Rehmannia, Shu Di Huang 熟地黄

Prepared Chinese Foxglove root
Shu Di Huang (TCM)
Picture
Picture Edwards’s Botanical Register (1837)

Picture Rehmannia glutinosa flower
(Photo by 阿橋) (Wikimedia)

Botanical name:


Rehmannia glutinosa

Parts used:


Prepared Root

Temperature & Taste:


Warm, moist. Sweet

Classification:


N. Blood Tonic     N. Yin Tonic

Uses:


1. Tonifies the Blood:
-weakness, pale face and tongue, deficient and thin pulse
-Dizziness, poor Memory
-Palpitations, Insomnia
-Uterine Bleeding, Postpartum Bleeding
-Threatened Miscarriage and Ante-partum disorders of deficiency

2. Strengthen the Kidneys, Nourishes Yin:
-weakness of the Lower Back and Knees
-Dizziness, Tinnitus
-Tidal Fever, Night-sweats
-Nocturnal Emission
-Wasting and Thirsting Disorders; Diabetes
-“Pain under the umbilicus is a sign of Kidney disorder. Shudihuang is the only drug that can deal with it”. (Zhang Yuan Su)

3. Nourishes and Increases Essence:
-Premature Aging; premature greying of hair; support during aging
-Delayed development in children
-Impotence, Infertility

Dose:


Decoction: 9–30 grams
Powder: 1–4 grams

Comment:


1. Sheng Di Huang (dried Rehmannia root) clears Heat from the Blood while supporting Yin. Shu Di Huang (the prepared root) nourishes Blood and Yin.
2. According to Porter Smith, Digitalis (Foxglove) which is called Mao Di Huang was previously used synonymously with Rehmannia root. This seems unlikely.

Substitute:


Early missionaries in China equated Shu Di Huang with Comfrey. The two plants are related and not dissimilar in appearance. Comfrey has long been used for its Yin tonifying qualities in the West. It may be an acceptable substitute in some instances.

Correctives:


1. Alisma Ze Xie prevents the heavy, cloying effect, as in Liu Wei Di Huang Wan.
2. Amomum Sha Ren or Costus (Mu Xiang) is added to prescriptions with Rehmannia to avoid the heavy, cloying effect and promote digestion.

Preparation:

 
1. Wine=Prepared Rehmannia (Shu Di Huang)
  The root is steamed, then laid out to partly dry. It is then mixed with wine and steamed again. It is then taken out and dried, and kept for use.
  Li Shi Zhen complained that the pharmacies in his time typically only prepared the drug with wine which is “no good for medicinal use”.
2. Juice prepared Rehmannia:
  According to older sources, the dru can be prepared the same way, but using the juice of fresh Rehmannia instead of wine.
3. Amomum Sha Ren Prepared Rehmannia.
  Dried Rehmannia root is steamed with wine and a little Amomum Sha Ren powder until completely dry. It is then added to more wine and Amomum Shar Ren and the process repeated. This was repeated 9 times in total. The Amomum is added to correct the greasy, heavy nature of Rehmannia.
  This harmonises the Five Organs and leads Qi to the Dan Tian in the lower abdomen. Li Shi Zhen said this was a common method of preparation in his day.

Main Combinations:


