Portulaca, Purslane, Ma Chi Xian 马齿苋

Kulfa (Ayurveda)
Kharfah, Kulfa (Unani)
Ma Chi Xian (TCM)
Picture
Picture Ortus Sanitatis, Meydenbach, 1491
Picture New Kreuterbuch, Matthiolus, 1563

Picture Thomé, Flora von Deutschland Österreich und der Schweiz, 1885

Botanical name:


Portulaca oleracea
Two types were differentiated: Garden with Broad leaves (best); Wild with Narrow leaves

Parts used:


Leaf, Seed

Temperature & Taste:


Cool, moist. Sour. It is more moist when fresh.
It is Cold in the Third and Moist in the last stage of the Second degree“. (Avicenna)

Classifications:


2N. REPELLENT.    2O. ASTRINGENT.    2P. HEMOSTATIC
3B. FEBRIFUGE & ANTIPYRETIC.    3Q. ANTHELMINTIC
4a. CEPHALIC.    4e. STOMACHIC.     4f. SPLENETIC.    4g. HEPATIC.    4h. NEPHRITIC.    4i. UTERINE
TCM:
B. Clears Heat and Toxin     B. Clears Deficient Heat

Uses:


1. Clears Heat and Toxin (TCM, West, Ayurveda):
-’Used chiefly to abate Feverish Heat, and in Putrid Malignant Fevers’. (Schroder)
-hot, toxic skin conditions including Boils, Carbuncles
-hot inflammations of the eyes, mouth, and throat.

Snake and Insect bites

2. Clears Heat, Calms the Mind, Eases Pain:
-cools the body and promote rest when there is excess heat; the flowers are calming and sedative.

‘It cools all the inward parts, eases Pain … causes Sleep’. (Salmon)

3. Clears Heat of the Liver and Stomach (TCM, West, Ayurveda):
-headache, red eyes, irritability, constipation, heat-type pain, insomnia
-redness and inflammation of the eyes, Tinnitus and Deafness
-thirst or vomiting from stomach heat
-heat and inflammation of the Bowels; Diarrhea, Dysentery and Appendicitis.
recently used for Hypertension
-“
removes Yellow Bile”. (Avicenna)

4. Clears Deficient Heat, Nourishes the Fluids (TCM, West, Ayurveda):
-thirst, dry mouth and
throat, and other symptoms of heat, dryness, or Yin deficiency from heat.
-‘It
quenches thirst caused by Stomach, Heart, Liver and Kidney fire’ (13th Century Arab text).
-‘a certain cure for Consumption’ (Salmon)
-‘Venerous dreams’, and to ‘allaieth the outrageous Lust of the body’.
-“The
general belief is that it reduces Sexual urge but Masarjawaih thinks otherwise and holds it to be an Aphrodisiac. It may act thus in persons of Hot or Dry temperament”. (Avicenna)
-Diabetes (Seed; Ayurveda, Unani, West)

5. Clears Heat and Damp, Promotes Urine:
hot, sharp and painful urination.
Salmon listed it to ease pain in Gonorrhea

6. Clears Heat, Stops Coughs:
-dry coughs, shortness of Breath, Phthisic;


7. Cools the Blood, Stops Bleeding:
-heat-type bleeding including excess menstruation, spitting of blood, bleeding hemorrhoids, and
spontaneous bleeding from heat
-postpartum uterine bleeding
-Blood-Heat skin diseases, Eczema, Psoriasis

8. Kills Worms:
-‘Commended against Worms in young children and is singular good, especially if they be feverish withall, for it both allaies the overmuch Heat, and killeth the Worms: which thing is done through the Saltness mixed therewith, which is not only an enemy to Worms, but also to putrefaction’
(Gerard)
-Said to be best for Hookworm. (Seed is best; usually boiled in wine)

9. Externally:
-Inflamed or Ulcerated Genitals, Hemorrhoids;
Gerard said as a douche it is good for inflammation and Ulcers of the Uterus.
-applied to Acne and heat type skin conditions
-hot, poisonous Sores and Carbuncles (TCM)
-applied to various skin diseases including Erysipelas (Ayurveda); also Eczema and Psoriasis
-juice of the stem soothes Itching. Also used for Prickly Heat in India. (Ayurveda)

-juice with Oil of Roses is applied to Burns, heat type Mastitis, and to hinder the heat of sores etc.
-Leukoderma: “It is a good drug to be used in leukoderma. For this purpose its leaves are plastered and left for six hours. Barley flour should be used after applying the plaster”. (Avicenna)
-Pityriasis: “Application of pounded drug on pityriasis and exposure to sun light till it dries up and then rubbed off, cures the disease”. (Avicenna)
-“
Warts may be removed when rubbed with Purslane”. (Avicenna)
-good for sore and Swollen Mouth and Gums, and to fasten Loose Teeth. (Apply juice or crushed herb)
-applied to Gout pains, hardness and cramps of the Sinews.
-externally for heat, especially of the head; applied to
the forehead and temples to promote rest and calm the mind (Culpeper)
-applied to pain and swelling from Wasp Stings and Snake Bites.
-applied to Burns, Scalds
-applied to the breasts to stop the flow of milk.

-in enemas for fluxes and ulcers of the bowels.


Dose:


1. Fresh herb is more Cool and Moist
2. Fresh Herb is eaten as a vegetable
Seed in Decoction or Infusion: 3–6 grams;
Dried Herb in Decoction: 6–20 grams (fresh herb 20–60 grams or more)
Seed in Powder: 1–3 grams

Correctives:


1. Peppermint
2. Mastic

Substitutes:


Ispaghol seed (for Purslane seed) (Avicenna)

Preparation:


Roasted Purslane seed stops Diarrhea. (Avicenna)

Main Combinations:


1. To clear Heat from the Stomach and Liver, cool the Blood and promote rest, Purslane seed and Endive juice are prepared into a syrup with Vinegar. (as in Syrup of Purslane Seed)
2. High Fever:
i. Melon seed, Purslane seed, Licorice, Tragacanth (as in Troches for Burning Fever of Galen)
ii. Purslane seed with Rose, Tabasheer, Licorice juice, Tragacanth (as in Troches of Spodium of Nicholas)
3. Strong Heat, Purslane seed, Lettuce seed, Poppy seed, Gourd seed, Watermelon seed, Licorice juice, Tragacanth (Mesue)
4. Blood Heat, with Sorrel, Mallow, Plantain, Endive, Aniseed, Borage, Violet (as in Decoction to Cool the Blood)
5. Excess Menstruation and internal Bruising, Purslane, Terra Lemnia (or Red Earth), Amber, Gum Arabic and Dragons Blood (as in Powder for Excess Menstruation of Serapion)
6. Hematuria, thickened Purslane juice is made into pills with Gum Arabic and Tragacanth
7. Burning Urine, Purslane seed with the 4 Cold Seeds and Poppy seed, Henbane seed (Powder for Burning Urine of Renodeus)
8. Kidney Ulcers, with White Poppy seed, Endive seed, Lettuce seed, Water Lily flower (as in Powder of Montagnana for Kidney Ulcers)
9. Diabetes from Heat, Purslane seed, Plantain seed, Coriander seed, Red Earth, Tormentil, Nutmeg (as in Powder for Diabetes of Riverius)
10. Abscess of Ulcer of the Bladder, with 4 Cold Seeds and Marshmallow root (Alexander Benedictus)
11. Bleeding during Pregnancy, with Bistort, Plantain and Coriander (as in Powder for Bleeding During Pregnancy)
12. Threatened Miscarriage, with Aloeswood, Sandalwood, Red Coral, Bistort, Mastic, Cowry shell (as in Powder Against Miscarriage of Unani)
13. To promote Sleep, Purslane seed, Poppy seed (Philon)
14. Internal Abscess, decoct Purslane and Dandelion together.
15. Worms, Purslane seed powder with burnt Deer Horn and Syrup of Sorrel

Major Formulas:


Decoction of Fruit
Decoction to Cool the Blood (Wirtzung)
Water for Cancer
Powder for Diabetes (Riverius)
Powder to Promote Sleep (Philon)
Troches for Burning Fever (Galen)
Troches of Camphor (Nicholas)
Troches of Spodium (Trochisci Spodii) (Nicholas)
Troches of Spodium (Trochisci Spodii) (Avicenna)
Expert Troches of Mahomet
Electuary of Elecampane (Unani)

Cautions:


1. Not used in Cold bodies
2. Not used in Pregnancy

Main Preparations used:


Dehydrated Juice, Distilled Water, Syrup of the Juice, Compound Syrup, Conserve of the Leaves

1. Conserve of Purslane:
i. Purslane leaf (1 part), White Sugar (2 parts). Beat together and heat slightly.

2. Water of Purslane:
i. Purslane (5 parts), Water (12 ½ parts). Distil 10 parts. Pour the distillate on 10 parts Purslane and distil 10 parts again. It can be repeated a third time. (Pharmacopoeia Gallica, 1818)

