-type Cough, Scutellaria Huang Qin with Platycodon Jie Geng, Gypsum (Shi Gao), Licorice
iii. Heat-type Cough, Scutellaria Huang Qin with Aster Zi Wan and Fritillaria Bei Mu
iv. Phlegm-heat Cough, Scutellaria Huang Qin, Trichosanthes Tian Hua Fen and Pinellia Ban Xia,
iv. Chronic Bronchitis, Scutellaria Huang Qin with Lepidium Ting Li Zi
17. Lung Heat Cough, Glauber’s Salt with Scutellaria Huang Qin.

Liver Heat, Jaundice:
18. Liver Heat:
i. Scutellaria Huang Qin with Self Heal (Xia Ku Cao)
ii. Scutellaria Huang Qin with Gentian (Long Dan Cao)
iii. Scutellaria Huang Qin with Coptis Huang Lian, Rhubarb (Da Huang)
19. Liver heat Headache, Red Eyes, Irritability:
i. Scutellaria Huang Qin with Self Heal. This combination can also be used for Hyperthyroidism.
ii. Liver Wind-Heat with Dizziness, Scutellaria Huang Qin with Cassia tora Jue Ming Zi with Gastrodia Tian Ma, Self Heal (Xia Ku Cao).
20. Sore, Red Eyes from Liver heat or Wind-Heat:
i. Wind-Heat, Scutellaria Huang Qin with Schizonepeta Jing Jie, Peppermint (Bo He), Chrysanthemum Ju Hua
ii. Liver heat, Scutellaria Huang Qin with Cassia tora Jue Ming Zi and Gentian (Long Dan Cao)
21. Damp-Heat Jaundice
i. Scutellaria Huang Qin with Rhubarb, Gardenia Zhi Zi and Artemisia Yin Chen.
ii. Damp-Heat Jaundice with Fever, Scutellaria Huang Qin with Coptis Huang Lian and Paeonia Bai Shao.

Heat-type Bleeding:
22. Bleeding from Heat:
i. from Heat and Yin deficiency, Scutellaria Huang Qin with Ophiopogon Mai Men Dong and Madder (Qian Cao)
ii. Vomiting of Blood, Scutellaria Huang Qin with Paeonia Mu Dan Pi and Rhubarb.
iii. Blood in the Stool from Heat, Scutellaria Huang Qin with Burnet root
iv. Diarrhea and Dysentery with Blood, Scutellaria Huang Qin with Madder (Qian Cao), Coptis Huang Lian
v. Vomiting of Blood from Heat, Paeonia Mu Dan Pi with Scutellaria Huang Qin

Other:
23. Heat and Damp affecting the Stomach, Amomum Bai Dou Kou with Scutellaria Huang Qin
24. Restless Fetus, Scutellaria Huang Qin with Atractylodes Bai Zhu and Dang Gui.

Major Formulas:

Chai Hu Gui Zhi Tang
Chai Hu Gui Zhi Gan Jiang Tang
Da Chai Hu Tang
Da Huang Zhe Chong Wan
Dang Gui Liu Huang Tang
Fang Feng Tong Sheng San
Gan Cao Xie Xin Tang
Gan Jiang Huang Qin Huang Lian Ren Shen Tang
Huang Lian E Jiao Tang 
Huang Lian Jie Du Tang
Long Dan Xie Gan Tang
Niu Huang Jie Du Pian
Qing Qi Hua Tan Wan
Tian Ma Gou Teng Yin
Tai Shan Pan Shi San
Xiao Chai Hu Tang

Cautions:

1. Not used in Cold and Weakness of the Digestive system.

Main Preparations used:

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GENERAL / REVIEW –Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. –A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis –Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review –Simulated gastrointestinal tract metabolism and pharmacological activities of water extract of Scutellaria baicalensis roots –Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods –Traditional uses, ten-years research progress on phytochemistry and pharmacology, and clinical studies of the genus Scutellaria COMBINATIONS –Pharmaceutical Advantages of GenoTX-407, A Combination of Extracts from Scutellaria baicalensis Root and Magnolia officinalis Bark –The Combination of Scutellaria baicalensis Georgi and Sophora japonica L. ameliorate Renal Function by Regulating Gut Microbiota in Spontaneously Hypertensive Rats –Supplementation With Chinese Medicinal Plant Extracts From Lonicera hypoglauca and Scutellaria baicalensis Mitigates Colonic Inflammation by Regulating Oxidative Stress and Gut Microbiota in a Colitis Mouse Model –Herbal Combination of Phyllostachys pubescens and Scutellaria baicalensis Inhibits Adipogenesis and Promotes Browning via AMPK Activation in 3T3-L1 Adipocytes –Whether Co-Administration of Garlic has Negative Influence on Scutellaria Baicalensis Georgi in Treating Models Rats with Pelvic Inflammation? –Analgesic Effects of a Standardized Biofavonoid Composition from Scutellaria baicalensis and Acacia catechu –A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee –Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised of Morus alba, Scutellaria baicalensis, and Acacia catechu –The Herbal Medicine Scutellaria-Coptis Alleviates Intestinal Mucosal Barrier Damage in Diabetic Rats by Inhibiting Inflammation and Modulating the Gut Microbiota –Herbal pair Huangqin-Baishao: mechanisms underlying inflammatory bowel disease by combined system pharmacology and cell experiment approach –The Medicinal Plant Pair Bupleurum chinense–Scutellaria baicalensis – Metabolomics and Metallomics Analysis in a Model for Alcoholic Liver Injury ANTI-INFLAMMATORY –Comparison of Anti-Inflammatory and Anti-Nociceptive Activities of Curcuma Wenyujin Y.H. Chen et C. Ling and Scutellaria Baicalensis Georgi –Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF- κB and MAPK in RAW 264.7 Cells ANTI-ALLERGY –Baicalein, wogonin, and Scutellaria baicalensis ethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release ANTI-VIRAL –Baicalin from Scutellaria baicalensis blocks respiratory syncytial virus (RSV) infection and reduces inflammatory cell infiltration and lung injury in mice –Extract of Scutellaria baicalensis inhibits dengue virus replication –Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses –Antiviral Properties of Baicalin: a Concise Review COVID –Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review –Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro –The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro ANTI-FUNGAL –Antifungal activity and mechanism of action of Ou-gon (Scutellaria root extract) components against pathogenic fungi EFFECT ON COPD FROM SMOKING –Scutellaria baicalensis Attenuates Airway Remodeling via PI3K/Akt/NF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model ALCOHOLIC LIVER INJURY –The Medicinal Plant Pair Bupleurum chinense–Scutellaria baicalensis – Metabolomics and Metallomics Analysis in a Model for Alcoholic Liver Injury PULMONARY FIBROSIS –Baicalin alleviates bleomycin-induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway –A metabolomic approach to elucidate the inhibitory effects of baicalin in pulmonary fibrosis CARDIOVASCULAR EFFECT –Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review CARDIOPROTECTIVE –Baicalein Protects Against Doxorubicin-Induced Cardiotoxicity by Attenuation of Mitochondrial Oxidant Injury and JNK Activation IMMUNE EFFECT –Investigation of the immune effects of Scutellaria baicalensis on blood leukocytes and selected organs of the chicken’s lymphatic system HEPATOPROTECTIVE –Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice NEPHROPROTECTIVE –Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response NEUROPROTECTIVE –Characterizing the Neuroprotective Effects of S/B Remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) in Spinal Cord Injury –Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice –Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review –Neuroprotective Effects of Baicalein, Wogonin, and Oroxylin A on Amyloid Beta-Induced Toxicity via NF-κB/MAPK Pathway Modulation –Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis

COGNITION IMPROVER –Clinical and Preclinical Cognitive Function Improvement after Oral Treatment of a Botanical Composition Composed of Extracts from Scutellaria baicalensis and Acacia catechu –Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review PARKINSON’S DISEASE –Baicalin Represses C/EBPβ via Its Antioxidative Effect in Parkinson’s Disease ANTI-DEPRESSANT –Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea ANTI-HYPERTHYROID –Therapeutic Effect of Scutellaria baicalensis on L-Thyroxine-Induced Hyperthyroidism Rats ANTI-DIARRHEA –Anti-diarrheal effect of Scutellaria baicalensis is associated with suppression of smooth muscle in the rat colon COLITIS / ULCERATIVE COLITIS / INFLAMMATORY BOWEL DISEASE –Supplementation With Chinese Medicinal Plant Extracts From Lonicera hypoglauca and Scutellaria baicalensis Mitigates Colonic Inflammation by Regulating Oxidative Stress and Gut Microbiota in a Colitis Mouse Model –Herbal pair Huangqin-Baishao: mechanisms underlying inflammatory bowel disease by combined system pharmacology and cell experiment approach –The Comparative Study of the Therapeutic Effects and Mechanism of Baicalin, Baicalein, and Their Combination on Ulcerative Colitis Rat –Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine –Baicalein Inhibits Dextran Sulfate Sodium-induced Mouse Colitis –Baicalin down regulates the expression of TLR4 and NFkB-p65 in colon tissue in mice with colitis induced by dextran sulfate sodium ANTI-OBESITY –Antiobesity Effects of the Combined Plant Extracts Varying the Combination Ratio of Phyllostachys pubescens Leaf Extract and Scutellaria baicalensis Root Extract MIGRAINE –The Effectiveness of Scutellaria baicalensis on Migraine: Implications from Clinical Use and Experimental Proof PRURITIS –Anti-pruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice OSTEOARTHRITIS –A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee CANCER –The Extraction, Anticancer Effect, Bioavailability, and Nanotechnology of Baicalin –Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors BRAIN –Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells BREAST –Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells COLORECTAL –Baicalin, the major component of traditional Chinese medicine Scutellaria baicalensis induces colon cancer cell apoptosis through inhibition of oncomiRNAs –Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway –Baicalein and baicalin inhibit colon cancer using two distinct fashions of apoptosis and senescence –Inhibition of Autophagy Amplifies Baicalein-Induced Apoptosis in Human Colorectal Cancer HEMATOLOGICAL CANCER –Exploring Therapeutic Potentials of Baicalin and Its Aglycone Baicalein for Hematological Malignancies LEUKEMIA –Induction of Apoptosis Scutellaria baicalensis Georgi Root Extract by Inactivation of the Phosphatidyl Inositol 3-kinase/Akt Signaling Pathway in Human Leukemia U937 Cells LIVER –Baicalin induces apoptosis in hepatic cancer cells in vitro and suppresses tumor growth in vivo LUNG –The Root Extract of Scutellaria baicalensis Induces Apoptosis in EGFR TKI-Resistant Human Lung Cancer Cells by Inactivation of STAT3 –Scutellaria baicalensis and Their Natural Flavone Compounds as Potential Medicinal Drugs for the Treatment of Nicotine-Induced Non-Small-Cell Lung Cancer and Asthma ORAL –The potential anticancer activity of extracts derived from the roots of Scutellaria baicalensis on human oral squamous cell carcinoma cells –Exploring the Mechanism of Scutellaria baicalensis Georgi Efficacy against Oral Squamous Cell Carcinoma Based on Network Pharmacology and Molecular Docking Analysis OVARIAN –Anti-cancer effect of Scutellaria baicalensis in combination with cisplatin in human ovarian cancer cell –Wogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway PANCREATIC –BAICALEIN, A COMPONENT OF SCUTELLARIA BAICALENSIS, INDUCES APOPTOSIS BY MCL-1 DOWN-REGULATION IN HUMAN PANCREATIC CANCER CELLS –Baicalein inhibits pancreatic cancer cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and ERK signaling pathways MELANOMA –Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition SYNERGY WITH CHEMOTHERAPY –Baicalin Enhances Chemosensitivity to Doxorubicin in Breast Cancer Cells via Upregulation of Oxidative Stress-Mediated Mitochondria-Dependent Apoptosis –Anti-cancer effect of Scutellaria baicalensis in combination with cisplatin in human ovarian cancer cell –Wogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway