Gastrodia, Tian Ma 天麻

Tian Ma (TCM)
Picture
Picture Picture Gastrodia elata
(Photo by Qwert1234) (Wikimedia)

Picture Sichuan Gastrodia Tian Ma root (Adam, 2016)

Picture  Above: Sliced fresh Tian Ma available at the Chengdu Medicine
Market. (Adam, 2018)

Picture














Gastrodia, Collection des Orchidées … Indien et du Japon, 1858

Botanical name:


Gastrodia elata
The best quality is Winter Gastrodia from Yunnan and Sichuan

Parts used:


Root
Collected from Winter to Spring; washed well, steamed, then sliced and dried at a low temperature.

Temperature & Taste:


Neutral, Sweet, Pungent

Classification:


I. Medicines for Internal Wind

Uses:


1. Calms the Liver, Settles Wind, Stops Spasms:
-Headache, Dizziness, Vertigo, Tinnitus
-Vertigo with Blurred Vision (Liver deficiency with Wind)
-Epilepsy, Childhood Convulsions
-childhood restlessness or anxiety
-Tonic-clonic spasms, Tetanus, Spasm of the Limbs
-Loss of Speech

2. Settles Wind, Stops Pain:
-Headache, Migraine (from Wind-Phlegm)
-Hemiplegia, Numbness in the extremities

3. Clears Wind-Damp, Relieves Pain:
-Wind-Damp pain and numbness of the lower back and extremities
-‘Puffiness in the Lower Extremities’. (Ming Yi Bie Lu)
-strengthens the Tendons (Kai Bao Ben Cao)
-especially for moving-type Wind pain

4. Benefits Qi and Yin:
-‘Long-term use reinforces strength, replenishes Yin and helps the person put on weight’. (Shen Nong Ben Cao)
-‘Makes the person happy and able to enjoy a long life’. (Shen Nong Ben Cao)
-‘Replenishes the conditions of the Five Overstrains and Seven Damages’. (Da Ming)
-Neurodegenerative disorders, Parkinson’s Diseases, Alzheimer’s Disease


Dose:


Decoction: 3–9 grams
Powder: 1–3 grams

Comment:


1. Gastrodia Tian Ma is listed on CITES as endangered. However, over 80% of the market is supplied with cultivated product. (Bensky)

Preparation:


‘Some people preserve the drug with honey’ (Ben Cao Gang Mu)

Main Combinations:


Often combined with Uncaria Gou Teng

1. Internal Wind disorders:
i. Gastrodia Tian Ma with Uncaria Gou Teng, Tribulus Ci Ji Li, Chrysanthemum Ju Hua
ii. Gastrodia Tian Ma from Wind-Heat with Uncaria Gou Teng, Abalone Shell (Shi Jue Ming), Scutellaria Huang Qin, Achyranthes Niu Xi, Mistletoe (Sang Ji Sheng) (as in Tian Ma Gou Teng Yin from New Concepts for Diagnosis and Treatment in Miscellaneous Diseases)
2. Hemiplegia, Loss of Speech Gastrodia Tian Ma with Pinellia Ban Xia and Earthworm (Di Long)
3. Hypertension:
i. Gastrodia Tian Ma with Prunella Xia Ku Cao, Motherwort (Yi Mu Cao)
ii. due to stress (Qi stagnation with Wind), Gastrodia Tian Ma, Tribulus Ci Ji Li, Polygala Yuan Zhi, Ligusticum Chuan Xiong, Schizonepeta Jing Jie, Magnetite (Ci Shi) (Formulas of Dr. John H.F. Shen)
iii. Gastrodia Tian Ma, Mistletoe (Sang Ji Sheng), Paeonia Bai Shao, Scutellaria Huang Qin
iv. Gastrodia Tian Ma with Uncaria Gou Teng, Achyranthes Niu Xi, Rhubarb (Da Huang)
4. Dizziness, Vertigo:
i. Gastrodia Tian Ma, Uncaria Gou Teng, Chrysanthemum Ju Hua, Abalone shell (Shi Jue Ming)
ii. Gastrodia Tian Ma with equal parts Ligusticum Chuan Xiong (Chinese Lovage root) (as in Tian Ma Wan from Prescriptions of Universal Relief).
iii. Gastrodia Tian Ma with Uncaria Gou Teng, Paeonia Bai Shao, Chrysanthemum Ju Hua
iv. from Wind-Phlegm Gastrodia Tian Ma with Atractylodes Bai Zhu, Pineilla Ban Xia, Citrus Chen Pi (Tangerine peel) (as in Ban Xia Bai Zhu Tian Ma Tang from Medical Revelations)
5. Headache, Migraine:
i. Gastrodia Tian Ma with equal parts Ligusticum Chuan Xiong (Chinese Lovage root) (as in Tian Ma Wan from Prescriptions of Universal Relief).
ii. Gastrodia Tian Ma with Pseudoginseng San Qi
iii. Gastrodia Tian Ma with Saposhnikovia Fang Feng, Dang Gui, Angelica Bai Zhi, Ligusticum Chuan Xiong, Asarum Xi Xin
6. Tinnitus, Gastrodia Tian Ma with Dioscorea Shan Yao, Cassia semen Jue Ming Zi, Oyster shell (Mu Li), Lycium Gou Qi Zi, Cuscuta Tu Si Zi, Rehmannia Sheng Di Huang (The Formulas of Dr. John H.F. Shen)
7. Childhood Convulsions:
i. from Wind-Heat Gastrodia Tian Ma with Tabasheer, Pearl, Amber
ii. from Wind-Heat, Gastrodia Tian Ma with Arisaema Dan Nan Xiang (Bile prepared Tian Nan Xing), Coptis Huang Lian, Bezoar, Scorpion
iii. Febrile Convulsions, Gastrodia Tian Ma with Antelope horn (Ling Yang Jiao), Uncaria Gou Teng, Tabasheer
iv. Gastrodia Tian Ma with Uncaria Gou Teng, Antelope Horn (Ling Yang Jiao), Scorpion (Quan Xie) (as in Gou Teng Yin from Golden Mirror of Orthodox Medicine).
v. Gastrodia Tian Ma with Arisaema Dan Nan Xing, White Dead Silkworn (Bai Jiang Can) (as in Tian Ma Wan from Formulas of Dr. Wei’s Family Treasure).
vi. Gastrodia Tian Ma with White Dead Silkworm (Bai Jiang Can) with Coptis Huang Lian, Arisaema prepared with Bile (Dan Nan Xing), Scorpion, Bezoar, Borneo Camphor, Licorice (as in Qian Jin Powder)
vii. Chronic Childhood convulsions with deficiency, Gastrodia Tian Ma with Ginseng, Atractylodes Bai Zhu, White Dead Silkworn (Bai Jiang Can) (as in Xing Pi Wan from Prescriptions for Universal Relief).
viii. Childhood convulsions from Internal Wind, Gastrodia Tian Ma with Uncaria Gou Teng, Scorpion (Quan Xie), White Silkworm (Bai Jiang Can), Cicada shell (Chan Tui) (as in Gou Teng Yin Zi from Xiao Er Yao Zheng Zhi Jue [Key to Syndrome Identification and Treatment of Diseases in Infants]).
8. Night Terrors, Restless or Crting Infants, Gastrodia Tian Ma with White Dead Silkworm (Bai Jiang Can), Amber, Pearl, Tabasheer
9. Tetanic Convulsions:
i. Gastrodia Tian Ma with Saposhnikovia Fang Feng, Arisaema Tian Nan Xing, Angelica dahurica Bai Zhi
ii. Gastrodia Tian Ma with Arisaema (Tian Nan Xing), Typhonium (Bai Fu Zi), Saposhnikovia (Fang Feng). (as in Yu Zhen San from True Lineage of External Medicine).
10. Phlegm-Damp obstructing the Mind with confusion, mental dullness, dizziness:
i. Gastrodia Tian Ma with Polygala Yuan Zhi, Pinellia Ban Xia
ii. Gastrodia Tian Ma with Calamus (Shi Chang Pu)
11. Wind-Damp Arthritic and Rheumatic pain:
i. Gastrodia Tian Ma with Saposhnikovia Fang Feng, Mistletoe (Sang Ji Sheng)
ii. Gastrodia Tian Ma with Gentiana Macrophylla Qin Jiao, Notopterygium Qiang Huo, Mulberry Twig (Sang Zhi) (as in Qin Jiao Tian Ma Tang from Medical Revelations)
12. Arthritic pain, apoplectic paralysis, Gastrodia Tian Ma with Aconitum Chuan Wu, Myrrh, Musk (as in Tian Ma Wan from Complete Record of Holy Benevolence).
13. Wandering Arthritic Pain, Paralysis of the limbs, Gastrodia Tian Ma with Achyranthes Niu Xi, Eucommia Du Zhong, Aconitum Fu Zi as a medicated wine (as in Tian Ma Jiu from Convenient and Effective Prescriptions that Contain few Herbs).
14. Pain from Blood stasis and Wind, Gastrodia Tian Ma with Olibanum (Ru Xiang), and Scorpion
15. Liver deficiency, Gastrodia Tian Ma with Ligusticum Chuan Xiong (Li Gao)
16. As a tonic, Gastrodia Tian Ma with Conioselinum univittatum, made into pills with Honey.

Major Formulas:
Ban Xia Bai Zhu Tian Ma Tang
Bo Ying Compound
Ding Xian Wan
Tian Ma Gou Teng Yin
Shi Xiang Fan Sheng Wan
Yu Zhen San

Cautions:


Generally very safe
1. Use cautiously in Qi and Blood deficiency (use with tonics)
2. Use with caution during Pregnancy and avoid full doses.
3. Occasional allergic reactions are reported
4. ‘It is reported that some people, after long-term consumption of Gastrodia Tian Ma develop a red skin eruption all over the body. This happens when pathogenic Wind has been dispersed. (Li Shi Zhen)

Main Preparations used:




GENERAL / REVIEW
Gastrodia elata BI.:A Comprehensive Review of Its Traditional Use, Botany, Phytochemistry, Pharmacology, and Pharmacokinetics
Gastrodia elata Blume Polysaccharides: A Review of Their Acquisition, Analysis, Modification, and Pharmacological Activities
Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents
Discovery of Herbal Pairs Containing Gastrodia elata Based on Data Mining and the Delphi Expert Questionnaire and Their Potential Effects on Stroke through Network Pharmacology
Gastrodiae Rhizoma (天麻tiān má): a review of biological activity and antidepressant mechanisms

ANALGESIC
Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation

INHIBITS PLATELET AGGREGATION / ANTI-THROMBOTIC
Gastrodia elata Blume and Zanthoxylum schinifolium Siebold & Zucc Mixed Extract Suppress Platelet Aggregation and Thrombosis

HEPATOPROTECTIVE
Protective effects of Gastrodia elata Blume on acetaminophen-induced liver and kidney toxicity in rats

PROTECTS AGAINST CEREBRAL ISCHEMIA / ARTERY OCCLUSION
The protective effects of Gastrodia elata Blume extracts on middle cerebral artery occlusion in rats
Gastrodia and Uncaria (tianma gouteng) water extract exerts antioxidative and antiapoptotic effects against cerebral ischemia in vitro and in vivo

NEUROPROTECTIVE
Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease
Constituents of Gastrodia elata and Their Neuroprotective Effects in HT22 Hippocampal Neuronal, R28 Retinal Cells, and BV2 Microglial Cells
Neuroprotective Effects of Vanillyl Alcohol in Gastrodia elata Blume Through Suppression of Oxidative Stress and Anti-Apoptotic Activity in Toxin-Induced Dopaminergic MN9D Cells
Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities
Gastrodin exerts robust neuroprotection in the postischemic brain via its protective effect against Zn2+-toxicity and its anti-oxidative effects in astrocytes

PROTECT FROM METHAMPHETAMINE-INDUCED DOPAMINERGIC TOXICITY
Gastrodia Elata Bl Attenuates Methamphetamine-Induced Dopaminergic Toxicity Via Inhibiting Oxidative Burdens

PSYCHOSIS / SCHIZOPHRENIA
Effects of Gastrodia Elata Bl on Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice
IMPROVES LEARNING / MEMEORY
Prolonged oral administration of Gastrodia elata extract improves spatial learning and memory of scopolamine-treated rats

IMPROVES COGNITION
Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice

DEPRESSION
Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice
Antidepressant effects of Gastrodia elata Bl. at the genomic level
Gastrodiae Rhizoma (天麻tiān má): a review of biological activity and antidepressant mechanisms

ALZHEMIER’S DISEASE / DEMENTIA
Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer’s disease
Neuropharmacological Potential of Gastrodia elata Blume and Its Components
Gastrodia elata Blume (Tianma): Hope for Brain Aging and Dementia

PARKINSON’S DISEASE
Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease
Neuropharmacological Potential of Gastrodia elata Blume and Its Components
Gastrodia elata Blume alleviates L-DOPA-induced dyskinesia by normalizing FosB and ERK activation in a 6-OHDA-lesioned Parkinson’s disease mouse model
Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study
Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson’s disease model
Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin-Induced Parkinson’s Disease Model

MULTIPLE SCLEROSIS
A Review of Herbal Therapy in Multiple Sclerosis

EPILEPSY
Chinese Herbal Medicine for Treating Epilepsy

DIABETES
Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism

OSTEOPOROSIS
Gastrodin alleviates glucocorticoid induced osteoporosis in rats via activating the Nrf2 signaling pathways

ANTI-AGEING
Structure Characterization and Action Mechanism of an Antiaging New Compound from Gastrodia elata Blume
Gastrodia elata Blume (Tianma): Hope for Brain Aging and Dementia