1. Blood deficiency and Menstrual disorders associated with Blood deficiency, Rehmannia Shu Di Huang with Dang Gui, Paeonia Bai Shao, Ligusticum Chuan Xiong (as in Si Wu Tang)
2. To strengthen the Kidneys and Nourish the Yin or Yang, combine Rehmannia Shu Di Huang with Cornus Shan Zhu Yu and Dioscorea Shan Yao. This trio forms the basis of the most important formulas used to strengthen the Kidneys. Alone, they nourish Kidney Yin and are usually corrected with the addition of Poria Fu Ling, Alisma Ze Xie and Paeonia Mu Dan Pi (as in Liu Wei Di Huang Wan, ‘Rehmannia ‘). When Cinnamon (Rou Gui) and Aconitum Fu Zi is added it is called Shen Qi Wan (Kidney Qi Pill) and is used for Yang deficiency.
3. To strengthen Kidney Yang:
i. Rehmannia Shu Di Huang with Cinnamon and prepared Aconitum Fu Zi.
4. Heat with Yin deficiency, Rehmannia Shu Di Huang with Turtle shell (Gui Ban), Phellodendron Huang Bai and Anemarrhena Zhi Mu.
5. To more strongly nourish Yin and clear Heat, strengthen the bones an calm the Mind and Nerves, combine with Pearl.
6. Insomnia from Heart Yin deficiency, Rehmannia Shu Di Huang with Ophiopogon Mai Men Dong, Poria Fu Ling, Zizyphus Semen Suan Zao Ren, Schisandra Wu Wei Zi
7. Diabetes
i. Rehmannia Shu Di Huang with Coptis Huang Lian (see research below)
ii. Rehmannia Shu Di Huang with Dioscorea Shan Yao, Cinnamon
8. Excess Sex resulting in weakness and cough, Rehmannia Shu Di Huang with Ginseng, Poria Fu Ling made into pilsl with Honey.

Major Formula:


Liu Wei Di Huang Wan
Er Long Zuo Ci Wan
Ma Wei Di Huang Wan
Ming Mu Di Huang Wan
Qi Ju Di Huang Wan
Zhi Bai Di Huang Wan
Jin Gui Shen Qi Wan
Zuo Gui Wan
You Gui Wan
Zuo Gui Yin
You Gui Yin
Da Bu Yin Wan (Great Tonify Yin Pill)
Si Wu Tang
Shi Quan Da Bu Tang
Ba Zhen Tang
Bai He Gu Jin Tang
Bu Gan Tang
Dang Gui Liu Huang Tang
Ren Shen Yang Rong Tang
Tai Shan Pan Shi San
Yang Xin Tang

Cautions:


1. Not used in Spleen weakness with poor appetite, loose bowels, abdominal pain and distention
2. Not used in cases with excess Phlegm and Damp
3. Avoid Onions, Garlic and Radish while taking Rehmannia.

Main Preparations used:




  • Extra Info
  • Research
GENERAL / REVIEW
Rehmannia glutinosa: review of botany, chemistry and pharmacology.

COMBINATIONS
The synergistic effect of Angelica sinensis (Oliv.) Diels and Rehmannia glutinosa (Gaertn.) DC. on antioxidant activity and protective ability against cell injury.
Baihe Dihuang (Lilium Henryi Baker and Rehmannia Glutinosa) decoction attenuates somatostatin interneurons deficits in prefrontal cortex of depression via miRNA-144-3p mediated GABA synthesis and release.
UPLC-Q/TOF-MS-Based Serum Metabolomics Reveals Hypoglycemic Effects of Rehmannia glutinosa, Coptis chinensis and Their Combination on High-Fat-Diet-Induced Diabetes in KK-Ay Mice.
UPLC-Q-TOF/MS-based metabolic profiling comparison of four major bioactive components in normal and CKD rat plasma, urine and feces following oral administration of Cornus officinalis Sieb and Rehmannia glutinosa Libosch herb couple extract.
Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells.

PROCESSING
Structural changes, and anti-inflammatory, anti-cancer potential of polysaccharides from multiple processing of Rehmannia glutinosa.
Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa roots.
Effects of growth conditions and processing on Rehmannia glutinosa using fingerprint strategy.
[Studies on Rehmanniae radix. III. The relation between changes of constituents and improvable effects on hemorheology with the processing of roots of Rehmannia glutinosa].
[Determination of total saccharide and several main saccharides in Rehmannia glutinosa Libosh, and its processed products].
[Analysis and comparison of free amino acids in Rehmannia glutinosa Libosch, and its processed products].

