Scrophularia, Figwort, Xuan Shen 玄参

Xuan Shen (Chinese Figwort)
Gyer shing pa  གཡེར་ཤིང་པ  (Tibetan)
Picture
Picture Ortus Sanitatis, Meydenbach, 1491

Picture Flora von Deutschland (17), Kohler, 1884

Picture Scrophularia nodosa
(Photo by Franz Xaver) (Wikimedia)


Botanical name:


Scrophularia spp.
  1. S. nodosa, S. umbrosa (“Water Betony”) (Europe)
  2. S. ningpoensis, S. buergeriana (TCM)
  3. S. incisa, S. ningpoensis, S. koelzii, S. dentata (Tibetan)
  4. S. peregrina (Unani)
  5. S. striata, S. kotschyana, S. amplexicaulis (Iran)
  6. S. syriaca (syn. S. hypericifolia)
A large number of Scrophularia species have been used, most appearing to have similar uses.

Parts used:


Root. In the West, sometimes the herb and root together were used, especially in external compounds.

Temperature & Taste:


Cold, dry (warm in the West). Bitter

Classifications:


2D ATTENUATERS OF CONGEALED BLOOD
TCM:
B. Clears Heat from the Blood    B. Clears Deficient Heat

Uses:


1. Clears Heat, Moves the Blood, Clears Stasis, Resolves Masses (TCM, West):
-‘
possesses the potency of dissolving Induration (hardness)’. (Avicenna)
-‘Hard mass due to Blood Stasis’. (Ming Yi Bie Lu)

-Lymphatic Swellings, Scrofula, Lymphadenitis etc.
-various Tumors and Cancers in both east and west; Matthiolus listed it for Cancer
-‘fit to discuss the most obstinate Tumors’ (
Medicina Britannica, 1746).
-Fistulas (decocted in Wine)
-Hemorrhoids
-chronic Liver diseases with inflammation.
-chronic inflammation with exudation due to low vitality.
-chronic Ulcers, Fistulas (int. and topically)
-“
useful in Rodent and Malignant Ulcers” (Avicenna)

2. Clears Heat and Poison from the Blood (TCM, West):
-obstinate and chronic skin diseases including Eczema, Psoriasis, Leprosy, chronic itching
-‘redness, spots and freckles in the Face’.
-Secondary Syphilis.


3. Clears Heat and Toxin, Benefits the Throat (TCM, West):
-heat and toxin type swellings of the throat including Tonsillitis.
-chronic Sore Throat, and those with Heat, Toxin, and
Yin deficiency.

4. Clears Deficient Heat, Benefits the Yin (TCM, West):
-useful for conditions associated with both Yin deficiency and heat, including chronic infections, chronic fevers, and the aftermath of various chronic diseases.
-adjunct in the treatment of Diabetes etc.


5. Moves the Blood, Promotes Menstruation (West):
-although infrequently used for this purpose, it is useful to relieve the pain of Menstruation if the decoction is taken freely.
-restores Lochial Discharge.
-female Debility (
King’s).
-Postpartum Heat by some Chinese authorities (Bensky)


6. Promotes Urine, Benefits the Kidneys (West, TCM):
-‘They exert an unusually excellent influence on the Kidneys, moderately promoting the flow of urine, relieving torpor, and imparting a soothed and toned impression to these organs’. (
Cooks Dispenstaory)
-‘replenishes Kidney Qi’ (Shen Nong Ben Cao)
-‘Enhances the Male function and reinforces Vital Essence’. (Ming Yi Bie Lu)


7. Kills Worms (West).

8. Externally:

-externally (and internally) as a Wound herb; Wounds, Bruising, Hematomas, inflammations of the Breast etc.
-ointment may be used on all Swellings, Nodes, Scrophula, Ringworm, Gout, Eczema, Hemorrhoids etc.
-‘Application of its lukewarm plaster twice a day is useful in cancerous swellings, scrofula and other kinds of swellings’. (Avicenna)
-‘
useful in Rodent and Malignant Ulcers’. (Avicenna)
-‘dries up the superfluous moisture of hollow and corroding ulcers’ (Culpeper)
-‘virulent Tumors that pit not, and to soften Malignant Tumors, as Scrophulas, &c.’ (Schroder)
-‘Its juice cleanses the most putrid Ulcers, even though carcinomatous [cancerous]’ (
Medicina Britannica, Thomas Short, 1746)
-powdered root is sprinkled on moist Ulcers.
-distilled water is used for Pimples and Redness of the Face
-Earache, with Saltpeter (Bock)



Dose:


Often Decocted in Wine or the Powder is taken with wine to move the Blood and resolve Swellings and Tumors.
Decoction: 6–15 grams
Powder: 1–3 grams
Tincture (1:5): 2–4 drams
Acid (Vinegar) Tincture: enough is added to water or wine to make it acid.

