Embelia, Vidanga

Vidanga, Viranga (Ayurveda)
Vayvidankam (Siddha)
Birang-e-Kabuli, Bao Birang (Unani)
Byi tang ga  བྱི་ཏང་ག  (Tibetan)
Xian Suan Qiang (TCM)
Picture
Picture Kirtikar & Basu, Indian medicinal plants, 1918

Picture Embelia ribes
(Photo by Dinesh Valke) (Wikimedia)

Picture Embelia fruit
(Calcutta Unani College, Adam, 2019)


Botanical name:


Embelia ribes, E. robusta

Parts used:


Dried Fruit; Seed; sometimes the root
Avicenna said there are 2 varieties:
  1. Small without holes (best)
  2. Larger with holes

Temperature & Taste:


Warm, dry. Bitter, pungent

Uses:


1. Kills Worms: (Seed; Ayurveda, Unani)
-Roundworm, Threadworm, especially Tapeworm
-“It expels Phlegm, Tapeworms and other worms from Intestines”. (Avicenna)

2. Warms the Stomach, Clears Damp, Benefits Qi: (TCM, Tibet, Ayurveda)
-Colic, Flatulence; prevents Constipation
-a few of the fruit added to children’s Milk to prevent Colic and Worms

3. Clears Wind-Phlegm and Damp:
-Traditionally as a purgative of Phlegm, Pituitous and Burnt Bile Humors
-Cough, Bronchitis, Wheezing
-Scrofula, swollen glands, Tumors from Melancholy and Phlegm
-Vitiligo and skin pigmentation problems; Leprosy
-Headache
-“It is useful in Rheumatism and Gout. It expels the Phlegm from the Joints’. (Avicenna)
-Wind-Damp obstructing the nerves: Hemiplegia, Paralysis, Facial Paralysis, Tremors, Nerve disorders (Unani)

4. Clears Damp, Promotes Urine:
-Edema, Ascites
-Dysuria, cloudy urine, Gravel, Stones
-high Uric acid
-Jaundice

5. Moves the Blood, Promotes Menstruation:
-Amenorrhea, Dysmenorrhea
-used as a Contraceptive
-Hemorrhoids (Tibet)

6. Rasayana:
-strengthens the Body; tonic to the 7 body constituents (Rasayana); regarded as preventing Old age. (Susruta)
-Diabetes related to Phlegm

7. Externally:
-applied to Ringworm and fungal infections
-in gargles and mouth washes for Sore Throat and Mouth Sores
-seed or root-bark is applied to Toothache
-used in nasal medications in India


Comment:


The Urine may become red with its use.

Dose:


Tincture has been generally accepted as the most effective preparation for expelling Worms:
Powder: 2–5 grams, up to 15 grams daily (traditionally taken with Milk in Ayurveda);
Tincture (1:3 in 25% alcohol): 3–15 mls daily (1 teaspoonful, 2–3 times daily)
For Worms: 3–12 grams with Milk, or a teaspoon of the powder can be given to children, a dessertspoon for adults.

Correctives:


1. Milk (Ayurveda)
2. Tragacanth (Unani)
3. Mastic (Unani)

Substitutes:


1. Lupin seed (Unani)
2. Equisetum sylvaticum, E. arvense (Tibetan Medicine–Buryat)
3. Myrsine africana

Main Combinations:


1. As a tonic, and to delay old age:
i. Embelia with Licorice root (Susruta)
ii. Embelia, Triphala, Withania
iii. strengthen the Stomach, clear Phlegm and promote longevity, the Five Myrobalans, Embelia and Lupin,
2. Worms 
i. Embelia powder taken with Honey on an empty stomach, then take Castor oil or Rhubarb to purge the dead worms.
ii. Embelia with Holarrhena, Garlic
III. Embelia with Veronia anthelmintica seed
iv. Embelia with Chebulic Myrobalan, Costus, Calamus, Aconitum heterophyllum (Tibetan)
v. with Indigestion, Embelia with Sulphur, Black and Long Pepper, Black Salt (as in Habb-e-Kibreet of Unani)
vi. Anacardium with Embelia ribes for Guinea Worm
vii. Myrrh with Fern, Embelia ribes, Turpeth, Lupin, Myrrh, Mallotus philippinensis (equal parts) (Dispensatory of Ibn at Timid)
viii. Embelia with Mica Bhasma, taken with Ghee.
3. Indigestion, Hepatitis, Embelia with Sal Ammoniac, Rock Salt, Black Salt, Chebulic and Black Myrobalans, Zedoary, Black Pepper, Ginger (as in Habb-e-Kabid Naushadari of Unani)
4. Hyperacidity, Embelia with Ginger, Black Pepper, Triphala, Cyperus rotundus, Lesser Cardamon, Clove, Cinnamon, Sugar. A teaspoonful of the powder is taken before meals with Lemon juice. (Ayurveda)
5. Skin diseases:
i. Embelia with Hemidesmus, Psoralea, Madder
6. Urinary disorders:
i. Embelia with Boehaavia, Tribulus
7. Diabetes from Phlegm:
i. Embelia, Turmeric, Barberry, Cassia tora
ii. Embelia, Barberry, Catechu, Sandalwood
8. Obesity:
i. Embelia, Ginger, Long Pepper, Emblic Myrobalan
II. Embelia, Cyperus rotundus, Plumbago (this is called Trimad and has proven efficacy)
iii. Embelia, Lesser Cardamon, Tinospora (Guduchi), Emblic and Belleric Myrobalan, Bdellium (Guggulu) (as in Amrutadi Guggulu)
9. Hemiplegia, Facial Paralysis, Tremors, Nerve disorders, Embelia with Calamus, Long Pepper, Ginger, Cumin, Caraway, Triphala, Bdellium (as in Majun Jograj Gugul, Electuary of Bdelliun of Unani)
10. As an oral contraceptive, equal parts of Borax, Long Pepper and Embelia ribes. (Ayurveda)