ANTI-INFLAMMATORY
Structural changes, and anti-inflammatory, anti-cancer potential of polysaccharides from multiple processing of Rehmannia glutinosa.
Bioassay-guided isolation of anti-inflammatory components from the root of Rehmannia glutinosa and its underlying mechanism via inhibition of iNOS pathway.
Rehmannia glutinosa suppresses inflammatory responses elicited by advanced glycation end products.

ANTIOXIDANT
Phytochemical Profiles and Antioxidant Activity of Rehmannia glutinosa from Different Production Locations.
ANTIOXIDANT PROPERTIES OF METHANOLIC EXTRACTS FROM THE SHOOTS AND ROOTS OF pRi-TRANSFORMED PLANTS OF REHMANNIA GLUTINOSA LIBOSCH.

ANTI-ALLERGY
Effect of Rehmannia glutinosa on immediate type allergic reaction.

IMMUNE EFFECT
The Effects of Oral Rehmannia glutinosa Polysaccharide Administration on Immune Responses, Antioxidant Activity and Resistance Against Aeromonas hydrophila in the Common Carp, Cyprinus carpio L.
Optimization on preparation conditions of Rehmannia glutinosa polysaccharide liposome and its immunological activity.
Immunoenhancement effect of rehmannia glutinosa polysaccharide on lymphocyte proliferation and dendritic cell.
Effects of Rehmannia glutinosa polysaccharide b on T-lymphocytes in mice bearing sarcoma 180.

ANTIFIBROTIC
Radix Rehmannia Glutinosa inhibits the development of renal fibrosis by regulating miR-122-5p/PKM axis.

NEUROPROTECTIVE
Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa.

ANTIDEPRESSANT
Ethanol extract of Rehmannia glutinosa exerts antidepressant-like effects on a rat chronic unpredictable mild stress model by involving monoamines and BDNF.

ANTICONVULSANT
Catalpol and Mannitol, Two Components of Rehmannia glutinosa, Exhibit Anticonvulsant Effects Probably via GABAA Receptor Regulation.

BLOOD TONIC
[Studies of Rehmannia glutinosa Libosch. f. hueichingensis as a blood tonic].

OSTEOPOROSIS
Effects of Rehmannia glutinosa polysaccharides on bone tissue structure and skeletal muscle atrophy in rats with disuse.
Rehmannia glutinosa Libosch Extracts Prevent Bone Loss and Architectural Deterioration and Enhance Osteoblastic Bone Formation by Regulating the IGF-1/PI3K/mTOR Pathway in Streptozotocin-Induced Diabetic Rats.
Dried root of Rehmannia glutinosa prevents bone loss in ovariectomized rats.
Effect of Rehmannia glutinosa Libosch extracts on bone metabolism.

HEPATOPROTECTIVE
Isolation, characterization, and hepatoprotective effects of the raffinose family oligosaccharides from Rehmannia glutinosa Libosch.
Hepatoprotective iridoid glycosides from the roots of Rehmannia glutinosa.
Hot water extracted Lycium barbarum and Rehmannia glutinosa inhibit liver inflammation and fibrosis in rats.
ANTI-AGEING
Rehmannia glutinosa exhibits anti-aging effect through maintaining the quiescence and decreasing the senescence of hematopoietic stem cells.

HEPATIC FIBROSIS
Hot water extracted Lycium barbarum and Rehmannia glutinosa inhibit liver inflammation and fibrosis in rats.

RENOPROTECTIVE
Renoprotective activity of a new amide and a new hydroxycinnamic acid derivative from the fresh roots of Rehmannia glutinosa.
Protective effects and mechanisms of Rehmannia glutinosa leaves total glycoside on early kidney injury in db/db mice.

RENAL FAILURE
Rehmannia glutinosa ameliorates the progressive renal failure induced by 5/6 nephrectomy.

GLOMERULONEPHRITIS
Treatment of primary chronic glomerulonephritis with Rehmannia glutinosa acteosides in combination with the angiotensin receptor blocker irbesartan: a randomized controlled trial.

DIABETES
Rehmannia glutinosa Libosch Extracts Prevent Bone Loss and Architectural Deterioration and Enhance Osteoblastic Bone Formation by Regulating the IGF-1/PI3K/mTOR Pathway in Streptozotocin-Induced Diabetic Rats.
UPLC-Q/TOF-MS-Based Serum Metabolomics Reveals Hypoglycemic Effects of Rehmannia glutinosa, Coptis chinensis and Their Combination on High-Fat-Diet-Induced Diabetes in KK-Ay Mice.
Antidiabetic and antioxidant effects of catalpol extracted from Rehmannia glutinosa (Di Huang) on rat diabetes induced by streptozotocin and high-fat, high-sugar feed.
Rehmannia glutinosa (Gaertn.) DC. polysaccharide ameliorates hyperglycemia, hyperlipemia and vascular inflammation in streptozotocin-induced diabetic mice.
Ameliorating effect and potential mechanism of Rehmannia glutinosa oligosaccharides on the impaired glucose metabolism in chronic stress rats fed with high-fat diet.
Plasma glucose lowering mechanisms of catalpol, an active principle from roots of Rehmannia glutinosa, in streptozotocin-induced diabetic rats.
Characterization of the anti-diabetic and antioxidant effects of rehmannia glutinosa in streptozotocin-induced diabetic Wistar rats.
[Effect of Rehmannia glutinosa Libosch water extraction on gene expression of proinsulin in type 2 diabetes mellitus rats].
[Effect of Rehmannia glutinosa water extraction on insulin resistance and gene expression of resistin in type 2 diabetes mellitus rats].
[Effects of Rehmannia glutinosa oligosaccharides on proliferation of HepG2 and insulin resistance].
Stachyose extract from Rehmannia glutinosa Libosch. to lower plasma glucose in normal and diabetic rats by oral administration.
Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism.
[Hypoglycemic activity of polysaccharide fraction from rhizome of Rehmannia glutinosa Libosch. f. hueichingensis Hsiao and the effect on carbohydrate metabolism in normal mouse liver].

DIABETIC NEPHROPATHY
Protective Effects of Total Glycoside From Rehmannia glutinosa Leaves on Diabetic Nephropathy Rats via Regulating the Metabolic Profiling and Modulating the TGF-β1 and Wnt/β-Catenin Signaling Pathway.

LEARNING & MEMORY
Rehmannia glutinosa ameliorates scopolamine-induced learning and memory impairment in rats.

MENOPAUSE
A Herbal Formula HT051, a Combination of Pueraria lobata and Rehmannia glutinosa, Prevents Postmenopausal Obesity in Ovariectomized Rats.

OBESITY
A Herbal Formula HT051, a Combination of Pueraria lobata and Rehmannia glutinosa, Prevents Postmenopausal Obesity in Ovariectomized Rats.
Rehmannia glutinosa reduced waist circumferences of Korean obese women possibly through modulation of gut microbiota.

MUSCULAR ATROPHY
Effects of Rehmannia glutinosa polysaccharides on bone tissue structure and skeletal muscle atrophy in rats with disuse.

CANCER
Effects of Rehmannia glutinosa polysaccharides on the proliferation and apoptosis of K562 cells.
Rehmannia glutinosa polysaccharide induces toll-like receptor 4 dependent spleen dendritic cell maturation and anti-cancer immunity.
Rehmannia glutinosa polysaccharide induced an anti-cancer effect by activating natural killer cells.
LIVER
Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells.
LUNG
Structural changes, and anti-inflammatory, anti-cancer potential of polysaccharides from multiple processing of Rehmannia glutinosa.

CHEMOTHERAPY TOXICITY
Protective effect of Rehmannia glutinosa on the cisplatin-induced damage of HEI-OC1 auditory cells through scavenging free radicals.

ALLEVIATES METHOTREXATE TOXICITY
Steamed root of Rehmannia glutinosa Libosch (Plantaginaceae) alleviates methotrexate-induced intestinal mucositis in rats.