Comment:
1. The appearance, functions, uses and constituents of the Eastern and Western species of Scrophularia are similar enough to be considered synonymous. The Chinese Xuan Shen may be used in place of European Figwort.
2. According to Zhang Yuan Su it ‘plays an important role in regulating the ascent and descent of all sorts of Qi’.
3. This is one of the ‘Shen‘ roots of TCM which are often tonic medicines and which includes Ginseng (Ren Shen). Older TCM texts recognized more tonic qualities, some claiming it tonifies Qi and Yin.

Substitute:


In treating Fire with Yin deficiency, Rehmannia Sheng Di Huang may be used.

Main Combinations:



Scrofula, Tumors:
1. Scrofula, Neck Swellings:
i. from Heat and Yin deficiency, Figwort with Comfrey root
ii. from heat and toxin, Figwort with Burdock root and Bittersweet
iii. from heat and toxin, Figwort with Black Nightshade
iv. with Heat, Figwort with Self Heal
v. Heat and Toxin, Figwort with Bittersweet
vi. Figwort with China root and Agrimony
vii. Figwort, Self Heal, Kelp
viii. Scrophularia Xuan Shen with Oyster shell (TCM)
ix. Scrophularia Xuan Shen, Self Heal (Xia Ku Cao), Forsythia Lian Qiao (TCM)
x. Figwort, Herb Robert, Agrimony, Mugwort, Water Cress, Horseradish, Caraway seed, Fennel seed
2. Lymphadenitis, Figwort with Poke root
3. Hard Swellings, Figwort with Polypody, Betony and Cyclamen (Wirtzung)
4. Cancer, Figwort with Herb Robert, Agrimony, Tormentil, Nettle seed, Elder flower, Rosemary (as in Decoction for Cancer)
5. Lung Cancer, Figwort, Comfrey, Elecampane, Licorice

Heat and Toxin:
6. Chronic Sore Throat:
i. from Heat and Toxin, Scrophularia Xuan Shen with Burdock seed and Licorice
ii. from Heat and Yin deficiency, Scrophularia Xuan Shen with Rehmannia Sheng Di (TCM)
iii. Sore, dry Throat from Yin deficiency and Heat, with Scrophularia Xuan Shen with Ophiopogon Mai Men Dong and Licorice
7. Furuncles, Boils and Abscesses Scrophularia Xuan Shen, Chrysanthemum indicum (Ye Ju Hua), Coptis Huang Lian
8. Erysipelas and Purpuric Rashes, Scrophularia Xuan Shen with Paeonia Mu Dan Pi (TCM)
9. Obstinate skin diseases, Figwort, Borage, Fumitory
10. Psoriasis, Figwort with Red Clover, Nettle, Cleavers
11. Scaly chronic skin conditions, Figwort with Yellow Dock root

Deficienct Heat:
12. Diabetes, Figwort with Mistletoe, Comfrey root, Feverfew
13. Low-Grade fever, thirst, Scrophularia Xuan Shen, Dendrobium Shi Hu, with Rehmannia Sheng Di Huang

Externally:
14. Redness, Spots and Freckles of the Face, distilled Water of Figwort with Saltpeter. (Salmon)
15. As a plaster for Tumors and Swellings, Figwort with Foxglove, Hounds Tongue, White Dead Nettle

Major Formulas:


Decoction of Figwort
Decoction for Cancer (Fuller)
Wine for Scrophula (Renodeus)
Water for Cancer
Electuary of Figwort (Avicenna)

Bai He Gu Jin Tang
Tian Wang Bu Xin Wan
Xiao Luo Wan
Yang Yin Qing Fei Tang
Zhen Gan Xi Feng Tang
Zi Xue Dan

Cautions:


Not used in Cold and Weak digestion

Main Preparations used:


Distilled Water of the root, Oil of Figwort, Ointment of Figwort

1. Oil of Figwort.
i. Fresh herb and root of Figwort (3 parts), Olive oil (1 part). Infuse in warmth, express.

2. Ointment of Figwort:
i. Bruise the roots, put in a jar and add equal parts of Beet suet or Hogs Lard with Olive oil. Sealed in a glass jar and leave in the sun for 15 or 20 days then boil gently on a fire for an hour, strain while hot, and keep in a jar for use.
ii. Boil the roots in Oil, then add Wax to form an ointment.
  Applied to Scrofula, Lymphatic swellings, Hemorrhoids, Tumors, Ulcers, Leprosy etc.


