Costus, Mu Xiang 木香

Mu Xiang (‘Wood Fragrance’) (TCM)
Kuth, Kushta (Ayurveda)
Koddam (Siddha)
Qust, Qust Shirin, Kuth (Unani)
Ru Rta  རུ་རྟ  (Tibetan)
Picture
Picture Sweet and Bitter varieties of Costus
(This is not Saussurea lappa)
Herbarium Blackwellianum, 1757

Picture Picture
Arabian Costus
A Complete History of Drugs, Pomet, London, 1748

Pseudocostus
Kreutterbuch, Matthiolus, 1586

Picture Saussurea costus
(Photo by Dinesh Valke) (Wikimedia)

Picture Herbarium, showing various Costus types, A. Bitter Costus;
B. Sweet Costus; C and D, Another Costus; E. Costus iridem;
F. Costus stem / root crown; G. Arabian Costus
(Kreutterbuch, Matthiolus, 1586)

Picture Aromaticum et Simplicium Aliquot, de Orta, 1579

Picture
Picture S. lappa from Yunnan (Yun Mu Xiang) (Adam, 2016)

Picture
Vladimiria souliei (Chuan Mu Xiang)
(Adam, 2016)
Costus root used in Tibetan Medicine (Zang Mu Xiang) (Adam, 2016)

Botanical name:


Saussurea lappa (syn. S. costus, Aucklandia lappa, Dolomiaea costus) (Official)
Sources for Costus (Mu Xiang) are varied and complex; alternate species used in TCM include:
  1. Inula helenium, I. racemosa (Tu Mu Xiang; used in India)
  2. Jurinea souliei (Chuan Mu Xiang; used in Sichuan, China)
  3. Dolomiaea soulei (syn. Vladimiria souliei), D. denticulata, D. berardioidea, D. platylepsis, D. edulis (Chuan Mu Xiang)
  4. Aristolchia debilis, A. contorta (Ching Mu Xiang); no longer used due to its toxicity.

Arabian, Bitter and Sweet varieties were traditionally known in the West, but only the Arabian (S. lappa) was commonly available in Europe, and was regarded as best. The Arabian was said to be heavy, ashen colored, hard to break, with a strong smell and aromatic taste and a little bitterness.
The varieties available in the West included:
  1. Arabian, White, Sweet, or Ancient Costus: Saussurea lappa (best)
  2. Indian, Black, or Bitter Costus: Inula racemosa (some sources say Orris)
  3. Syrian Costus: heavy, dark with an overpowering scent (lowest quality)
According to some sources, Sweet and Bitter Costus are both derived from the same plant (Saussurea lappa) with the Sweet being the younger root and the Bitter being derived from the mature root.
Some authorities (Dymock, Pharmacographia Indica, 1893; Khare, Indian Herbal Remedies) have stated Sweet Costus of the Arabs is Orris root (Iris germanica) which is also listed in Hamdard (Unani) publications.

Tibetan Medicine also recognises a ‘White’ (Vladimira) and ‘Black’ (Saussurea) type of Costus.

Parts used:


Root

Temperature & Taste:


Warm, dry. Pungent, Bitter, Aromatic.
“Hot in the third and dry in the second degree” (Avicenna)

Classifications:


2A APERIENT.    2B ATTENUATERS.    2C INCIDER.    2G. CLEANSING.    2H. CARMINATIVE.    2I. ANTISPASMODIC.    2Q. ANODYNE.    2S. STRENGTHENING.    2U. SUPPURATIVE
3C. ALEXIPHARMIC.   3D. CORDIALS & CARDIACS.    3E. DIURETIC.    3G. EMMENAGOGUE
4c. CARDIAC.    4e. STOMACHIC.   4g. HEPATIC.    4j. NERVINE.    4k. ARTHRITIC
TCM:
J. Regulate Qi

Uses:


