Prunella, Self-heal, Xia Ku Cao 夏枯草

Also called Consolida minor
Xia Ku Cao (TCM)
Picture
Picture Ortus Sanitatis, Meydenbach, 1491

Picture Picture
New Kreuterbuch, Matthiolus, 1563

Kurtzes Handtbuchlein, Ryff, 1599
Picture Dietrich, Flora regni borussici, 1834

Botanical name:


Prunella vulgaris
Prunella hispida is also used in parts of China.

Parts used:


Flowering tops; Herb

Temperature & Taste:


Cool, dry. (Warm in the West). Slightly Sweet, Bitter, Pungent
Bitter, Cleansing, Binding

Classifications:


2D ATTENUATERS OF CONGEALED BLOOD
2T. GLUTINATE
TCM:
B. Clear Strong Heat or Fire

Uses:


1. Clears Liver Heat (TCM, West):
-red, swollen, painful eyes
-Headache, Dizziness, Convulsions, Vertigo, Epilepsy
-Hepatitis
-Hypertension; it has also been regarded as effective for Hypotension
-Hyperthyroidism

2. Clears Heat and Poison:
-Toxic Sores, Abscesses, Carbuncles
‘the bites of Mad Dogs and Venomous beasts’ (Culpeper)
-also taken to prevent Infection during epidemics including Measles

Quinsey [Tonsillitis], sores and ulcers of the mouth and jaws’. (Salmon)
-Dysentery (TCM)
-Viral infections including Herpes, Glandular Fever, Mumps, HIV etc.


3. Clears Heat and Poison, Resolves Masses:
-phlegm and heat-type
Scrofula, Goiter, Lymphadenitis, Swollen Glands in the neck, and various other nodes and swellings
-used as a stand-alone herb for Scrofula, including those that have ruptured or ulcerated
-special for Mastitis, Abscesses, Tumors and Cancer of the Breast
-other Tumors and Cancers including Lymphoma


4. Clears Heat, Clears Stasis, Promotes Healing:
-A valuable Vulnerary (Wound herb); long used internally or externally for all sorts of Wounds, Bruises, internal Bleeding
-internal or external Ulcers, including Ulcers of the mouth, anus, vagina, and Lungs.
-Fractures and Dislocations (int. & ext.)
-‘used chiefly in Wounds of the Lungs’. (Schroder)

‘the Essence hereof taken inwardly causes all wounds inward and outwardly to heal’. (Salmon)

5. Moves the Blood, Clears Blood Stasis:
-Amenorrhea, sluggish Menstruation
-Postpartum Hemorrhage
-‘Expels a dead child’
(Culpeper)
‘Dissolves congealed blood’. (Salmon)

6. Clears Heat and Damp, Promotes Urine:
-Difficult Urination and Edema.
-‘helps all joint aches’ and ‘is excellent for all griefs of the Sinews’
(Culpeper); Gout and Arthritis (TCM, West).
-In Europe it has also been used for Jaundice, Gravel and Stones.


7. Clears Heat, Stops Cough:
-‘A Great Pectoral’
(Salmon)
-heat-type Cough and Lung disease


8. Kills Worms.

9. Externally:
-topically for all inflammations (plaster)
-topically to minor skin Sores, Infections and Rashes
-used for various Wounds and Ulcers (plaster, or fresh herbs beaten and
applied)
-topically applied to the bites of Rabid Dogs and other venomous Bites.
(plaster, or fresh herb beaten and applied)
-applied to Cramps, Pain and Spasms of the Sinews and Tendons. (the
ointment or plaster is applied topically)
-as a mouth wash or gargle for all sores and inflammations of the Mouth,
Gums and Throat.


Comment:


Prunella is a valuable medicine, used in East and West, with several important spheres of activity:
1. Liver Heat
2. Hyperthyroidism; Scrofula and nodules of the neck; Cancer
3. Wounds; congealed Blood
4. Various Viral diseases
Despite the fact that it is viewed as Cold in TCM, Prunella is drunk as a health beverage in parts of China.

Dose:


It is drank as tea during the summer to clear heat.
DECOCTION or LONG INFUSION: 6–15 grams, up to 30 grams in severe cases (20–60 grams fresh). Around 45 grams is the normal maximum daily dose of the dried herb, which is built up to and used only if needed;
POWDER: 1–4 grams
TINCTURE (1:5): 2–5 mls;
FRESH JUICE: 5 drops up to 10 mls. are added to a glass of warm water, and this is taken as a dose.
SYRUP of the FRESH JUICE made with HONEY: taken in teaspoonful doses

Substitute:


1. Bugle
2. Prunella is a substitute for Stoechas in Unani medicine.

Main Combinations:


1. Liver Heat:
i. Self Heal with Dandelion, Peppermint
ii. Self Heal with Gentian, Scutellaria Huang Qin (TCM)
iii. Self Heal with headache, dizziness, red and sore eyes, with Cyperus rotundus and Licorice (Xia Ku Cao San from the Zhang Shi Yi Tong [Comprehensive Medicine according to Master Zhang]).
2. Hyperthyroidism, Liver Heat:
i. Self Heal with Balm
ii. from excess Liver heat, Self Heal with Scutellaria Huang Qin, Gardenia Zhi Zi, Gentiana Long Dan Cao
3. Scrofula, Lymphatic swelling:
i. Self Heal with Figwort
ii. Self Heal with Kelp, Licorice (as in Decoction of Self Heal and Kelp)
iii. Self Heal with Hyssop and Peppermint (as in Decoction of Self Heal)
iv. Self Heal with Balm, Walnut leaf, St. John’s wort, Calendula
v. Self Heal with Kelp and Figwort (Xuan Shen) (TCM)
vi. Self Heal with Fritillaria Bei Mu, Cyperus rotundus (Xiang Fu) for Phlegm-heat with Liver Qi stagnation (Xia Ku Cao Tang from Wai Ke Zheng Zong [True Lineage of External Medicine]).
4. Goiter, Self Heal, Oyster shell (Mu Li), Fritillaria Bei Mu
5. Hypertension:
i. Self Heal with Mistletoe, Peony
ii. Self Heal with Hawthorn, Balm
6. Sore, red eyes:
i. Self Heal with Eyebright
ii. Self Heal with Goji berries and Chrysanthemum (Ju Hua)
iii. Self Heal with Chrysanthemum (Ju Hua) and Cassia seed Jue Ming Zi
iv. Redness, tearing, pain of the eyeballs, photophobia, Self Heal with Cyperus rotundus (Bu Gan San from Jian Yao Ji Zhong Fang [Brief Prescriptions that Aid All People])
v. Liver deficient Eye pain, Self Heal, Cyperus rotundus
7. Deviation of the Eyes and Mouth (ie. Post Stroke), Self Heal, Saposhnikovia Fang Feng, Arisaema prepared with Bile (Dan Nan Xing) (from Southern Yunnan Materia Medica)
8. Sore and Swollen Throat, Tonsilitis:
i. decoct 60–90 grams of fresh Self Heal, decoct and drink over the day. (Compilation of Simple Prescriptions of Herbal Medicine and Herbal Medicine)
ii. Self Heal with Sage, Tormentil, Marshmallow, Elder flower, Licorice (Gazophylacium Medico-Physicum, Woyts, 1746)
9. Mastitis, Breast Lumps:
i. Self Heal, Dandelion (Pu Gong Ying) (equal parts). decocted in wine or made into pills
ii. Self Heal, Bupleurum Chai Hu, Fritillaria Bei Mu, Paeonia rubra Chi Shao Yao
10. Bleeding, take 1 teaspoonful of Self Heal powder with rice soup.
11. Leukorrhea with Blood, take 6 grams of the powder of Self Heal
12. Wound including Knife wounds, chew fresh Self Heal and apply
13. Non-healing Wounds, Self Heal, Lady’s Mantle, Sanicle, Tormentil (Herbarium Horstianum, 1630)
14. Wash for Sores and skin inflammations, Self Heal with Honeysuckle flower (Jin Yin Hua) or Camomile
15. A wash for Wounds and Ulcers, Self Heal with Bugle and Sanicle (Culpeper)
16. Fractures, combine Self Heal with Comfrey, both internally and topically
17. Plaster for Dislocations and Trauma of the Joints, Self Heal with Hollyhock root, Frankincense, Myrrh, Shilajit and Turpentine, made into a plaster with Suet and Oil (The Compleat Bone-setter, Turner, 1656)
18. Headache from Heat and inflammation, Self Heal juice with Vinegar of Roses, applied topically. (Herbarium Horstianum, 1630)

Major Formulas:


Decoction of Self Heal
Decoction of Self Heal and Kelp
Decoction of Timaei (modified)
Powder for Cancerous Ulcers (Gabelhover)
Plaster for Dislocations

Cautions:


Generally Safe.
1. In TCM it is not used for marked weakness (Qi deficiency).
2. It may lower Thyroid function and aggravate Hypothyroid conditions.

