Leonurus, Motherwort, Yi Mu Cao 益母草

Also called Cardiaca, Matricaria
Yi Mu Cao (TCM)
Picture Picture
Picture Picture
Herbarius latinus, Petri, 1485

Kurtzes Handtbuchlein, Ryff, 1599

Picture L. cardiaca
Oeder et al., Flora Danica, 1756 (1761-1883)

Botanical name:


Leonurus cardiaca (syn. L. crispus, L. campestris, L. glabra, L. discolor)
In TCM L. heterophyllus (syn. L. artermisia), L. sibiricus, L. macrathus and L. turkestanicus (in Xinjiang) are used.

Parts used:


Herb

Temperature & Taste:


Cool, dry (regarded as Warm in the West); Pungent, Bitter.

Classifications:


3D. CORDIALS & CARDIACS.    3G. EMMENAGOGUE
4c. CARDIAC.    4i. UTERINE
K. Move the Blood

Uses:


1. Moves the Blood, Resolves Stasis, Promotes Menstruation (TCM, West):
-chiefly for cold and windy diseases of the Womb
-irregular Menstruation, Menstrual cramping and pain, heavy menstruation with clotting
-PMS, irritability associated with Menstruation; Menopausal symptoms
-Infertility, especially associated with Blood stasis or Damp
-‘want of Venery’.
-traditionally used to promote easier Childbirth; difficult or prolonged Labor
-Retained Lochia, Postpartum abdominal Pain, Postpartum Bleeding
-fixed abdominal masses and tumors
-Traumatic pain, Bruising, Hematoma

2. Moves the Blood, Calms the Mind and Nerves, Benefits the Heart (West):
‘infirmities of the Heart’. (Gerard)
-‘there is no better herb to take Melancholy vapours from the Heart … and makes a merry, cheerful Soul … of much use in trembling of the Heart’.
(Culpeper)
Oppression or Pain of the Chest, Palpitations, Rapid Heartbeat, Fainting, especially when related to Anxiety.
-Hypertension, Tachycardia
-Nervous Debility, Irritability in the elderly; Restlessness and Insomnia; Hyperthyroidism (especially with Palpitations)
-Migraine


3. Promotes Urine (TCM, West):
-Edema
-Nephritis, Hematuria, acute Renal Failure
-Gravel, Stones

4. Clears Heat, Stops Bleeding (TCM, West):
-Blood in the Urine, in the Stool, Uterine Bleeding, Postpartum Bleeding, Bloody Dysentery

5. Clears Phlegm, Relieves Wheezing (West):
-cold phlegm in the Lungs; Coughs and Asthma


6. Clears Heat, Resists Poison:
-Putrid Fevers (West)
-sores, abscesses, eczema, erysipelas, toxic swellings, itchy skin rashes (TCM, West)

7. Kills Worms (West)

8. Externally:
-externally for ‘suffocation of the Womb’, to promote Menstruation (as a Pessary)
-hardness of the Breasts (in a poultice)
-eases Gout pain
-relieves Fever



Dose:


Decoction: 6–15 grams
Powder: 1–3 grams

Comment:


1. The various species of Motherwort are used very similarly, especially in regards of its gynecological effects. The Chinese name Yi Mu Cao translates as ‘Benefit Mother herb’, a clear sign that its traditional use is akin to the western Motherwort.
2. The Chinese also use Motherwort seed (Chong Wei Zi); used similarly for irregular Menstruation, Dysmenorrhea, Amenorrhea, Postpartum abdominal pain; also for Liver heat with Headache, red and painful Eyes.

Substitutes
Mugwort has been used as a substitute.

