Piper longum, Long Pepper, Bi Ba 荜茇

Bi Ba (TCM)
Pippali (Ayurveda)
Thippili (Siddha)
Filfil Daraz, Peepal (Unani)
Pi pi ling  པི་པི་ལིང༌  (Tibetan)
The root of Long Pepper is called Peepalmool (Unani), Thippiliver (Siddha)
Picture Long Pepper, Parkinson, Theatrum Botanicum, 1640

Picture Piper longum
Woodville, Hooker, Spratt, Medical Botany, 1832
Picture Long Pepper (Adam, 2017)

Botanical name:


Piper spp.
  1. P. longum
  2. P. officinum
Classical Ayurvedic texts list 3 other varieties of Pippali:
  1. Gaja Pippali: Piper chaba–Java Long Pepper fruit
  2. Sainghali: Piper retrofractum
  3. Vana-pippali: Piper peepuloides, Piper sylvaticum

Parts used:


Mature ripe fruit
The root of Long Pepper is also used in Ayurveda. It has similar effects but is considered  more heating.

Temperature & Taste:


Hot, dry. Pungent

Classifications:


2H. CARMINATIVE.    2S. STRENGTHENING
3C. ALEXIPHARMIC
4e. STOMACHIC
TCM:
M. Warm to Expel Cold

Uses:


1. Warms the Stomach, Clears Damp, Promotes Digestion (TCM, West, Ayurveda, Tibetan):
-cold-type abdominal pain, indigestion, bloating, vomiting, diarrhea.
-Long Pepper is taken with Honey for Diarrhea
-Hyperacidity
-like Black Pepper, it is important for clearing Ama in Ayurveda (Ama is the toxic residue left from imperfect digestion; ‘Damp’ of TCM).

2. Clears Cold, Warms the Kidneys (TCM, West, Ayurveda, Tibetan):
-Edema or urinary disorders from Cold Kidneys
-chronic Nephritis
-Impotence, Infertility
-Rheumatic conditions

3. Clears Cold Phlegm (TCM, West, Ayurveda, Tibetan):
-cold phlegm of the Lungs, Stomach, or Bowels
-Cold Cough
-Long Pepper is used in Ayurveda for Asthma and Bronchitis, especially in Children (with Jaggery or Milk or Honey)

4: Stops Wind, Eases Pain, Clears Cold and Damp:
-pacifies Vata/Wind in Ayurveda, and is said to help downward movement of Qi within the body;       
-Headaches, Toothache, and Arthritis from Wind, Cold, and Damp;
-Sinusitis

5. Rasayana (tonic to the 7 Body Tissues):
-Ayurveda considers Long Pepper to be Rasayana, beneficial for Longevity, and a promoter of Intellect.
-Neurasthenia, Amnesia
-strengthening, and it is given for Diabetes and Tuberculosis. (Taken with Honey, or Honey and Ghee)

6. Resists Poison:
-Food poisoning
-Chronic Fevers, Malaria and Intermittent Fevers. (Ayurveda)
Long Pepper decoction taken alone is believed to separate bad blood from healthy blood. (Tibet)
    
7. Externally:
-can be used as Black Pepper


Dose:


Fruit in Powder: 250mg–2 grams (up to 5 grams)
Fruit in Decoction: 1.5–5 grams
Root in powder: 1–3 grams

Correctives:


1. Gum Arabic
2. Tragacanth
3. Sandalwood
4. Rose, Rose Water

Substitutes:


1. White or Black Pepper
2. Ginger (Unani)
3. Zedoary

Comment:


1. Black, White and Long Pepper are used similarly. White Pepper is regarded as hottest but is least used. Black Pepper is better for the Stomach and Upper Body, while the Long Pepper is better for the Spleen and Kidneys and is regarded as more tonifying and strengthening. Clinically, either Black and Long Peppers, or all three Peppers, are used together.
2. Root of Long Pepper is used occasionally in Ayurveda and Unani. It has anti-fertility effects. It is often combined with Long Pepper fruit or Trikatu, for example in Powder of China root. It is also regarded as more strengthening so is used in tonic formulas, often with Withania, as in Balivivan.

Main Combinations:


Trikatu:
  This is a mix of equal parts of Black Pepper, Long Pepper, and Ginger. It is both a stand-alone formula, and an important component of larger compounds. It warms the Stomach, increases Digestion, resolves Damp, Cold-Phlegm and Ama (toxic residue of undigested food). Used alone for Indigestion, Hyperacidity, Cold and Flu, Cough, Bronchitis and Asthma. It is regarded as useful in Obesity and Diabetes. It enhances bio-availability, meaning it increases effectiveness of other medicines it is combined with.

