Juniperus, Juniper

Abhal (Unani)
Picture
Picture Juniper
Gart der Gesundheit
, Cuba, 1485

Picture Herbarius latinus, Petri, 1485

Picture Ortus Sanitatis, Meydenbach, 1491

Picture Koehler’s Medizinal Pflanzen, 1887


Botanical name:


Juniperus communis

Parts used:


Fruit; rarely the Wood or Gum

Temperature & Taste:


Warm, dry. Pungent, Bitter
Some physicians hold it to be Hot and Dry in the Third degree”. (Avicenna)

Classifications:


2B ATTENUATERS.    2D ATTENUATERS OF CONGEALED BLOOD.    2F. PURIFYING.    2H. CARMINATIVE.    2I. ANTISPASMODIC
2S. STRENGTHENING
3A. SUDORIFICS & DIAPHORETICS.    3C. ALEXIPHARMIC.    3E. DIURETIC.    3F. LITHONTRIPTIC.    3G. EMMENAGOGUE.   3K. EXPECTORANT
3L. ANTI-TUSSIVE.  
4a. CEPHALIC.    4e. STOMACHIC.    4h. NEPHRITIC.    4i. UTERINE.   4j. NERVINE

Uses:


1. Warms and Strengthen the Kidneys, Clears Damp, Promotes Urine:
-promotes Urine, clears slime from the Kidney and Bladder
-Gravel, Stones (Kneipp)
-Arthritis, chronic Rheumatism, chronic Back Pain, Sciatica
-Diabetes

2. Warms the Uterus, Promotes Menstruation:
-promotes Menstruation (Hippocrates)
-Uterine obstructions, chronic Uterine swelling
-Promotes Labor (Hippocrates)
-taken in the last weeks of pregnancy to facilitate easier birth
-Leukorrhea (Hippocrates)
-very good for Hysteria and Uterine pain (Avicenna)

3. Resists Poison:
-Alexipharmic, promotes Sweat, Cordial, resists Poison
-protects from infection in Plague and Epidemic diseases (Matthiolus)
-Blood purification (Paracelsus)
chronic skin rashes, scabies, herpes, persistent ulcers
-Wood has been used for Syphilis
-“
counteracts the adverse effects of Insect Bites and Smoking” (Avicenna)

4. Warms the Stomach, Opens Obstructions:
weakness of the digestive system; bloating, indigestion
-opens the Spleen; swelling of the Spleen or Liver
-Gall Stones (Kneipp)

-Wind, Colic, Flatulence
-“
very good for the Stomach” (Avicenna)

5. Clears Cold Phlegm, Stops Cough:
-benefits the Lungs, for Cough, Whooping Cough, shortness of Breath
-Lung disorders (Hildegard)
-“very effective in cases of chest pain and Cough” (Avicenna)


6. Warms the Brain, Settles Wind, Clears Damp:
-strengthens the Brain and Nerves, helps Epilepsy, Apoplexy, Paralysis (Wood and Berry)
-Nerve weakness or dysfunction from Wind-Damp
-Frenzy and Madness

7. Regulates the Heart:
-tincture can be used instead of Digitalis (Bachmaier)

8. Externally:
-the Gum discusses, condenses, good for the Nerves when cooled and contracted
-wood shavings were sewn into caps for the Brain and Nerves; also in fumigations
Joint Pains, Rheumatism, Osteoarthritis, Gout, Sciatica (oil, in washes or baths)
-Oil strengthens the Nerves (Haller)
-Earache or Tinnitus (oil or fumes topically)
-“when cooked with sesame oil in an iron pan till the nut grows black are used as ear drops, help in Deafness”. (Avicenna)
-smoke is inhaled for Toothache
-applied to the sutures of the skull for Epilepsy, Apoplexy, Vertigo, Migraine; topically for nerve diseases, Lameness, Paralysis etc. (oil)
-Wounds, Fistulas (Hippocrates)
-the gum dries Ulcers and fills them with flesh
-“Its powder is useful when sprinkled with honey on corroding, putrid and spreading black ulcers”. (Avicenna)
-the smoke or incense of the leaves and wood was said to drive away infection and purify corrupted air. French Hospitals at the end of the 19th century still burned Juniper berries and Rosemary to purify the air
-Oil applied every 4 hours with a feather, relieves Hemorrhoids
-bark ashes are applied to skin conditions


Dose:


DECOCTION of the FRUIT: 3–9 grams;
FRUIT in POWDER: 1–3 grams
POWDERED WOOD: 3–6 grams, up to 15 grams for Syphilis
FRUIT TINCTURE (1:5 in 75% alcohol): 1–3 or 4 mls, 2-3 times daily;
ESSENTIAL OIL: 1–3 drops, up to 5 drops taken on sugar, in egg yolk, or in a suitable syrup;
SPIRIT of JUNIPER (B.P.): 20–60 drops;
SOLID EXTRACT: 300mg–1 gram.
RIPE BERRIES
: 10–12 may be eaten every morning, or up to 3 times daily. One old method of use was to take 4 berries the first day, 5 on the second, 6 on the third, continuing for 12 days until 15 berries are reached, then reducing by one berry per day until 5 are taken, this constituting a course of treatment;
BATHS 100–200 grams for Arthritis, Rheumatism etc.

Correctives:


Honey, Butter

Substitute:


1. Indian leaf and Rue (for the Stomach)
2. “Cinnamon, twice in quantity serves the same purpose as Juniper does”. (Avicenna)
 

Main Combinations:


Urinary
1. Strengthen the Kidneys and promote Urine:
i. Juniper with Licorice, Aniseed
ii. Juniper with Parsley root and seed, Asparagus root
2. Promote Urine in Edema, fluid swelling, Dampness:
i. from Cold and Weak Kidneys, Juniper with Parsley
ii. with Liver sluggishness, with Wormwood
iii. Juniper with Aniseed, Caraway, Coriander seed
iv. Juniper with Caraway, Fennel (Compound Spirit of Juniper, London Pharmacopoea)
v. Cold Kidneys, Juniper with Cinnamon and Orange peel (Electuary of Juniper, Pharmacopoeia Sardoa, 1773)
vi. Juniper with Birch leaf, Broom, Dandelion root (Krug)
vii. Juniper with Mustard seed, Horseradish (Diuretic Wine, Pharmacopoeia extemporanea, Augustin, 1822)
viii. Juniper with Mustard seed, Carrot seed, Wormwood (Pharmacopoeia medici practici universalis, Bruxelles, 1817)
ix. with Cold-Phlegm Juniper with Ginger, Horseradish, Squill, Wormwood, Lesser Centaury
x. Juniper with Parsley seed, Fennel seed (2 drams each), Juniper wood, Senega root, Couch Grass root, Dandelion root, Chicory root (2 oz. each). Infuse 1 tablespoonful in 1.5 liters of water and drink over the day. (‘Selle’s Diaphoretic-Diuretic Tea)
xi. Juniper with Zedoary, Squill, Cinnamon (Pharmacopoeia extemporanea, Augustin, 1822)
xii. Diuretic Wine, Juniper with Squill, Orange peel, Wormwood, Angelica, Calamus
xiii. Rob of Juniper berries (1 oz.), Parsley Water (6 oz.), Oxymel of Squill, Syrup of Buckthorn (½ oz. each)
3. To strongly promote Urine:
i. Juniper with Squill
ii. Juniper (4 parts), Squill (2 parts), Foxglove (1 part)
iii. Squill, Digitalis (½ scruple each), Gentian (1 scruple), Oil of Juniper (8 drops), make 12 pills with syrup of Buckthorn. (Sobernheim, 1840)
iv. Oil of Juniper (½ dram), Spirit of Cinnamon, Tincture of Digitalis (½ oz. each). Dose: 20–30 drops in water
v. Juniper with Saltpeter, Squill
4. Dysuria, Juniper with Marshmallow root, Tansy
5. Urinary retention, Juniper with Celery seed, Saltpeter, Madder, Asarum, Fennel seed, Indian Spikenard, Bitter Almond, Melon seed (as in Pills for Retention of Urine)
6. Stones, Juniper, Parsley, Pellitory, Agrimony, Mercury (herb), Marshmallow as an emollient cataplasm for Stones

Joint:
7. Lumbago:
i. Juniper, Walnut
ii. Juniper, Comfrey
iii. Juniper, Tansy, Bearberry, Bog Bean, Blue Cohosh (Valuable Herbal Prescriptions, late ‘s)
8. Sciatica, Juniper with Poplar tremuloides bark (1 oz. each), Myrica cerifera (half oz.), Ginger (quarter oz.). Decoct in a quart (approx 1 liter) of water for 5 minutes. Take a wineglassful 3 or 4 times daily. (Valuable Herbal Prescriptions, late ‘s)

Stomach, Digestion:
9. Nervous indigestion, Juniper, Gentian, Valerian
10. Colic, Juniper, Betony decocted in water (Herbarium Horstianum, 1630)
11. Gastritis, Colitis, Juniper with Mint, Wormwood, Camomile (Tschirner)

Gynecology:
12. To Promote Menstruation, Juniper with Bay berry, Rosemary, Cinnamon, Saffron (as in Decoction Against Retention of Menstruation)
13. Obstruction of the Uterus, decoction of Juniper, Betony, Balm, Pennyroyal (Herbarium Horstianum, 1630)
14. To promote Labor or expel a Dead Fetus, take 4 ounces of Juniper Water. (Secrets of Alexis)


Acute Disease/Epidemic Disease:
15. Against Poison and Infection:
i. Juniper with Earth of Lemnos (as in King Nicomedes Antidote)
ii. Juniper, Walnut, Fig, Rue
iii. Preservative during Epidemics, Juniper with Angelica, Dittany, Cinnamon, Sealed Earth, Coral, Pearl, Saffron, Camphor (as in Antidote of Juniper Berry)
16. Wind-Cold diseases of the Head, Headache Epilepsy Dizziness Vertigo:
i. Juniper with Peony, Calamus, Mistletoe, Betony, Sage, Rue, Peony, Rosemary (as in Cephalic Decoction of Charras)

Head, Brain, Nerves
17. Dizziness, Vertigo:
i. Juniper with Betony, Centaury (Wirtzung)
ii. Juniper with Sage, Lavender, Hyssop, Mint, Clove, Nutmeg, Zedoary, Galangal, Calamus, Peony seed
18. Apoplexy, Juniper with Rosemary, Sage, Lavender (as in Wine for Apoplexy)

Liver, Blood:
19. Cleanse the Blood, Juniper with Yarrow and Water Cress (Fischer)
20. Liver inflammation, Juniper with Agrimony, Cleavers, Yarrow, Centaury, Dandelion (as in Decoction for Hepatitis)
21. Scrofula, Juniper with Burnt Sponge and Rosehip (as in Powder of Burnt Sponge)

Major Formulas:


Decoction Against Retention of Menstruation
Syrup of Mugwort (Augustana)
Powder of Juniper for Vertigo (Wirtzung)
Powder of Maximillian for Gravel
Tincture of Juniper Compound
Pills for Retention of Urine (Wirtzung)

1. Sudorific Powder:
i. Juniper wood, Burdock root (6 parts), Couch Grass root, Juniper berry (3 parts), Licorice (2 parts) (Pharmacopoeia Rossica, 1803)

2. Green Ointment:
i. Green Juniper berries (3 oz.), Fresh herbs of Southernwood, Mugwort, Easter Daisy, Betony, Fennel, Hyssop, Mint, Liverwort, Yarrow, Marjoram, Plantain, Veronica, Vervain, Sage, Rue (of each 1 oz.), Butter (48 oz.). Boil until the herbs crisp, then strain.
Externally for Bruising, Trauma and Pain; internally after Trauma in a dose of 1–2 spoonfuls. (Pharmacopoeia Generalis, 1783)

Cautions:


1. Not used in full doses during Pregnancy, except when used to prepare for Labor.
2. Not in acute Kidney inflammation
3. Not used in Heat conditions

Main Preparations used:


Oil was distilled from both Fruit and Wood, Distilled Water, Spirit, Salt from the Ashes, Honey of Juniper, Extract of the Berries, Tincture of Juniper Berry

1. Conserve of Juniper:
i. Fresh Juniper berries (8 oz.), bruise them, adding gradually White Sugar (4 oz). Heat slightly to dissolve the Sugar. (Pharmacopoeia medici practici universalis, Bruxelles, 1817)

2. Juniper Water:
i. Juniper (2 parts), Water (15 parts); distil 4 parts. (Pharmacopoeia Sardoa, 1773)

3. Spirit of Juniper:
i. Juniper (1 part), Alcohol (12 parts); macerate 24 hours, distil. (Pharmacia rationalis, 1806)
ii. Juniper (15 lbs.), Sugar (half pound), Yeast (2 oz.). Add a sufficient quantity of warm water to mix the whole well together, and keep warm to ferment; after the fermentation, pour it into an alembic: add twice its quantity of water, and eight pounds of spirit from grain. Distil a Spirit from 18–20%. (Pharmacia rationalis, 1806)

4. Extract of Juniper:
i. Juniper herb (1 part), Warm Water (4 parts), infuse for 48 hours, stirring occasionally; strain, set aside, and decant the liquor; evaporate slowly to an extract. (Formulaire Pharmaceutitique a l’usage des Hospitaux Militaires de France, 1821)
ii. Juniper, any quantity. Reduce to a pulp with sufficient water, then boil for 15 minutes; strain through a sieve and express the residue. Dissolve 1 part Sugar in four parts of liquor and evaporate to the consistency of an extract. (Dispensatorium medico pharmaceuticum Palatinatus, 1764)

5. Elixir of Juniper:
  Juniper berries, well bruised


Infuse them in their own Distilled Water which has been impregnated with their own Salt; strain, and inspissate to the consistency of an Extract, or Honey. Mix this with 12 times as much of the rectified Spirit of Juniper; digest in the Sun, or a gentle B.M. for 40 days.

“Very great secret in the Stone and all Pestilential distempers”.
Dose: 1 spoonful. (Salmon)



6. Hydragogue Potion:
A potent diuretic remedy.made entirely from Juniper.
i. Rob of Juniper (4 oz.), Juniper Water (2 lbs.), mix, then add Spirit of Juniper (2 oz.). Mix. (Pharmacopoeia extemporanea, Augustin, 1822)

Pliny on Juniper:
The juniper is of a warming and resolvent nature beyond all other plants : in other respects, it resembles the cedar. There are two species of this tree, also, one of which is larger than the other: the odour of either, burnt, repels the approach of serpents. The seed is good for pains in the stomach, chest, and sides; it dispels flatulency and sudden chills, soothes cough, and brings indurations to a head. Applied topically, it checks the growth of tumours; and the berries, taken in red wine,
act astringently upon the bowels: they are applied also to tumours of the abdomen. The seed is used as

an ingredient in antidotes of an aperient nature, and is diuretic in its effects. It is used as a liniment for defluxions of the eyes, and is prescribed for convulsions, ruptures, griping pains in the bowels, affections of the uterus, and sciatica, either in a dose of four berries in white wine, or in the form, of a decoction of twenty berries in wine. There are persons who rub the body with juniper berries as a preventive of the attacks of serpents.’ (The Natural History of Pliny, trans. by Bostock and Riley, Vol. 5, 1856)
GENERAL / REVIEW
A Phytopharmacological Review on a Medicinal Plant: Juniperus communis.
Zimbro (Juniperus communis L.) as a Promising Source of Bioactive Compounds and Biomedical Activities: A Review on Recent Trends.
Biological Activity of Essential Oils of Four Juniper Species and Their Potential as Biopesticides.
Biological investigations of essential oils extracted from three Juniperus species and evaluation of their antimicrobial, antioxidant and cytotoxic activities.
A Review of Conifers in Iran: Chemistry, Biology and their Importance in Traditional and Modern Medicine.

ANTIBACTERIAL
Biological investigations of essential oils extracted from three Juniperus species and evaluation of their antimicrobial, antioxidant and cytotoxic activities.
Efficacy-directed discrimination of the essential oils of three Juniperus species based on their in-vitro antimicrobial and anti-inflammatory activities.
Comparative Evaluation of Piper nigrum, Rosmarinus officinalis, Cymbopogon citratus and Juniperus communis L. Essential Oils of Different Origin as Functional Antimicrobials in Foods.
Chemical Composition, Cytotoxic and Antibacterial Activities of Essential Oils of Cultivated Clones of Juniperus communis and Wild Juniperus Species.
In-vitro Antimicrobial Activities of Some Iranian Conifers. Afsharz
Antioxidant and antimicrobial activities of branches extracts of five Juniperus species from Turkey.

ANTIMYCOBACTERIAL
Antimycobacterial potential of the juniper berry essential oil in tap water.
Anti-mycobacterial natural products from the Canadian medicinal plant Juniperus communis.
Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae).
Activity against multidrug-resistant Mycobacterium tuberculosis in Mexican plants used to treat respiratory diseases.

ANTI-VIRAL
Screening of the essential oil effects on human H1N1 influenza virus infection: an in vitro study in MDCK cells.

ANTIFUNGAL
Genoprotective, antioxidant, antifungal and anti-inflammatory evaluation of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills.
Antifungal Effect of Essential Oils against Fusarium Keratitis Isolates.
Essential oil of Juniperus communis subsp. alpina (Suter) Čelak needles: chemical composition, antifungal activity and cytotoxicity.
Antifungal activity of Juniperus essential oils against dermatophyte, Aspergillus and Candida strains.

ANTI-INFLAMMATORY
Efficacy-directed discrimination of the essential oils of three Juniperus species based on their in-vitro antimicrobial and anti-inflammatory activities.
Genoprotective, antioxidant, antifungal and anti-inflammatory evaluation of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills.

ANTIOXIDANT
Biological investigations of essential oils extracted from three Juniperus species and evaluation of their antimicrobial, antioxidant and cytotoxic activities.
Genoprotective, antioxidant, antifungal and anti-inflammatory evaluation of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills.
Chemical characterization, antioxidant, genotoxic and in vitro cytotoxic activity assessment of Juniperus communis var. saxatilis.
Antioxidant and Hepatoprotective Potential of Phenol-Rich Fraction of Juniperus communis Linn. Leaves.
Antioxidant and antimicrobial activities of branches extracts of five Juniperus species from Turkey.

HEPATOPROTECTIVE
Antioxidant and Hepatoprotective Potential of Phenol-Rich Fraction of Juniperus communis Linn. Leaves.
Synergistic hepatoprotective potential of ethanolic extract of Solanum xanthocarpum and Juniperus communis against paracetamol and azithromycin induced liver injury in rats.
GENOPROTECTIVE
Genoprotective, antioxidant, antifungal and anti-inflammatory evaluation of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills.

HORMONAL EFFECTS
Hormonal properties of ethanolic extract of juniperus communis linn.

ALZHEIMER’S DISEASE
In vitro cholinesterase inhibitory and antioxidant effect of selected coniferous tree species.
Insights into cholinesterase inhibitory and antioxidant activities of five Juniperus species.

DIURETIC
[Diuretic substance from juniper (Juniperus communis L.)].

DIABETES
Enzyme inhibitory and radical scavenging effects of some antidiabetic plants of Turkey.
Hypoglycemic activity of juniper “berries”.

ARTHRITIS
Modulatory effect of standardised amentoflavone isolated from Juniperus communis L. agianst Freund’s adjuvant induced arthritis in rats (histopathological and X Ray anaysis).

ANTI-FERTILITY
Antifertility effects of fruits of Juniperus communis.

CYTOTOXIC
Biological investigations of essential oils extracted from three Juniperus species and evaluation of their antimicrobial, antioxidant and cytotoxic activities.
Chemical Composition, Cytotoxic and Antibacterial Activities of Essential Oils of Cultivated Clones of Juniperus communis and Wild Juniperus Species.
Chemical characterization, antioxidant, genotoxic and in vitro cytotoxic activity assessment of Juniperus communis var. saxatilis.
Essential oil of Juniperus communis subsp. alpina (Suter) Čelak needles: chemical composition, antifungal activity and cytotoxicity.

CANCER
The Water Extract of Juniperus communis L. Induces Cell Death and Sensitizes Cancer Cells to Cytostatic Drugs through p53 and PI3K/Akt Pathways.
Polyphenolic Profile and Targeted Bioactivity of Methanolic Extracts from Mediterranean Ethnomedicinal Plants on Human Cancer Cell Lines.
BRAIN
Cellular Stress and p53-Associated Apoptosis by Juniperus communis L. Berry Extract Treatment in the Human SH-SY5Y Neuroblastoma Cells.
Juniperus Communis Extract Exerts Antitumor Effects in Human Glioblastomas Through Blood-Brain Barrier.
BREAST
Deoxypodophyllotoxin isolated from Juniperus communis induces apoptosis in breast cancer cells.
COLORECTAL
Juniperus communis extract induces cell cycle arrest and apoptosis of colorectal adenocarcinoma in vitro and in vivo.
Cytotoxic effects of some animal and vegetable extracts and some chemicals on liver and colon carcinoma and myosarcoma
ESOPHAGEAL
Cell cycle arrest and apoptosis induction by Juniperus communis extract in esophageal squamous cell carcinoma through activation of p53-induced apoptosis pathway.
LIVER
Evaluation of anticancer effects of Juniperus communis extract on hepatocellular carcinoma cells in vitro and in vivo.
Cytotoxic effects of some animal and vegetable extracts and some chemicals on liver and colon carcinoma and myosarcoma
MELANOMA
Juniperus communis Suppresses Melanoma Tumorigenesis by Inhibiting Tumor Growth and Inducing Apoptosis.
ORAL
Suppression of oral cancer by induction of cell cycle arrest and apoptosis using Juniperus communis extract.

SKIN LIGHTENING EFFECT
The Standardized Extract of Juniperus communis Alleviates Hyperpigmentation in Vivo HRM-2 Hairless Mice and in Vitro Murine B16 Melanoma Cells.