Main Preparations used:


Distilled Water of the Herb, Juice, Conserve of the Flowers

1. Conserve of the Flowers:
i. fresh Flower (1 part), Sugar (2 parts). Beat.

2. Juice of Self Heal:
i. Fresh Self Heal; bruise in a stone mortar, sprinkling with a little water; express strongly. Set aside the juice, then decant the clear liquid, preserving in bottles, adding to every pound, 1 dram of alcohol.
(Pharmacopoeia Herbipolitania, 1796)

3. Syrup of Self Heal:
i. Juice of Self Heal depurated and reduced to half by slow evaporation (9 oz.), White Sugar (16 oz.). Dissolve. (Pharmacopoeia Wirtembergica, 1798)
  • Extra Info
  • Research
ANTIBACTERIAL
Broad-spectrum Antibacterial: effective against Shigella, Typhoid Bacillus, Vibrio cholerae, Escherichia coli, Proteus, Pseudomonas aeruginosa, Staphylococcus, Streptococcus etc.
Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection

ANTIOXIDANT
In vitro antioxidant and anticancer effects of solvent fractions from prunella vulgaris var. lilacina
Antioxidant Activities of Total Phenols of Prunella vulgaris L. in Vitro and in Tumor-bearing Mice

ANTI-VIRAL
Identification and evaluation of the inhibitory effect of Prunella vulgaris extract on SARS-coronavirus 2 virus entry
Inhibition of HIV-1 infection by aqueous extracts of Prunella vulgaris L.
Inhibition of lentivirus replication by aqueous extracts of Prunella vulgaris
Characterization of the inhibitory effect of an extract of Prunella vulgaris on Ebola virus glycoprotein (GP)-mediated virus entry and infection
Potential of selected Lamiaceae plants in anti(retro)viral therapy

IMMUNOMODULATORY
Effects of Prunella vulgaris on the Mice Immune Function

HEPATOPROTECTIVE
Invivo hepatoprotective potential of extracts obtained from floral spikes of Prunella vulgaris L

THYROID NODULES
Safety and efficacy of Prunella vulgaris preparation in adjuvant treatment of thyroid nodules: A meta-analysis

THYROIDITIS
Analysis of the Molecular Mechanisms of the Effects of Prunella vulgaris against Subacute Thyroiditis Based on Network Pharmacology
Initial treatment combined with Prunella vulgaris reduced prednisolone consumption for patients with subacute thyroiditis
Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling

HASHIMOTO’S THYROIDITIS
Network Pharmacology to Explore the Molecular Mechanisms of Prunella vulgaris for Treating Hashimoto’s Thyroiditis
Innate Immune-Modulatory Activity of Prunella vulgaris in Thyrocytes Functions as a Potential Mechanism for Treating Hashimoto’s Thyroiditis
Effect of large dosage of Prunella on Hashimoto’s thyroiditis: A protocol of systematic review and meta-analysis of randomized clinical trials
DIABETES
Study on the Mechanism of Prunella Vulgaris L on Diabetes Mellitus Complicated with Hypertension Based on Network Pharmacology and Molecular Docking Analyses

HYPERTENSION
Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

VASCULITIS
Prunella vulgaris Suppresses HG-Induced Vascular Inflammation via Nrf2/HO-1/eNOS Activation
The protective effect of Prunella vulgaris ethanol extract against vascular inflammation in TNF-α-stimulated human aortic smooth muscle cells

ANTI-ESTROGENIC
Characterization of Antiestrogenic Activity of the Chinese Herb, Prunella vulgaris, Using In Vitro and In Vivo (Mouse Xenograft) Models

CANCER
In vitro antioxidant and anticancer effects of solvent fractions from prunella vulgaris var. lilacina
BREAST
Oral Administration of Prunella vulgaris L Improves the Effect of Taxane on Preventing the Progression of Breast Cancer and Reduces Its Side Effects
COLORECTAL
Spica Prunellae Extract Enhances Fluorouracil Sensitivity of 5-Fluorouracil-Resistant Human Colon Carcinoma HCT-8/5-FU Cells via TOP2α and miR-494
GASTRIC
Extracts of endophytic fungus xkc-s03 from Prunella vulgaris L. spica inhibit gastric cancer in vitro and in vivo
LUNG
Identification of Two Polysaccharides from Prunella vulgaris L. and Evaluation on Their Anti-Lung Adenocarcinoma Activity
Combination of Active Components Enhances the Efficacy of Prunella in Prevention and Treatment of Lung Cancer
LYMPHOMA
A Study on Inhibitory Effect of Spica Prunellae Extract on T Lymphoma Cell EL-4 Tumour
THYROID
The Chinese herb Prunella vulgaris promotes apoptosis in human well-differentiated thyroid carcinoma cells via the B-cell lymphoma-2/Bcl-2-associated X protein/caspase-3 signaling pathway
The Antitumour Effect of Prunella vulgaris Extract on Thyroid Cancer Cells In Vitro and In Vivo
UTERINE
Characterization and anti-uterine tumor effect of extract from Prunella vulgaris L.

AGEING
Prunella vulgaris L. Exerts a Protective Effect Against Extrinsic Aging Through NF-κB, MAPKs, AP-1, and TGF-β/Smad Signaling Pathways in UVB-Aged Normal Human Dermal Fibroblasts