1. Cold-Phlegm:
i. of the Stomach, the Three Peppers are combined with Thyme, Annis and Ginger. (This is Trikatu with Thyme and Annis) (Powder of Three Peppers) (Diatrion Piperion) of Mesue)
ii. to purge Cold-Phlegm, Long Pepper with Triphala, Caradamon, Cinnamon, Ginger, Turbith, Senna (Ayurveda)
2. Indigestion, Food Stagnation, Long Pepper with Cumin, Rue, Saltpeter (as in Lesser Cumin Composition (Diospoliticum) of Galen)
3. Nausea, Bloating, Indigestion, Long Pepper with Coriander, Fennel, Aniseed, Cinnamon, Clove, Nutmeg (as in Peptic Powder)
4. Gastric pain, Long Pepper, Cumin, Calamus, Bayberry (as in Electuary for Gastric Pain)
5. Poor appetite and digestion, Long and Black Pepper, Ginger, Celery seed, Cumin, Asafetida, Rock Salt (as in Hingvastaka Churna)
6. Acid Reflux, Heartburn, Nausea, Long Pepper with Calcite, Safflower, Costus, Pomegranate seed, Lesser Cardamon (as in Calcite 6 of Tibetan Medicine)
7. Diarrhea, Gastritis, Long Pepper, Wormwood, Cyperus, Mastic, Red Coral, Pomegranate flower, Sumac, Cinnamon (as in Powder to Warm and Bind the Belly of Roneletius)
8. Cough from Wind, Long Pepper, Zedoary, Nigella, Plumbago, Rock Salt (Ayurveda)
9. To Warm the Yang, Aphrodisiac:
i. Long Pepper with Pyrethrum and Galangal (Culpeper)
ii. Long Pepper powder is made into an Electuary with Ghee and Honey. (Unani)
iii. Long Pepper, Nutmeg (half dram each), Stavesacre seed, Pyrethrum root (2 scruples each), Mustard, Oregano (1 scruple), Honey (sufficient). (as in Stimulant Pastilles from Memorial Pharmaceutique, 1824)
10. Poor or Failing Memory:
i. Long Pepper with Chebulic Myrobalan (as in Expert Electuary for the Memory)
11. Dizziness and Vertigo:
i. Long Pepper with Chebulic Myrobalan and Dill seed (Ayurveda)
ii. Long Pepper with Peony, Nutmeg, Mistletoe, Galangal, Rosemary (as in Powder for Dizzyness and Vertigo)
12. Joint Pain, Arthritis, Rheumatoid Arthritis, Long Pepper with Chebulic Myroabaln and Aconitum ferox (as in Pill of Three Tastes of Mongolian Medicine)
13. Consumption, Long Pepper is taken with Triphala and Honey
14. To promote Longevity, Virility and Intellect, and cure diseases of aging, combine Long Pepper with Tabasheer, Rock Salt, Licorice and Triphala (Ayurveda)

Major Formulas


Powder of Three Peppers (Diatrion Piperion) (Mesue)
Antidotum Apollonii Laodicensis (Nicholas)
Antidote for Wind and Cold (Nicholas)
Electuary of Calamus (Diacorum) (Mesue)
Electuary for Gastric Pain

Raisin Electuary (Mrdvikadi Leha) (Ayurveda)
Balivivan (Ayurveda)
Powder of Clove (Ayurveda)
Powder of Camphor (Ayurveda)
Sitopaladi Powder (Ayurveda)
Pomegranate 5 (Se bru 5)
Tabasheer 9
Costus 6 Powder (Ru rta drug pa) (Tibetan Medicine)
Cardamon 10 (Sug smel bcu pa) (Tibetan Medicine)
Mental Happiness (Sems kyi bde skyid) (Tibetan Medicine)
Pill of Three Tastes (Mongolian Medicine)
Su He Xiang Wan

Cautions:


1. Full doses are not suitable for use in Heat conditions or Yin deficiency.
2. Generally not used in Diabetes, Tuberculosis, Lupus Erythematosus, and Menopausal syndrome

Drug Interactions:


Used in full doses it can interfere with various medication. It can enhance blood levels of certain medication due to it increasing bio-availability. In some cases it can reduce blood levels of medication due to stimulating Liver activity. This is not usually a problem as it is usually used as a small part of a larger formula.

Main Preparations used:


Species Diatrion pipereon, Strong Species, Distilled Oil of Pepper

  • Extra Info
  • Research
GENERAL / REVIEW
Overview for various aspects of the health benefits of Piper longum linn. fruit.

ANTI-INFLAMMATORY
Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L.
Anti-inflammatory activity of two varieties of Pippali (Piper longum Linn.).
Antiinflammatory Activity of Piper longum Fruit Oil.

ANALGESIC
Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain.
Analgesic activity of Piper longum Linn. root.

COVID
In Silico Studies of Phytoconstituents from Piper longum and Ocimum sanctum as ACE2 and TMRSS2 Inhibitors: Strategies to Combat COVID-19.
In Silico Investigation of Phytoconstituents of Medicinal Herb ‘Piper Longum‘ Against SARS-CoV-2 by Molecular Docking and Molecular Dynamics Analysis.
A pilot clinical study of an add-on Ayurvedic formulation containing Tinospora cordifolia and Piper longum in mild to moderate COVID-19.

INCREASES BIOAVAILABILITY
Enhanced Bioavailability of Boswellic Acid by Piper longum: A Computational and Pharmacokinetic Study.

