Er Xian Tang 二仙汤
Two Immortals Decoction
TCM
Prepare a standard decoction.
Also used as Pills or Powder.
Tonifies Yin and Yang, clears Deficient Heat, Nourishes Essence,
Flushing, sweating, irritability, insomnia with a Pale tongue, a thin coating and thready or faint and rapid pulse.
1. Menopausal Syndrome
2. Menopausal Hypertension
3. Infertility
4. Male Menopause
5. Chronic Glomerulonephritis
6. Psoriasis
7. Lupus erythematosis
8. Aplastic Anemia
The above decoction is divided into 3 equal doses to be taken over the course of a day.
Alternatively in Powder or Pills, 3–6 grams can be taken 2–3 times daily.
None noted
1. Menopausal Syndrome with markedly weak Kidneys, take with Zuo Gui Wan
2. Menopausal syndrome with Insomnia, add Zizyphus spinosa Suan Zao Ren, Polygala Yuan Zhi.
3. Hypertension during Menopause, add Eucommia Du Zhong, Achyranthes Niu Xi, Mistletoe (Sang Ji Sheng)
4. Hot Flushes, add Oyster shell (Mu Li)
5. Mensopausal Sweating, add Schisandra Wu Wei Zi.
6. Severe Hot Flushes, add Oyster shell (Mu Li), Picrorrhiza Hu Huang Lian
7. Menopausal syndrome with Depression, take with Xiao Yao San or Dan Zhi Xiao Yao San.
8. Infertility, add Atractylodes Bai Zhu, Dodder seed (Tu Si Zi), Cornus Shan Zhu Yu.
9. Fibrocytic Breast Disease, take with Xiao Yao San or Dan Zhi Xiao Yao San.
10. Also for Fibrocytic Breast Disease, add Ligusticum Nu Zhen Zi, Curcuma Yu Jin, Zedoary (E Zhu), Paeonia Mu Dan Pi
11. Psoriasis, take with Si Wu Tang
12. Also for Psoriasis, add Paeonia Mu Dan Pi, Paeonia Chi Shao Yao, Rehmannia Sheng Di Huang
This is a highly regarded formula for Menopausal Syndrome in TCM. Interestingly, it is a comparatively new formula, being introduced within the last century. This suggests the Menopausal syndrome as we know it today was less common in the past.
The dosage range given for each herb means that it can be tailored to suit the individual. If there is more Kidney deficiency, Curculigo Xian Mao and Epimedium Yin Yang Huo can be increased; if there is greater Blood deficiency, Dang Gui can be given in fuller doses; if there is less Heat symoptoms, Phellodendron Huang Bai and Anemarrhena Zhi Mu can be used in lower doses. If there is strong Heat symptoms, the latter 2 medicines can be given in larger doses.
GENERAL / REVIEW:
–Identification of the major chemical constituents and their metabolites in rat plasma and various organs after oral administration of effective Erxian Decoction (EXD) fraction by liquid chromatography-mass spectrometry.
MENOPAUSAL SYNDROME:
–Erxian decoction, a Chinese herbal formula, for menopausal syndrome: An updated systematic review.
–Effects of Guizhi and Erxian Decoction on menopausal hot flashes: insights from the gut microbiome and metabolic profiles.
–Kaempferol exerts antioxidant effects in age-related diminished ovarian reserve by regulating the HSP90/NRF2 pathway.
–Erxian Decoction-induced serum exosomes slowed bone marrow mesenchymal stem cell senescence through mitophagy.
–Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells
–Steroidogenic effect of Erxian decoction for relieving menopause via the p-Akt/PKB pathway in vitro and in vivo.
–Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms.
–A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome.
–Treatment of menopausal symptoms with Er-xian decoction: a systematic review.
MENOPAUSAL HYPERTENSION:
–Efficacy and safety of Chinese herbal medicine for patients with postmenopausal hypertension: A systematic review and meta-analysis.
MENOPAUSAL SWEATING:
–Ameliorating effect of Erxian decoction combined with Fructus Schisandrae chinensis (Wu Wei Zi) on menopausal sweating and serum hormone profiles in a rat model.
MENOPAUSAL DRY EYES:
–Erxian Decoction modulates Th17/Treg cells differentiation through LFA-1/ICAM-1/STAT3 pathway in menopausal dry eye disease.
ANTIANGIOGENIC:
–Anti-angiogenic activity of Erxian Decoction, a traditional Chinese herbal formula, in zebrafish.
CARDIOPROTECTIVE:
–The protective effect of Er-Xian decoction against myocardial injury in menopausal rat model.
PREMATURE OVARIAN FAILURE:
–Research Progress on the Effect of Traditional Chinese Medicine on Signal Pathway Related to Premature Ovarian Insufficiency.
–Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells
–Effect of Er-Xian decoction on autoimmune premature ovarian failure in mice.
–Systems Pharmacology Uncovers Multiple Mechanisms of Erxian Decoction () for Treatment of Premature Ovarian Failure.
POLYCYSTIC OVARIAN SYNDROME (PCOS):
–A network pharmacology approach to explore the mechanisms of Erxian decoction in polycystic ovary syndrome.
OLIGOSPERMIA:
–[Effect of Erxian Decoction on cyclophosphamide-induced oligospermia in mice].
NEUROGENESIS:
–[Preliminary study on cerebrospinal fluid proteomics of Erxian Decoction against neurogenesis impairment in late-onset depression].
LATE-ONSET DEPRESSION
–[Preliminary study on cerebrospinal fluid proteomics of Erxian Decoction against neurogenesis impairment in late-onset depression].
–Erxian Decoction, a Famous Chinese Medicine Formula, Ameliorate Depression- Like Behavior in Perimenopausal Mice.
–Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice.
OSTEOPOROSIS:
–Er-xian decoction drug-containing serum promotes Mc3t3-e1 cell proliferation and osteogenic differentiation via regulating BK channel.
–Er-Xian decoction attenuates ovariectomy-induced osteoporosis by modulating fatty acid metabolism and IGF1/PI3K/AKT signaling pathway.
–The Effects of Er Xian Decoction Combined with Baduanjin Exercise on Bone Mineral Density, Lower Limb Balance Function, and Mental Health in Women with Postmenopausal Osteoporosis: A Randomized Controlled Trial.
–Analysis of Molecular Mechanism of Erxian Decoction in Treating Osteoporosis Based on Formula Optimization Model.
OSTEOARTHRITIS:
–GCTOF-MS Combined LC-QTRAP-MS/MS Reveals Metabolic Difference Between Osteoarthritis and Osteoporotic Osteoarthritis and the Intervention Effect of Erxian Decoction.
SPINAL CORD INJURY:
–Erxian decoction inhibits apoptosis by activating Akt1 and repairs spinal cord injury in rats.
APLASTIC ANEMIA:
–Network pharmacology and experimental verification of the potential mechanism of Er-Xian decoction in aplastic anemia.
–[Clinical observation and experimental study of the treatment of aplastic anemia by warming and tonifying the spleen and kidney].
CANCER:
–An in vitro and in vivo investigation of the antimetastatic effects of a Chinese medicinal decoction, erxian decoction, on human ovarian cancer models.
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Two Immortals Decoction
Tradition:
TCM
Source / Author:
Herb NameXian Mao (Curculigo)Yin Yang Huo (Epimedium) Ba Ji Tian (Morinda) Dang Gui (Chinese Angelica) Huang Bai (Phellodendron) Zhi Mu (Anemarrhena) |
|
Preparation:
Prepare a standard decoction.
Also used as Pills or Powder.
Function:
Tonifies Yin and Yang, clears Deficient Heat, Nourishes Essence,
Use:
Flushing, sweating, irritability, insomnia with a Pale tongue, a thin coating and thready or faint and rapid pulse.
1. Menopausal Syndrome
2. Menopausal Hypertension
3. Infertility
4. Male Menopause
5. Chronic Glomerulonephritis
6. Psoriasis
7. Lupus erythematosis
8. Aplastic Anemia
Dose:
The above decoction is divided into 3 equal doses to be taken over the course of a day.
Alternatively in Powder or Pills, 3–6 grams can be taken 2–3 times daily.
Cautions:
None noted
Modifications:
1. Menopausal Syndrome with markedly weak Kidneys, take with Zuo Gui Wan
2. Menopausal syndrome with Insomnia, add Zizyphus spinosa Suan Zao Ren, Polygala Yuan Zhi.
3. Hypertension during Menopause, add Eucommia Du Zhong, Achyranthes Niu Xi, Mistletoe (Sang Ji Sheng)
4. Hot Flushes, add Oyster shell (Mu Li)
5. Mensopausal Sweating, add Schisandra Wu Wei Zi.
6. Severe Hot Flushes, add Oyster shell (Mu Li), Picrorrhiza Hu Huang Lian
7. Menopausal syndrome with Depression, take with Xiao Yao San or Dan Zhi Xiao Yao San.
8. Infertility, add Atractylodes Bai Zhu, Dodder seed (Tu Si Zi), Cornus Shan Zhu Yu.
9. Fibrocytic Breast Disease, take with Xiao Yao San or Dan Zhi Xiao Yao San.
10. Also for Fibrocytic Breast Disease, add Ligusticum Nu Zhen Zi, Curcuma Yu Jin, Zedoary (E Zhu), Paeonia Mu Dan Pi
11. Psoriasis, take with Si Wu Tang
12. Also for Psoriasis, add Paeonia Mu Dan Pi, Paeonia Chi Shao Yao, Rehmannia Sheng Di Huang
This is a highly regarded formula for Menopausal Syndrome in TCM. Interestingly, it is a comparatively new formula, being introduced within the last century. This suggests the Menopausal syndrome as we know it today was less common in the past.
