Endometriosis
Endometriosis is a condition where Uterine tissue grows outside the Uterus, particularly on the ovaries or fallopian tubes and in the tissue lining the pelvis. In severe cases adhesions can occur on the intestines, bladder, vagina and abdominal surgery scars. It is believed to affect between 2–10% of woman of child-bearing age in the U.S. and is more common between the ages of 30–40. Around 50% of Infertile women have Endometriosis.Symptoms include pain during menstruation, heavy menstruation, pain during intercourse, painful urination or defecation during menstruation, Infertility, and may also include nausea, diarrhea or irregular bowels. There is not a direct relationship between severity of pain and severity of disease as some woman with advanced endometriosis have little or no pain, while some with mild disease have severe pain.
In Traditional Medicine it is generally classed with Dysmenorrhea, or painful Menstruation. It can also fall under other headings such as Heavy Menstrual Bleeding. Some TCM doctors believe that when Dysmenorrhea has not responded to regular treatment, Endometriosis should be suspected.
Traditional treatment revolves around moving Blood and Qi and regulating Menstruation. If there is Damp/Phlegm or excess Heat, these should be treated also. In addition, deficiency of Qi or Blood should be treated simultaneously.
Most used TCM formula and Herbs
In a study of Taiwanese Databases in the treatment of ‘s of Endometriosis patients over a 5 year period (2008–2013) it was found that the most commonly used formula were:
- Gui Zhi Fu Ling Wan (28%)
- Dan Zhi Xiao Yao San
- Dang Gui Shao Yao San.
- Cyperus rotundus Xiang Fu (18% of all formulas)
- Corydalis Yan Hu Suo (17%)
- Motherwort (Yi Mu Cao) (11%).
Acupuncture & Moxa
In a review of studies, the primary acupoints used for Endometriosis were: CV4 (30%), Sp6, CV6 and CV3, in descending order.. Needling with moxa (“warm needling”) was more effective (95%) than acupuncture alone (77%). Ginger Moxa on the above points along with ST36 and Zi Gong (Extra) had an effective rate of 95%. One study showed 100% effectiveness when Acupuncture and Chinese Herbal Medicine were combined.
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Western Tradition Simples
Formulas 1. Bdellium (Guggulu) with Agnus Castus, Dandelion root 2. Zedoary, Cyperus rotundus, Saffron 3. Bitter Almond, Myrrh, Zedoary, Rhubarb, Saffron Cold/Phlegm and Qi Stagnation Aromatic Hysteric Powder Compound Syrup of Vinegar Antimoron (Nicholas) Caragana 6 Decoction (Mdzo mo drug thang) Podophyllum 25 (‘Ol se nyer lnga) (Tibetan) Rolled Turquoise 13 (Gyu dril 13) (Tibetan) Blood Stasis Emmenagogue Syrup Troches of Myrrh (Rhasis) Powder of Gum Lacca Lesser (Dialacca Minor) (Rhasis) Troches Praised for Liver Hardness (Nicholas) Podophyllum 25 (‘Ol se nyer lnga) (Tibetan) Excess Heat (Bile) / Heat & Damp Pushyanuga Churna Phlegm and Blood Stasis Pills of Rhubarb (Greater) (Pil. de Raved Sceni) (Mesue) Caragana 6 Decoction (Mdzo mo drug thang) Podophyllum 25 (‘Ol se nyer lnga) (Tibetan) Rolled Turquoise 13 (Gyu dril 13) (Tibetan) |
Chinese Classification Simples
Formulas 1. Motherwort (Yi Mu Cao), Bitter Orange (Zhi Ke), Typha pollen (Pu Huang) 2. Ligusticum Chuan Xiong, Corydalis Yan Hu Suo, Myrrh (Mo Yao) 3. Zedoary (E Zhu), Cyperus rotundus (Xiang Fu), Paeonia Chi Shao Yao 4. Zedoary (E Zhu), Sparganum San Leng, Peach kernel (Tao Ren), Cyperus rotundus Xiang Fu, Paeonia Mu Dan Pi 5. Rhubarb (Da Huang) (9 grams), Cyperus rotundus (Xiang Fu) (6 grams), Leech (Shui Zhi) (3 grams), prepared as capsules. 6. Soft-Shelled Turtle Shell (Bie Jia) (30 grams), Vinegar-fried Rhubarb (15 grams), Amber (5 grams) Cold with Blood stasis Dang Gui Si Ni Tang Wen Jing Tang Heat and Damp Xiao Chai Hu Tang Blood Stasis Gui Zhi Fu Ling Wan Shao Fu Zhu Yu Tang Xue Fu Zhu Yu Tang Ge Xia Zhu Yu Tang Tao He Cheng Qi Tang Tao Hong Si Wu Tang Sheng Hua Tang Shi Xiao San Da Huang Mu Dan Tang Shen Tong Zhu Yu Tang Di Dang tang |
Special Formula
Dan’e Mixture
Zedoary
Salvia Dan Shen
This combionation was used in a clinical trial with an effective rate of 95%. (See research here)
Huangzhi Neiyi capsule
Rhubarb (Da Huang) 9 grams
Cyperus Xiang Fu 6 grams
Leech (Shui Zhi) 3 grams
This was formulated by a Professor of TCM for Endometriosis and has shown clinical efficacy. This has been compared to Gestrinone (a hormone commonly used in Endometriosis treatment) and found to be similarly effective. (see here)
Tong Jing Wan (Painful Menstruation Pills)
Peach kernel (Tao Ren)
Peony (Bai Shao)
Salvia Dan Shen
Typha Pu Huang
Lindera Wu Yao
Corydalis Yan Hu Suo
Dang Gui
Cyperus Xiang Fu
Ligusticum Chuan Xiong
Safflower (Hong Hua)
Panax notoginseng San Qi
Menstrual pain that is severe, sharp and stabbing in nature.
Dan’e-fukang soft extract
Salvia Dan Shen
Zedoary (E Zhu)
Sparganum Sang Leng
Bupleurum Chai Hu
Dang Gui
Licorice (Gan Cao)
Corydalis Yan Hu Suo
Paeonia Rubra Chi Shao Yao
Cyperus Xiang Fu
It was the first TCM drug to receive National Drug Approval for the treatment of endometriosis in China.
Evaluation of Efficacy and Safety of Dan’e-Fukang Soft Extract in the Treatment of Endometriosis: A Meta-Analysis of 39 Randomized Controlled Trials Enrolling 5442 Patients
E Leng Capsule
Zedoary (E Zhu) 2 parts
Sparganium Sang Leng 2 parts
Salvia Dan Shen 5 parts
Paeonia Chi Shao 1 part
Leech (Shui Zhi) 5 parts
Turtle shell (Bie Jia) 5 parts
Bitter Orange (Zhi Ke) 4 parts
Dang Gui 3.4 parts
This is prepared as capules, each capsules containing extract equivalent to 1.6 grams. It is a prescription of the Guangdong Hospital of TCM and has been used for Endometriosis for a number of years.
Exploration of the Modulatory Property Mechanism of ELeng Capsule in the Treatment of Endometriosis Using Transcriptomics Combined With Systems Network Pharmacology
Fu Liu Pill
Rhubarb (Da Huang) 90 grams
Peach kernel (Tao Ren) 90 grams
Dang Gui 80 grams
Salvia Dan Shen 80 grams
Notoginseng San Qi 60 grams
Sparganium Sang Leng 60 grams
Zedoary (E Zhu) 40 grams
The herbs are powdered and formed into Honey pills. Dose is 6 pills three times daily. A course of treatment is 60 days. Within 1–6 courses of treatment, approximately 30% were cured, 26% markedly improved with a total effective rate of 92%.
Xiao Liu Fang
fried Turtle shell (Bie Jia)
Deer Horn (Lu Rong)
Leech Shui Zhi
Wingless Cockroach (Tu Bie Chong)
Vaccaria Wang Bu Liu Xing
Zedoary (E Zhu)
steamed buns,
Salvia Dan Shen
China root (Tu Fu Ling)
Codonopsis Dang Shen
Ginger
Used for Endometriosis, Uterine Myone, Uterine Fibroids.
Research
1. Anti-Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms
2. Novel Drug Targets with Traditional Herbal Medicines for Overcoming Endometriosis
3. Toxic Animal-Based Medicinal Materials Can Be Effective in Treating Endometriosis: A Scoping Review
4. Modular Characteristics and Mechanism of Action of Herbs for Endometriosis Treatment in Chinese Medicine: A Data Mining and Network Pharmacology–Based Identification
5. An Overview on the Conservative Management of Endometriosis from a Naturopathic Perspective: Phytochemicals and Medicinal Plants
6. The Complementary and Alternative Medicine for Endometriosis: A Review of Utilization and Mechanism
7. Complementary and Alternative Medicine for Dysmenorrhea Caused by Endometriosis: A Review of Utilization and Mechanism
8. The Formidable yet Unresolved Interplay between Endometriosis and Obesity
9. Phytoestrogens for the Management of Endometriosis: Findings and Issues
10. Length of Menstrual Cycle and Risk of Endometriosis: A Meta-Analysis of 11 Case–Control Studies
11. Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis
FORMULAS
12. Identifying Chinese Herbal Medicine Network for Endometriosis: Implications from a Population-Based Database in Taiwan
13. Meta-Analysis of Chinese Traditional Medicine Bushen Huoxue Prescription for Endometriosis Treatment
14. The Traditional Chinese Medicine Prescription Pattern of Endometriosis Patients in Taiwan: A Population-Based Study
15. A Review on the Mechanism and Application of Keishibukuryogan (Gui Zhi Fu Ling Wan)
16. Traditional Chinese medicine prescription Guizhi Fuling Pills in the treatment of endometriosis
17. Comparative efficacy and safety of traditional Chinese patent medicine for endometriosis
18. [Clinical and experimental study on the treatment of endometriosis with dan’e mixture].
19. Effect of Taoren Quyu Decoction on human endometrial cells and its anti-endometriosis activity in rats.