Eurycoma, Tongkat Ali

Long Jack, “Malaysian Ginseng”, “Ali’s Walking Stick”
Pla Lai Phueak (Thai)
Pasak Bumi (Indonesia)
Cay Ba Binh (Vietnam)
Chang Ye Kuan Mu (TCM)
Picture Eurycoma longifolia–the principle variety used
(Photo by Mokkie) (Wikimedia)

Picture Jackiopsis ornata–source of Red Tongkat Ali
Wallich, Plantae Asiaticae Rariores (1830-1832)

Picture Tongkat Ali root for sale in Indonesia)
(Photo by Kembangraps) (Wikimedia)

Botanical name:


Eurycoma spp.:
  1. E. longifolia
  2. E. apiculata (said to be strongest)
There are 3 main types of Tongkat Ali according to their color:
  1. Yellow (or White) Tongkat Ali–Eurycoma longifolia; bigger roots, yellowish, bitter
  2. Black Tongkat Ali–Polyalthia bullata; root-bark is black
  3. Red Tongkat Ali–Jackiopsis ornata or Stema tuberosa reddish in color, slightly sweet

Parts used:


Root; Root-bark

Temperature & Taste:


Neutral, Bitter
The Yellow and Black Tongkat Ali are very bitter, whereas the Red variety is slightly sweet.

Classification:



Constituents:


Eurycoma:
-Quassinoids-eurycolactones
(gives the bitter taste)
-tirucallane-type triterpenes
-squalene derivatives
-biphenylneolignans

-beta-carboline alkaloids

Uses:


1. Clears Heat and Poison:
-Cold, Flu, Fever
-acute Cough
-Diarrhea, Dysentery
-Poisoning
-Tuberculosis
-Sunstroke
-traditionally for Malaria (antimalarial activities against drug-resistant strains has been shown)
-root-bark is most used for this function


2. Tonifies Yang:
-Impotence, as a male sexual stimulant
-Infertility
-increases Sperm production and motility
-increases strength, stamina and endurance
-lumbago and bone pain
-Edema, Obesity and Diabetes from cold, weak Kidneys
-tonic after birth (Malaysia)
-root is most used for this function

3. Resolves Swellings:
-traditionally for Swellings
-has demonstrated anti-tumor, cytotoxic and anti-cancer activity

4. Bitter Tonic:
-used as a bitter tonic to stimulate digestion

5. Kills Worms:
-bark is used to kill worms and parasites, internally and topically

6. Externally:
-topically for skin parasites (bark or leaves)
-bark is used topically for Wounds and Ulcers
-bark is applied for headaches
-mouthwash for bleeding gums


Dose:


Decoction: 3–6 grams
Powder: 500mg–2 grams

Substitute:


1. Stemona tuberosa has been listed by several sources as an alternate variety of Tongkat Ali (although this appears unlikely). However, Stemona might be a suitable substitute for Worms and Parasites. 

Comment:


1. Locally it has been known as “the Tree that cures 100 Diseases”
2. Numerous sources list Stema tuberosa and the source of Red Tongkat Ali. However, no plant with that name exists. Some have listed Stemona tuberosa (Bai Bu of TCM). However, that root is whiote in color, not red, and has very different therapeutic indications.

Preparation:




Main Combinations:


1. Impotence, Erectile Dysfunction:
-Eurycoma with Ginseng and Epimedium Yin Yang Huo
-Eurycoma longifolia, Tribulus terrestris, and Leuzea carthamoides (this was tested in Boars and found effective)
-Eurycoma with Yohimbine
2. Increase testosterone”
-Eurycoma with Tribulus and Sesame seed
-Eurycoma with Ginseng and Epimedium Yin Yang Huo
-Eurycoma with Shen Qi Wan
3. Increases Semen quality, quantity and motility:
-Eurycoma with Tribulus and Sesame seed
-Eurycoma longifolia, Tribulus terrestris, and Leuzea carthamoides (this was tested in Boars and found effective)
-Eurycoma with Chlorophytum, Hygrophila seed, Mucuna, Astragalus root, Bombax ceiba resin
-Eurycoma with Liu Wei Di Huang Wan
4. Menopause:
–Eurycoma with Labisia pumila
–Eurycoma with Dang Gui, Asparagus Shatavari

Major Formulas:



Cautions:


The plant contains quassinoids which are toxic in overdose.

Toxicity:


-oral LD50 of the alcohol extract of E. longifolia in mice is between 1500–2000 mg/kg.
-oral LD50 of the aqueous extract in mice is over 3000 mg/kg
Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack)

Main Preparations used:




Nothing at Present
GENERAL / REVIEW
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
Bioactive Constituents from the Roots of Eurycoma longifolia
American Botanical Council-Tongkat Ali

ANTIBACTERIAL:
A Systematic Review on Antimicrobial and Antiparasitic Activity of Eurycoma longifolia Jack (Tongkat Ali)

BLASTOCYSTIS:
Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocystis sp.

ANTI-PARASITIC:
A Systematic Review on Antimicrobial and Antiparasitic Activity of Eurycoma longifolia Jack (Tongkat Ali)

ANTI-MALARIAL:
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
Medicinal plants as a fight against murine blood-stage malaria

ANTI-INFLAMMATORY:
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
A Review of Malaysian Medicinal Plants with Potential Anti-Inflammatory Activity

ERECTILE DYSFUNCTION:
Effects of Root Extracts of Eurycoma longifolia Jack on Corpus Cavernosum of Rat
Rho-Kinase II Inhibitory Potential of Eurycoma longifolia New Isolate for the Management of Erectile Dysfunction

APHRODISIAC, IMPROVES SEXUAL PERFORMANCE:
Exploring scientifically proven herbal aphrodisiacs
A Review on Plants Used for Improvement of Sexual Performance and Virility

ENHANCE MALE FERTILITY:
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
Eurycoma longifolia Jack in managing idiopathic male infertility
Male Infertility: The Effect of Natural Antioxidants and Phytocompounds on Seminal Oxidative Stress
Effect of Herbal Medicine on Fertility Potential in Experimental Animals – an Update Review
Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

INCREASES SPERMATOGENSIS:
The Effect of Eurycoma Longifolia Jack on Spermatogenesis in Estrogen-Treated Rats

INCREASE TESTOSTERONE LEVELS:
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials
Effect of Eurycoma longifolia standardised aqueous root extract–Physta® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicentre study
Effects of Eurycoma longifolia on Testosterone Level and Bone Structure in an Aged Orchidectomised Rat Model

INCREASE QUALITY OF LIFE AND REDUCE FATIGUE IN AGEING MALES:
Effect of Eurycoma longifolia standardised aqueous root extract–Physta® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicentre study

FEMALE HORMONAL EFFECT:
Effect of herbal extract Eurycoma longifolia (Physta®) on female reproductive hormones and bone biochemical markers: an ovariectomised rat model study

MENOPAUSE
Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled study

INCREASE IN STRENGTH AND MUSCLE MASS:
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology

PERFORMANCE ENHANCING:
Effects of Eurycoma Longifolia Jack Supplementation Combined with Resistance Training on Isokinetic Muscular Strength and Power, Anaerobic Power, and Urinary Testosterone: Epitestosterone Ratio in Young Males
Review Ergogenic Effect of Long Jack, Eurycoma Longifolia
ANTI-ANXIETY:
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects

NEPHROPROTECTIVE:
Nephroprotective Effect of Herbal Extract Eurycoma longifolia on Paracetamol-Induced Nephrotoxicity in Rats

OBESITY:
Selection of Thai Medicinal Plants with Anti-Obesogenic Potential via In Vitro Methods

ANTI-DIABETIC:
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
The Powdered Root of Eurycoma longifolia Jack Improves Beta-Cell Number and Pancreatic Islet Performance through PDX1 Induction and Shows Antihyperglycemic Activity in db/db Mice

OSTEOPOROSIS:
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
The Effects of Quassinoid-Rich Eurycoma longifolia Extract on Bone Turnover and Histomorphometry Indices in the Androgen-Deficient Osteoporosis Rat Model
Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model
Eurycoma longifolia: Medicinal Plant in the Prevention and Treatment of Male Osteoporosis due to Androgen Deficiency
An Evidence-Based Review: The Effects of Malaysian Traditional Herbs on Osteoporotic Rat Models
Role of Medicinal Plants and Natural Products on Osteoporotic Fracture Healing
Botanicals in Postmenopausal Osteoporosis

CANCER
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
The In Vitro Anti-Cancer Activities and Mechanisms of Action of 9-Methoxycanthin-6-one from Eurycoma longifolia in Selected Cancer Cell Lines
Quassinoids from the Roots of Eurycoma longifolia and Their Anti-Proliferation Activities
A Quassinoid Diterpenoid Eurycomanone from Eurycoma longifolia Jack Exerts Anti-Cancer Effect through Autophagy Inhibition
Quassinoids from the Root of Eurycoma longifolia and Their Antiproliferative Activity on Human Cancer Cell Lines
BREAST-6 compounds showed potent effect against Breast Cancer cell lines
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
COLORECTAL
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
DHOK Exerts Anti-Cancer Effect Through Autophagy Inhibition in Colorectal Cancer
LEUKEMIA
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
Anti-Tumor Activity of Eurycoma longifolia Root Extracts against K-562 Cell Line: In Vitro and In Vivo Study
LIVER:
Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53
LUNG ADENOCARCINOMA CELL LINES
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
MELANOMA
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
PROSTATE
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology
The In Vitro and In Vivo Anti-Cancer Activities of a Standardized Quassinoids Composition from Eurycoma longifolia on LNCaP Human Prostate Cancer Cells
Prostate cancer: Therapeutic prospect with herbal medicine