The creeping annual Purslane has probably been long used as a domestic remedy by the Hindus. The Sanskrit name is Loni. The fresh leaves are acid, and are prescribed when bruised as a cooling external application in erysipelas, and an infusion of them is given as a diuretic. In Arabic and Persian works the herb is called Baklat-el-Humaka or Baklat-el-Mubarika and Kurfah; two kinds are described, the large and the small. The former is probably the P. oleracea, as its use as a vegetable is noticed. Both kinds are said to be cold and moist, and to have detergent and astringent properties. Portulaca is the [?] of Dioscorides ii., 113, and is
mentioned by Celsus, who calls it Portulaca, and by Pliny who calls it Andrachne. The plant and seeds are recommended in a great many diseases of the kidneys, bladder, and lungs, which are supposed to be caused by hot or bilious humours. They are also praised as an external application in burns, scalds, and various forms of skin disease. Ainslie mentions P. quadrifida and P. oleracea as being used in Southern India by Tamil physicians. These herbs can be obtained in most vegetable markets, and the seeds of P. oleracea are kept in the druggists’ shops. (Vegetable Materia Medica of Western India, Dymock, 1885)
GENERAL /REVIEW
A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)
Portulaca oleracea L.: A Review of Phytochemistry and Pharmacological Effects
A Pharmacological Review on Portulaca oleracea L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities
Purslane Weed (Portulaca oleracea): A Prospective Plant Source of Nutrition, Omega-3 Fatty Acid, and Antioxidant Attributes
Characterization of physico-chemical properties and antioxidant activity of oil from seed, leaf and stem of purslane (Portulaca oleracea L.)
Evaluation of Antioxidant Compounds, Antioxidant Activities, and Mineral Composition of 13 Collected Purslane (Portulaca oleracea L.) Accessions
Impact of dehydration of purslane on retention of bioactive molecules and antioxidant activity

ANTIOXIDANT
A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)
Portulaca oleracea L.: A Review of Phytochemistry and Pharmacological Effects
Anti-Inflammatory and Anti-Oxidant Activity of Portulaca oleracea Extract on LPS-Induced Rat Lung Injury
Attenuation of Oxidative Stress and Inflammation by Portulaca oleracea in Streptozotocin-Induced Diabetic Rats
Antioxidant and Synergistic Antidiabetic Activities of a Three-Plant Preparation Used in Cameroon Folk Medicine

ANTIBACTERIAL
A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)
Portulaca oleracea L.: A Review of Phytochemistry and Pharmacological Effects
Component Composition and Antimicrobial Activity of CO2 Extract of Portulaca oleracea, Growing in the Territory of Kazakhstan
Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L.
In vitro growth-inhibitory effects of Portulaca oleracea L. formulation on intestinal pathogens
Antibacterial Attributes of Apigenin, Isolated from Portulaca oleracea L.

ANTI-VIRAL
A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)
Overview of Viral Pneumonia Associated With Influenza Virus, Respiratory Syncytial Virus, and Coronavirus, and Therapeutics Based on Natural Products of Medicinal Plants

ANTI-CANDIDA
Assessment of herbal drugs for promising anti-Candida activity

ANTI-INFLAMMATORY
A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)
Portulaca oleracea L.: A Review of Phytochemistry and Pharmacological Effects
Anti-Inflammatory and Anti-Oxidant Activity of Portulaca oleracea Extract on LPS-Induced Rat Lung Injury
Anti-Inflammatory Activity of a Medicinal Herb Extract Mixture, HM-V, on an Animal Model of DNCB-Induced Chronic Skin Inflammation

HIGH CHOLESTEROL
Clinical Effects of Portulaca Oleracea Seeds on Dyslipidemia in Obese Adolescents: a Triple-blinded Randomized Controlled Trial

OBESITY
Antiobesity and Antidiabetic Effects of Portulaca oleracea Powder Intake in High-Fat Diet-Induced Obese C57BL/6 Mice
Anti-adipogenic Effect of Homoisoflavonoids from Portulaca Oleracea (P06-015-19)

IMMUNOMODULATORY
A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)
A Pharmacological Review on Portulaca oleracea L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities

REPRODUCTIVE EFFECTS
Effects of Portulaca oleracea ethanolic extract on reproductive system of aging female mice

SURGICAL ADEHESIONS
Evaluation of the Therapeutic Effects of the Hydroethanolic Extract of Portulaca oleracea on Surgical-Induced Peritoneal Adhesion

NEUROPROTECTIVE
A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)
Portulaca oleracea L.: A Review of Phytochemistry and Pharmacological Effects

PARKINSON’S DISEASE
Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown

PSORIASIS
Portulaca oleracea L. aids calcipotriol in reversing keratinocyte differentiation and skin barrier dysfunction in psoriasis through inhibition of the nuclear factor κB signaling pathway

HEMORRHOIDS
An Evidence-Based Study on Medicinal Plants for Hemorrhoids in Medieval Persia

ANTI-ULCER
Portulaca oleracea L.: A Review of Phytochemistry and Pharmacological Effects

ULCERATIVE COLITIS
Protective effects of ethanol extract from Portulaca oleracea L on dextran sulphate sodium-induced mice ulcerative colitis involving anti-inflammatory and antioxidant
HEPATOPROTECTIVE
Portulaca oleracea L.: A Review of Phytochemistry and Pharmacological Effects
Portulaca oleracea methanolic extract attenuate bile duct ligation-induced acute liver injury through hepatoprotective and anti-inflammatory effects
Effects of Portulaca Oleracea Extract on Acute Alcoholic Liver Injury of Rats
Ethanol extract of Portulaca Oleracea L. reduced the carbon tetrachloride induced liver injury in mice involving enhancement of NF-κB activity
Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats
A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine

HYPERTHYROIDISM
A comparison of the effects of Portulaca oleracea seeds hydro-alcoholic extract and Vitamin C on biochemical, hemodynamic and functional parameters in cardiac tissue of rats with subclinical hyperthyroidism

THYROTOXICOSIS
A comparison between the effects of Portulaca oleracea seeds extract and valsartan on echocardiographic and hemodynamic parameters in rats with levothyroxine-induced thyrotoxicosis

ASTHMA
A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)
Anti-Asthmatic Effects of Portulaca Oleracea and its Constituents, a Review
Modulation of lung inflammation and immune markers in asthmatic rats treated by Portulaca oleracea
Hydro-Ethanolic Extract of Portulaca Oleracea Ameliorates Total and Differential WBC, Lung Pathology and Oxidative Biomarkers in Asthmatic Rats

PULMONARY EDEMA
The Effects of Portulaca oleracea on Hypoxia-Induced Pulmonary Edema in Mice

ARTHRITIS
Anti-nociceptive effect of Portulaca oleracea L. ethanol extracts attenuated zymosan-induced mouse joint inflammation via inhibition of Nrf2 expression

DIABETES
A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)
Portulaca oleracea L.: A Review of Phytochemistry and Pharmacological Effects
Anti-Diabetic Effect of Portulaca oleracea L. Polysaccharideandits Mechanism in Diabetic Rats
Attenuation of Oxidative Stress and Inflammation by Portulaca oleracea in Streptozotocin-Induced Diabetic Rats
Hypoglycemic and pancreatic protective effects of Portulaca oleracea extract in alloxan induced diabetic rats
A Portulaca oleracea L. extract promotes insulin secretion via a K+ATP channel dependent pathway in INS-1 pancreatic β-cells
Portulaca oleracea Ameliorates Diabetic Vascular Inflammation and Endothelial Dysfunction in db/db Mice
EFFECT OF HYDROALCOHOLIC EXTRACT OF PURSLANE (PORTULACA OLERACEA L.) ON DIABETIC VARIABLES IN D-GALACTOSE INDUCED AGING MOUSE MODEL
Antiobesity and Antidiabetic Effects of Portulaca oleracea Powder Intake in High-Fat Diet-Induced Obese C57BL/6 Mice
Portulaca oleracea L. alleviates liver injury in streptozotocin-induced diabetic mice
The Aqueous Extract of Portulaca Oleracea Ameliorates Neurobehavioral Dysfunction and Hyperglycemia Related to Streptozotocin-Diabetes Induced in Ovariectomized Rats
Therapeutic Screening of Herbal Remedies for the Management of Diabetes
Antioxidant and Synergistic Antidiabetic Activities of a Three-Plant Preparation Used in Cameroon Folk Medicine
Biomolecular Characterization of Putative Antidiabetic Herbal Extracts
Purslane (Portulaca oleracea) Seed Consumption And Aerobic Training Improves Biomarkers Associated with Atherosclerosis in Women with Type 2 Diabetes (T2D)
A Mechanistic Review on Medicinal Plants Used for Diabetes Mellitus in Traditional Persian Medicine
Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects
The effect of purslane seeds on glycemic status and lipid profiles of persons with type 2 diabetes: A randomized controlled cross-over clinical trial

ANTI-TUMOR
A Pharmacological Review on Portulaca oleracea L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities

CANCER
A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)
Portulaca oleracea L.: A Review of Phytochemistry and Pharmacological Effects
Cytotoxicity and apoptogenic properties of the standardized extract of Portulaca oleracea on glioblastoma multiforme cancer cell line (U-87): a mechanistic study
Assessment of cytotoxicity of Portulaca oleracea Linn. against human colon adenocarcinoma and vero cell line
Antihepatocarcinoma Effect of Portulaca oleracea L. in Mice by PI3K/Akt/mTOR and Nrf2/HO-1/NF-κB Pathway
Anti-cervical carcinoma effect of Portulaca oleracea L. polysaccharides by oral administration on intestinal dendritic cells
BRM270 targets cancer stem cells and augments chemo-sensitivity in cancer
Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells
Antioxidant and Antiproliferative Activities of Purslane Seed Oil
Modulation of Apoptosis by Plant Polysaccharides for Exerting Anti-Cancer Effects: A Review
Effects of portulacerebroside a on apoptosis of human leukemia HL60 cells and p38/JNK signaling pathway