Main Combinations:


Motherwort & Cyperus

Gynecology
1. Promote Menstruation, Amenorrhea:
i. Motherwort, Calamint, Balm
ii. Motherwort with Balm, Pennyroyal
iii. and clear Wind of the Womb, Motherwort with Pennyroyal, Mugwort, Balm, Vervain, Bay berry (as in Decoction for the Womb)
iv. Motherwort with Southernwood, Pennyroyal, Balm, Vervain
v. Motherwort, Rue, Camomile (Matricaria), Wintergreen (equal parts as a decoction) (Valuable Herbal Prescriptions, late ‘s)
vi. Motherwort with Valerian, Tansy, Mugwort, Wormwood, Mint, Marjoram, Pennyroyal, Ginger, Saffron (as in Hysteric Water of Poterius)
2. Dysmenorrhea:
i. obstructed by Cold, Motherwort with Cinnamon, Cumin
ii. obstructed by Blood stagnation, Motherwort with Myrrh, Zedoary
iii. obstructed by Blood stagnation, Motherwort with Dang Gui and Ligusticum Chuan Xiong (TCM)
iv. Motherwort with Restharrow, Madder, Horehound, Mugwort, Rosemary, Parsley seed, Saffron, Cinnamon (Formulaire de Montpellier, 1822)
3. Irregular or scanty Menstruation or Infertility from Blood stasis, combine Motherwort with Dang Gui and Salvia Dan Shen (TCM)
4. Hysteris, PMS: Motherwort, Mugwort, Juniper berry, Savin, Nigella, Amber, Aniseed, Lesser Cardamon (as in Hysterical Extract of Lazarus Riverius)
5. Coldness of the Womb, Motherwort (Yi Mu Cao), wine-fried Dang Gui, Mugwort (Ai Ye), Salvia Dan Shen, Ginger, Cinnamon (The Formulas of Dr. John H.F. Shen)
6. Ovarian pain and inflammation:
i. Motherwort with Cyperus rotundus, Wormwood, Calendula
ii. Motherwort with Horehound, Sunflower and Wormwood
7. Endometriosis:
i. Motherwort, Cyperus rotundus, Paeonia Mu Dan Pi, Safflower (Hong Hua)
ii. Motherwort, Dang Gui, Salvia Dan Shen, Dodder seed (Tu Si Zi), Paeonia Bai Shao, Corydalis Yan Hu Suo, Costus
8. To promote Fertility:
i. Motherwort, Balm, Mugwort, decoction orally or as a bath (Herbarius latinus, Petri, 1485)
ii. Motherwort, Balm, Ivory (Herbarius latinus, Petri, 1485)

Obstetrics:
9. Threatened Miscarriage:
i. Motherwort with Balm and Fennel seed (as in Decoction for Threatened Miscarriage)
ii. Chinese Mortherwort, Poria Fu Ling, Atractylodes Bai Zhu, Myrrh, Cyperus rotundus, Coriander seed, powder and form pills with Honey. These are called Preserve Pregnancy pills and were used for Threatened Miscarriage and to prepare for Labor. (Chinese Materia Medica, Stuauoft)
10. Postpartum:
i. abdominal pain, Motherwort (Yi Mu Cao) with Hawthorn (Shan Zha) (TCM)
ii. abdominal pain, Motherwort (Yi Mu Cao) with Safflower (Hong Hua) and Dang Gui
iii. Postpartum tonic, Motherwort, St. John’s wort, Nettle, Balm
iv. the whole plant of Chinese Motherowrt is dried and powdered, and formed into Honey pills. They are especially used for difficulties during Pregnancy and the Puerperal period. The were called Restore the Yin and Bring Back the Soul Pills. (Chinese Materia Medica, Stuauoft)

Heart, Circulatory:
11. To benefit the Heart:
i. Motherwort with Cinnamon, Saffron
ii. Motherwort with Hawthorn, Rosemary and Mistletoe
iii. Motherwort with Bugle, Lily of the Valley, Hawthorn berry
iv. Motherwort, Couch Grass, Mistletoe, Balm, Yarrow, Shepherd’s Purse, Rue, Yarrow, Dandelion, Fumitory (Treben)
v. Motherwort with Rose hip, Rosemary, Hawthorn, Calendula
12. Heart disorders with Anxiety or nervousness:
i. Motherwort with Balm, St. Johns wort
ii. Motherwort with Valerian, Balm
iii. Motherwort with Dang Gui and Salvia Dan Shen (TCM)
iv. Motherwort, Water Plantain leaf, Plantain, Southernwood, Valerian (The Medical Herbalist)
v. Valerian with Lavender, Motherwort, Caraway seed, Fennel seed (Meyer)
13. Hypotension, Motherwort with Rosemary, Balm and Hawthorn
14. Hypertension, Motherwort with Valerian, Mistletoe

Other:
15. Hyperthyroidism, Motherwort with Balm
16. Glandular swellings around the ears or groin, scarify, then apply powder of Motherwort and Mullein. (Herbarius latinus, Petri, 1485)
17. Paralysis, Motherwort with Asparagus root, Peony root, Betony, Cowslip, Four Cold Seeds, Calendula, Rosemary, Cinnamon, Raisins (as in Tincture for Paralysis)
18. Nephritis, Motherwort with Mugwort, Burdock, Valerian, Betony and Plantain (The Medical Herbalist)
19. Glomerulonephritis, Motherwort (Yi Mu Cao) with Astragalus (TCM)

Major Formulas


Decoction for Threatened Miscarriage (Gabelhover)
Decoction for the Womb (Schroder)
Tincture for Paralysis
Tian Ma Gou Teng Yin

Cautions:


1. Generally not used during pregnancy. Specialists in China have used the Chinese Motherwort in some ante-partum disorders associated with Blood stagnation, but it must be used cautiously. It has also been used for threatened Miscarriage in the West (see Decoction for Threatened Miscarriage, above). It is only suitable for cases with Heat and excess in which case it can be used for Bleeding during pregnancy, but dosage should be low-to-moderate. It has been used in the time leading up to Birth to prepare the Uterus.
2. Not used in marked Qi and Blood weakness or signs of Cold.

Drug Interactions:


1. May interact with anticoagulant medication.

Main Preparations used:


Distilled Water, Salt of the Ashes, Syrup, less commonly the Distilled Oil

1. Motherwort Extract (Chinese Pharmacopoeia):
‘Decoct 500 g of Herba Leonuri with water for 3 times, 2 hours, 1.5 hours and 1 hour respectively, filter, combine the filtrates, and concentrate to about 250 ml. Allow to cool, add the same volume of ethanol, stir well, stand for 24 hours. Filter, recover ethanol in vacuum (or just evaporate away, Adam) and concentrate to a thick extract. Dilute with water to 500 ml, refrigerate for 24 hours, filter, add an appropriate quantity of flavoring agents to the filtrate, adjust the total volume to 1000 ml with water, stir well, filter, pack and sterilize.’
  Used for
Menstrual disorders, lochiorrhea after childbirth due to stagnation of blood, continuous dripping of menstrual blood, postpartum subinvolution of the uterus. Dose: 10–20 mls 3 times daily.

GENERAL / REVIEW
Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology.
Phytochemical and Psychotropic Research of Motherwort (Leonurus cardiaca L.) Modified Dry Extracts.
Phytochemical Profile and Biological Activities of Crude and Purified Leonurus cardiaca Extracts.
Leonurus cardiaca L. as a Source of Bioactive Compounds: An Update of the European Medicines Agency Assessment Report (2010).

SPECIES COMPARISION
Microscopic and Phytochemical Comparison of the Three Leonurus Species L. cardiaca, L. japonicus, and L. sibiricus.
Leonurus japonicus, Leonurus cardiaca, Leonotis leonurus: a novel HPLC study on the occurrence and content of the pharmacologically active guanidino derivative leonurine.

ANTIBACTERIAL
Optimum extraction of polysaccharides from motherwort leaf and its antioxidant and antimicrobial activities.
Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. and Their Chemical Composition.
Antibacterial activity of Leonurus sibiricus aerial parts.

ANTIOXIDANT
Antioxidant effect of aqueous extract of four plants with therapeutic potential on gynecological diseases; Semen persicae, Leonurus cardiaca, Hedyotis diffusa, and Curcuma zedoaria.
Optimum extraction of polysaccharides from motherwort leaf and its antioxidant and antimicrobial activities.
Antioxidant and free radical scavenging activities of some medicinal plants from the Lamiaceae.
The ethanol extract of Leonurus sibiricus L. induces antioxidant, antinociceptive and topical anti-inflammatory effects.
Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. and Their Chemical Composition.

ANTI-INFLAMMATORY
Leonurine exerts anti-inflammatory effect by regulating inflammatory signaling pathways and cytokines in LPS-induced mouse mastitis.
The ethanol extract of Leonurus sibiricus L. induces antioxidant, antinociceptive and topical anti-inflammatory effects.
Anti-inflammatory activity of Motherwort (Leonurus sibiricus L.).
Analgesic and anti-inflammatory activity of Leonurus sibiricus.

ANALGESIC
The Study of Analgesic Effects of Leonurus cardiaca L. in Mice by Formalin, Tail Flick and Hot Plate Tests.
Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology.
Analgesic and anti-inflammatory activity of Leonurus sibiricus.

SEDATIVE
Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology.

ANXIETY
[Effects of melatonin and motherwort tincture on the emotional state and visual functions in anxious subjects].

ANTIHYPERTENSIVE
Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology.
Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders.

IMMUNOMODULATORY
The immunomodulatory potential of Leonurus cardiaca extract in relation to endothelial cells and platelets.
HEPATOPROTECTIVE
Hepatoprotection of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L.

NEPHROPROTECTIVE
Leonurine ameliorates LPS-induced acute kidney injury via suppressing ROS-mediated NF-κB signaling pathway.
The nephroprotective effects of the herbal medicine preparation, WH30+, on the chemical-induced acute and chronic renal failure in rats.

GASTROPROTECTIVE
Gastroprotective action of the ethanol extract of Leonurus sibiricus L. (Lamiaceae) in mice.

DIABETES
Extracts from Leonurus sibiricus L. increase insulin secretion and proliferation of rat INS-1E insulinoma cells.

CARDIAC EFFECTS
Adonis sp., Convallaria sp., Strophanthus sp., Thevetia sp., and Leonurus sp. – Cardiotonic Plants with Known Traditional Use and a Few Preclinical and Clinical Studies.
Identification of Cardioactive Leonurus and Leonotis Drugs by Quantitative HPLC Determination and HPTLC Detection of Phenolic Marker Constituents.
The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart.
Cardiac and electrophysiological effects of primary and refined extracts from Leonurus cardiaca L. (Ph.Eur.).

ENDOCARDITIS
Molecular Mechanisms of Leonurus Cardiaca L. Extract Activity in Prevention of Staphylococcal Endocarditis-Study on in Vitro and ex Vivo Models.
Leonurus cardiaca L. herb–a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis.

UTERUS STIMULATING EFFECT
[Stimulating action of Carthamus tinctorius L., Angelica sinensis (Oliv.) Diels and Leonurus sibiricus L. on the uterus].

ENDOMETRITIS
Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis.

INHIBITS WEIGHT GAIN AFTER MENOPAUSE
Inhibitory effects of Leonurus sibiricus on weight gain after menopause in ovariectomized and high-fat diet-fed mice.

ANTIPROLIFERATIVE
Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. and Their Chemical Composition.

CANCER
Anticancer Activity of Leonurus sibiricus L.: Possible Involvement of Intrinsic Apoptotic Pathway.
An In Vitro Estimation of the Cytotoxicity and Genotoxicity of Root Extract from Leonurus sibiricus L. Overexpressing AtPAP1 against Different Cancer Cell Lines.
The Extract of Leonurus sibiricus Transgenic Roots with AtPAP1 Transcriptional Factor Induces Apoptosis via DNA Damage and Down Regulation of Selected Epigenetic Factors in Human Cancer Cells.
Transformed Root Extract of Leonurus sibiricus Induces Apoptosis through Intrinsic and Extrinsic Pathways in Various Grades of Human Glioma Cells.
A preliminary study of apoptosis induction in glioma cells via alteration of the Bax/Bcl-2-p53 axis by transformed and non-transformed root extracts of Leonurus sibiricus L.
Further study on the effects of motherwort (Leonurus sibiricus L) on preneoplastic and neoplastic mammary gland growth in multiparous GR/A mice.