Melissa, Balm
Lemon Balm; Mountain Balm, Sweet BalmMelissophyllum, Apiastrum
Billilotan (Unani)
Ortus Sanitatis, Meydenbach, 1491
Della Materia Medicinale, Andrea Valuassori, 1562 |
Kurtzes Handtbuchlein, Ryff, 1599 |
Koehler’s Medizinal Pflanzen, 1887
Melissa officinalis
(Photo by Takács István) (Wikimedia)
Botanical name:
Melissa officinalis
A number of varieties were recognised:
Parts used:
Herb
Temperature & Taste:
Mildly Cool (usually classed as Warm in the West), dry. Pungent, Sweet
Classifications:
2H. CARMINATIVE.
3A. SUDORIFICS & DIAPHORETICS. 3C. ALEXIPHARMICS. 3D. CORDIALS & CARDIACS. 3G. EMMENAGOGUE
4a. CEPHALIC. 4c. CARDIAC. 4e. STOMACHIC. 4i. UTERINE. 4k. ARTHRITIC
Uses:
1. Clears Wind-Heat, Resists Poison, Promotes Sweat:
-colds, flu, fever and catarrh (infusion with Lemon juice);
-resists all Poison, including infectious diseases; Mushroom poisoning
-Poisonous bites: ‘Balm drunk in wine is good against the bitings of venomous beasts’; Scorpion, Spider, Rabid Dog bites
–Pliny said, it is ‘a present remedy against the stinging of Bees’.
-Viral infections (inc. Herpes)
-candida, intestinal worms, allergies, tumors
2. Clears Liver Heat, Stops Wind:
-good for the Head, Apoplexy, Epilepsy, Migraine, Paralysis, troublesome Sleep, Fainting, Melancholy etc.
-Liver Headache, Hypertension, Anger
-Hyperthyroidism
3. Moves Qi, Opens Obstructions:
–tension, anxiety, depression, sadness, pensiveness, phobias
–‘drives cares and troublesome thoughts out of the mind’
-PMS, Menopausal symptoms
-hardness of the Spleen and Liver (Arnold de Villa Nova)
-Hypochondriac Melancholy (Spirit was especially recommended, Salmon)
-also for Asthma and Breathlessness
4. Benefits the Heart, Calms the Mind and Spirit:
-Cordial, good for the Heart
–‘Much commended for Fainting and Beating of the Heart’ (Pechy)
-‘Strengthen the memory, sharpen the Wit, and make a man industrious’.
-‘Causes pleasant dreams’. (Salmon)
5. Benefits the Stomach, Promotes Digestion:
-‘Serapio affirmeth it to be comfortable for a moist and cold Stomach, to stir up concoction’. (Gerard)
-indigestion, flatulence, and dyspepsia, especially when related to anxiety
6. Moves the Qi, Regulates Menstruation:
-promotes menstruation when hindered by Constrained Qi (emotions), or Liver Heat;
-good for the Uterus, ‘crudities in Terms, after-burden stopped, in suffocation of the Womb’. (Schroder)
-Menopause and PMS
-promotes Fertility
-promotes Birth and Afterbirth (Juice with wine, or the Essence)
7. Promotes Longevity:
-Traditionally used to Promote Longevity; Paracelsus claimed it to retard old age
–London Dispensatory listed it to promote Longevity when taken every morning
-‘Renews Youthful Vigor, Strengthens the Brain, relieves Languishing Nature and prevents Baldness’.
-‘This is so fragrant and friendly, that it strengthens Nature in all its Faculties’. (A Compendius Herbal, John Archer, London, 1673)
8. Externally:
-Applied with salt to Cysts, Sores, Scrofula, hard Swellings and Kernels.
-traditionally applied to Gout
-juice made up with oil, or an ointment or poultice is good to be applied to fresh Wounds
-‘a most efficient remedy for the healing and sealing of Wounds’.
-decoction is gargled for Toothache.
-Cataplasm of Balm laid on a woman’s Breast was said to stop them growing
-the Oil made of the herb boiled is applied to cold pains including back ache
-in Baths for Uterine diseases
-Boils, Cysts, Nodes, Kernels, hard Swellings, especially of the Neck, beat the fresh herb to a paste with Niter and apply. (Salmon)
-applied to Scorpion bite
-chewed or applied to Toothache
Dose:
Powder: 500mg–3 grams
Infusion: 1 teaspoonful
Brief Decoction: 3–9 grams
Expressed Juice: 3–6 spoonfuls in Wine to cause Labor
Substitutes:
1. Galen said Balm is similar to Horehound, but weaker. This is especially in regarded to its Hysteric effects. Balm is a stronger Cordial.
2. Peppermint can replace Balm is some instances.
3. Billilotan in Unani medicine is also supplied by Nepeta cataria and N. hindostana. These may therefore be regarded as substitutes.
Main Combinations:
Balm & St. Johns wort
Brain, Mind:
1. Pensiveness, Worry, Insomnia, and as an exhilarant:
i. Balm, Saffron
ii. Balm with Diamoschu Dulce, Confectio Alkermes, Amber and Pearls
2. Nervousness, nervous Headaches, nervous Stomach, nervous Heart disorders, insomnia, Balm with Elecampane, Angelica, Ginger, Gentian, Cinnamon, Clove, Galangal, Nutmeg, Cardamon (as in Klosterfrau Melissengeist, the Monastic Spirit of Melissa)
3. Anxiety:
i. Balm, Valerian (this has been studied)
ii. Balm, Mint, Sage, Camomile
iii. Balm, Elecampane, Peony, Cyperus rotundus, Orange peel
3. Headache, Migraine, with Betony, Feverfew, Vervain, St Johns wort (as in Betony Infusion Compound)
4. Strengthen Memory:
i. Balm, Calamus
ii. Balm, Frankincense (this has been studied)
iii. Balm, Rosemary, Sage (this has been studied)
iv. Balm with Betony, Peony seed, Basil seed, Zedoary, Nutmeg, Clove, Licorice, Black Myrobalan, Frankincense, Mastic (as in Powder to Strengthen the Memory)
5. Insomnia:
i. Balm, Camomile
ii. Balm, Sandalwood, Pearl
iii. Balm with Hops, Angelica, Rosemary, Lavender, Yarrow
6. Alzhemier’s Disease:
i. Balm, Frankincense, Long Pepper, Cinnamon, Winter Cherry (Physalis) (this has been studied: see below)
ii. Balm, Saffron, Frankincense, Cyperus rotundus, Calamus
iii. Balm, Rosemary, Sage, Centella
6. Melancholy:
i. Conerve of Balm, Conserve of Borage (Herbarium Horstianum, 1630)
ii. Balm with Pearl
iii. Balm with Saffron, Amber
iv. Balm with Ginger, Coriander, Cardamon, Saffron, Marjoram (as in Powder for Melancholy of Philon)
v. Balm with Black Myrobalan, Horehound, Dodder, Agaric, Black Hellebore, Basil seed, Clove, Citron peel, Bugloss
vi. Balm seed with Saffron, Citron peel, Peony seed, Nutmeg, Mastic, Chebulic and Emblic Myrobalans (as in Letificans of Rhasis)
vii. Balm with Peony, Triphala, Frankincense, Saffron, Dodder, Senna, Lapis Lazuli, Aloe (as in Pilulae ad Melancholiam Validores)
viii. Burnt Humors: Conerve of Balm, Conserve of Borage, Conserve of Fumitory (Herbarium Horstianum, 1630)
7. Depression:
i. Balm, Lavender (this combination has been studied)
ii. Balm, Saffron, Pearl
iii. Balm, Borage flower, Sandalwood, Cinnamon, Saffron
8. Madness:
i. Balm with Pearl
ii. Balm, St. John’s wort, Borage, Fumitory
Heart:
9. Strengthen the Heart, benefit the Memory, comfort Nature and strengthens the whole Body, Balm with Bugloss, Scorzonera, White Dittany, Rosemary, Blessed Thistle seed, Fennel seed, Cinnamon, Sandalwood (as in Syrup of Balm)
10. Palpitations or Heart weakness:
i. Balm with Borage
ii. Balm, Cinnamon, Red Coral, Amber (as in Powder to Strengthen the Heart)
11. Syncope and to strengthen the Heart, Balm with Citron peel and Cinnamon (Arnold de Villa Nova)
Stomach, Digestion:
12. Carminative, for Wind and Indigestion:
i. Balm with Fennel and Licorice (Armen Pharmacopoea, Hufeland, 1825)
ii. Balm with Aniseed, Fennel, Coriander (Formulaire Magistral et Memorial Pharmaceutique, 1823)
13. Infantile Colic:
i. Balm, Camomile
ii. Balm, Dill seed, Mint, Camomile
12. Hyper-acidity:
i. Balm with Fennel, Licorice (Armen Pharmacopoea, Hufeland, 1825)
ii. Balm with Valerian, Fennel seed, St. Johns wort, Camomile
13. Gastric Ulcers:
i. Balm, Mastic
ii. Balm with Camomile, Peppermint, Caraway, Licorice, Angelica
Gynecology:
14. Hysteria, PMS:
i. Balm with Bay berry, Cumin, Myrrh
ii. Balm with Rose, Cyperus, Spikenard
iii. Balm with Agnus Castus, St. John’s wort
15. To promote menstruation; Amenorrhea:
i. decoct Balm with Mugwort and Feverfew in wine. (Arnold de Villa Nova)
ii. Balm with Cinnamon, Myrrh, Saffron, Madder, Pennyroyal, Mugwort (as in Tincture for Suppressed Menstruation)
iii. Primary Amenorrhea, Balm with Wormwood, Motherwort, Blessed Thistle, Galangal (as in Tincture for Feotid Color in Virgins)
16. To promote Fertility, Balm, Mugwort, Motherwort (Herbarius latinus, Petri, 1485)
17. To prevent Miscarriage, Balm with Motherwort, Fennel seed (as in Decoction for Threatened Miscarriage)
18. To bring away the Afterbirth and perfectly cleanse the womb after labor, Balm Essence is taken with Rose Water and Sugar (Salmon)
19. Premenstrual Syndrome: Balm, Sage, St. John’s wort
20. Menopause:
i. Balm, Sage, Agnus Castus
ii. Balm, Fenugreek, Cinnamon
iii. Balm, Pearl
Others:
19. To restore youth, resist Old Age, benefit Memory, prevent Grey hair and relieve a languishing nature, Balm with Celandine, Rosemary, Poppy flower
20. Prevent the hair from greying, drink 2 ounces of distilled water of Balm morning and night and wash the hair with the same. (The Secrets of Alexis, 1615)
21. Asthma, Breathlessness, decoct Balm with Orris and Licorice in wine (Arnold de Villa Nova)
22. To strengthen in Arthritis, Conserve of Balm, of Betony, of Borage, with Diamoschu Dulce (Sweet Powder of Musk) (Herbarium Horstianum, 1630)
23. Hyperthyroidism, Balm with Self Heal
24. Open Obstructions:
i. Conserve of Balm, Conserve of Rosemary (Herbarium Horstianum, 1630)
25. Hardness of the Spleen, Balm with Wormwood, Oregano, St. John’s wort, Rue, Dodder, Pennyroyal (as in Tincture for Schirrus of the Spleen)
26. For young babies, to calm them, promote digestion, and relieve wind:
i. Balm with Fennel seed
ii. Balm, Camomile, Dill seed
27. Mushroom poisoning, Balm with Nitre. (Dioscorides)
Externally:
28. Toothache, chew Balm with Pyrethrum (Arnold de Villa Nova)
29. Joint pain, apply Balm with Camomile, Primula and Dwarf Elder (Arnold de Villa Nova)
Major Formulas
Powder for Loss of Memory and Stupidity (Philon)
Betony Infusion Compound
Syrup of Balm (Fernelius)
Tincture Against Schirrus of the Spleen
Tincture of Life (Mynsichts)
Powder for Melancholy (Philon)
Powder to Strengthen the Heart (Wirtzung)
1. Eau Des Carmes (Carmelite Water):
i. Balm (2 lbs.), Lemon peels (10), Cinnamon, Angelica root (3 oz. each), Coriander (6 oz.), Alcohol (11 lbs.), Water (6 lbs.), distil 10 pounds. (Austrian Pharmacopoea)
ii. Fresh Balm (1 ½ lbs.), Fresh Lemon Peel (4 oz.), Nutmeg, Coriander (2 oz. each), Cinnamon, Cloves (1 oz. each), Alcohol (6 lbs.), Water of Balm (3 lbs.). Digest 3 days, distil 6 lbs. (Pharmacopoeia Sardoa, 1773)
iii. Balm (12 oz.), Lemon peel (2 oz.), Nutmeg (1 oz.), Coriander (4 oz.), Clove, Cinnamon (1 oz. each), Angelica root (half oz.), Alcohol (64 oz.). Infuse several days, distil 88 oz. (Pharmacopoeia Generalis, 1783)
2. Compound Spirit of Balm:
i. Balm, Peppermint, Sage, Rosemary, Lavender, Fennel (3 oz. each), Angelica root (2 oz), Calamus (4 oz.), Alcohol (4 lbs.), Water (sufficient); macerate 24 hours, distil 12 pounds. (Niemann)
ii. Cinnamon, Clove, Nutmeg, Aniseed, Coriander (1 part each), Hyssop, Rosemary, Marjoram, Sage, Thyme (2 parts each), fresh Lemon peel, Angelica root (4 parts), Fresh Balm (12 parts), Proof Spirit (192 parts), Water (576 parts); distil 128 parts. (Pharmacopee Usuelle, Louvain, 1821)
Cautions:
Generally Safe.
Main Preparations used:
Distilled Water, Spirit, Essence, Oil, Extract, Conserve, Syrup of the Juice, Tincture of Balm, Fixed Salt, Expressed Juice
1. Conserve of Balm:
i. Fresh Balm leaves (1 part), White Sugar (2 parts). Mix.
Strengthens the Heart, Head and benefits Brain and Memory.
2. Syrup of Balm:
i. Dried Balm (4 oz.), Distilled Water of Balm (1 lb.); digest for 2 days in a covered vessel, express, add White Sugar (16 oz.), boil for a few minutes to dissolve the sugar. (Pharmacopoeia Wirtembergica, 1798)
3. Tincture of Balm:
i. Balm (1 part), Alcohol 20% (8 parts). Infuse 3 days, filter.
4. Distilled Water of Balm:
i. Balm (1 part), Water (4 parts), distil 2 parts. (Dispensatorium medico pharmaceuticum Palatinatus, 1764)
ii. Balm (1 part), Water (8 parts), distil 4 parts. (Pharmacia rationalis, 1806)
iii. fresh Balm (1 part), Water (4 parts), distil half; re-distil with fresh Herb. (Pharmacopoeia Sardoa, 1773)
iv. Fresh Balm (3 parts); suspend in a bag in the center of a cucurbit containing Water (12 parts) so that it does not touch the water and distil 6 parts. (Dispensatorium Fuldense, 1791)
5. Spirit of Balm:
i. Balm (1 part), Alcohol 20% (2 parts), Water (sufficient); distil a spirit of 28%
ii. Balm (1 part), Alcohol (3 parts), Water 96 parts); distil off 2 and a half parts. (Pharmacopee Usuelle, Louvain, 1821)
iii. Balm (1 part), Water of Balm (2 parts), Alcohol (8 parts). Macerate 24 hours, distil 6 parts. (Pharmacopoeia Rossica, 1803)
6. Oil of Balm:
i. Fresh Balm (1 part), Water (4 parts); distil. Preserve the Oil.
7. Extract of Balm:
i. Balm (1 part), Water (3 parts). Boil, express, clarify with egg white then evaporate to an extract.
ii. Fresh herb of Balm (8 lbs.); bruise and digest it for 3 days in an alembic; then distil from it about 2 oz. of water in a water-bath; pour thrice its weight of water upon the residue, boil to two-thirds, strain, clarify, and evaporate the decoction to the consistency of a thick electuary, and add the distilled water to it when it is only warm. (Pharmacopoeia Sardoa, 1773)
A way to cause merry dreams When you go to bed, to eat Balm, and you cannot desire more pleasant sights then will appear to you; Fields, Gardens, Trees, Flowers, Meadows, and all the Ground of a pleasant Green, and covered with shady Bowers: wheresoever you cast your eyes, the whole World will appear pleasant and Green’.
(Natural Magick, Porta, Giambattista della, 1669)
GENERAL / REVIEW:
–An Updated Review on The Properties of Melissa officinalis L.: Not Exclusively Anti-anxiety.
–Melissa officinalis: Composition, Pharmacological Effects and Derived Release Systems-A Review.
–Melissa officinalis L. – A review of its traditional uses, phytochemistry and pharmacology.
–Harvest Stage and Brewing Conditions Impact Mineral Content, Phenolic Compounds, and Antioxidant Capacity of Lemon Balm (Melissa officinalis L.) Herbal Tea.
–A Perspective on Missing Aspects in Ongoing Purification Research towards Melissa officinalis.
–Phytochemical Composition and Bioactive Potential of Melissa officinalis L., Salvia officinalis L. and Mentha spicata L. Extracts.
–Toxicity and Physiological Effects of Nine Lamiaceae Essential Oils and Their Major Compounds on Reticulitermes dabieshanensis.
–Minerals, Essential Oils, and Biological Properties of Melissa officinalis L.
–Melissa officinalis L: A Review Study With an Antioxidant Prospective.
–Assessment of rosmarinic acid content in six Lamiaceae species extracts and their antioxidant and antimicrobial potential.
–[Chemical Constituents from Melissa officinalis Leaves].
ANTI-NOCICEPTIVE:
–Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models.
–Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice.
ANALGESIC:
–Analgesic Effect of Intrathecal Melissa officinalis in the Rat Model of Hot-Water and Formalin-Induced Pain.
