Scorpion, Quan Xie 全蝎

Chinese Gold Scorpion, Manchurian Scorpion (TCM)
Quan Xie (TCM)
Aqrab (Unani)
Picture Picture
Picture Dioscorides Materia Medica, Mathias, 1563

Picture Buthus mariefranceae (from Morocco), related to the species used in TCM.
Photo by Christian Ferrer) (Wikimedia)

Picture Picture
Scorpion species used in Medicine
Shaw, G. Zoological Lectures delivered at the Royal Institution, 1809

Bulk Scorpions as used in TCM (Adam, 2011)

Entomological name:


Various species have been used, especially of the Scorpio, Buthus and Typopellis genus.
TCM uses Buthus martensii (official species), however a number of species are available on the market..
In Europe, the common European Scorpion (Buthus occitanus) has been used medicinally, although mostly externally.

Parts used:


Whole dried Scorpion

Temperature & Taste:


Neutral. Salty, pungent. Slightly Poison.

Classifications:


2I. ANTISPASMODICS    2M. DRAWING
3E. DIURETIC    3F. LITHONTRIPTIC
TCM:
I. Medicines for Internal Wind

Uses:


1. Calms the Internal Wind, Calms Spasms (TCM):
-internal Wind and phlegm type Spasms, Childhood Convulsions, Tics, Lockjaw, Seizures, Opisthotonos
-Strokes, Facial Paralysis, Hemiplegia, Vertigo
-considered by Old TCM physicians to be ‘indispensible’ for convulsive diseases.
-Lunatics and Madness
-Hypertension (proven prolonged anti-hypertensive effect)

2. Clears Wind and Damp, Stops Pain (TCM, Tibetan, West):
-severe Headaches, Migraines, and other severe pain from wind and dampness blocking the circulation
-chronic cases of Arthritis, Sciatica and Rheumatic pains.
-In Europe, a tincture was used for Joint Pain and Sciatica
-in pills for Gout and Arthritis in Tibetan Medicine.

3. Clears Damp, Promotes Urine, Break Stones:
-ashes potently promote urine and break Stones
-Scorpion powder is used in Tibetan Medicine for Kidney disease also.
-Oil of Scorpions was used internally and externally over the Kidneys (West)
-helps Jaundice (West since Dioscorides; Tibetan Medicine)
-“The burnt scorpion when taken orally, dissolves cystolith and nephrolith effectively”. (Avicenna)
-“And a common Scorpion roasted and eaten by those that have the Stone, makes them piss the stone without torment” (Magic of Kirani)

4. Clears Poison, Resolves Nodules:
-Poisonous Sores, Swellings, Neck Lumps, Scrofula.
-Hard swellings under the Jaw
-Acute Mastitis (proven effect)
-Urticaria, Poisonous Bites (TCM, West)
-In Europe they were used for Cancer, old sores, and the Plague. (Salmon, Mesue)
-proven effective in Whooping Cough

5. Benefits Sight:
-The ash has been used for poor Eyesight. (Galen, Mesue, Salmon)

6. Kills Worms:
-occasionally listed to Kill Worms (Salmon, others)

7. Externally:
-deafness, gout, inflammations.
-Oil of Scoprion is applied to suppurating otitis media and earache. (Avicenna)
-powdered and mixed with vinegar, it is applied to Leucoderma (Unani)
-topically with Rose Vinegar to gout, inflammations, and skin deformities.
-oil in which scorpions have been infused is applied to burns (Europe)


Dose:


1. The tail is considered stronger and is given in half to one-third the dose given below.
2. The Tail was traditionally used for Convulsions, Toxin and High Fever while the Body was preferred for Paralysis and Hemiplegia. Today, the whole Scorpion is used for all functions by most practitioners.
3. When used in Decoction, it is best to take the powder with the decoction rather than decocting the Scorpion.
Decoction: 2–4 grams (up to 9 grams)
Powder: 500mg–1 gram (up to 3 grams)
Ashes of Burnt Scorpion: 100–500mg

Comment:


Scorpion and Centipede are similar in use and often used together. Scorpion is regarded as stronger for Twitching and Tremors while Centipede is stronger for Spasms, Convulsions and Toxic Swellings.

Substitute:


1. Centipede (Wu Gong) is similar in use.
2. The toxin in Scoprion is similar in effect to Viper toxin.

Preparation:


1. In TCM, they are washed, boiled briefly in water, then dried in the sun or in an oven.
2. They maybe soaked in wine, then dried. This enhances their blood-moving effect, is better for Wind-Damp and stronger to ease pain.
3. In the West, they were sometimes carbonized or burnt to ashes.

Main Combinations:


Often combined with Centipede (Wu Gong) in TCM. The two are combined for muscle twitches, rigidity or spasms of the whole body, and convulsions, as well as Paralysis, Hemiplegia etc. The pair are powdered in equal parts and are known as Zhi Jiang San, and given in doses of 1–2 grams.

Wind, Nerves, Spasmodic disorders
1. Internal Wind, Convulsions, Epilepsy, Paralysis, Hemiplegia:
i. in chronic Epilepsy, Scorpion taken for 6–12 months gave marked relief in around 80% of cases.
ii. Scorpion with Centipede (Wu Gong) (as in Zhi Jiang San)
iii. Scorpion, Paeonia Bai Shao, Gastrodia Tian Ma, Saposhnikovia Fang Feng
iv. Wind-Phlegm Epilepsy, Scorpion, Pinellia Ban Xia, bile-prepared Arisaema Dan Nan Xing, White Silkworm (Bai Jiang Can) (as in Wu Xian Wan, Pill for 5 Kinds of Epilepsy)
2. Infantile Convulsions:
i. chronic infant convulsions with weakness, Scorpion with Codonopsis Dang Shen, Astragalus Huang Qi, Gastrodia Tian Ma
ii. Scorpion with Tabasheer (Tian Zhu Huang), Amber (Hu Po), Saposhnikovia Fang Feng (as in Bo Ying Compound)
iii. Febrile Convulsions from High Fever, Scorpion with Antelope horn (Ling Yang Jiao), Uncaria Gou Teng
iv. Wind-Heat or Heat-Phlegm, Scorpion, bile-prepared Arisaema Dan Nan Xing, Pearl, Amber, Tabasheer, Bezoar, Water Buffalo Horn extract
v. from Phlegm-Heat, Scorpion, Curcuma Yu Jin, Alum (Bai Fan)
vi. Febrile Convulsions, Scorpion, Uncaria Gou Teng, Bezoar (Niu Huang), Cinnabar (Zhu Sha)
3. Epilepsy, Mania from Phlegm-Heat, Scorpion, Alum (Bai Fan), Cicada Slough (Chan Tui), Curcuma Yu Jin
4. Tetanus with Spasms and Convulsions: Scorpion with Centipede (Wu Gong), Cicada Slough (Chan Tui), bile-prepared Arisaema Dan Nan Xing
5. Headache and Migraine from Wind:
i. Scorpion with Ligusticum Chuan Xiong, Gastrodia Tian Ma, Saposhnikovia Fang Feng,
ii. Scorpion with Centipede (Wu Gong), White Dead Silkworm (Bai Jiang Can), Ligusticum Chuan Xiong
iii. Scorpion with Placenta (equal parts), powder, and take 900mg three times daily. This was used in a trial and found to give marked relief in 12 hours and total relief in nearly all subjects in 48 hours. (Chen & Chen)
6. Facial Paralysis, Scorpion, White Dead Silkworm (Bai Jiang Can), Typhonium Bai Fu Zi
7. Cerebral Embolism, Scorpion, Centipede (Wu Gong), Bungarus Bai Hua She (Viper),
8. Sesquele of Stroke with Hemiplegia etc.:
i. Scorpion with Centipede, Ligusticum Chuan Xiong, Safflower (Hong Hua), Peach kernel (Tao Ren), Salvia Dan Shen (as in Zhong Feng Hui Chu Wan, ‘Stroke Rejuvenation Tablets)
ii. Scorpion, Viper (Agkistrodon, Qi She), Ligusticum Chuan Xiong, Dang Gui roots.
iii. Scorpion, Earthworm, Centipede, Pearl

Stones, Arthritic disorders
9. Stones:
i. Scorpion ashes with Maidenhair, Gentian, Jews stone, Cucumber seed, Pumpkin seed, Aniseed (as in Electuary for Stones)
ii. Scorpion with the Four Cold Seeds, Marshmallow seed, Fennel seed, Jews Stone, Maidenhair (as in Powder for Kidney Stones from Heat of Unani)
10. Obstinate Arthritis, Rheumatoid Arthritis:
i. Scorpion with prepared Nux Vomica (Ma Qian Zi), Silkworm (Bai Jiang Can), Frankincense (Ru Xiang), Myrrh (Mo Yao), Ephedra Ma Huang, Achyranthes Niu Xi, Atractylodes Cang Zhu, Licorice (as in Feng Shi Ma Qian Pian)
ii. with poor joint mobility, Scorpion, Aconitum Chuan Wu, Viper (Agkistrodon, Qi She), Myrrh (Mo Yao)

Toxin, Sores & Swellings
11. Furuncle, Toxic Sores:
i. Scorpion can be fried in oil and taken alone
ii. Scorpion with Centipede (Wu Gong) and Realgar (Xiong Huang) topically.
iii. Scorpion, Gardenia Zhi Zi (7 of each), fry in sesame oil until crisp, strain, add beeswax and form an ointment.
12. Scrophula, Nodes:
i. Scorpion, Forsythia Lian Qiao, Self Heal (Xia Ku Cao)
ii. Scoprion, Nux Vomica (Ma Qian Zi), Pinellia Ban Xia, Trogopterus Wu Ling Zhi, made into pills
iii. Scorpion, Centipede, Earthworms
13. Mastitis: taking 2 Scorpions or 3 grams of the powder daily has been very effective in resolving acute Mastitis. (Chen & Chen)
14. Whooping Cough, cook one Scorpion and take with an Egg twice daily. In a trial of 74 patients all recovered in 4–7 days. (Chen & Chen)
15. Thromboangiitis obliterans and Tuberculosis of the bones, Scorpion, Centipede (Wu Gong), Earthworm (Di Long), Eupolyphaga (Tu Bie Chong), made into powder or pills. This combination has proven effective and is also used for Scrofula.
16. Tuberculosis of the Bones and Joints,
Scorpion, Centipede, Earthworms
17. Otitis, Scorpion boiled in olive oil with Rue (Europe)
18. Mumps, stir fry Scorpions until yellow, powder and give in divided doses.


Major Formulas:


Confection of Ashes
Electuary for Stones (Azaricon)
Electuary of Scorpion (Unani)
Powder for Kidney Stones from Heat (Unani)

Bo Ying Compound
Ding Xian Wan
Feng Shi Ma Qian Pian
Hui Chun Dan
Qu Feng Zhi Bao Dan
Zhi Jing San (Scorpion & Centipede Powder, equal parts)

Precious Wish Fulfilling Jewel (Rin chen ratna bsam ‘phel) (Tibetan)

Cautions:


1. Avoid overdose.
2. Not used during Pregnancy.
3. Not used in Wind disorders from Blood or Yin deficiency.

Toxicity:


1. Overdose occurs when 30–60 grams is taken in Decoction, or more than 20 grams in powder.
2. Symptoms of overdose include dizziness, fever, photophobia, nausea, leading to decrease or increase of heart rate, hypo- or hyper-tension, seizure, unconsciousness and respiratory depression. Blood and protein in the urine has also been reported.
3. LD50 for intraperitoneal injection in mice is 2.4 mg/kg.

Antidotes:
Traditional Western Medicine:
1. Sage, Scordium, Wormwood, Agrimonia, Dandelion, Mother of Thyme, Basil, Gentian, Birthwort, Bay berry. Wild Parsnip seed, Fennel, Radish

From TCM:
1. A dose of 20 grams of Sodium sulphate (Mang Xiao) to purge the toxin.
2. Decoction of Rhubarb (Da Huang) 15 grams, Sodium sulphate (Mang Xiao) 6 grams, divided into 3 equal doses.
3. Decoction of Lonicera Jin Yin Hua 30 grams, Lobelia chinensis Ban Bian Lian 10 grams, China root (Tu Fu Ling) 15 grams, Mung Bean (Lu Dou) 15 grams, Licorice 10 grams.
4. Decoction of Flying Squirrel Feces (Wu Ling Zhi) 10 grams, Typha Pu Huang 9 grams, Realgar (Xiong Huang) 3 grams. Divide into 3 equal doses and take one every 4 hours with Vinegar. (Chen & Chen)

Main Preparations used:


Powder, Ashes, Oil, Compound Oil

1. Oil of Scorpions:
Applied externally to venomous Bites, also rubbed on the loins and pubis for Calculi.
i. Scorpions (100), Olive oil (2 lbs.). Digest 3 days in a water-bath, strain. (Pharmacopoeia Sardoa, 1773)

2. Compound Oil of Scorpions:
i. Scorpions (50), Olive oil (1 lb.), Round Birthwort root, Gentian root, Cypress root, Caper root-bark (6 drams each). Digest for 24 hours in a moderate heat. (Pharmacopoeia Wirtembergica, 1798)
ii. Oil of St. Johns wort (4 lbs.), Scordium, Rue, Dittany of Crete (2 handfuls each), Zedoary, Round Birthwort, Angelica, Saffron, Storax (1 oz. each), Turpentine (3 oz.), Mithridate, Theriac (half oz.), Living Scorpions (300). Digest leaves, root, and saffron for 3 days in a water-bath, then express strongly. Then dissolve the Storax, Mithridate and Theriac in the expressed oil, and lastly add the Scorpions. Digest another three days in a water-bath, when cold, express strongly. (Pharmacopoeia Sardoa, 1773)

NOTE: The folowing research is mostly focused on species used in TCM. However, a number of other species are also cited.

1. GENERAL/REVIEW:
Research progress on medicinal values of scorpion venom components.
Autonomic effects of some scorpion venoms and toxins.
Scorpion Venom: Detriments and Benefits
Thermostable potassium channel-inhibiting neurotoxins in processed scorpion medicinal material revealed by proteomic analysis: Implications of its pharmaceutical basis in traditional Chinese medicine.
Review Scorpion Venom Peptides as a Potential Source for Human Drug Candidates.

2. ANTI-BACTERIAL:
Insects, arachnids and centipedes venom: A powerful weapon against bacteria. A literature review.
Scorpion Venom: Detriments and Benefits
Antimicrobials from Venomous Animals: An Overview

3. ANTI-VIRAL
Scorpion Venom: Detriments and Benefits
Anti-HIV-1 Activity of a New Scorpion Venom Peptide Derivative Kn2-7
Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1
The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-I Interferon Response
A scorpion venom peptide Ev37 restricts viral late entry by alkalizing acidic organelles

4. ANTI-FUNGAL
Scorpion Venom: Detriments and Benefits
Activity of Scorpion Venom-Derived Antifungal Peptides against Planktonic Cells of Candida spp. and Cryptococcus neoformans and Candida albicans Biofilms

5. ANTI-INFLAMMATORY:
Study of Anti-Inflammatory and Analgesic Activity of Scorpion Toxins DKK-SP1/2 from Scorpion Buthus martensii Karsch (BmK).

