Er Miao San  二妙散
Two Marvel Powder

Tradition:


TCM

Source / Author:


Teachings of Dan-xi (Dan Xi Xin Fa)

Herb Name

Huang Bai (Phellodendron)
Cang Zhu (Dark Atractylodes)

Latin


Phellodendron chinense
Atractylodes lancea

Amount


6–12 grams
6–12 grams

Preparation:


When prepared as a Powder, equal parts are stir-fried, then ground into powder.
It may also be prepared a standard decoction with the amounts given above.

Function:


Clears Heat and Damp

Use:


Scanty, yellow urine with a greasy tongue coating
1. Urinary Tract Infections
2. Edema with Damp Heat
3. Vaginitis
4. Gout
5. Rheumatoid Arthritis
6. Gonococcal Arthritis
7. Weakness of the lower limbs
8. Red, swollen painful knees and joint
9. Leukorrhea that is Yellow, foul-smelling
10. Damp sores of the lower body
11. Eczema
12. Herpes of the Genitals
13. Gonorrhea
14. Fungal Infetions

Dose:


As a powder, 3–6 grams.
Prepared as a decoction, it is divided into 3 equal doses to be taken over the course of a day.

Cautions:


None noted

Modifications:


1. Leukorrhea, add Euryale Qian Shi, Poria Fu Ling
2. Sores of the Lower Body, add Gentiana Long Dan Cao, Job’s Tears (Yi Yi Ren)
3. Ecemza or Sores of the Lower Body, add Rhubarb
4. Eczema, take with Bei Xie Shen Shi Tang
5. Pain and swelling of the legs, add Job’s Tears (Yi Yi Ren), Achyranthes Niu Xi
6. Arthritis with Damp-Heat and Toxin, add China root (Tu Fu Ling), Job’s Tears (Yi Yi Ren)
7. Genital Herpes, take with Long Dan Xie Gan Tang

ANTI-INFLAMMATORY:
Elucidation of the anti-inflammatory mechanism of Er Miao San by integrative approach of network pharmacology and experimental verification
Er-Miao-San, a traditional herbal formula containing Rhizoma Atractylodis and Cortex Phellodendri inhibits inflammatory mediators in LPS-stimulated RAW264.7 macrophages through inhibition of NF-κB pathway and MAPKs activation.

ARTHRITIS:
Effect of Er Miao San on peritoneal macrophage polarisation through the miRNA-33/NLRP3 signalling pathway in a rat model of adjuvant arthritis.
Er Miao San, a traditional Chinese herbal formula, attenuates complete Freund’s adjuvant-induced arthritis in rats by regulating Th17/Treg cells.
The Protective Effect of Different Polar Solvent Extracts of Er Miao San on Rats with Adjuvant Arthritis.

RHEUMATOID ARTHRITIS:
Mechanism of Action of Ermiao San on Rheumatoid Arthritis Based on Bioinformatics and Molecular Dynamics
Wnt/β-catenin signaling pathway promotes abnormal activation of fibroblast-like synoviocytes and angiogenesis in rheumatoid arthritis and the intervention of Er Miao San.

HYPERURICEMIA / GOUT:
Potential molecular mechanisms of Ermiao san in the treatment of hyperuricemia and gout based on network pharmacology with molecular docking.
Chinese Herbal Formulas Si-Wu-Tang and Er-Miao-San Synergistically Ameliorated Hyperuricemia and Renal Impairment in Rats Induced by Adenine and Potassium Oxonate.
Study on the compatibility effect and active constituents of Atractylodis Rhizoma in Ermiao Wan against Acute Gouty Arthritis

ENDOMETRITIS:
Revealing active ingredients, potential targets, and action mechanism of Ermiao fang for treating endometritis based on network pharmacology strategy
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