  • Extra Info
  • Research
NOTE: The following research is collected from numerous species of Scrophularia. While some indications (such as Diabetes and Breast Cancer) are represented by a number of species, some indications have only been shown in specific species. Nevertheless, the genus supplies many species which have been used medicinally in various countries, and it would appear that a number of species share similar or synonymous uses.

GENERAL / REVIEW
The genus Scrophularia: a source of iridoids and terpenoids with a diverse biological activity.
Scrophularia ningpoensis Hemsl: a review of its phytochemistry, pharmacology, quality control and pharmacokinetics.
Pharmacology, phytochemistry, and traditional uses of Scrophularia ningpoensis Hemsl.

ANTIBACTERIAL
Total phenolic, total flavonoids, antioxidant and antimicrobial activities of scrophularia striata boiss extracts.
Biological screening of Scrophularia nodosa extract and its fractions.
Study of chemical composition and antimicrobial activity of leaves and roots of Scrophularia ningpoensis.
Antibacterial activity of the phenolic acids fractions of Scrophularia frutescens and Scrophularia sambucifolia.

ANTIFUNGAL
Biological screening of Scrophularia nodosa extract and its fractions.

ANTI-INFLAMMATORY
Anti-inflammatory secondary metabolites from Scrophularia kotschyana.
Polysaccharides of Scrophularia ningpoensis Hemsl.: Extraction, Antioxidant, and Anti-Inflammatory Evaluation.
Scrophularia Tenuipes Coss and Durieu: Phytochemical Composition and Biological Activities.
Iridoid glycosides isolated from Scrophularia dentata Royle ex Benth. and their anti-inflammatory activity.
Anti-inflammatory glycoterpenoids from Scrophularia auriculata.
Anti-inflammatory activity in rats and mice of phenolic acids isolated from Scrophularia frutescens.
Antiinflammatory effects of different extracts and harpagoside isolated from Scrophularia frutescens L.

ANTIOXIDANT
Polysaccharides of Scrophularia ningpoensis Hemsl.: Extraction, Antioxidant, and Anti-Inflammatory Evaluation.
Scrophularia Tenuipes Coss and Durieu: Phytochemical Composition and Biological Activities.
Antioxidant and neuroprotective effects of Scrophularia striata extract against oxidative stress-induced neurotoxicity.
Total phenolic, total flavonoids, antioxidant and antimicrobial activities of scrophularia striata boiss extracts.

ANALGESIC
Biological screening of Scrophularia nodosa extract and its fractions.

ANTISPASMODIC
Spasmolytic effects of Scrophularia nodosa extract on isolated rabbit intestine.

MALARIA
Screening of Anti-Malarial Activity of Different Extracts Obtained from Three Species of Scrophularia Growing in Iran.

ASTHMA
Protective effects of Scrophularia striata in Ovalbumin-induced mice asthma model.

NEUROPROTECTIVE
Harpagide from Scrophularia protects rat cortical neurons from oxygen-glucose deprivation and reoxygenation-induced injury by decreasing endoplasmic reticulum stress.
Chemical characterization of polysaccharides isolated from scrophularia ningpoensis and its protective effect on the cerebral ischemia/reperfusin injury in rat model.
Neuroprotective effects of Scrophularia buergeriana extract against glutamate-induced toxicity in SH-SY5Y cells.
Screening and identification of neuroprotective compounds from Scrophularia buergeriana using cell extraction coupled with LC-MS.
Neuroprotective Effect of Total and Sequential Extract of Scrophularia striata Boiss. in Rat Cerebellar Granule Neurons Following Glutamate- Induced Neurotoxicity: An In-vitro Study.
Antioxidant and neuroprotective effects of Scrophularia striata extract against oxidative stress-induced neurotoxicity.
Iridoids from Scrophularia buergeriana attenuate glutamate-induced neurotoxicity in rat cortical cultures.
Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots.
Scrophularia buergeriana Extract (Brainon) Attenuates Neuroinflammation in BV-2 Microglia Cells and Promotes Neuroprotection in SH-SY5Y Neuroblastoma Cells.
Neuroprotective phenylpropanoid esters of rhamnose isolated from roots of Scrophularia buergeriana.

CEREBRAL ISCHEMIA
Harpagide from Scrophularia protects rat cortical neurons from oxygen-glucose deprivation and reoxygenation-induced injury by decreasing endoplasmic reticulum stress.
Chemical characterization of polysaccharides isolated from scrophularia ningpoensis and its protective effect on the cerebral ischemia/reperfusin injury in rat model.

ANXIETY & DEPRESSION
Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects of Scrophularia striata extract in rats.

