Huang Lian Jie Du Tang 黄连解毒汤
Coptis Clear Toxin Decoction
TCM
Arcane Essentials from the Imperial Library, 752
Prepare a standard Decoction
Clears Heat and Toxin
High Fever, Irritability, Insomnia, dry throat, thirst
1. Severe Acne, Boils
2. Red Skin Rashes and Lesion associated with Heat-toxicity; Skin infections
3. Severe Tonsillitis
4. Pneumonia
5. Urinary Tract Infections
6. Dysentery
7. Encephalitis
8. Septicemia
a small cupful twice or thrice daily; the above can be taken over the course of a day. When prepared as a powder, 1–2 grams can be taken twice daily with warm water.
None noted
1. Severe Heat-Toxin, or with Constipation, add Rhubarb root. When made as a powder, some practitioners prefer to add Rhubarb regardless as it potently clears heat and toxin.
2. Jaundice from Heat obstruction, add Artemisia Yin Chen Hao and Rhubarb root
3. Urinary Tract Infections add Alisma Ze Xie and Plantain seed
GENERAL / REVIEW:
–Composition and Bioactivity of a Modified Huang-Lian-Jie-Du Decoction.
ANTI-INFL;AMMATORY:
–Anti-inflammatory and anti-allergic effects and underlying mechanisms of Huang-Lian-Jie-Du extract: Implication for atopic dermatitis treatment.
–Anti-inflammatory effects of Huang-Lian-Jie-Du decoction, its two fractions and four typical compounds.
ANTI-ALLERGIC:
–Anti-inflammatory and anti-allergic effects and underlying mechanisms of Huang-Lian-Jie-Du extract: Implication for atopic dermatitis treatment.
FEVER:
–Effect of huanglianjiedu tang on fever in rats induced by 2, 4-dinitrophenol.
ANTI-SEPSIS:
–Evaluation of anti-sepsis activity by compounds with high affinity to lipid a from HuanglianJiedu decoction.
–Comparative study of single/combination use of Huang-Lian-Jie-Du decoction and berberine on their protection on sepsis induced acute liver injury by NMR metabolic profiling.
–Protection by Huang-Lian-Jie-Du decoction and its constituent herbs of lipopolysaccharide-induced acute kidney injury.
PNEUMONIA:
–Decoding the Mechanism of Huanglian Jiedu Decoction in Treating Pneumonia Based on Network Pharmacology and Molecular Docking.
ULCERATIVE COLITIS:
–Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviating acute ulcerative colitis in mice: Regulating arachidonic acid metabolism and glycerophospholipid metabolism.
–Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice.
–Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function.
DERMATITIS:
–Huang-Lian-Jie-Du extract ameliorates atopic dermatitis-like skin lesions induced by 2,4-dinitrobenzene in mice via suppression of MAPKs and NF-κB pathways.
–Anti-inflammatory and anti-allergic effects and underlying mechanisms of Huang-Lian-Jie-Du extract: Implication for atopic dermatitis treatment.
NEUROPROTECTIVE:
–Protective effect of Huanglianjiedu Decoction on microcystin-LR induced nerve injury.
–Huang-Lian-Jie-Du decoction attenuates cognitive dysfunction of rats with type 2 diabetes by regulating autophagy and NLRP3 inflammasome activation.
–Rapid screening of neuroprotective components from Huang-Lian-Jie-Du Decoction by living cell biospecific extraction coupled with HPLC-Q-Orbitrap-HRMS/MS analysis.
–Induced cortical neurogenesis after focal cerebral ischemia–Three active components from Huang-Lian-Jie-Du Decoction.
DEPRESSION:
–Huang-Lian-Jie-Du decoction alleviates depressive-like behaviors in dextran sulfate sodium-induced colitis mice via Trem2/Dap12 pathway.
INSOMNIA:
–Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial.
–The efficacy and safety of a Huanglian-jie-du decoction on Hwa-byung patients: A study protocol for a randomized controlled trial.
STROKE:
–Intermodule Coupling Analysis of Huang-Lian-Jie-Du Decoction on Stroke.
–Deciphering the pharmacological mechanism of the Chinese formula huanglian-jie-du decoction in the treatment of ischemic stroke using a systems biology-based strategy.
ALZHEIMER’S DISEASE:
–Effects of Huang-Lian-Jie-Du Decoction on Oxidative Stress and AMPK-SIRT1 Pathway in Alzheimer’s Disease Rat.
–Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease.
–A Co-Module Regulated by Therapeutic Drugs in a Molecular Subnetwork of Alzheimer’s Disease Identified on the Basis of Traditional Chinese Medicine and SAMP8 Mice.
–Gene expression patterns of hippocampus and cerebral cortex of senescence-accelerated mouse treated with Huang-Lian-Jie-Du decoction.
ATHEROSCLEROSIS:
–Metabolomics and lipidomics combined with serum pharmacochemistry uncover the potential mechanism of Huang-Lian-Jie-Du decoction alleviates atherosclerosis in ApoE-/- mice.
–Huang-Lian-Jie-Du Decoction Attenuates Atherosclerosis and Increases Plaque Stability in High-Fat Diet-Induced ApoE-/- Mice by Inhibiting M1 Macrophage Polarization and Promoting M2 Macrophage Polarization.
DIABETIC NEPHROPATHY:
–Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice.
DIABETIC ENCEPHAOLOPATHY:
–Explore of the beneficial effects of Huang-Lian-Jie-Du Decoction on diabetic encephalopathy in db/db mice by UPLC-Q-Orbitrap HRMS/MS based untargeted metabolomics analysis.
RHEUMATOID ARTHRITIS:
–A Preliminary Inquiry Into the Potential Mechanism of Huang-Lian-Jie-Du Decoction in Treating Rheumatoid Arthritis via Network Pharmacology and Molecular Docking.
CANCER:
LIVER:
–Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation Huanglian-Jiedu decoction in human hepatocellular carcinoma.
MOUTH:
–Huanglianjiedu Decoction as an effective treatment for oral squamous cell carcinoma based on network pharmacology and experimental validation.
Back to DECOCTIONS
Back to FORMULAS
How to Modify a Formula
Substitutes
Weights & Measures
Coptis Clear Toxin Decoction
Tradition:
TCM
Source / Author:
Arcane Essentials from the Imperial Library, 752
Herb NameHuang Lian (Coptis)Huang Qin (Baical Skullcap) Huang Bai (Amur cork-tree bark) Zhi Zi (Gardenia fruit) |
|
Preparation:
Prepare a standard Decoction
Function:
Clears Heat and Toxin
Use:
High Fever, Irritability, Insomnia, dry throat, thirst
1. Severe Acne, Boils
2. Red Skin Rashes and Lesion associated with Heat-toxicity; Skin infections
3. Severe Tonsillitis
4. Pneumonia
5. Urinary Tract Infections
6. Dysentery
7. Encephalitis
8. Septicemia
Dose:
a small cupful twice or thrice daily; the above can be taken over the course of a day. When prepared as a powder, 1–2 grams can be taken twice daily with warm water.
Cautions:
None noted
Modifications:
1. Severe Heat-Toxin, or with Constipation, add Rhubarb root. When made as a powder, some practitioners prefer to add Rhubarb regardless as it potently clears heat and toxin.
2. Jaundice from Heat obstruction, add Artemisia Yin Chen Hao and Rhubarb root
3. Urinary Tract Infections add Alisma Ze Xie and Plantain seed
GENERAL / REVIEW:
–Composition and Bioactivity of a Modified Huang-Lian-Jie-Du Decoction.
ANTI-INFL;AMMATORY:
–Anti-inflammatory and anti-allergic effects and underlying mechanisms of Huang-Lian-Jie-Du extract: Implication for atopic dermatitis treatment.
–Anti-inflammatory effects of Huang-Lian-Jie-Du decoction, its two fractions and four typical compounds.
ANTI-ALLERGIC:
–Anti-inflammatory and anti-allergic effects and underlying mechanisms of Huang-Lian-Jie-Du extract: Implication for atopic dermatitis treatment.
FEVER:
–Effect of huanglianjiedu tang on fever in rats induced by 2, 4-dinitrophenol.
ANTI-SEPSIS:
–Evaluation of anti-sepsis activity by compounds with high affinity to lipid a from HuanglianJiedu decoction.
–Comparative study of single/combination use of Huang-Lian-Jie-Du decoction and berberine on their protection on sepsis induced acute liver injury by NMR metabolic profiling.
–Protection by Huang-Lian-Jie-Du decoction and its constituent herbs of lipopolysaccharide-induced acute kidney injury.
PNEUMONIA:
–Decoding the Mechanism of Huanglian Jiedu Decoction in Treating Pneumonia Based on Network Pharmacology and Molecular Docking.
ULCERATIVE COLITIS:
–Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviating acute ulcerative colitis in mice: Regulating arachidonic acid metabolism and glycerophospholipid metabolism.
–Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice.
–Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function.
DERMATITIS:
–Huang-Lian-Jie-Du extract ameliorates atopic dermatitis-like skin lesions induced by 2,4-dinitrobenzene in mice via suppression of MAPKs and NF-κB pathways.
–Anti-inflammatory and anti-allergic effects and underlying mechanisms of Huang-Lian-Jie-Du extract: Implication for atopic dermatitis treatment.
NEUROPROTECTIVE:
–Protective effect of Huanglianjiedu Decoction on microcystin-LR induced nerve injury.
–Huang-Lian-Jie-Du decoction attenuates cognitive dysfunction of rats with type 2 diabetes by regulating autophagy and NLRP3 inflammasome activation.
–Rapid screening of neuroprotective components from Huang-Lian-Jie-Du Decoction by living cell biospecific extraction coupled with HPLC-Q-Orbitrap-HRMS/MS analysis.
–Induced cortical neurogenesis after focal cerebral ischemia–Three active components from Huang-Lian-Jie-Du Decoction.
DEPRESSION:
–Huang-Lian-Jie-Du decoction alleviates depressive-like behaviors in dextran sulfate sodium-induced colitis mice via Trem2/Dap12 pathway.
INSOMNIA:
–Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial.
–The efficacy and safety of a Huanglian-jie-du decoction on Hwa-byung patients: A study protocol for a randomized controlled trial.
STROKE:
–Intermodule Coupling Analysis of Huang-Lian-Jie-Du Decoction on Stroke.
–Deciphering the pharmacological mechanism of the Chinese formula huanglian-jie-du decoction in the treatment of ischemic stroke using a systems biology-based strategy.
ALZHEIMER’S DISEASE:
–Effects of Huang-Lian-Jie-Du Decoction on Oxidative Stress and AMPK-SIRT1 Pathway in Alzheimer’s Disease Rat.
–Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease.
–A Co-Module Regulated by Therapeutic Drugs in a Molecular Subnetwork of Alzheimer’s Disease Identified on the Basis of Traditional Chinese Medicine and SAMP8 Mice.
–Gene expression patterns of hippocampus and cerebral cortex of senescence-accelerated mouse treated with Huang-Lian-Jie-Du decoction.
ATHEROSCLEROSIS:
–Metabolomics and lipidomics combined with serum pharmacochemistry uncover the potential mechanism of Huang-Lian-Jie-Du decoction alleviates atherosclerosis in ApoE-/- mice.
–Huang-Lian-Jie-Du Decoction Attenuates Atherosclerosis and Increases Plaque Stability in High-Fat Diet-Induced ApoE-/- Mice by Inhibiting M1 Macrophage Polarization and Promoting M2 Macrophage Polarization.
DIABETIC NEPHROPATHY:
–Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice.
DIABETIC ENCEPHAOLOPATHY:
–Explore of the beneficial effects of Huang-Lian-Jie-Du Decoction on diabetic encephalopathy in db/db mice by UPLC-Q-Orbitrap HRMS/MS based untargeted metabolomics analysis.
RHEUMATOID ARTHRITIS:
–A Preliminary Inquiry Into the Potential Mechanism of Huang-Lian-Jie-Du Decoction in Treating Rheumatoid Arthritis via Network Pharmacology and Molecular Docking.
CANCER:
LIVER:
–Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation Huanglian-Jiedu decoction in human hepatocellular carcinoma.
MOUTH:
–Huanglianjiedu Decoction as an effective treatment for oral squamous cell carcinoma based on network pharmacology and experimental validation.
Back to DECOCTIONS
Back to FORMULAS
How to Modify a Formula
Substitutes
Weights & Measures