The dosage range given for each herb means that it can be tailored to suit the individual. If there is more Kidney deficiency, Curculigo Xian Mao and Epimedium Yin Yang Huo can be increased; if there is greater Blood deficiency, Dang Gui can be given in fuller doses; if there is less Heat symoptoms, Phellodendron Huang Bai and Anemarrhena Zhi Mu can be used in lower doses. If there is strong Heat symptoms, the latter 2 medicines can be given in larger doses.
GENERAL / REVIEW:
–Identification of the major chemical constituents and their metabolites in rat plasma and various organs after oral administration of effective Erxian Decoction (EXD) fraction by liquid chromatography-mass spectrometry.
MENOPAUSAL SYNDROME:
–Erxian decoction, a Chinese herbal formula, for menopausal syndrome: An updated systematic review.
–Effects of Guizhi and Erxian Decoction on menopausal hot flashes: insights from the gut microbiome and metabolic profiles.
–Kaempferol exerts antioxidant effects in age-related diminished ovarian reserve by regulating the HSP90/NRF2 pathway.
–Erxian Decoction-induced serum exosomes slowed bone marrow mesenchymal stem cell senescence through mitophagy.
–Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells
–Steroidogenic effect of Erxian decoction for relieving menopause via the p-Akt/PKB pathway in vitro and in vivo.
–Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms.
–A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome.
–Treatment of menopausal symptoms with Er-xian decoction: a systematic review.
MENOPAUSAL HYPERTENSION:
–Efficacy and safety of Chinese herbal medicine for patients with postmenopausal hypertension: A systematic review and meta-analysis.
MENOPAUSAL SWEATING:
–Ameliorating effect of Erxian decoction combined with Fructus Schisandrae chinensis (Wu Wei Zi) on menopausal sweating and serum hormone profiles in a rat model.
MENOPAUSAL DRY EYES:
–Erxian Decoction modulates Th17/Treg cells differentiation through LFA-1/ICAM-1/STAT3 pathway in menopausal dry eye disease.
ANTIANGIOGENIC:
–Anti-angiogenic activity of Erxian Decoction, a traditional Chinese herbal formula, in zebrafish.
CARDIOPROTECTIVE:
–The protective effect of Er-Xian decoction against myocardial injury in menopausal rat model.
PREMATURE OVARIAN FAILURE:
–Research Progress on the Effect of Traditional Chinese Medicine on Signal Pathway Related to Premature Ovarian Insufficiency.
–Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells
–Effect of Er-Xian decoction on autoimmune premature ovarian failure in mice.
–Systems Pharmacology Uncovers Multiple Mechanisms of Erxian Decoction () for Treatment of Premature Ovarian Failure.
POLYCYSTIC OVARIAN SYNDROME (PCOS):
–A network pharmacology approach to explore the mechanisms of Erxian decoction in polycystic ovary syndrome.
OLIGOSPERMIA:
–[Effect of Erxian Decoction on cyclophosphamide-induced oligospermia in mice].
NEUROGENESIS:
–[Preliminary study on cerebrospinal fluid proteomics of Erxian Decoction against neurogenesis impairment in late-onset depression].
LATE-ONSET DEPRESSION
–[Preliminary study on cerebrospinal fluid proteomics of Erxian Decoction against neurogenesis impairment in late-onset depression].
–Erxian Decoction, a Famous Chinese Medicine Formula, Ameliorate Depression- Like Behavior in Perimenopausal Mice.
–Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice.
OSTEOPOROSIS:
–Er-xian decoction drug-containing serum promotes Mc3t3-e1 cell proliferation and osteogenic differentiation via regulating BK channel.
–Er-Xian decoction attenuates ovariectomy-induced osteoporosis by modulating fatty acid metabolism and IGF1/PI3K/AKT signaling pathway.
–The Effects of Er Xian Decoction Combined with Baduanjin Exercise on Bone Mineral Density, Lower Limb Balance Function, and Mental Health in Women with Postmenopausal Osteoporosis: A Randomized Controlled Trial.
–Analysis of Molecular Mechanism of Erxian Decoction in Treating Osteoporosis Based on Formula Optimization Model.
OSTEOARTHRITIS:
–GCTOF-MS Combined LC-QTRAP-MS/MS Reveals Metabolic Difference Between Osteoarthritis and Osteoporotic Osteoarthritis and the Intervention Effect of Erxian Decoction.
SPINAL CORD INJURY:
–Erxian decoction inhibits apoptosis by activating Akt1 and repairs spinal cord injury in rats.
APLASTIC ANEMIA:
–Network pharmacology and experimental verification of the potential mechanism of Er-Xian decoction in aplastic anemia.
–[Clinical observation and experimental study of the treatment of aplastic anemia by warming and tonifying the spleen and kidney].
CANCER:
–An in vitro and in vivo investigation of the antimetastatic effects of a Chinese medicinal decoction, erxian decoction, on human ovarian cancer models.
Back To DECOCTIONS
Back to FORMULAS
How to Modify a Formula
Substitutes
Weights & Measures