COGNITIVE ENHANCEMENT
Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice.
ALZHEIMER’S DISEASE
Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles.

CARDIOPROTECTIVE
Cardioprotective Effects of Methanolic Extract of Scrophularia frigida on Ischemia-Reperfusion-Induced Injuries in Isolated Rat Heart.
Monoterpene pyridine alkaloids and phenolics from Scrophularia ningpoensis and their cardioprotective effect.

HEPATOPROTECTIVE
In Vivo Hepatoprotective and Nephroprotective Activity of Acylated Iridoid Glycosides from Scrophularia hepericifolia.
Evaluation of the hepatroprotective and nephroprotective activities of Scrophularia hypericifolia growing in Saudi Arabia.
Hepatoprotective phenylpropanoids from Scrophularia buergeriana roots against CCl(4)-induced toxicity: action mechanism and structure-activity relationship.

NEPHROPROTECTIVE
In Vivo Hepatoprotective and Nephroprotective Activity of Acylated Iridoid Glycosides from Scrophularia hepericifolia.
Evaluation of the hepatroprotective and nephroprotective activities of Scrophularia hypericifolia growing in Saudi Arabia.

DIABETES
A trisaccharide phenylethanoid glycoside from Scrophularia flava Grau with potential anti-type 2 diabetic properties by inhibiting α-glucosidase enzyme and decreasing oxidative stress.
Scrophularia Tenuipes Coss and Durieu: Phytochemical Composition and Biological Activities.
Antidiabetic and protective effects of Scrophularia striata ethanolic extract on diabetic nephropathy via suppression of RAGE and S100A8 expression in kidney tissues of streptozotocin-induced diabetic rats.
Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles.
Scropolioside-D2 and harpagoside-B: two new iridoid glycosides from Scrophularia deserti and their antidiabetic and antiinflammatory activity.

CANCER
Phytochemical analysis and antiproliferative activity of the aerial parts of Scrophularia subaphylla.
Chemical Composition of Scrophularia lucida and the Effects on Tumor Invasiveness in Vitro.
Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers.
Effects of Scrophularia ningpoensis Hemsl. on Inhibition of Proliferation, Apoptosis Induction and NF-κB Signaling of Immortalized and Cancer Cell Lines.
Study of Anti Cancer Property of Scrophularia striata Extract on the Human Astrocytoma Cell Line (1321).
BRAIN
Scrophularia orientalis extract induces calcium signaling and apoptosis in neuroblastoma cells.
BREAST
In vitro anticancer activity of Scrophularia amplexicaulis extracts on MCF-7 and WEHI-164 cell line.
Cytotoxic and Apoptotic Effects of Scrophularia Umbrosa Dumort Extract on MCF-7 Breast Cancer and 3T3 Cells.
Scrophularia Atropatana Extract Reverses TP53 Gene Promoter Hypermethylation and Decreases Survivin Antiapoptotic Gene Expression in Breast Cancer Cells.
The Cytotoxic and Apoptotic Effects of Scrophularia Atropatana Extracts on Human Breast Cancer Cells.
Growth inhibitory effect of Scrophularia oxysepala extract on mouse mammary carcinoma 4T1 cells in vitro and in vivo systems.
Extracts of Scrophularia frigida Boiss display potent antitumor effects in human breast cancer cells by inducing apoptosis and inhibition of expression of the human epidermal growth factor receptor 2.
Cytotoxic and Apoptotic Activities of Methanolic Subfractions of Scrophularia oxysepala against Human Breast Cancer Cell Line.
Apoptosis Cell Death Effect of Scrophularia Variegata on Breast Cancer Cells via Mitochondrial Intrinsic Pathway.
Dichloromethane fractions of Scrophularia oxysepala extract induce apoptosis in MCF-7 human breast cancer cells.
Dichloromethane and Methanol Extracts of Scrophularia oxysepala Induces Apoptosis in MCF-7 Human Breast Cancer Cells.
COLON:
Effects of Scrophularia oxysepala Methanolic Extract on Early Stages of Dimethylhydrazine-Induced Colon Carcinoma in Rats: Apoptosis Pathway Approach.
LEUKEMIA
Induction of apoptosis and G2 /M cell cycle arrest by Scrophularia striata in a human leukaemia cell line.

SYNERGISTIC WITH CHEMO:
Scrophularia amplexicaulis increases anti-cancer potential of doxorubicin in gastric cancer cells.  

WOUNDS
Wound healing activity of acylated iridoid glycosides from Scrophularia nodosa.

BURN WOUNDS
The healing effect of scrophularia striata on experimental burn wounds infected to pseudomonas aeruginosa in rat.