Corydalis, Yan Hu Suo 延胡索 Yan Hu Suo (TCM) Su mi  སུ་མི  (Tibet)

Corydalis yanhusuo

Corydalis glaucescens
Gartenflora [E. von Regel], vol. 27 (1878)

Corydalis decumbens
(Photo by KENPEI) (Wikimedia)

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Botanical name:

Corydalis yanhusuo (syn. C. ternata)
Others used in various parts of China include C. turtschaninovii (classical source), C. repens, C. ambigua var. amurensis, C. glaucescens

Parts used:

Root, prepared Root

Temperature & Taste:

Warm, dry. Pungent, Bitter.

Classifications:

K. Move the Blood

Uses:

1. Moves Qi and Blood, Eases Pain:
-Chest pain, Abdominal pain, Lower back pain
-Coronary Heart Disease, Angina Pectoris, Arrhythmia (proven effects)
-Amenorrhea, Dysmenorrhea
-Blood Stasis following Birth
-Pain and Swelling from Trauma
-one of the strongest herbs for pain associated with Blood stagnation
-in Tibetan Medicine, C. meifolia is used for Pain caused by Wind, and swelling of the limbs.

Dose:

Decoction: 3–9 grams
Powder: 1–3 grams

Comment:

1. This is a potent pain reliever, being one of the strongest non-narcotic analgesics.

Preparation:

… available in PRO version

Main Combinations:

1. Amenorrhea, Dysmenorrhea:
i. Corydalis Yan Hu Suo with … available in PRO version
ii. from Qi and Blood stagnation, Corydalis Yan Hu Suo with … available in PRO version
iii. from Blood stagnation Corydalis Yan Hu Suo with … available in PRO version
iv. from Blood stagnation Corydalis Yan Hu Suo with … available in PRO version
v. from Cold, Corydalis Yan Hu Suo with … available in PRO version
vi. Corydalis Yan Hu Suo  with … available in PRO version
2. Menstrual disorders, dysmenorrhea, metrorrhagia, Corydalis Yan Hu Suo with … available in PRO version
3. Chest Pain and Angina from Qi and Blood stangation:
i. Corydalis Yan Hu Suo with … available in PRO version
ii. Corydalis Yan Hu Suo with … available in PRO version
iii. Corydalis Yan Hu Suo with … available in PRO version
iv. from Heart diseases, Corydalis Yan Hu Suo with … available in PRO version
4. Irregular Heart Beat, Arrhythmia, Corydalis Yan Hu Suo with … available in PRO version
5. Headache associated with Blood Stagnation, Corydalis Yan Hu Suo with … available in PRO version
6. Pain from Trauma:
i. Corydalis Yan Hu Suo with … available in PRO version
ii. Corydalis Yan Hu Suo with … available in PRO version
7. Pain associated with Inflammation, Corydalis Yan Hu Suo with … available in PRO version
8. Lumbago, Corydalis Yan Hu Suo with … available in PRO version
9. Joint Pain:
i. Corydalis Yan Hu Suo with … available in PRO version
ii. Corydalis Yan Hu Suo with … available in PRO version
10. Abdominal pain:
i. Corydalis Yan Hu Suo with … available in PRO version
ii. Corydalis Yan Hu Suo with … available in PRO version
iii. from Qi and Blood stasis, Corydalis Yan Hu Suo with … available in PRO version
iv. Cold-type Abdominal pain, Corydalis Yan Hu Suo with … available in PRO version
v. Cold-type Abdominal pain, Corydalis Yan Hu Suo with … available in PRO version
vi. associated with internal Abscess, Corydalis Yan Hu Suo with … available in PRO version
11. Pain from excess Stomach acid：
i. Corydalis Yan Hu Suo with … available in PRO version
ii. Vinegar-fried Corydalis Yan Hu Suo, … available in PRO version
iii. Corydalis Yan Hu Suo with … available in PRO version
12. Abdominal Masses from Blood stagnation:
i. Corydalis Yan Hu Suo with … available in PRO version
ii. Corydalis Yan Hu Suo with … available in PRO version

Cautions:

1. Not used in Pregnancy.

Toxicity:

–Systematic review of published data on herb induced liver injury.