1. Benefits Stomach and Intestines, Moves the Qi: (TCM, Ayurveda, Tibet, West)
-benefits the Stomach; poor appetite and digestion
-abdominal distention and epigastric pain (TCM, West, Tibet)
-colic, abdominal pain; Hernia
-Hiccups, Belching, Bloating
-Food Stagnation
-Diarrhea with Spleen deficiency or Cold and Damp
-with Tonic herbs to prevent their heavy, rich nature from causing stagnation

2. Moves Qi, Opens Obstructions: (TCM, Ayurveda, Tibet, West)
-pain over Liver and Gall Bladder; Tumors of the Liver
-Gall stones, Cholecystitis, Jaundice
-Chest, abdominal or Epigastric pain
-“Costus is useful for all the organs requiring warmth and absorbs humours from deep parts of the body.”. (Avicenna)

3. Clears Wind and Damp: (Ayurveda, Tibet, West, TCM)
-Rheumatism and Wind diseases including Paralysis
-Urticaria, skin eruptions, promotes Complexion (Ayurveda)
-promotes Urine, clears Edema
-“Relieves pain and Cold in the Urinary Bladder”. (Da Ming)

4. Resists Poison: (Ayurveda, Tibet, West, TCM)
-Malaria, Cholera, Leprosy, Diphtheria
-Scorpion Bites; bites of Viper (Dioscorides, Avicenna)
-used in Antidotes
-“disperses invasion of pathogenic factors, toxin and evil things”. (Shen Nong Ben Cao)

5. Moves Qi, Clears Phlegm, Stops Cough: (Ayurveda, Tibet, West, TCM)
-spasmodic Cough, bronchial Asthma, chronic Bronchitis (mostly in Ayurveda)
-Pneumonia (Tibet)
-Chest Pain from stagnation of Qi and Cold
-“disperses stagnant Qi in the Lung”. (Zhang Yuan Su)
-“purges excess in the Lungs”. (Ben Cao Gang Mu)

6. Regulates Qi, Strengthens Brain and Nerves: (Ayurveda, Tibet, West, TCM)
-Unani texts say it is tonic for Heart, Liver and Brain
-Some sources have regarded it as Tonic and Aphrodisiac in Ayurveda, Tibetan Medicine and TCM
-taken with Honey, it is Aphrodisiac (Dioscorides); Avicenna said taken in wine to vitalize sexual powers.
-Mental disorders associated with Wind or Qi stagnation (Ayurveda); psychosomatic, neurological disorders
-Hemiplegia, Paralysis (Ayurveda, West)
-promotes Intellect, rejuvenates
-said to turn grey hair black in both West and TCM (Porter Smith)
-“It relaxes the Nerves” (Avicenna)
-“strengthens will power … Long-term use prevents nightmares”. (Shen Nong Ben Cao)

7. Moves the Qi, Promotes Menstruation
-Amenorrhea; Menstrual Pain
-“provokes the courses, helps to cleanse the Womb from impurity, and helps Conception”. (Pemell, 1652)
-old TCM texts list it to prevent Miscarriage
-“Soothes the Fetus”. (Da Ming)
-“Useful in torn muscles”. (Avicenna)

8. Kills Worms:
-especially Broad-worms (Pemell, 1652)
Gu syndrome (due to Parasites and Worms) (TCM)

9. Externally:
-oil of Costus is good for Cold and Weak Muscles and Sinews, Sciatica, Arthritis
-compound Oil of Costus; strengthens Nerves, Muscles and Tendons; applied to the Spine in Fevers; also for Colic, Pains; prevents Grey hair
-“
often used to make bathing water by boiling the drug in water”.  (Tao Hong Jing)
-decoction makes a good hair wash to strengthen the hair
-Wounds, Ulcers, Ringworm, chronic Skin Diseases and Tumors (ointment or paste)
-powder is applied to dry moist Sores, Wounds and Ulcers (Avicenna, Pemell)
-headache, mixed with powder with oil and apply to the forehead (Unani)
-powder is applied to Toothache
-as a fumigant or incense during Infectious diseases to prevent infection
-powder with water and honey is applied as a paste to skin discolorations and blemishes, Freckles, Vitiligo, Leucoderma (Unani, Pemell)
-Uterine Pain, it is used in pessaries or douches (Avicenna)
-as a cosmetic; smeared on the skin with water or honey (Avicenna)
-repels moths and insects from clothes if kept with them


Dose:


1. Taken with Wine to move the Blood, ease pain and open Obstructions. (West, TCM)
2. Taken with Wine and Honey to cure Poison and Venom.
3. Taken with Honey, it is aphrodisiac (Dioscorides). Also with wine for this purpose.
4. The unprepared root is best to move Qi; the stir-fried root is best for Diarrhea and diseases of the Large Intestine.
Powder: 1–3 grams;
Decoction: 2–6 grams, up to 9 grams

Comment:


Some older writers considered Costus to have tonifying effects: “When the drug is assisted by tonifying drugs, it has the function of tonifying. When used together with a purgative as a principal drug, it becomes a purgative too.” (Wang Ji, from Ben Cao Gang Mu)

Corrective:


1. Aniseed
2. Rose Conserve

Substitutes:


1. The Costus we have from TCM and Ayurvedic sources can generally be used for Sweet and Bitter Costus.
2. Elecampane; Inula racemosa, I. royleana have also been used
3. Zedoary (Pharmacopoeia Augustana)
4. Angelica
5. Gentian
6. Carduus nutans (reportedly) .
7. “
Half quantity of Pellitory [Pyrethrum] acts as a substitute for Costus.” (Avicenna) .
8. roots of Mentha hortensis corymbifera, Agirocynera from Italy.

Preparation:


1. Stir-fried Costus Mu Xiang:
  The root is mixed with wheat flour and gently stir-fried or baked.
  This moderates it Qi moving effect and enhances its astringent effect of the Large Intestine. This was traditionally preferred when used for the Large intestine.
2. Wine-fried Costus Mu Xiang
  The root is sprinkled with rice wine or brandy, then gently stir-fried to dry.
  This is more suited to move the Blood, promote Menstruation, and for Arthritic and Rheumatic pain.

Adulterants:
Due to the high demand and increasing rarity of the wild plant, adulterants are not uncommon.
1. Saussurea hypoleuca, Aplotoxis auriculata (syn. S. auriculata) are commonly substituted.
2. Orris, Elecampane and others have also been substituted.

The official plant (S. lappa) is now grown commercially in Yunnan province, China. The Chinese supply is stable and cheap.

Main Combinations:


Costus and Elecampane/Inula spp.
  Costus has been regularly combined with Elecampane (and related Inula species). They are related herbs and support one another in action. Costus is more aromatic and better to move Qi. Elecampane is more strengthening and better to tonify Qi. Together, they strongly strengthen and regulate the Qi, especially of the Stomach and Intestines.
Costus and Greater Cardamon
  Costus is also commonly combined with Greater Cardamon (Amomum Sha Ren). While both are Warm, highly aromatic and Pungent, Costus is slightly Bitter and more appropriated to the Intestines and Liver, and stronger to open obstructions, Greater Cardamon is more approriated to the Stomach and Spleen, and is regarded as slightly strengthening. Together, they strongly regulate the Digestion, resolve Damp, and stop Diarrhea.

Abdomen / Digestion:
1. Poor appetite and Digestion, Costus with Chebulic Myrobalan, Ajowan, Ginger, Long Pepper, Calamus (Ayurveda)
2. Indigestion, Bloating, Rumbling, Diarrhea:
i. Costus with Cardamon, Fennel, Ginger (Ayurveda)
ii. Costus with Amomum Sha Ren and Tangerine peel (Chen Pi) (TCM)
iii. Costus with Amomum, Caraway, Clove (as in Amomum 4 (Ko la 4) of Tibetan Medicine)
3. Accumulation and Stagnation in the Center (Stomach and Spleen), Costus Mu Xiang with Betel nut (Bing Lang)
4. Stomach pain, Nausea, Hiccups, Costus, Indian Spikenard, Cassia, Rose, Saffron, Aloes. Opium was added in cases with strong pain. (Syrian ‘Book of Medicine‘, Budge, 1913)
5. Hiccup: Costus, Saffron, Rose, Mastic, Spikenard (½ oz. each), Asarum (2 drams), Aloes, Opium (1 dram each). Dose, 1 dram (Pemell, 1652)
6. Diarrhea with Blood and Mucus in the stool:
i. Costus with Madder, Picrorhiza, Swertia (Ayurveda)
ii. Costus with charred Rhubarb, Red Earth
7. Constipation and to promote peristalsis:
i. Costus with Cassia Fistula and Senna
ii. Costus with Triphala and Rhubarb

Chest / Lungs:
8. Sore Throat, Hoarseness, Cough, Chest pain Costus with Clove, Tabasheer, Licorice, White Gentian (Gentian algida), Chebulic Myrobalan (as in Clove 6 (Li shi drug pa) of Tibetan Medicine)
9. Cough, Asthma, Costus combines well with Cardamon (Unani)
10. Asthma:
i. Costus with Trikatu (Long and Black Peppers, Ginger)
ii. Costus with Long Pepper, Ephedra, Licorice (Ayurveda)
11. Chest Pain, Costus with Wormwood in wine (Dioscorides)
12. Pleurisy: Take Costus 1 dram in Dill infusion and a spoonful of Olive oil. (Syrian “Book of Medicine“, trans. by Wallis Budge, 1913)

Obstruction:
13. Organ Pain and obstructions of the Organs, combine Costus with Cinnamon, Asarum, Celery seed, Aniseed, Rhubarb, Saffron and Myrrh (as in Diacostum)
14. Liver obstruction, Liver heat, Hepatitis, Cholecystitis, Costus with Gentian, Greater Cardamon, Wormwood, Agrimony, Bitter Almond, Black Pepper, Aniseed (as in Decoction for the Liver of Nicholas)
15. Liver Hardness, Costus, Agrimony, Lupin, Fenugreek, Pepper (equal parts)
16. Bruising, Costus with Madder, Scabious, St Johns wort, Rhubarb (as in Powder Against Bruising)

Reproductive:
17. Uterine Cramps, Dysmenorrhea:
i. Costus with Cyperus rotundus, Pennyroyal
ii. Costus with Cyperus rotundus, Dang Gui, Ligusticum Chuan Xiong
iii. Costus with Asparagus Shatavari, Ammi, Turmeric, Rose
18. Hysteria, Costus with Calamus, Asafetida, Valerian (Ayurveda)
19. To improve Sperm quality, Costus with Withania, Shilajit (Ayurveda)

Wind / Joint Diseases
20. Brain tonic:
i. Costus with Calamus, Withania, Almond
ii. Costus with Centella, Withania
iii. Costus with Calamus and Gold Bhasma (Ayurveda)
21. Mental diseases, Costus with Calamus, Bacopa and Convolvulus Shankhapushpi made into a medicated Ghee. (Ayurveda)
22. Gout from Wind-Damp-Heat, Costus with Tinospora (Ayurveda)
23. Chronic Rheumatism:
i. Costus with Cardamon, Cinnamon, Clove
ii. Costus with Celery seed, Centaury, Frankincense
iii. Costus with Aconitum Fu Zi, Atractylodes Bai Zhu, Poria Fu Ling, Saposhnikovia Fang Feng

Other:
24. Yang weakness and general debility:
i. Costus Mu Xiang and Chebula (He Zi)
ii. Costus, Withania, Cinnamon, Clove
25. All types of venomous Bites including Snake Bite, Costus, Wormwood, Wine (Avicenna)

Externally:
26. As an oil externally, Costus with Elecampane, Marjoram, boiled in Sesame oil (as in Oil of Costus)
27. Powder of Costus is mixed with Mustard oil and applied to Prurigo (chronic severe itching)
28. Chronic Joint diseases, combine Costus with Rock Salt, Mustard oil, Vinegar, form a paste and apply topically. (Ayurveda)

Major Formulas


Electuary of Costus (Diacostum) (Mesue)
Electuary of Clove and Costus (Caryocostinum)
Troches of Gum Lacca (Trochisci de Lacca) (Unani)
Electuary of Gentian (Unani)
Confection of Rhubarb (Nichoals)
Antidotum Immortale
Antidote for the Liver and Chronic Cough
Oil of Costus

Agnimurkh Churna (Ayurveda)
Sarasvata Churna (Ayurveda)
Amomum 4 (Ko la 4) (Tibetan)
Blood Medicine 7 (Khrag sman bdun pa) (Tibetan)
Calamus 4 (Tibetan)
Calcite 6 Powder (Tibetan)
Clove 6 (Li shi drug pa) (Tibetan)
Costus 6 Powder (Ru rta drug pa) (Tibetan)
Costus 13 (Ru rta bcu gsum) (Tibetan)
Costus Garuda (Ru khyung) (Tibetan)
Greater Universal Women’s Disease Conqueror (Mo nad spyi ‘joms chen mo) (Tibetan)
Sea Buckthorn 5 (Star bu 5) (Tibetan)
Selinum 6 (Tang kug drug thang) (Tibetan)

Mu Xiang Liu Qi Yin (TCM)
Mu Xiang Shun Qi Wan (TCM)
Xiang Sha Liu Jun Zi Tang (TCM)
Zhen Ren Yang Zang Tang (TCM)

Cautions:


1. Drying, so not suitable in Yin deficiency
2. Very activating, so not used in Qi weakness (but can be combined with Qi tonics)

Main Preparations used:


Diacostum, Oil of Costus

Costus or Costum, Latin, [?] Grecor. Kost or Chast, Arab. These Names are given to several Roots which it is very difficult to distinguish. Dioscorides reckons three Species of Costus (viz.) the Arabian, Indian and the Syrian. The Arabian Costus, he says, is of a white Colour and light, with a very sweet Smell, and biting hot Taste; the Indian-is light, full, and black; and the Syrian heavy, of a Colour something like Box, and of a strong Scent affecting the Head.

Galen, on Antidotes, commends. the white Arabian Costus, and in his Book, concerning the Virtues of Simple Medicines, speaks of a certain Bitterness in Costus, though very gentle; but its Acrimony he says is so great as to produce Ulceration. 

Pliny tells us, that Costus is the Root of a certain Shrub, and that it has a burning hot Taste and excellent Smell. He makes two Kinds; the black and the white: of which he says the latter is preferable.

The ancient Arabians, as Serapio and Avicenna, in regard of the Distinction of this Drug into the sweet and bitter Costus, which at this Time prevails, are entirely silent; having taken whatever they have delivered concerning it from Dioscorides,
as if the Costus then made use of were the same with that of the ancient Greeks. Serapio, in particular, has nothing relating to it, but what he transcribed from that Author; though Avicenna indeed adds something of his own. He says, for Instance, that the Arabian Costus is white, but withal has a Tendency to a red or Citron-Colour; that the Indian is lighter than the Arabian, of a bitter Taſte, with a ſtrong Clove-like Smell, and a Colour inclining to black. The Syrian Coſtus of Dioscorides he calls Roman Costus, and says it has a Colour like Box, and a strong Smell.

The Greek and Latin Authors, who have Wrote any thing on the Materia Medica for five hundred Years past and upwards, mention two Kinds (viz.) Costus dulcis and Costus amarus, the sweet and the bitter Costus. Thus Actuarius and the modern Grecians distinguish the [?] and the [?] and Macer the Poet, de Speciebus exotcis, has the following Lines.

    Coſti sunt gemina Species; gravis una rubensque,
    Est et amara nimis: haec Indica dicitur esse.
    Altera vero levis, nec amara, colore sed albo


Whence it appears, that the Root which at present in the Shops is called Costus, and which alone has been used for some Ages as the true Sort, is not the same with the Costus of the Ancients.

But to make this more evident, we must take notice that Dioscorides speaks of no Bitterness belonging to Costus; and though Galen does, yet he tells us it is very gentle; and they both observe that it has an acrid, biting, hot or burning Taste. It is true Avicenna says, from Dioscorides, the Arabian Costus is white, but adds of himself, that it has a Tendency to redness, which was the Colour of what was then made use
of. He like wise says from Dioscorides, that the Indian

Costus is black; but afterwards adds that it is bitter. Macer, on the contrary, describes the Indian Costus as having a reddish Colour, and an extremely bitter Taste. Further, the Costus of the Ancients had a very strong fragrant Smell, even so as to prove offensive to the Head. They used it in aromatick Compounds and Perfumes; and they burnt it also Upon their Altars as Incense, Whence this Line of Propertlus:

   Costum molle date, et blandi mihi Thuris Honores

And Pliny likewise expresses himself thus: “These Roots are purchased on Account of their Smell, to mix with Unguents and Dainties, or, If I may be allowed to say so, for the Sake of Superstition; because, says he, we use Frankincense. and Costus in religious Worship.”  Now as this exquisite Fragrancy and strong Smell, taken Notice of by Dioscorides, Galen and Pliny, is not observable in the Costus of our Shops, l think we may reasonably conclude that it is entirely different from that of the Ancients.

Moreover, the Druggists are not agreed upon, the true Costus; since in their Shops we sometimes meet with three Sorts, under the Names of
the Arabian, bitter and sweet Costus; which Pomet, in his History of Drugs, describes thus: “The Arabian Costus, says he, is an oblong, heavy Root, of a gray or whitish Colour On the out side, and reddish within, hard to be broken, of a fragrant Smell, and aromatick bitterish Taste, The bitter Costus is thick, dense, hard, woody, light, and shining, and in Appearance rather like a Piece of Wood than the Fragment of a Root; And the sweet Costus is a small yellow Root, resembling pretty much, in its Colour, Form and Thickness, the Root of Turmerick.”

But these Descriptions are imperfect, or at least they agree not with the Costus which we now find in the Shops of Apothecaries: For this, which is almost universally received or substituted for the Arabian or true Costus, is a Root Cut into oblong Pieces, an Inch thick, light, porous, and hard, but of a friable Texture, a little resinous, of a whitish, or sometimes yellowish gray Colour, an acrid, aromatick, bitterish Taste, and fragrant Smell, something like the Smell of Florentine 0rris or Violets. 

According to Commelinus, and after him Dale in his Pharmacologia, it is the Root of a Plant called Tsiana Kua, Hort. Malaþ. and Ponvo Bramanun, which is the Costus Iridem redolens seu Indicus, C. B; Costus, Linn. Hort. Cliff. Pag. 2. Paco Caatinga Brasilensibus, Marcgr. Bras. p.48. Pison. Bras. p. 98. Anonyma, Mer. Surin. 36. T. 36. It grows in the Forests of Malabar, Brasile, and Surinam.

This Root has a Place amongst Cephalicks, Expectorants, and Uterines. It attenuates and divides the Humours, and provokes Urine and Perspiration. The Dose in Substance is ½ dram. and from 2 drams to ½ oz. in Infusion’. (A Treatise on Foreign Drugs, Geoffroy and Thicknesse, 1749)
1. PHARMACOLOGY / OVERVIEW:
Saussurea costus (Falc.) Lipsch.: a comprehensive review of its pharmacology, phytochemicals, ethnobotanical uses, and therapeutic potential.
[Study on chemical constituents from roots of Saussurea lappa].
Saussurea costus: botanical, chemical and pharmacological review of an ayurvedic medicinal plant.
Medico-historical review of drug Kustha.

2. ANTI-BACTERIAL:
Saussurea lappa inhibits the growth, acid production, adhesion, and water-insoluble glucan synthesis of Streptococcus mutans.
Investigation of antibacterial and antifungal activity of Saussurea costus root extracts.
Inhibitory Activity of Saussurea costus Extract against Bacteria, Candida, Herpes, and SARS-CoV-2.
Anti-Struvite, Antimicrobial, and Anti-Inflammatory Activities of Aqueous and Ethanolic Extracts of Saussurea costus (Falc) Lipsch Asteraceae.

3. ANTI-FUNGAL:
Acylated flavone glycosides from the roots of Saussurea lappa and their antifungal activity.
Antifungal activity of Saussurea lapp Clarke.
Investigation of antibacterial and antifungal activity of Saussurea costus root extracts.
Inhibitory Activity of Saussurea costus Extract against Bacteria, Candida, Herpes, and SARS-CoV-2.

4. ANTI-VIRAL:
Protective Potential of Saussurea costus (Falc.) Lipsch. Roots against Cyclophosphamide-Induced Pulmonary Injury in Rats and Its In Vitro Antiviral Effect.
Inhibitory Activity of Saussurea costus Extract against Bacteria, Candida, Herpes, and SARS-CoV-2.

5. COVID:
Investigation of the Antiviral Effects of Saussurea lappa Root Extract against SARS-CoV-2 Virus.

6. ANTI-OXIDANT:
Anti-oxidant Activity of Saussurea lappa C.B. Clarke Roots.

7. ANTI-INFLAMMATORY:
Inhibition of TNF-α-Induced Inflammation by Sesquiterpene Lactones from Saussurea lappa and Semi-Synthetic Analogues.
Evaluation of anti-inflammatory potential of the ethanolic extract of the Saussurea lappa root (costus) on adjuvant-induced monoarthritis in rats.
Alantolactone from Saussurea lappa Exerts Antiinflammatory Effects by Inhibiting Chemokine Production and STAT1 Phosphorylation in TNF-α and IFN-γ-induced in HaCaT cells.
Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice.
Evaluation of sesquiterpene lactone fraction of Saussurea lappa on transudative, exudative and proliferative phases of inflammation.
Preliminary evaluation of anti-inflammatory and anti-arthritic activity of S. lappa, A. speciosa and A. aspera.
In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa.
Sesquiterpenoids from the roots of Aucklandia costus and their anti-inflammatory activities.
Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases.
Anti-Struvite, Antimicrobial, and Anti-Inflammatory Activities of Aqueous and Ethanolic Extracts of Saussurea costus (Falc) Lipsch Asteraceae.

8. ANTI-ALLERGIC:
Dehydrocostus lactone, a sesquiterpene from Saussurea lappa Clarke, suppresses allergic airway inflammation by binding to dimerized translationally controlled tumor protein.
Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments.

9. LUNG DISEASE:
Protective Potential of Saussurea costus (Falc.) Lipsch. Roots against Cyclophosphamide-Induced Pulmonary Injury in Rats and Its In Vitro Antiviral Effect.

10. NEUROLEPTIC:
Effect of dehydrocostus lactone and costunolide from Saussurea root on the central nervous system in mice.

11. ANTISPASMODIC:
Presence of cholinergic and calcium antagonist constituents in Saussurea lappa explains its use in constipation and spasm.

12. ANTI-ARTHRITIC:
Preliminary evaluation of anti-inflammatory and anti-arthritic activity of S. lappa, A. speciosa and A. aspera.

13. IMMUNOSTIMULANT:
Effects of Saussurea lappa roots extract in ethanol on leukocyte phagocytic activity, lymphocyte proliferation and interferon-gamma (IFN-gamma).

14. CARDIOTONIC/CARDIOPROTECTIVE:
Cardiotonic activity of methanolic extract of Saussurea lappa Linn roots.
Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats.

15. THROMBOLYTIC:
In vitro thrombolytic activity of Dhamasa (Fagonia arabica Linn.), Kushta (Saussurea lappa Decne.), and Guduchi (Tinospora cordifolia Thunb.).
16. HEPATOPROTECTIVE:
Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysaccharide-induced hepatitis in mice.

17. HYPOTHYROIDISM:
Metabolomic insights into the therapeutic mechanisms of costus (Saussurea costus (Falc.) Lipsch.) root extract in propylthiouracil-induced hypothyroidism rat model.

18. ANTI-ULCER:
Evaluation of Aucklandia lappa Decne extracts as antiulcer activity in animals.

19. ANTI-CANCER:
Potential of Aucklandia Lappa Decne Ethanolic Extract to Trigger Apoptosis of Human T47D and Hela Cells
Bioassay-guided isolation of dehydrocostus lactone from Saussurea lappa: A new targeted cytosolic thioredoxin reductase anticancer agent.
A new sesquiterpene lactone from the roots of Saussurea lappa: structure-anticancer activity study.
HPLC-PDA Method for Quantification of Bioactive Compounds in Crude Extract and Fractions of Aucklandia costus Falc. and Cytotoxicity Studies against Cancer Cells.
BREAST CANCER:
Saussurea lappa extract suppresses TPA-induced cell invasion via inhibition of NF-κB-dependent MMP-9 expression in MCF-7 breast cancer cells.
Saussurea lappa Clarke-Derived Costunolide Prevents TNF α -Induced Breast Cancer Cell Migration and Invasion by Inhibiting NF- κ B Activity.
Modulation of mammary tumour progression using murine model by ethanol root extract of Saussurea costus (falc.) lipsch.
HPLC-ESI/MS-MS characterization of compounds in Dolomiaea costus extract and evaluation of cytotoxic and antiviral properties: molecular mechanisms underlying apoptosis-inducing effect on breast cancer.
Investigation of Molecular Mechanisms Involved in Sensitivity to the Anti-Cancer Activity of Costunolide in Breast Cancer Cells.
COLON CANCER:
Inhibition of Wnt/β-Catenin Pathway by Dehydrocostus Lactone and Costunolide in Colon Cancer Cells.
ESOPHAGEAL:
Dehydrocostus lactone inhibits the proliferation of esophageal cancer cells in vivo and in vitro through ROS-mediated apoptosis and autophagy.
GASTRIC CANCER:
Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells.
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
LEUKEMIA:
Dehydrocostus lactone enhances tumor necrosis factor-alpha-induced apoptosis of human leukemia HL-60 cells.
LIVER CANCER:
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.
Volatile oil from Saussurea lappa exerts antitumor efficacy by inhibiting epithelial growth factor receptor tyrosine kinase-mediated signaling pathway in hepatocellular carcinoma.
Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells.
Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells.
PROSTATE CANCER:
Anticancer effect of Saussurea lappa extract via dual control of apoptosis and autophagy in prostate cancer cells.
Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa.
ORAL CANCER:
Anticancer activity of Saussurea lappa extract by apoptotic pathway in KB human oral cancer cells.

20. CYTOTOXIC:
Cytotoxic sesquiterpene lactones from the root of Saussurea lappa.
Cytotoxic constituents of Saussurea lappa.

21. ANTI-ULCER:
In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases.

22. ORGAN PROTECTIVE EFFECT:
Saussurea lappa Ethanolic Extract Attenuates Triamcinolone Acetonide-Induced Pulmonary and Splenic Tissue Damage in Rats via Modulation of Oxidative Stress, Inflammation, and Apoptosis
Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats

23. PROTECTIVE EFFECT ON MALE REPRODUCTION:
Ameliorative effects of Saussurea lappa root aqueous extract against Ethephon-induced reproductive toxicity in male rats.

24. DERMATITIS:
Topical treatments of Saussurea costus root and Thuja orientalis L. synergistically alleviate atopic dermatitis-like skin lesions by inhibiting protease-activated receptor-2 and NF-κB signaling in HaCaT cells and Nc/Nga mice.