Major Formula:


Embelia 7 (Byi tang bdun pa) (Tibetan)
Nutmeg Powder (Jatiphaladi Churna) (Ayurveda)
Powder of China root (Chobchini Churna) (Ayurveda)
Rolled Turquoise 13 (Gyu dril 13) (Tibetan)
Toothache Powder 7 (So snum bdun pa) (Tibetan)
Mahasudarsana Churna
Amrutadi Guggulu

Cautions:


1. Generally not used long-term in full doses.
2. Not used during pregnancy
3. Avoid in excess Heat (Pitta-Bile) conditions.
4. Research has shown it to reduce testosterone levels and can reduce male fertility.
5. It has been banned in some countries including U.K.

Toxicity:


Visual deficits and retinotoxicity caused by the naturally occurring anthelmintics, Embelia ribes and Hagenia abyssinica.

Main Preparations used:




Click the Tabs above for more information on this Medicin
GENERAL / REVIEW:
Reviewing the Traditional/Modern Uses, Phytochemistry, Essential Oils/Extracts and Pharmacology of Embelia ribes Burm.
Synthesis and Biological Activity of Embelin and its Derivatives: An Overview.
Plant Derived Phytocompound, Embelin in CNS Disorders: A Systematic Review.
Embelin – a drug of antiquity: shifting the paradigm towards modern medicine.

ANTIBACTERIAL:
Antibacterial activity of embelin.
Screening of antibacterial potentials of some medicinal plants from Melghat forest in India.
Antimicrobial evaluation of some medicinal plants for their anti-enteric potential against multi-drug resistant Salmonella typhi.

ANTI-VIRAL:
HEPATITIS:
Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity.
INFLUENZA:
Antiviral activity of Embelia ribes Burm. f. against influenza virus in vitro.

ANTI-FUNGAL:
In vitro Evaluation of Antifungal Activity of the Seed Extract of Embelia Ribes.

ANALGESIC:
Non-narcotic orally effective, centrally acting analgesic from an Ayurvedic drug.
Toxicity studies with potassium embelate, a new analgesic compound.
Possible interaction of potassium embelate, a putative analgesic agent, with opiate receptors.

MALARIA:
Anti-plasmodial and Chloroquine Resistance Suppressive Effects of Embelin.

α-GLUCOSIDEASE INHIBITOR:
α-Glucosidase inhibitors from the leaves of Embelia ribes.
α-Glucosidase inhibitors from the stems of Embelia ribes.

ANTIPLATELET / ANTI-THROMBOTIC:
Embelin as a Novel Inhibitor of PKC in the Prevention of Platelet Activation and Thrombus Formation.

CARDIOPROTECTIVE:
Cardioprotective effect of aqueous extract of Embelia ribes Burm fruits against isoproterenol-induced myocardial infarction in albino rats.
Cardioprotective effect of embelin on isoproterenol-induced myocardial injury in rats: possible involvement of mitochondrial dysfunction and apoptosis.

HEPATOPROTECTIVE:
Effects of embelin on lipid peroxidation and free radical scavenging activity against liver damage in rats.

CHRONIC DISEASE:
Embelin and Its Role in Chronic Diseases.
Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases.

ASTHMA:
Embelin Alleviates Severe Airway Inflammation in OVA-LPS-Induced Rat Model of Allergic Asthma.

ANTI-ULCER:
Plants with potential anti-ulcerogenic activity and possible mechanism of actions based on their phyto-constitutional profile.

ULCERATIVE COLITIS:
Protective effect of embelin against acetic acid induced ulcerative colitis in rats.

DIABETES:
Antidiabetic activity of Embelia ribes, embelin and its derivatives: A systematic review and meta-analysis.
Beneficial effect of Embelia ribes ethanolic extract on blood pressure and glycosylated hemoglobin in streptozotocin-induced diabetes in rats.
Effect of ethanolic extract of Embelia ribes on dyslipidemia in diabetic rats.
Embelia ribes extract reduces high fat diet and low dose streptozotocin-induced diabetic nephrotoxicity in rats.
Further studies on antioxidant potential and protection of pancreatic beta-cells by Embelia ribes in experimental diabetes.
Hypoglycaemic activity of Embelia ribes berries (50% etoh) extract in alloxan induced diabetic rats.
Antihyperglycaemic activity of aqueous extract of Embelia ribes Burm in streptozotocin-induced diabetic rats.

RHEUMATOID ARTHRITIS:
Simulation-Based Research on Phytoconstituents of Embelia ribes Targeting Proteins with Pathophysiological Implications in Rheumatoid Arthritis.
NEUROPROTECTIVE:
Protective effect of aqueous extract of Embelia ribes Burm fruits in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.
Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats.
Evaluation of antioxidant and neuroprotective effect of ethanolic extract of Embelia ribes Burm in focal cerebral ischemia/reperfusion-induced oxidative stress in rats.

HUNTINGTON’S DISEASE:
Effect of embelin against 3-nitropropionic acid-induced Huntington’s disease in rats.

ANTI-CONVULSIVE:
Anticonvulsant activity of embelin isolated from Embelia ribes.

ALZHEIMER’S DISEASE:
Identification of embelin, a 3-undecyl-1,4-benzoquinone from Embelia ribes as a multitargeted anti-Alzheimer agent.
Anti-Alzheimer activity of isolated karanjin from Pongamia pinnata (L.) pierre and embelin from Embelia ribes Burm.f.
Design, Synthesis, and Pharmacological Evaluation of Embelin-Aryl/alkyl Amine Hybrids as Orally Bioavailable Blood-Brain Barrier Permeable Multitargeted Agents with Therapeutic Potential in Alzheimer’s Disease: Discovery of SB-1448.
Amelioration of Cognitive Deficit by Embelin in a Scopolamine-Induced Alzheimer’s Disease-Like Condition in a Rat Model.

ANTIPSYCHOTIC:
Antipsychotic activity of embelin isolated from Embelia ribes: A preliminary study.

CANCER:
Embelin: a benzoquinone possesses therapeutic potential for the treatment of human cancer.
Embelin: A multifaceted anticancer agent with translational potential in targeting tumor progression and metastasis.
Embelin (2,5-dihydroxy-3-undecyl-p-benzoquinone): a bioactive molecule isolated from Embelia ribes as an effective photodynamic therapeutic candidate against tumor in vivo.
Embelin (2,5-Dihydroxy-3-undecyl-p-benzoquinone) for photodynamic therapy: study of their cytotoxicity in cancer cells.
Embelin inhibits TNF-α converting enzyme and cancer cell metastasis: molecular dynamics and experimental evidence.
BRAIN:
Embelin induces apoptosis in human glioma cells through inactivating NF-κB.
BREAST:
Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells.
BLADDER:
XIAP inhibitor Embelin inhibits bladder cancer survival and invasion in vitro.
LEUKEMIA:
Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells.
OSTEOSARCOMA:
X-linked inhibitor of apoptosis protein inhibitor Embelin induces apoptosis via PI3K/Akt pathway and inhibits invasion in osteosarcoma cells.
PROSTATE:
Embelin-Induced Apoptosis of Human Prostate Cancer Cells Is Mediated through Modulation of Akt and β-Catenin Signaling.

CONTRACEPTIVE / ANTI-FERTILITY:
The quest for a herbal contraceptive.
Antifertility properties of Embelia ribes : (embelin).
Research on plants for fertility regulation in India.
Antifertility properties of Embelia ribes.
Antifertility effects of embelin in male rats.
Antifertility effects of Embelia ribes Burm.
Antispermatogenic effect of embelin, a plant benzoquinone, on male albino rats in vivo and in vitro.
[Biological evaluation of some medicinal plant extracts for contraceptive efficacy in females].
A study of an indigenous drug Maswin as an oral contraceptive.

ANTHELMINTIC:
Note on Embelia Ribes as a Remedy for Tape-Worm.
Note on the Use of Bábarang (Embelia Ribes) as an Efficient Remedy for Tapeworm.
The anthelmintic efficacy of five plant products against gastrointestinal trichostrongylids in artificially infected lambs.

WOUND HEALING:
Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm.