Cissampelos, Patha

Velvet-Leaf Pareira
Patha (Ayurveda)
Patha (Unani)
Apatta (Siddha)
Ya Hu Nu (TCM)
Picture Cissampelos pareira
Medicinal Plants, Bentley and Triman, 1875

Picture Cissampelos pareira
Weinmann, J.W., Phytanthoza iconographia (1737-1745)

Botanical name:


Cissampelos pareira, C. pareira var. hirsuta
Cyclea peltata is used as a source of Patha in South India.

Parts used:


Root; or the whole herb or leaf

Temperature & Taste:


Cool, dry. Bitter, Sweet

Classification:




Uses:


1. Clears Heat, Resists Poison:
-Fevers; Fevers with rigor (Charaka)
-Burning Sensation
-regarded as Detoxifying, used for acute and chronic toxicity in Ayurvedic texts

2. Clears Heat and Damp, Promotes Urine:
-Burning urine, Chronic Cystitis (especially useful), Nephritis
-Spermatorrhea, Gonorrhea, Leukorrhea
-Jaundice
-Edema, Stones
-Diarrhea, Dysentery
-Arthritic and Rheumatic complaints with heat (internally and topically)

3. Moves the Blood, Promotes Menstruation:
-Dysmenorrhea, Menorrhagia
-Uterine diseases
-Prevents Miscarriage (must be used cautiously)
-has been used as a Contraceptive in rural India
-regarded as Aphrodisiac in classical texts.

4. Moves the Blood, Resolves Stasis:
-Trauma, Bruising (TCM)
-Wounds, Fractures (Ayurveda)
-also Heart disease (TCM)

5. Stimulates Digestion
-bitter tonic in Nausea, Poor appetite
-abdominal bloating and colic (Ayurveda); Irritable Bowel syndrome

6. Promotes Milk:
-promotes and enhances Breast Milk (Charaka)
-also regarded as cleansing or purifying Breast Milk.

7. Clears Phlegm, Stops Wheezing:
-Cough and Wheezing from Phlegm (Ayurveda)
-Asthma (TCM)

8. Kills Worms
-adjunct for Worms

9. Externally:
-Trauma and Bruising, mix the powder with alcohol or egg white and apply
-Traumatic Bleeding, apply the powder topically
-paste of the root is anti-inflammatory topically
-poultice of the leaf is applied to abscess, boils, burns, sores, pimples, scabies, itch
-root paste is applied to Scabies, Eczema and skin eruptions

-decoction used as a wash for Wounds and Ulcers
-One-sided Headache, use the root as a snuff on the affected side


Dose:


1. Whole herb or root are used in similar doses
2. Larger doses are aperient
Powder: 1–3 grams (up to 5 grams)
Decoction: 5–10 grams; or, 1 in 8 taken in 50–100mls. doses.
In Europe, 2–3 drams were boiled in 1.5 pints of water down to 1 pint, which is divided into 3 doses to be taken over the day. One–2 pints per day of the standard decoction were recommended in the treatment of Jaundice and Rheumatism.

Juice: 1 teaspoonful each morning for 3 days for Fever.
 

Substitute:


1. Stephania hernandifolia (syn. S. japonica) and S. glabra were classically regarded as varieties of Patha (Raj Patha). S. japonica is available from Chinese suppliers.
2. Cyclea arnotii, C. peltata is used as a source of Patha in South India.


Main Combinations:


1. Fever, Cissampelos with Vetiveria, Pavonia
2. Dengue Fever, Cissampelos, Neem, Hippophae
3. Burning Urine, the root paste is taken, or a decoction is taken, 4–6 cups per day.
4. Spermatorrhea, leaf juice is left to stand for 4–5 hours where it will thicken. It is given twice daily for 7 days.
5. To enhance Speech, Memory and Intelligence, Cissampelos with Chebula, Trikatu, Calamus, Moringa and Rock Salt, decocted in water, Goat Milk and Ghee to form an oily concentrate. (as in Sarasvata Ghirta of Ayurveda)
6. Hemiplegia, Facial Paralysis, Tremor, Cissampelos with Bdellium, Calamus, Celery seed, Cumin, Wrightia, Embelia, Plumbago, Trikatu (as in Majun Jograj Guggul of Unani)
7. Diarrhea:
i. Cissampelos with Trikatu, Picrorrhiza, Eclipta, Plumbago
ii. infective Diarrhea, Cissampelos, Andropgraphis, Cyperus rotundus, Fumitory, Ginger
iii. Diarrhea, Dysentery, Cissampleos with Long Pepper, Ginger, Holarrhena
8. Abdominal diseases, Spleen disorders, Abdominal masses, Cissampelos with Boerhaavia, Sida, Tinospora, Plumbago, Solanum surrattense (as in Punarnavady Arista)
9. Excessive Urination, Cissampelos with Aloeswood (Sushruta)
10. Burninhgs sensation, skin diseases from  Bile/Heat, Itching, Cissampelos, Picrorrhiza, Neem, Barberry, Fumitory, Gentian, Swertia, Cyperus rotundus, Long Pepper, Sandalwood, made into a paste with Ghee. (as in Tiktaka Ghirta)
11. Menstrual disorders, Cissampelos with Cyperus rotundus, Symplocos bark, Safflower
12. Menorrhagia, Cissampales, Red Earth, Red Sandalwood, Licorice
13. To promote easy Labor, a paste of Cissampelos with Sacred Basil, Adhatoda, Achyranthes, Holarrhena as a paste applied to the umbilicus. lower abdomen and vulva. (Ayurveda)
14. Internal Abscess, Cissampelos root with Honey, take with Rice water.
15. Toothache, gum swelling and pain, Cissampelos with Costus, Madder, Barberry bark, Cyperus, Picrorrhiza (Ayurveda)
16. Anal Fistula, Cissampelos with Plumbago, Turpeth, Calamus, Gloriosa, Nerium, Celastrus, Euphorbia neriifolia, boiled in Sesame oil (with water), and applied topically (as in Citrakadi Taila)

Major Formulas:


Pushyanuga Churna (Ayurevda)
Sarasvata Churna (Ayurveda)
Tiktaka Ghirta
Yogaraja Guggulu
Majun Jograj Guggul
Citrakadi Taila

Cautions:


None noted.
While it is not contraindicated during Pregnancy, it should be used cautiously, and in reduced dosage. It has reportedly been used for Threatened Miscarriage, but has also been used as a Contraceptive in rural India. Its use is probably best avoided in those wishing to become pregnant.

Main Preparations used:




GENERAL / REVIEW
Cissampelos pareira L.: A review of its traditional uses, phytochemistry, and pharmacology.
Phytochemical investigation and pharmacognostic standardization of Cissampelos pareira root

SUBSTITUTE
CYCLEA PELTATA DIELS – A POSSIBLE SUBSTITUTE FOR CISSAMPELOS PAREIRA LINN
Comparative antipyretic and analgesic activities of Cissampelos pareira Linn. and Cyclea peltata (Lam.) Hook. F. & Thomas

ANTIPYRETIC
Comparative antipyretic and analgesic activities of Cissampelos pareira Linn. and Cyclea peltata (Lam.) Hook. F. & Thomas

ANTI-VIRAL
Transcriptome analysis and connectivity mapping of Cissampelos pareira L. provides molecular links of ESR1 modulation to viral inhibition
Cissampelos pareira Linn: Natural Source of Potent Antiviral Activity against All Four Dengue Virus Serotypes

COVID
Anti-SARS-CoV-2 potential of Cissampelos pareira L. identified by connectivity map-based analysis and in vitro studies
Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus
Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

ANALGESIC
Comparative antipyretic and analgesic activities of Cissampelos pareira Linn. and Cyclea peltata (Lam.) Hook. F. & Thomas
ANTIOXIDANT
Antioxidant and Immunomodulatory Activity of the Alkaloidal Fraction of Cissampelos pareira Linn.

DIURETIC
Evaluation of Diuretic Activity of Alcoholic Extract of Roots of Cissampelos Pareira in Albino Rats

URINARY STONES
Evalution of Antiurolithic Activity of Alcoholic Extract of Roots of Cissampelos Pareira in Albino Rats

IMMUNOMODULATORY
Antioxidant and Immunomodulatory Activity of the Alkaloidal Fraction of Cissampelos pareira Linn.

ANXIETY
Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals

MEMORY DEFICIT / ALZHEMIER’S DISEASE
Effects of medicinal plants on Alzheimer’s disease and memory deficits
Natural Therapeutics in Aid of Treating Alzheimer’s Disease: A Green Gateway Toward Ending Quest for Treating Neurological Disorders

ANTI-FERTILITY
Antifertility Activity of T Methanolic Leaf Extract of Cissampelos Pareira in Female Albino Mice

CANCER
Anticancer activity of cissampelos pareira against dalton’s lymphoma ascites bearing mice
Cytotoxic Polyhydroxylated Oleanane Triterpenoids from Cissampelos pareira var. hirsuta
Cytotoxic polyhydroxylated pregnane glycosides from Cissampelos pareira var. hirsuta
In vitro cytotoxic activity of menispermaceae plants against HeLa cell line