6. ANALGESIC
Purification and characterization of an analgesic peptide from Buthus martensii Karsch.
Scorpion Venom: Detriments and Benefits

7. ANTI-CONVULSANT / ANTI-EPILEPTIC:
Chinese herbal compounds containing scorpion in the treatment of epilepsy: A protocol for systematic review and meta-analysis.
Effects of scorpion venom heat-resistant peptide on the hippocampal neurons of kainic acid-induced epileptic rats.
Influences of “spasmolytic powder” on pgp expression of Coriaria Lactone-kindling drug-resistant epileptic rat model.

8. ANTI-HYPERTENSIVE

9. CARDIOVASCULAR, ANTI-THROMBOTIC, INHIBIT PLATELET AGGREGATION:
Cardiovascular effects of Buthus martensii (Karsch) scorpion venom.
Anticoagulant Activity of Low-Molecular Weight Compounds from Heterometrus laoticus Scorpion Venom

10. DIABETES
Therapeutic Potential of Peptides Derived from Animal Venoms: Current Views and Emerging Drugs for Diabetes

11. UTERUS-STIMULATING EFFECT
12. IMMUNE / IMMUNO-MODULATORY
Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes
The Effects of Isolated Fractions of Mesobuthus eupeus Scorpion Venom on Humoral Immune Response

13. ANTI-TUMOR / ANTI-CANCER:
Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway
Anti-tumoral effect of scorpion peptides: Emerging new cellular targets and signaling pathways.
Scorpion Venom: Detriments and Benefits
Triggering of cancer cell cycle arrest by a novel scorpion venom-derived peptide-Gonearrestide.
Voltage-Gated K+/Na+ Channels and Scorpion Venom Toxins in Cancer
Pleiotropic Anticancer Properties of Scorpion Venom Peptides: Rhopalurus princeps Venom as an Anticancer Agent
In vitro and in vivo antitumor effects of the Egyptian scorpion Androctonus amoreuxi venom in an Ehrlich ascites tumor model
BRAIN
Anti-metastatic effect of 131I-labeled Buthus martensii Karsch chlorotoxin in gliomas.
BREAST
Scorpion venom induces apoptosis in the triple negative human breast cancer cell line MDA-MB-231.
Rhopalurus junceus scorpion venom induces antitumor effect in vitro and in vivo against a murine mammary adenocarcinoma model
Inhibition Effects of Scorpion Venom Extracts (Buthus Matensii Karsch) on the Growth of Human Breast Cancer MCF-7 Cells
Scorpion Venom Causes Apoptosis by Increasing Reactive Oxygen Species and Cell Cycle Arrest in MDA-MB-231 and HCT-8 Cancer Cell Lines.
Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-xL and BID Protein Expression by Modulating Signaling Proteins Erk1/2 and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines
In vitro analysis of the anticancer properties of scorpion venom in colorectal and breast cancer cell lines
CERVICAL
Scorpion Venom Induces Apoptosis in Cervical Cancer Cell Lines.
Tityus serrulatus Scorpion Venom Induces Apoptosis in Cervical Cancer Cell Lines
COLORECTAL
Scorpion Venom Causes Apoptosis by Increasing Reactive Oxygen Species and Cell Cycle Arrest in MDA-MB-231 and HCT-8 Cancer Cell Lines.
Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-xL and BID Protein Expression by Modulating Signaling Proteins Erk1/2 and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines
In vitro analysis of the anticancer properties of scorpion venom in colorectal and breast cancer cell lines
GASTRIC
Scorpion venoms in gastric cancer.
LEUKEMIA
Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells
LIVER
Scorpion inhibits epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma.
PROSTATE
Application of network pharmacology and molecular docking to elucidate the potential mechanism of Astragalus-Scorpion against prostate cancer.

14. ANTI-PARASITIC
Scorpion Venom: Detriments and Benefits