Cuscuta Herba, Dodder herb

Cassutha
Aftimoon (Unani)
Akash Bel (Hindi)
Tu Si Cao (TCM)
Picture Picture
Picture Picture
Herbarius latinus, Petri, 1485

Gart der Gesundheit, Cuba, 1485

Picture Left: Dodder, Cuscuta ; Right: Dodder of Thyme, Epithymum
Kreutterbuch, Matthiolus, 1586

Picture Left: Epithymum; Right: Cuscuta
Museum Museorum, Valentini, 1704

Picture Picture
E. europea
British Phaenogamous Botany
, Baxter, 1834

C. vulgaris
Flora von Deutschland
(16), Kohler, 1884
Picture Cuscuta europea
Icones Plantarum Medicinalium. 1788

Botanical name:


Cuscuta spp.
The Dodder of the West is supplied by C. europea, C. epithymum (syn. C. minor), C. vulgaris, C. reflexa
Greater and Lesser types, as well as White and Red types were recognised.
It is a parasitic herb on Hops, Nettle and Flax, among others. Schroder said the whole herb in flower was used, chiefly that from Flax. Unani regularly collects Dodder from plants including Zizyphus mauritiana, Acacia nilotica etc.
Two types were known in the West:
  1. Epithymum (best, collected from Thyme; best for the Spleen and Melancholy)
  2. Cuscuta (collected from Flax, Nettle, Hops and numerous other plants; better for the Liver)

Parts used:


Herb (most used in the Western tradition)
See also Dodder Seed

Temperature & Taste:


Warm, dry. Bitter, slightly Pungent
“It is slightly Hot in the beginning of the First degree and Dry in the last phase of the Third degree. It is, however, composed of constituents with contradictory potencies” (Avicenna)

Classifications:


2A APERIENT.    2B ATTENUATERS.    2F. PURIFYING.    2G. CLEANSING.    2H. CARMINATIVE.    2I. ANTISPASMODIC
3B. FEBRIFUGE & ANTIPYRETIC.    3E. DIURETIC.    3G. EMMENAGOGUE
4a. CEPHALIC.    4e. STOMACHIC.   4f. SPLENETIC.    4g. HEPATIC
Preparers and Purgers of Melancholy
Preparers and Purgers of Phlegm
Laxative, Purgatives and Cathartics

Uses:


1. Benefits the Spleen, Clears Melancholy:
-mainly used for the Spleen and Melancholy; Depression, Mania, Mental Illness, Schizophrenia
-opens obstructions of the Spleen, clears Black Jaundice, good for Scabs, Ulcers, Leprosy, hard Tumors from Melancholy.
-purifies the Blood, resolves Swellings
-important for Fibroids and Cancer
-Liver and Spleen obstructions and hardness
-regarded as Nutritive and tonic in Unani
-“Dodder is a purifier and it removes tenuously superfluous
matters from the vessels” (Avicenna)
-“When taken orally with vinegar, it relieves hiccough and removes hepatic and gastric obstructions” (Avicenna)


2. Benefits Brain and Nerves, Clears Wind and Damp:
-Epilepsy, Paralysis, Facial Paralysis, Hemiplegia, Numbness; Insensibility in Unani
-Myalgia, Arthritis, Rheumatism and Sciatica
-useful in diseases of the Brain and Nerves

3. Clears Damp, Promotes Urine:
-Strangury, Jaundice, Dysentery

4. Tonifies Yin and Yang, Secures the Essence:
-Impotence, Infertility, Oligospermia
-regarded as having anti-aging effects
-weakness, palpitations and sensitive digestion in the elderly
-‘It has also a strengthening property’. (Pemell, 1652)
-Diabetes

5. Stops Bleeding:
-Bleeding from the Bowels, Coughing and Spitting Blood, and Uterine Bleeding associated with Heat. (TCM)
-is used to promote menstruation

6. Clears Phlegm, Stops Cough:
-Asthma, Bronchitis (Ayurveda)

7. Kills Worms

8. Externally:
-distilled water clears the Sight if dropped into the Eyes. (Pemell, 1652)
-apply a paste of Dodder for Itchiness. (Unani)
-Baldness and Alopecia areata, grind the herb into a paste with water and apply twice daily to the Scalp for one month; or decoct the herb in Sesame oil and apply to the scalp twice daily. (Unani)
-Cataract, mix a little sugar in Dodder juice, filter, and drop into the eye.
-decoction is good to wash Wounds. (Unani)
-pains of the Sinews, Dodder (of Thyme) is applied as a liniment with vinegar
-fresh herb is beaten and applied to Scrofulous tumors. (Grieves)
-herb is fried in oil and made into a paste for chronic Ulcers (Unani)
-applied topically to Eczema (India).


Dose:


1. It shouldn’t be decocted for long, usually added in the last 10 minutes and steeped after removing from the heat.
2. To ‘dissolve Black Bile’, it is taken with sweet wine or Hydromel (Galen)
3. Given with salt for Liver disorders, respiratory diseases, and those with gas in the diaphragm (Galen)
4. Lower doses are used in Summer.
Decoction: 5–15 grams (added towards the end of decocting and then steeped after removing from the heat)
Powder: 1.5–5 grams

Preparation:


“The roasted dodder causes Constipation and stops Leucorrhea”. (Avicenna)

Correctives:


1. Dodder herb is corrected with Mastic, Licorice, or Raisins, or a decoction of Raisins, Violets or Borage (these mitigate its dryness).
2. Tragacanth or Almond oil also mitigate its dryness.
3. Mesue listed Whey, Hydromel, Indian Salt, Rock Salt, or Black Myrobalan to correct and enhance purgation of Melancholy.
4. Chicory and Lemon, or Chicory and Oxymel (Unani)
5. Because it works slowly, it is enhanced with Rock Salt, Ginger, or Black Hellebore

Substitutes:
1. The Barefoot Doctors Manual (Official Para-medical Manual of China) suggests that the herb and seed may be used interchangeably. Some western writers said the Seed could be used in place of the Herb.
2. Avicenna used Fumitory as a replacement for Dodder if the body was excessively Hot.
3. Dodder seed may be used if the body is excessively dry or in cases with Yin deficiency.
4. Wormwood, Turbith (Unani)
5. Stoechas, Polypody when used for Melancholy
6. For Black Bile, Turbith with one-third Thyme (Al-Biruni)
7. Wormwood and Thyme

Main Combinations:


Dodder & Wormwood

1. To Purge Melancholy humor:
i. Dodder with Black Myrobalan, Polypody, Turbith and Senna (as in Decoction of Dodder, Rhasis). This was one of the most commonly used medicine to purge the Melancholy Humor, and was used for Melancholy, Dementia, Fibroids, Cancer etc. Used in the long-term treatment of Cancer, it was said to lengthen life.
ii. Similarly used to the preceding is Syrup of Dodder of Mesue: Dodder, Yellow, Black, Emblic and Belleric Myrobalans, Polypody, Licorice, Agaric, Thyme, Fumitory, Aniseed, Sweet Prunes, Raisins, Tamarind.
2. Melancholy:
i. 7-14 grams of Dodder with Honey and Salt (Avicenna)
ii. Dodder with Senna, Aniseed, Licorice, Prunes (Pemell, 1652)
iii. Dodder with Balm, Rosemary, Borage, Bugloss, Yellow Myrobalan, Thyme, Senna, Polypody (Pemell, 1652)
iv. and Psychosis, Dodder with Agaric, Turpeth, Stoechas, Polypody (Pills of Dodder, Unani)
v. Dodder with Wormwood, Borage and Fumitory.
vi. Dodder with Balm, Rosemary, Borage, Yellow Myrobalan, Thyme, Senna, Polypody
vii. Dodder with Agaric, Polypody, Black Myrobalan, Aniseed
3. To purify the Blood:
i. Dodder with Fumitory and Chicory
ii. Dodder with Borage and Fumitory
4. To Purge Bile:
i. Dodder with Wormwood
ii. Dodder with Yellow Myrobalan, Rhubarb
5. Chlorosis, Dodder, Elecampane, Balm, Agrimony
6. Jaundice, Dodder with Agrimony, Hops
7. Arthritis of the Hip, Dodder seed with Sage (Pemell, 1652)
8. Children’s Fever, Dodder with Wormwood (Pemell, 1652)
9. Quartan Fever (Malarial Fever), Dodder with Lapis Lazuli (Pemell, 1652)
10. Alopecia, to promote Hair growth, Dodder with Eclipta alba

Major Formulas


Potion for Unulcerated Cancer
Decoction of Dodder of Thyme (Mesue)
Decoction of Dodder of Thyme (Rhasis)
Decoction of Thyme (Mesue)
Syrup of Dodder of Thyme (Mesue)
Syrup of Fumitory Compound (Augustana)
Tincture Against Schirrus of the Spleen
Powder Purging Melancholy (Fuchs)
Electuary of Dodder
Electuary of Dodder and Fumitory (Mesue)
Proven Electuary Against Vitiligo
Triphera of Dodder of Thyme (Mesue)
Triphala Electuary of Dodder (Unani)
Pills for Melancholy (Unani)

Cautions:


1. Use cautiously during Pregnancy.
2. Harmful for the Lungs in excess (Unani)
3. Avicenna said ‘It produces pain, vomiting and thirst in persons having excessive Bile’.

Toxicity:


Acute toxicity tests showed no mortality at up to 5000mg/kg of the extract given to rats.
Subacute Liver toxicity was noted at 200mg/kg and 500mg/kg in rats.

Main Preparations used:


Distilled Water of the whole Plant

  • More Info
  • History
  • Research
This is the Arabic form of the Greek word [?], “growing on thyme,” a name applied by Dioscorides to a plant growing in Cappidocia and Pamphylia, which was used for purging the body of pituitous humors and black bile, (iv. 172). His description of it is so unsatisfactory that it is doubtful whether he is speaking of the flowers of a kind of thyme, or of a parasitic plant growing on thyme. Pliny (26, 35), commences by speaking of Epithymon as the blossom of a sort of thyme similar to Savory, but ends by saying— “Some persons, again, give a different description of epithymon: according to them, it is a plant without a root, diminutive, and bearing a flower resembling a small hood, and of a red colour.” Epithymon is generally identified with Cuscuta Epithymum, Linn., the Lesser Dodder, a parasitic plant
upon Heath, Furze, Thyme and other small shrubby plants. (See Fl. Br. 283; Fl. Dan. t. 427.) The plant used medicinally in India as Aftimun is imported from Persia, and appears to be a larger species, probably C. europea, Linn., which is a native of Europe and of Western and Central Asia. Mahometan physicians consider this drug to be alterative and depurative, a purge for bile and black bile, useful in all affections of the brain such as fits, melancholy, insanity, &c. They also describe it as carminative; and apply it locally as an anodyne. The author of the Makhzan-el-Adwiya devotes a whole folio page of small print to a description of its properties and uses. In modern medicine the different species of Cuscuta are no longer used.” (Pharmacographia Indica, Dymock, 1891)
Last Updated 02/24

GENERAL / REVIEW:
A Review on Phytoconstituents and Biological activities of Cuscuta species
A Review on the Botanical, Phytochemical and Pharmacological Characteristics of Cuscuta Spp.
An updated review on the parasitic herb of Cuscuta reflexa Roxb.
Ethnopharmacology of Cuscuta epithymum: A comprehensive review on ethnobotany, phytochemistry, pharmacology and toxicity.
A SIMPLIFIED REVIEW ON AFTIMOON (CUSCUTA REFLEXA ROXB.), A PARASITIC VINE WITH SPECIAL REFERENCE TO UNANI MEDICINE
Evaluation of the in vivo and in vitro safety profile of Cuscuta epithymum ethanolic extract.
The genus Cuscuta (Convolvolaceac): An updated review on indigenous uses, phytochemistry, and pharmacology
Review on Pharmacological and Therapeutic Potential of Cuscuta species
Comparative in vitro biological activity analysis of Cuscuta reflexa Roxb. and C. campestris Yuncker.

ANTIBACTERIAL
Cuscuta reflexa and Carthamus Oxyacantha: potent sources of alternative and complimentary drug.
Exploration of nutraceutical potential of herbal oil formulated from parasitic plant.
Volatile analysis and antimicrobial screening of the parasitic plant Cuscuta reflexa Roxb. from Nepal.
Antibacterial activity of Cuscuta reflexa stem and Corchorus olitorius seed.
Mateen et al. Evaluation of antibacterial activity of Cuscuta reflexa and Abutilon indicum (Int j of Pharma and Bio Sci, 2011)

ANTI-VIRAL:
The purification and nature of an antiviral protein from Cuscuta reflexa plants.
Mahmood et al., Constituents of Cuscuta reflexa are anti-HIV agents. (Antivir Chem Chemother., 1997)

MALARIA:
Cuscuta reflexa Possess Potent Inhibitory Activity Against Human Malaria Parasite: An In Vitro and In Vivo Study.

ANTIOXIDANT:
Cuscuta reflexa and Carthamus Oxyacantha: potent sources of alternative and complimentary drug.

ANTI-PYRETIC:
Preliminary investigation on antipyretic activity of cuscuta reflexa in rats.

ANTI-INFLAMMATORY:
In vitro anti-inflammatory and anti-cancer activities of Cuscuta reflexa Roxb.

NEUROPROTECTIVE
Cuscuta epithymum Murr. crude extract pre-conditioning protects C6 cells from L-glutamate-induced neurotoxicity

RELAXANT / SEDATIVE
Evaluation of psychopharmacological effects of petroleum ether extract of Cuscuta reflexa Roxb. stem in mice.

ANTI-CONVULSIVE:
Studies on brain biogenic amines in methanolic extract of Cuscuta reflexa Roxb. and Corchorus olitorius Linn. seed treated mice.

ANTI-EPILEPTIC:
Borole, et al.; Evaluation of anti-epileptic activity of Cuscuta reflexa Roxb. (Res J of Pharma, Bio and Chem Sci, 2011)

POTENTIATES TRANQUILIZERS & SEDATIVES:
Evaluation of psychopharmacological effects of petroleum ether extract of Cuscuta reflexa Roxb. stem in mice.

ANALGESIC:
Evaluation of psychopharmacological effects of petroleum ether extract of Cuscuta reflexa Roxb. stem in mice.

SCHIZOPHRENIA
Effect of Cuscuta epithymum Acquainted with Risperidone on the Improvement of Clinical Symptoms and Cognitive Impairment in Patients with Schizophrenia: A Triple-Blind Randomized Placebo-Controlled Trial.

HEPATO-PROTECTIVE:
Balkrishnan et al, Effect of methanol extract of Cuscuta reflexa aerial parts on hepatotoxicity induced by antitubercular drugs in rats. (Int J of Applied Res in Nat Products; 2010)
Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats
Hepatoprotective effect of Cuscuta campestris ethanol extract on carbon tetrachloride-induced liver damage in mices

ANTI-ARTHRITIC
Appraisal of anti-arthritic and nephroprotective potential of Cuscuta reflexa.

NEPHRO-PROTECTIVE:
Appraisal of anti-arthritic and nephroprotective potential of Cuscuta reflexa.
ANTI-DIABETIC/HYPOGLYCEMIC
Antidiabetic effects of Cuscuta reflexa Roxb. in streptozotocin induced diabetic rats.
Cuscuta reflexa Roxb—A wonderful miracle plant in ethnomedicine
Hypoglycemic effect of methanol and chloroform extract of Cuscuta reflexa Roxb. in mice

ANTI-TUMOR:
Chatterjee et al. Evaluation of Antitumor Activity of Cuscuta Reflexa Roxb (Cuscutaceae) Against Ehrlich Ascites Carcinoma in Swiss Albino Mice. (Tropical Journal of Pharmaceutical Research August, 2011)

ANTI-CANCER
In vitro anti-inflammatory and anti-cancer activities of Cuscuta reflexa Roxb.
Cytotoxic components of Cuscuta
In vitro and in vivo antiproliferative potential of Cuscuta reflexa Roxb.
Cytotoxic effects of chloroform and hydroalcoholic extracts of aerial parts of Cuscuta chinensis and Cuscuta epithymum on Hela, HT29 and MDA-MB-468 tumor cells
Study of Anticancer Activity of Pratensein and Pratensein Glycoside Isolated from Cuscuta kotchiana
BREAST–The Cuscuta kotschyana effects on breast cancer cells line MCF7
Dichloromethane EXTRACT of Cuscuta epithymum inhibits triple-negative breast cancer development via inducing apoptosis and suppression of migration
Cytotoxic effects of hydroalcoholic extract of Cuscuta chinensis on PC3 and MCF7 cancer cell lines
The Effect of Hydroalcoholic Extract of Cuscuta Europaea on Breast Cancer Cells (Mcf7) in Comparison with Kidney Epithelial Cells (Vero cell line)
COLORECTAL–Natural products from Cuscuta reflexa Roxb. with antiproliferation activities in HCT116 colorectal cell lines.
Antitumor and hepatoprotective effect of Cuscuta reflexa Roxb. in a murine model of colon cancer
EHRLICH ASCITES–Evaluation of antitumor activity of Cuscuta reflexa Roxb (Cuscutaceae) against Ehrlich ascites carcinoma in Swiss albino mice
LEUKEMIA–Cuscuta campestris induces apoptosis by increasing reactive oxygen species generation in human leukemic cells
Cytotoxic effect of Cuscuta reflexa Roxb. and induction of apoptosis in human promyelocytic leukemia HL-60 cells
In vitro cytotoxic effects of Cuscuta chinensis whole extract on human acute lymphoblastic leukemia cell line
LIVER–Redounding of Cuscuta chinensis Lam. on BxPC-3, HepG2, and U2OS Human Cancer Cell Lines
LUNG–An RNA-seq transcriptome analysis for investigating the anti-lung cancer activity of medicinal Cuscuta chinensis Lam plant
Antioxidative and ROS-dependent apoptotic effects of Cuscuta reflexa Roxb. stem against human lung cancer: network pharmacology and in vitro experimental validation.
LYMPHOMA–Cytotoxic effects of Cuscuta extract on human cancer cell lines
Cytotoxic effects of cusuta extract on human cancer cell lines
MELANOMA–Cytotoxic effects of Cuscuta extract on human cancer cell lines
Evaluation of Chemoprotective and Anticarcinogenic Activity of Cuscuta reflexa
Cytotoxic effects of cusuta extract on human cancer cell lines
OSTEOSARCOMA–Redounding of Cuscuta chinensis Lam. on BxPC-3, HepG2, and U2OS Human Cancer Cell Lines
PANCREATIC–Redounding of Cuscuta chinensis Lam. on BxPC-3, HepG2, and U2OS Human Cancer Cell Lines
PROSTATE–Cytotoxic effects of hydroalcoholic extract of Cuscuta chinensis on PC3 and MCF7 cancer cell lines
Cytotoxic Cardiac Glycoside from the Parasitic Plant Cuscuta reflexa
RENAL–Cytotoxic Cardiac Glycoside from the Parasitic Plant Cuscuta reflexa

PREVENTS ALOPECIA CAUSED BY CHEMOTHERAPY:
A study on the extracts of Cuscuta reflexa Roxb. in treatment of cyclophosphamide induced alopecia.

ANTI-ANDROGENIC:
Evaluation of 5α-reductase inhibitory activity of certain herbs useful as antiandrogens.

ANTI-STEROIDOGENIC:
Anti-steroidogenic activity of methanolic extract of Cuscuta reflexa roxb. stem and Corchorus olitorius Linn. seed in mouse ovary.
Onset of puberty and ovarian steroidogenesis following administration of methanolic extract of Cuscuta reflexa Roxb. stem and Corchorus olitorius Linn. seed in mice.

ANDROGEN-INDUCED ALOPECIA:
A bibliometric study of scientific literature in Scopus on botanicals for treatment of androgenetic alopecia.
Effect of Cuscuta reflexa Roxb on androgen-induced alopecia.

ALOPECIA:
Development and evaluation of polyherbal formulation for hair growth-promoting activity.

INHIBITS ALPHA-GUCOSIDASE:
Alpha-glucosidase inhibitory constituents from Cuscuta reflexa.