ANTIBACTERIAL:
–Melissa officinalisessential oil loaded polycaprolactone membranes: evaluation of antimicrobial activities and cytocompatibility for tissue engineering applications.
–Melissa officinalis essential oil as an antimicrobial agent against Listeria monocytogenes in watermelon juice.
–HPLC-DAD Analysis, Antimicrobial and Antioxidant Properties of Aromatic Herb Melissa officinalis L., Aerial Parts Extracts.
–Evaluation of in vitro antibacterial effect of essential oil and some herbal plant extract used against mastitis pathogens.
–Antimicrobial Activity of Essential Oils Evaluated In Vitro against Escherichia coli and Staphylococcus aureus.
–The Antimicrobial Effect of Melissa officinalis L. Essential Oil on Vibrio parahaemolyticus: Insights Based on the Cell Membrane and External Structure.
–Chemical composition and antimicrobial activity of the essential oil from leaves of Algerian Melissa officinalis
–Chemical composition and in vitro antimicrobial activity of essential oil of Melissa officinalis L. from Romania.
–Radical scavenging, antibacterial, and antiproliferative activities of Melissa officinalis L. extracts.
–Triterpene, antioxidant, and antimicrobial compounds from Melissa officinalis.
–Traditional medicine in Sakarya province (Turkey) and antimicrobial activities of selected species.
–Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil.
ANTI-FUNGAL:
–Antifungal Activity and Type of Interaction of Melissa officinalis Essential Oil with Antimycotics against Biofilms of Multidrug-Resistant Candida Isolates from Vulvovaginal Mucosa.
–Essential oil composition and antifungal activity of Melissa officinalis originating from north-Est Morocco, against postharvest phytopathogenic fungi in apples.
ANTI-VIRAL:
–Antiviral Potential of Melissa officinalis L.: A Literature Review.
INFLUENZA:
–Potential anti-influenza effective plants used in Turkish folk medicine: A review.
–Potential antiviral effects of some native Iranian medicinal plants extracts and fractions against influenza A virus.
–Antiviral activity of the oseltamivir and Melissa officinalis L. essential oil against avian influenza A virus (H9N2).
COVID:
–Identification of Main Protease of Coronavirus SARS-CoV-2 (Mpro) Inhibitors from Melissa officinalis.
HERPES:
–A review study on the effect of Iranian herbal medicines against in vitro replication of herpes simplex virus.
–Attachment and penetration of acyclovir-resistant herpes simplex virus are inhibited by Melissa officinalis extract.
–Melissa officinalis extract inhibits attachment of herpes simplex virus in vitro.
–Melissa officinalis oil affects infectivity of enveloped herpesviruses.
–Inhibitory activity of Melissa officinalis L. extract on Herpes simplex virus type 2 replication.
–Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro.
–Antiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2.
–Balm mint extract (Lo-701) for topical treatment of recurring herpes labialis.
–Antiherpes effect of Melissa officinalis L. extracts.
HIV:
–Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density.
–Anti-HIV-1 activity of herbs in Labiatae.
ANTI-INFLAMMATORY:
–Anti-inflammatory and memory-enhancing properties of Chinese herbal extracts: The possible application in Alzheimer’s disease.
–Anti-inflammatory and Antioxidant Effects of Melissa officinalis Extracts: A Comparative Study.
–Melissa officinalis L. ameliorates oxidative stress and inflammation and upregulates Nrf2/HO-1 signaling in the hippocampus of pilocarpine-induced rats.
–In Vivo Potential Anti-Inflammatory Activity of Melissa officinalis L. Essential Oil.
ANTIOXIDANT:
–HPLC-DAD Analysis, Antimicrobial and Antioxidant Properties of Aromatic Herb Melissa officinalis L., Aerial Parts Extracts.
–Anti-inflammatory and Antioxidant Effects of Melissa officinalis Extracts: A Comparative Study.
–Does Melissa officinalis consumption improve the salivary antioxidant status of smokers?
–Triterpene, antioxidant, and antimicrobial compounds from Melissa officinalis.
–Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil.
–Melissa officinalis L. essential oil: antitumoral and antioxidant activities.
GENOPROTECTIVE (PROTECTS FROM GENETIC DAMAGE):
–A Study of Phytochemistry, Genoprotective Activity, and Antitumor Effects of Extracts of the Selected Lamiaceae Species.
NEUROPROTECTIVE:
–Melissa officinalis extract suppresses endoplasmic reticulum stress-induced apoptosis in the brain of hypothyroidism-induced rats exposed to γ-radiation.
–Coadministration of Dexamethasone and Melissa officinalis Has Neuroprotective Effects in Rat Animal Model with Spinal Cord Injury.
–Assessment of Neuroprotective Properties of Melissa officinalis in Combination With Human Umbilical Cord Blood Stem Cells After Spinal Cord Injury.
–Neuroprotective properties of Melissa officinalis after hypoxic-ischemic injury both in vitro and in vivo.
–Neuroprotective properties of melissa officinalis L. Extract against ecstasy-induced neurotoxicity.
–Neuroprotective and neurological properties of Melissa officinalis.
ANXIETY / STRESS:
–The potential of lemon balm (Melissa officinalis L.) essential oil as an anti-anxiety agent – is the citronellal the activity carrier?
–The effects of melissa officinalis on depression and anxiety in type 2 diabetes patients with depression: a randomized double-blinded placebo-controlled clinical trial.
–Lemon balm (Melissa officinalis L.) essential oil and citronellal modulate anxiety-related symptoms – In vitro and in vivo studies.
–The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis.
–Melissa officinalis L. hydro-alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis.
–Effects of Herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on insomnia severity, anxiety and depression in insomniacs: Randomized placebo controlled trial.
–The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina.
–Anti-stress effects of lemon balm-containing foods.
–Anxiolytic and antidepressant-like effects of Melissa officinalis (lemon balm) extract in rats: Influence of administration and gender.
–Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice.
–Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress.
DEPRESSION:
–The effects of melissa officinalis on depression and anxiety in type 2 diabetes patients with depression: a randomized double-blinded placebo-controlled clinical trial.
–Synergistic effects of Nepeta menthoides and Melissa officinalis aqueous extracts on reserpine-induced depressive-like behaviors in mice.
–The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis.
–A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression.
–Melissa officinalis L. hydro-alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis.
–Effects of Herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on insomnia severity, anxiety and depression in insomniacs: Randomized placebo controlled trial.
–The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina.
–A medicinal herb, Melissa officinalis L. ameliorates depressive-like behavior of rats in the forced swimming test via regulating the serotonergic neurotransmitter.
–Anxiolytic and antidepressant-like effects of Melissa officinalis (lemon balm) extract in rats: Influence of administration and gender.
EMOTIONAL DISTRESS:
–The possible “calming effect” of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomised, double-blinded, placebo-controlled clinical trial.
INSOMNIA:
–The possible “calming effect” of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomised, double-blinded, placebo-controlled clinical trial.
–The Effectiveness of Melissa Officinalis L. versus Citalopram on Quality of Life of Menopausal Women with Sleep Disorder: A Randomized Double-Blind Clinical Trial.
–Effects of Herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on insomnia severity, anxiety and depression in insomniacs: Randomized placebo controlled trial.
–The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina.
–Efficacy of a Combination of Melissa officinalis L. and Nepeta Menthoides Boiss. & Buhse on Insomnia: A Triple-Blind, Randomized Placebo-Controlled Clinical Trial.
MEMORY ENHANCING:
–Memory and cognition enhancing effects of combination of Melissa officinalis and Panax ginseng.
–Anti-inflammatory and memory-enhancing properties of Chinese herbal extracts: The possible application in Alzheimer’s disease.
–The effect of Melissa officinalis L. extract on learning and memory: Involvement of hippocampal expression of nitric oxide synthase and brain-derived neurotrophic factor in diabetic rats.
–A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age.
–Combined Administration of Melissa officinalis and Boswellia serrata Extracts in an Animal Model of Memory.
–Influence of the Melissa officinalis Leaf Extract on Long-Term Memory in Scopolamine Animal Model with Assessment of Mechanism of Action.
–Memory-improving activity of Melissa officinalis extract in naïve and scopolamine-treated rats.
ENHANCES LEARNING:
–The effect of Melissa officinalis L. extract on learning and memory: Involvement of hippocampal expression of nitric oxide synthase and brain-derived neurotrophic factor in diabetic rats.
COGNITION ENHANCING:
–Memory and cognition enhancing effects of combination of Melissa officinalis and Panax ginseng.
–Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial.
–Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties.
ACETYLCHOLINESTERASE INHIBITOR:
–Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.
ALZHEIMER’S DISEASE:
–Anti-inflammatory and memory-enhancing properties of Chinese herbal extracts: The possible application in Alzheimer’s disease.
–Evaluation of the Effectiveness of an Herbal Formulation of Boswellia sacra Flueck. In Improving Cognitive and Behavioral Symptoms in Patients with Cognitive Impairment and Alzheimer’s Disease.
–Natural remedies for Alzheimer’s disease: A systematic review of randomized controlled trials.