IMMUNOMODULATORY
Immunomodulatory and antitumor activity of Piper longum Linn. and piperine.
Antigiardial and immunostimulatory effect of Piper longum on giardiasis due to Giardia lamblia.

CARDIOPROTECTIVE
Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats.

ANTI-PLATELET
Antiplatelet effects of acidamides isolated from the fruits of Piper longum L.
Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist.
Inhibitory effect of ethanol extract of Piper longum L. on rabbit platelet aggregation through antagonizing thromboxane A2 receptor.

HIGH CHOLESTEROL
Screening of antidiabetic and antihyperlipidemic potential of oil from Piper longum and piperine with their possible mechanism.
Antihyperlipidemic compounds from the fruit of Piper longum L.

VASCULAR RELAXANT
Chemical constituents from the fruits of Piper longum L. and their vascular relaxation effect on rat mesenteric arteries.

ANTI-STRESS
Long lasting preventive effects of piperlongumine and a Piper longum extract against stress triggered pathologies in mice.

NEUROPROTECTIVE
Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L. on Permanent Focal Cerebral Ischemia Injury in Rats.
Alkaloids from piper longum protect dopaminergic neurons against inflammation-mediated damage induced by intranigral injection of lipopolysaccharide.
Protection effect of piperine and piperlonguminine from Piper longum L. alkaloids against rotenone-induced neuronal injury.
Neuroprotective effects of alkaloids from Piper longum in a MPTP-induced mouse model of Parkinson’s disease.
Studies on the neuroprotective role of Piper longum in C6 glioma induced rats.

PARKINSON’S DISEASE
A selective and sensitive UFLC-MS/MS method for the simultaneous determination of five alkaloids from Piper longum L. and its application in the pharmacokinetic study of 6-OHDA-induced Parkinson’s disease rats.
Neuroprotective effects of alkaloids from Piper longum in a MPTP-induced mouse model of Parkinson’s disease.
[Protective effect of alkaloids from Piper longum in rat dopaminergic neuron injury of 6-OHDA-induced Parkinson’s disease].
Tissue distribution profiles of three antiparkinsonian alkaloids from Piper longum L. in rats determined by liquid chromatography-tandem mass spectrometry.
MAO INHIBITOR
Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity.

ANTIDEPRESSANT
Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity.

HEPATOPROTECTIVE
Development, Characterization, and Evaluation of Hepatoprotective Effect of Abutilon indicum and Piper longum Phytosomes.
Cell cycle inhibitory activity of Piper longum against A549 cell line and its protective effect against metal-induced toxicity in rats.
Hepatoprotective action of ethanolic extracts of Melia azedarach Linn. and Piper longum Linn and their combination on CCl4 induced hepatotoxicity in rats.
Hepatoprotective action of ethanolic extracts of Melia azedarach Linn. and Piper longum Linn and their combination on CCl4 induced hepatotoxicity in rats.

LIVER FIBROSIS
Inhibition of CCl4-induced liver fibrosis by Piper longum Linn.?

ANTI-HEPATITIS B
Anti-HBV active constituents from Piper longum.

ANTI-VENOM
Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) against Russell’s viper venom: characterization of piperine as active principle.

SPERMICIDAL
Spermicidal activity of the hexane extract of Piper longum: an in vitro study.

ANTI-FERTILITY
Antifertility activity of Piper longum Linn. in female rats.
Antifertility effects of the fruits of Piper longum in female rats.

DIABETES
Screening of antidiabetic and antihyperlipidemic potential of oil from Piper longum and piperine with their possible mechanism.
Antidiabetic and antihyperlipidemic activity of Piper longum root aqueous extract in STZ induced diabetic rats.

RADIOPROTECTIVE
Protective effect of Piper longum fruit ethanolic extract on radiation induced damages in mice: a preliminary study.

CANCER
Molecular docking analysis of vascular endothelial growth factor receptor with bioactive molecules from Piper longum as potential anti-cancer agents.
Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L.
Cell cycle inhibitory activity of Piper longum against A549 cell line and its protective effect against metal-induced toxicity in rats.
Evaluation of the efficacy & biochemical mechanism of cell death induction by Piper longum extract selectively in in-vitro and in-vivo models of human cancer cells.
Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells.
Studies on the neuroprotective role of Piper longum in C6 glioma induced rats.
Immunomodulatory and antitumor activity of Piper longum Linn. and piperine.

ANTI-ANGIOGENIC
Piper longum inhibits VEGF and proinflammatory cytokines and tumor-induced angiogenesis in C57BL/6 mice.

CHEMOTHERAPY TOXICITY
Protective effect of hexane and ethanol extract of piper longum L. On gentamicin-induced hair cell loss in neonatal cultures.
Ethanol extract of Piper longum L. attenuates gentamicin-induced hair cell loss in neonatal cochlea cultures.

ANTI-GIARDIAL
Antigiardial and immunostimulatory effect of Piper longum on giardiasis due to Giardia lamblia.