Main Preparations used:

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GENERAL / REVIEW –Advances in phytochemical and modern pharmacological research of Rhizoma Corydalis. PROCESSING –[Effects of different types and standard of processing vinegaron inherent constituents in rhizoma of Corydalis yanhusuo]. –Influence of vinegar and wine processing on the alkaloid content and composition of the traditional Chinese medicine Corydalis Rhizoma (Yanhusuo). –[Study on method of Corydalis yanhusuo producing and concocting integration processing]. –Processing and Compatibility of Corydalis yanhusuo: Phytochemistry, Pharmacology, Pharmacokinetics, and Safety. ANTI-INFLAMMATORY –13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity. ANALGESIC –The Analgesic Properties of Corydalis yanhusuo. –Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels. –A network-based analysis and experimental validation of traditional Chinese medicine Yuanhu Zhitong Formula in treating neuropathic pain. –Dopamine D1 and D2 receptors mediate analgesic and hypnotic effects of l-tetrahydropalmatine in a mouse neuropathic pain model. –Role of Dehydrocorybulbine in Neuropathic Pain After Spinal Cord Injury Mediated by P2X4 Receptor. –The Antinociceptive Properties of the Corydalis yanhusuo Extract. –Pain: novel analgesics from traditional Chinese medicines. –[Analgesic effect of Corydalis yanhusuo in a rat model of trigeminal neuropathic pain]. DYSMENORRHEA –Investigation on Chinese herbal medicine for primary dysmenorrhea: implication from a nationwide prescription database in Taiwan. DRUG ADDICTION –The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence. –Chinese Herbal Medicine for the Treatment of Drug Addiction. –[Study on acting mechanism of anti-morphine conditioned place preference between aqueous extract of Corydalis yanhusuo and L-THP and comparison of their effects]. ANTIPLATELET AGGREGATION –Simultaneous screening and analysis of antiplatelet aggregation active alkaloids from Rhizoma Corydalis. CARDIOVASCULAR –[Analysis of chemical constituents of anti-myocardial ischemia fraction of Corydalis yanhusuo]. –Beneficial effects of the extract from Corydalis yanhusuo in rats with heart failure following myocardial infarction. –Corydalis yanhusuo rhizoma extract reduces infarct size and improves heart function during myocardial ischemia/reperfusion by inhibiting apoptosis in rats.

CARDIOPROTECTIVE –Identification of Metabolites of the Cardioprotective Alkaloid Dehydrocorydaline in Rat Plasma and Bile by Liquid Chromatography Coupled with Triple Quadrupole Linear Ion Trap Mass Spectrometry. ATHEROSCLEROSIS –Antiatherosclerotic effect of dehydrocorydaline on ApoE-/- mice: inhibition of macrophage inflammation. NEUROPROTECTIVE –Structural characterization and neuroprotective effect of a polysaccharide from Corydalis yanhusuo. ANTIDEPRESSANT –Dehydrocorydaline induced antidepressant-like effect in a chronic unpredictable mild stress mouse model via inhibiting uptake-2 monoamine transporters. –A 1H-NMR-Based Metabonomic Study on the Anti-Depressive Effect of the Total Alkaloid of Corydalis Rhizoma. ANXIOLYTIC –Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT1A Receptor. –Evaluation of the anxiolytic properties of tetrahydropalmatine, a Corydalis yanhusuo compound, in the male Sprague-Dawley rat. ALZHEIMER’S DISEASE –Protopine promotes the proteasomal degradation of pathological tau in Alzheimer’s disease models via HDAC6 inhibition. SCHIZOPHRENIA –A Natural Product with High Affinity to Sigma and 5-HT7 Receptors as Novel Therapeutic Drug for Negative and Cognitive Symptoms of Schizophrenia. INHIBITS ANGIOGENESIS –Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling. CANCER –13-Methyl-palmatrubine induces apoptosis and cell cycle arrest in A549 cells in vitro and in vivo. BREAST –Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. –Corydalis yanhusuo W.T. Wang extract inhibits MCF-7 cell proliferation by inducing cell cycle G2/M arrest. –Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways. BONE CANCER PAIN –Simultaneous inhibition of NMDA and mGlu1/5 receptors by levo-corydalmine in rat spinal cord attenuates bone cancer pain. LIVER –AMPK-Mediated Metabolic Switching Is High Effective for Phytochemical Levo-Tetrahydropalmatine (l-THP) to Reduce Hepatocellular Carcinoma Tumor Growth. LUNG –13-Methyl-palmatrubine shows an anti-tumor role in non-small cell lung cancer via shifting M2 to M1 polarization of tumor macrophages.