–Alzheimer’s disease treatment: The share of herbal medicines.
–Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer’s disease progression.
–Essential Oils as Treatment Strategy for Alzheimer’s Disease: Current and Future Perspectives.
–Potential benefits of phytochemicals against Alzheimer’s disease.
–Melissa officinalis Acidic Fraction Protects Cultured Cerebellar Granule Neurons Against Beta Amyloid-Induced Apoptosis and Oxidative Stress.
–Effect of plant extracts on Alzheimer’s disease: An insight into therapeutic avenues.
–A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer’s disease.
–The use of herbal medicine in Alzheimer’s disease-a systematic review.
–Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomised, placebo controlled trial.
ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)
–Phytotherapy for Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review and Meta-analysis.
–Herbal medicines in children with attention deficit hyperactivity disorder (ADHD): A systematic review.
AGITATION:
–A randomised controlled trial of Lavender (Lavandula Angustifolia) and Lemon Balm (Melissa Officinalis) essential oils for the treatment of agitated behaviour in older people with and without dementia.
–Pharmacological profile of an essential oil derived from Melissa officinalis with anti-agitation properties: focus on ligand-gated channels.
OPIATE WITHDRAWAL:
‘–A Review Study on the Effect of Iranian Herbal Medicines on Opioid Withdrawal Syndrome.
ANTICONVULSANT:
–New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm).
EPILEPSY:
–Melissa officinalis L. ameliorates oxidative stress and inflammation and upregulates Nrf2/HO-1 signaling in the hippocampus of pilocarpine-induced rats.
ANTIPLATELET:
–Quantitative Analysis of Phenolic Acids and Antiplatelet Activity of Melissa officinalis Leaf Extracts.
CARDIOPROTECTIVE:
–Melissa officinalis L. Supplementation Provides Cardioprotection in a Rat Model of Experimental Autoimmune Myocarditis.
–Melissa officinalis tea favourably affects the frequency of premature ventricular beats and cardiometabolic profile among patients with premature ventricular contraction: A randomised open-label controlled trial.
–Melissa officinalis L. as a Nutritional Strategy for Cardioprotection.
–Cardioprotective Effect of Ethanolic Leaf Extract of Melissa Officinalis L Against Regional Ischemia-Induced Arrhythmia and Heart Injury after Five Days of Reperfusion in Rats.
–Safety and efficacy of Melissa officinalis (lemon balm) on ApoA-I, Apo B, lipid ratio and ICAM-1 in type 2 diabetes patients: A randomized, double-blinded clinical trial.
–Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells.
–The effects of Melissa officinalis (lemon balm) pretreatment on the resistance of the heart to myocardial injury.
ARRHYTHMIAS / EFFECT ON CARDIAC RHYTHM:
–Evaluation of Melissa officinalis (Lemon Balm) Effects on Heart Electrical System.
–Negative Chronotropic and Antidysrhythmic Effects of Hydroalcoholic Extract of Lemon Balm (Melissa Officinalis L.) on CaCl2-Induced Arrhythmias in Rats.
–Efficacy of Melissa officinalis in suppressing ventricular arrhythmias following ischemia-reperfusion of the heart: a comparison with amiodarone.
HYPERLIPIDEMIA:
–Lemon balm: A promising herbal therapy for patients with borderline hyperlipidemia-A randomized double-blind placebo-controlled clinical trial.
–Lemon balm extract causes potent antihyperglycemic and antihyperlipidemic effects in insulin-resistant obese mice.
HYPERTENSION:
–Effect of Melissa officinalis on systolic and diastolic blood pressures in essential hypertension: A double-blind crossover clinical trial.
PALPITATION:
–Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety.
DIABETES:
–Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double-blind, clinical trial.
–Antinociceptive and antihyperglycemic effects of Melissa officinalis essential oil in an experimental model of diabetes.
–Lemon balm extract causes potent antihyperglycemic and antihyperlipidemic effects in insulin-resistant obese mice.
–Anti-diabetic effects of lemon balm ( Melissa officinalis) essential oil on glucose- and lipid-regulating enzymes in type 2 diabetic mice.
OBESITY:
–The herbal extract ALS-L1023 from Melissa officinalis alleviates visceral obesity and insulin resistance in obese female C57BL/6J mice.
–The lemon balm extract ALS-L1023 inhibits obesity and nonalcoholic fatty liver disease in female ovariectomized mice.
–Lemon balm extract causes potent antihyperglycemic and antihyperlipidemic effects in insulin-resistant obese mice.
HYPERTHYROIDISM:
–In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity.
–Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats.
–Extracts and auto-oxidized constituents of certain plants inhibit the receptor-binding and the biological activity of Graves’ immunoglobulins.
–Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes.
DYSMENORRHEA:
–The Effect of Melissa Officinalis Extract on the Severity of Primary Dysmenorrha.
PREMENSTRUAL SYNDROME (PMS)
–The effectiveness and safety of Iranian herbal medicines for treatment of premenstrual syndrome: A systematic review.
–Effect of Melissa officinalis Capsule on the Intensity of Premenstrual Syndrome Symptoms in High School Girl Students.
–Effect of Melissa officinalis capsule on the mental health of female adolescents with premenstrual syndrome: a clinical trial study.
FEMALE SEXUAL DYSFUNCTION:
–Effect of Melissa officinalis (Lemon balm) on Sexual Dysfunction in Women: A Double- blind, Randomized, Placebo-controlled Study.
MENOPAUSE:
–A review of effective herbal medicines in controlling menopausal symptoms.
–The Effectiveness of Melissa Officinalis L. versus Citalopram on Quality of Life of Menopausal Women with Sleep Disorder: A Randomized Double-Blind Clinical Trial.
MASTITIS:
–Evaluation of in vitro antibacterial effect of essential oil and some herbal plant extract used against mastitis pathogens.
POSTPARTUM:
–Investigating the Effect of Melissa Officinalis on After-Pains: A Randomized Single-Blind Clinical Trial.
PSORIASIS:
–The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial.
–Melissa officinalis ssp. altissima extracts: A therapeutic approach targeting psoriasis in mice.
INFANTILE COLIC:
–Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: An open randomized controlled trial.
GASTRIC ULCERS:
–The Effects of Methanolic Extract of Melissa officinalis on Experimental Gastric Ulcers in Rats.
ULCERATIVE COLITIS:
–Protective effect of Melissa officinalis against acetic acid-induced ulcerative colitis in rat models: an experimental study.
HEPATOPROTECTIVE:
–Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats.
–Melissa Officinalis L. aqueous extract pretreatment decreases methotrexate-induced hepatotoxicity at lower dose and increases 99mTc-phytate liver uptake, as a probe of liver toxicity assessment, in rats.
–Lemon balm and dandelion leaf extract synergistically alleviate ethanol-induced hepatotoxicity by enhancing antioxidant and anti-inflammatory activity.
LIVER FIBROSIS:
–ALS-L1023 from Melissa officinalis Alleviates Liver Fibrosis in a Non-Alcoholic Fatty Liver Disease Model.
CANCER:
–Anti Proliferative Properties of Melissa officinalis in Different Human Cancer Cells.
–Radical scavenging, antibacterial, and antiproliferative activities of Melissa officinalis L. extracts.
–Citral is a new inducer of caspase-3 in tumor cell lines.
–Melissa officinalis L. essential oil: antitumoral and antioxidant activities.
BREAST:
–Lemon Balm Extracts Prevent Breast Cancer Progression In Vitro and In Ovo on Chorioallantoic Membrane Assay.
–The herbal medicine Melissa officinalis extract effects on gene expression of p53, Bcl-2, Her2, VEGF-A and hTERT in human lung, breast and prostate cancer cell lines.
–Antitumoral effects of Melissa officinalis on breast cancer in vitro and in vivo.
COLON:
–Quantitative Proteome Analysis Reveals Melissa officinalis Extract Targets Mitochondrial Respiration in Colon Cancer Cells.
–Melissa officinalis Extract Induces Apoptosis and Inhibits Migration in Human Colorectal Cancer Cells.
–Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen species.
–Anti-proliferative effect of Melissa officinalis on human colon cancer cell line.
GLIOBLASTOMA:
–Rosmarinic Acid and Melissa officinalis Extracts Differently Affect Glioblastoma Cells.
–Apoptosis-inducing effects of Melissa officinalis L. essential oil in glioblastoma multiforme cells.
LUNG
–Melissa officinalis L. ethanolic extract inhibits the growth of a lung cancer cell line by interfering with the cell cycle and inducing apoptosis.
–The herbal medicine Melissa officinalis extract effects on gene expression of p53, Bcl-2, Her2, VEGF-A and hTERT in human lung, breast and prostate cancer cell lines.
PROSTATE:
–The herbal medicine Melissa officinalis extract effects on gene expression of p53, Bcl-2, Her2, VEGF-A and hTERT in human lung, breast and prostate cancer cell lines.
SYNERGISTIC WITH CHEMOTHERAPY:
–Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells.
CHEMOTHERAPY TOXICITY:
–Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells.