Er Zhi Wan 二至丸
Two Ultimate Pill
TCM
Analytic Collection of Medical Formules (Yi Fang Ji Jie)
Grind equal parts into powder and form into Honey Pills.
Some prefer to use a concentrated decoction of Eclipta Han Lian Cao and add the powdered Ligustrum with a bit of Honey to form pills.
It can also be used as a decoction using 9 grams of each herb.
Strengthens Liver and Kidneys
Lower back weakness and pain, Dizziness, blurred vision, premature greying, with a weak pulse and a red, dry tongue.
1. Premature ageing
2. Pain and weakness of the lower back and legs
2. Atrophy of the legs
3. Dizziness
4. Blurred vision
5. Spontaneous Seminal emission
6. Premature Graying of the Hair
7. Alopecia (see research below)
8. Chronic bleeding with Liver and Kidney deficiency
9. Osteoporosis (see research below)
10. Benign Prostatic Hypertrophy
6–9 grams of the powder with warm water.
If used as a decoction it is divided into 3 equal doses to be taken over the course of a day.
None noted
Liu Wei Di Huang Wan is similar in use. It is generally regarded as stronger, but Two Ultimate Pill is better for premature graying of hair, and cases with chronic bleeding.
GENERAL / REVIEW:
–A Comprehensive Study on the Chemical Constituents and Pharmacokinetics of Erzhi Formula and Jiawei Erzhi Formula Based on Targeted and Untargeted LC-MS Analysis.
ANTI-AGING:
–Integrated metabolomic and lipidomic analysis revealed the protective mechanisms of Erzhi Wan on senescent NRK cells through BRL cells.
–A novel strategy based on targeted cellular metabolomics for quantitatively evaluating anti-aging effect and screening effective extracts of Erzhi Wan.
STIMULATES MELANOGENESIS:
Integrative pharmacology reveals the mechanisms of Erzhi pills, A traditional Chinese formulation, stimulating melanogenesis.
ALOPECIA
–Promotion of Hair Regrowth in Androgenetic Alopecia with Supplemented Erzhi Wan: Exploring Its Mechanism Using Network Pharmacology and Molecular Docking.
RENOPROTECTIVE:
–Protective effects and mechanisms of the Erzhi formula on glucocorticoid induced primary cortical neuron injury.
–Erzhi Formula Extracts Reverse Renal Injury in Diabetic Nephropathy Rats by Protecting the Renal Podocytes.
DIABETIC NEPHROPATHY:
–Erzhi Formula Extracts Reverse Renal Injury in Diabetic Nephropathy Rats by Protecting the Renal Podocytes.
OSTEOPOROSIS:
–Anti-perimenopausal osteoporosis effects of Erzhi formula via regulation of bone resorption through osteoclast differentiation: A network pharmacology-integrated experimental study.
–Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats.
BENIGN PROSTATIC HYPERPLASIA:
–Combination of Ligustri Lucidi Fructus with Ecliptae Herba and their phytoestrogen or phytoandrogen like active pharmaceutical ingredients alleviate oestrogen/testosterone-induced benign prostatic hyperplasia through regulating steroid 5-α-reductase.
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Two Ultimate Pill
Tradition:
TCM
Source / Author:
Analytic Collection of Medical Formules (Yi Fang Ji Jie)
Herb NameNu Zhen Zi (Ligustrum)Han Lian Cao (Eclipta) |
|
Preparation:
Grind equal parts into powder and form into Honey Pills.
Some prefer to use a concentrated decoction of Eclipta Han Lian Cao and add the powdered Ligustrum with a bit of Honey to form pills.
It can also be used as a decoction using 9 grams of each herb.
Function:
Strengthens Liver and Kidneys
Use:
Lower back weakness and pain, Dizziness, blurred vision, premature greying, with a weak pulse and a red, dry tongue.
1. Premature ageing
2. Pain and weakness of the lower back and legs
2. Atrophy of the legs
3. Dizziness
4. Blurred vision
5. Spontaneous Seminal emission
6. Premature Graying of the Hair
7. Alopecia (see research below)
8. Chronic bleeding with Liver and Kidney deficiency
9. Osteoporosis (see research below)
10. Benign Prostatic Hypertrophy
Dose:
6–9 grams of the powder with warm water.
If used as a decoction it is divided into 3 equal doses to be taken over the course of a day.
Cautions:
None noted
Modifications:
Similar Formulas:
Liu Wei Di Huang Wan is similar in use. It is generally regarded as stronger, but Two Ultimate Pill is better for premature graying of hair, and cases with chronic bleeding.
GENERAL / REVIEW:
–A Comprehensive Study on the Chemical Constituents and Pharmacokinetics of Erzhi Formula and Jiawei Erzhi Formula Based on Targeted and Untargeted LC-MS Analysis.
ANTI-AGING:
–Integrated metabolomic and lipidomic analysis revealed the protective mechanisms of Erzhi Wan on senescent NRK cells through BRL cells.
–A novel strategy based on targeted cellular metabolomics for quantitatively evaluating anti-aging effect and screening effective extracts of Erzhi Wan.
STIMULATES MELANOGENESIS:
Integrative pharmacology reveals the mechanisms of Erzhi pills, A traditional Chinese formulation, stimulating melanogenesis.
ALOPECIA
–Promotion of Hair Regrowth in Androgenetic Alopecia with Supplemented Erzhi Wan: Exploring Its Mechanism Using Network Pharmacology and Molecular Docking.
RENOPROTECTIVE:
–Protective effects and mechanisms of the Erzhi formula on glucocorticoid induced primary cortical neuron injury.
–Erzhi Formula Extracts Reverse Renal Injury in Diabetic Nephropathy Rats by Protecting the Renal Podocytes.
DIABETIC NEPHROPATHY:
–Erzhi Formula Extracts Reverse Renal Injury in Diabetic Nephropathy Rats by Protecting the Renal Podocytes.
OSTEOPOROSIS:
–Anti-perimenopausal osteoporosis effects of Erzhi formula via regulation of bone resorption through osteoclast differentiation: A network pharmacology-integrated experimental study.
–Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats.
BENIGN PROSTATIC HYPERPLASIA:
–Combination of Ligustri Lucidi Fructus with Ecliptae Herba and their phytoestrogen or phytoandrogen like active pharmaceutical ingredients alleviate oestrogen/testosterone-induced benign prostatic hyperplasia through regulating steroid 5-α-reductase.
Back To PILLS
Back to FORMULAS
How to Modify a Formula
Substitutes
Weights & Measures