Cinnamonum, Cinnamon, Cassia Lignea, Rou Gui 肉皮

Cinnamon:
–Gui Pi
  桂皮 (TCM)
Tvak (Ayurveda)
Ilavankap Padtai (Siddha)
Dar Chini (Unani)
Shing tsha  ཤིང་ཚ  (Tibetan)
Cassia Lignea:
Rou Gui 肉皮 (TCM)
Taj Qalmi (Unani)
Picture
Picture Picture
Cassia Lignea
Ortus Sanitatis, Meydenbach, 1491

Cinnamon
Ortus Sanitatis
, Meydenbach, 1491
Picture Picture Above: Cinnamon leaf and bark (left); Cassia bark (right)
Parkinson, Theatrum Botanicum, 1640
Left: Cinnamon, Medical Botany, Stephenson and Churchill, 1836

Picture Picture
Cinnamon
Koehler’s Medizinal Pflanzen, 1887

Cassia
Koehler’s Medizinal Pflanzen, 1887

Picture Bulk Cinnamon at Chengdu Medicine Market (Adam, 2016)

Picture Packaging of imported Cinnamon bark. The dried bark is bundled
into pacakages of half to 2 kg, then packed into bamboo boxes.
(A Manual of Organic Materia Medica and Pharmacognosy, Sayre, 1907)

Picture Chinese Cinnamon bark (Adam, 2016)

Botanical name:


There are several main Cinnamonum species:
  1. Ceylon or “True” Cinnamon–Cinnamonum zeylanicum (syn. C. verum)
  2. Cassia Lingea, Chinese Cinnamon, Chinese Cassia, Rou Gui–C. cassia
  3. Indonesian Cinnamon–Cinnamomum burmannii
  4. Vietnamese or Saigon Cinnamon–Cinnamomum loureiroi (regarded as best)

Parts used:


Bark
In TCM, if the peel is removed from the inside and outside of the bark, it is called Gui Xin, “Heart of Cassia”
See also Cinnamon leaf (Indian leaf) and Cinnamon twig

Temperature & Taste:


Hot, dry. Pungent
“Hot and Dry in the Third degree”. (Avicenna)

Classifications:


2A APERIENT.    2B ATTENUATER.    2F. PURIFYING.    2H. CARMINATIVE.    2P. HEMOSTATIC
3C. ALEXIPHARMIC.    3D. CORDIALS & CARDIACS.    3G. EMMENAGOGUE.    3L. ANTI-TUSSIVE
4a. CEPHALIC.    4c. CARDIAC.    4e. STOMACHIC.    4f. SPLENETIC.    4g. HEPATIC.    4h. NEPHRITIC.    4i. UTERINE.    4j. NERVINE
TCM:
M. Warm to Expel Cold

Uses:


1. Warms the Stomach, Clears Cold:
-good in all cold diseases of the Head, Stomach and Womb
-benefits Digestion, helps Digestion, increases Appetite, abdominal pain or distention, abdominal masses
-chronic Diarrhea
-special function of helping distribute nutrition (West)
-“
tonifies a condition of general debility”. (TCM: Ming Yi Bie Lu)
-“
To stop lower abdominal pain in autumn and winter, Rougui is the only choice”. (TCM: Zhang Yuan Su)
-“Its dissolving properties facilitate the Purgative Drugs to elicit their affects”. (Avicenna)

2. Warms the Kidneys, Benefits Yang:
-Edema, Fluid Retention, Cold-type Back Pain
-Leukorrhea, Spermatorrhea
-Chronic Diabetes
-Impotence, Frigidity
-Cold extremities
useful in Cold Kidney and Bladder pain. (Avicenna)
-“Dissolves Hard and Cold Visceral Swellings”. (Avicenna)
-Cold-Damp joint pain, Arthritis; “
good for treating arthralgia due to invading pathogenic Cold”. (Li Shi Zhen)
-lowers the Yang back to its source in the lower abdomen (Dan Tian) (TCM)
-Regarded as Tonic to the 7 Body Tissues (Rasayana)
-“Long-term use prevents aging and enables one to enjoy a long life”. (TCM: Ming Yi Bie Lu)

3. Warms the Uterus, Promotes Menstruation and Birth:
-promotes Menstruation when obstructed by Cold
-Promotes Birth (1 dram taken with wine)
-expels Afterbirth
-very useful for Menopause
-“
Some physicians opine that the Cassia bark helps to expel the Fetus”. (Avicenna)

4. Warms the Uterus, Stops Bleeding:
-Uterine Bleeding, excessive Menstruation associated with Cold

-Postpartum Hemorrhage
-diseases of Pregnancy: Edema, Hypertension, Lumbago, Bleeding during pregnancy, Threatened Miscarriage
-other types of passive bleeding: Hemoptysis etc.

5. Warms the Heart, Cheers the Spirit, benefits Circulation:
-Cold chest pain, poor circulation
-Dizziness, Vertigo, Hypertension
-refreshes Spirits, good in weakness
-regarded as Exhilarant (Avicenna)
-also for Dim and Dark vision (Avicenna)


6. Clears Wind-Cold, Resists Poison:
-Influenza, Plague, Cholera
-used for Fevers
-“Cassia bark is taken orally in case of Snake Poisoning”. (Avicenna)

7. Warms the Lungs, stops Wheezing:
-Asthma, Bronchitis, difficulty Breathing, Consumption
-“It is useful in Chest affections”. (Avicenna)

8. Externally:
-oil is applied to Warts
-with Honey to remove Birthmarks and Freckles (Dioscorides)
-“Cassia bark is painted with honey on Acne”. (Avicenna)
-Headache, Rheumatic or Muscle pains are treated by applying a paste of the powder mixed with warm water
-applied to Insect and Scorpion bites (Avicenna)


Dose:


Decoction: 1 ½–5 grams
Powder: 250mg–2 grams

Comment:


Cinnamon twig (Gui Zhi) is regarded as thin and light whereas Cinnamon (or Cassia) bark is thick and heavier. Cinnamon twig therefore moves up and clears (Wind-Cold-Damp from) the Exterior, while Cinnamon (or Cassia) moves inwards and downwards, and warms and strengthens the Kidneys.

Correctives:


1. Tragacanth
2. Valerian

Substitutes:


1. Cassia can be substituted for Cinnamon and vice versa.
2. Indian leaf (Cinnamonum tamala leaf)
3. Double the amount of Cubeb or Juniper berry (Avicenna)

Main Combinations:


Cinnamon & Licorice
Cinnamon, Clove & Nutmeg
Cinnamon, Greater Cardamon, Cinnamon leaf (or Clove) (Trijata, the ‘Three Aromatics’ of Ayurveda)

Stomach, Digestion:
1. To warm the Stomach and Digestion:
i. Cinnamon with Ginger, Cardamon (as in Pulvis Aromaticus); this combination has also been used in Ayurveda.
ii. Cinnamon, Greater Cardamon, Indian leaf (Trijata, the ‘Three Aromatics’ of Ayurveda)
iii. Cinnamon with Citron peel, Mastic, Sugar of Rose (as in Powder to Strengthen the Stomach)
iv. Cinnamon with Ginger, Clove, Galangal, Nutmeg
2. To strengthen the Stomach and Spleen:
i. Cinnamon with Elecampane and Cumin (as in Powder of Cinnamon Compound of Mesue)
ii. Cinnamon with Rose, Sandalwood, Licorice (as in Aromaticum Rosatum)
iii. Cassia Lignea, Fennel seed, Mastic (The Secrets of Alexis, 1615)
3. To increase Appetite:
i. Cinnamon with Ginger, Bitter Orange peel
ii. Cinnamon with Fennel seed, Parsley seed and Clove
4. Nausea, Vomiting:
i. Cinnamon powder taken with an infusion of fresh Ginger root
ii. Cinnamon Water with Syrup of Lemon (A Treatise on Foreign Drugs, Geoffroy and Thicknesse, 1749)
5. To increase strength:
i. Cinnamon with Balm, Blessed Thistle (A Treatise on Foreign Drugs, Geoffroy and Thicknesse, 1749)
ii. Cinnamon with Elecampane, Licorice
iii. Cinnamon with confected Chebulic Myrobalan, confected Ginger
iv. Cinnamon, Date, Almond, Mastic
v. Cinnamon with Astragalus Huang Qi and Atractylodes Bai Zhu

Urinary, Kidneys
6. To Warm the Kidneys:
i. and as an Aphrodisiac, Cinnamon with Cardamon, Long Pepper, Licorice, Dates, Raisins and Honey (as in Eladi Pills, Ayurveda)
ii. for Back pain, Leukorrhea, Kidney weakness, Cinnamon with Nutmeg, Elecampane, Tormentil, Clove (as in Powder of Nutmeg)
iii. Cinnamon with Walnut, Juniper
7. Edema
i. Kidney cold, Cinnamon with Parsley seed, Juniper berry
ii. from Cold, Cinnamon with Squill
iii. Cinnamon with Asarum, Mastic, Wormwood, Aniseed, Fennel, Rhubarb, Indian Spikenard (as in Antidote for Edema of Nicholas)
8. Infertility, Cinnamon with Ram Testicles, Hare Uterus, Mace, Clove, Ginger, Saffron, Walnut (as in Decoction for Sterility)
9. Arthritis, Cinnamon with Currant, Guaiacum, China root, Licorice, Calamus, Barley (as in Decoction for Arthritis)

Gynecology, Obstetrics
10. Promote Menstruation:
i. Cinnamon and Myrrh (Dioscorides)
ii. Cinnamon with Iron
iii. Cinnamon with Saffron, Iron
iv. Cinnamon with Bay berry, Rosemary, Juniper berry, Saffron (as in Decoction Against Retention of Menstruation)
11. Menstrual Pain, Dysmenorrhea:
i. from Cold, Cinnamon with Fennel seed, Pennyroyal
ii. from Cold, Cinnamon with Fennel seed, Ginger (this has been studied: see below)
iii. from Blood stagnation, Cinnamon with Saffron, Myrrh
iv. Uterine congestion, Cinnamon, Turmeric, Ginger, Saraca
12. Leukorrhea, with Agnus Castus, Rue, Fennel
13. To prepare for Birth, take Cinnamon with Licorice for 2 weeks before the due date. (Culpeper’s Directory for Midwives)
14. To promote Labor:
i. Cinnamon with Saffron and Amber (as in Birth Powder)
ii. Cinnamon with Pennyroyal, Mugwort, Cassia Fistula, Saffron, Myrrh (as in Powder to Facilitate Birth)
15. Postpartum Pain:
i. Cassia wood, Cinnamon with Maidenhair, Aniseed, Raisins (as in Powder Against Postpartum Pain)
ii. Cinnamon with Amber, Peach kernel, Comfrey root

Other:
16. Lung congestion from Cold Phlegm, with Long Pepper, Adhatoda vasica, Tabasheer (Ayurveda)
17. To preserve from Poison and Infection:
i. Cinnamon with Blessed Thistle
ii. Cinnamon with Saffron, Myrrh, Costus, Spikenard
18. To strengthen the Heart and Circulation:
i. Cinnamon with Licorice; used for sweating, rapid Heart beat and Palpitations. (TCM)
ii. Cinnamon with Saffron, Amber
iii. Cinnamon with Rose, Amber, Bugloss, Balm, Saffron, Red Coral, Sandalwood (as in Powder to Strengthen the Heart)
iv. Cinnamon with Arjuna, Turmeric, Guggulu (Ayurveda)
19. Hemorrhoids:
i. Cinnamon with Caraway (Avicenna)
ii. Cinnamon, Aniseed, Fennel seed, Bdellium


Major Formulas


Infusion Purging Bile
Powder of Cinnamon Compound (Diacinnamonum) (Mesue)
Powder to Strengthen the Stomach and Digestion
Powder to Strengthen the Stomach (Nicholas)
Decoction Against Retention of Menstruation
Decoction for Sterility (Quercetan)
Powder Against Postpartum Pain
Powder for Loss of Appetite Greater (Nicholas)
Powder for Edema (Nicholas)
Antidote for Edema (Nicholas)
Powder for Leukorrhea
Powder to Promote Menstruation (Riverius)
Birth Powder
Powder to Facilitate Birth (Renodeus)
Powder to Cleanse the Afterbirth
Electuary of Sulphur (Unani)
Tincture of Life (Mynsichts)

Bao Yuan Tang
Jiao Tai Wan
Mu Xiang Liu Qi Yin
Ren Shen Yang Rong Tang
Shi Quan Da Bu Tang
Shao Fu Zhu Yu Tang
You Gui Yin
You Gui Wan

Sitopaladi Powder (Ayurveda)
Nutmeg Powder (Jatiphaladi Churna) (Ayurveda)
Pomegranate 5 (Se bru 5) (Tibetan Medicine)
Tabasheer 9
Raisin 7 (Tibetan Medicine)

1. Compound Powder of Cinnamon:
i. Cinnamon (2 oz.), Cardamon seed (1 ½ oz.), Ginger (1 oz.), Long Pepper (half oz.). (London)
ii. Cinnamon, Lesser Cardamon (2 oz. each), Ginger, Clove (½ oz. each) (Pharmacopoeia regni Poloniae, 1817)
iii. Cinnamon (2 oz.), Cardamon, Ginger, Nutmeg (1 oz. each) (Formulaire Magistral et Memorial Pharmaceutique, 1823)
iv. Cinnamon, Cardamon, Ginger, Nutmeg (1 oz. each) (Pharmacopoeia Amstelodamensis, 1792)
v. Elecampane, Calamus, Ginger, Aniseed, Orange peel, Black Pepper (1 oz. each), Clove, Cinnamon (½ oz. each). (Armen Pharmacopoea, Hufeland, 1825)

2. Compound Tincture of Cinnamon:
i. Cinnamon (6 drams), Cardamon seed (3 drams), Ginger, Long Pepper (2 drams each), Proof Spirit (2 pints). (London)
ii. Cinnamon, Lesser Cardamon (1 oz. each), Long Pepper (2 drams), Proof Spirit (2 ½ pounds). (Edinborough)
iii. Cinnamon (2 oz.), Lesser Cardamon, Clove, Galangal, Ginger (half oz. each), Alcohol (2 lbs.). (Pharmacopoeia Oldenburgica, 1801)
iv. Cinnamon, Calamus, Lesser Galangal (1 oz. each), Peppermint, Fresh Lemon peel (1 ½ oz. each), Lesser Cardamon, Ginger (2 drams each), Alcohol (30 oz.). Digest 4 days, express, filter. (Dispensarium Lippiacum, 1792)

3. Aromatic Stomach Tincture:
i. Cinnamon (1 oz.), Clove, Nutmeg, Saffron (half oz. each), Calamus (6 drams), Mace (2 drams), fresh Lemon peels (2), fresh Orange peel (1), Alcohol (1 ½ pound). Digest, express, filter. Dose: 50–80 drops. (Pharmacopoeia Wirtembergica, 1798)

Cautions:


1. Not used during pregnancy in Heat conditions
2. Not used in people with excess Heat.
3. Not used in Heat-type Bleeding
4. “It is a drug that should not be used in spring and summer” (TCM: Zhang Yuan Su)

Safety
Safety of Cinnamon: An Umbrella Review of Meta-Analyses and Systematic Reviews of Randomized Clinical Trials

Main Preparations used:


Confection, Distilled Water, Tincture of Cinnamon, Distilled Oil, Salt from the Ashes, Syrup of Cinnamon, Magistery of Cinnamon;

Tincture of Cinnamon:
i. Cinnamon (3 oz.), Proof Spirit (2 pints). Macerate 14 days, strain. (London)

  • More Info
  • History
  • Research
Cinnamon was held in high esteem in the most remote times of history. In the words of the learned Dr. Vincent Dean of West minster, it seems to have been the first spice sought after in all oriental voyages. Both cinnamon and cassia are mentioned as precious odoriferous substances in the Mosaic writings and in the Biblical books of Psalms, Proverbs, Canticles, Ezekiel and Revelations, also by Theophrastus, Herodotus, Galen, Dioscorides, Pliny, Strabo and many other writers of antiquity: and from the accounts which have thus come down to us, there appears reason for believing that the spices referred to were nearly the same as those of the present day. That cinnamon and cassia were extremely analogous, is proved by the remark of Galen, that the finest cassia differs so little from the lowest quality of cinnamon, that the first may be substituted for the second, provided a double weight of it be used.

It is also evident that both were regarded as among1 the most costly of aromatics, for the offering made by Seluucus II. Callinieus, king of Syria, and his brother Antiochus Hierax, to the temple of Apollo at Miletus, B.C. 243, consisting chiefly of vessels of gold and silver, and olibanum, myrrh, costus, included also two pounds of Cassia, and the same quantity of Cinnamon.

In connexion with this subject there is one remarkable fact to be noticed, which is that none of the cinnamon of the ancients was obtained from Ceylon. “In the pages of no author,” says Tennent, “European or Asiatic, from the earliest ages to the close of the thirteenth century, is there the remotest allusion to cinnamon as an indigenous production, or even as an article of commerce in Ceylon.” Nor do the annuals of the Chinese, between whom and the inhabitants of Ceylon, from the 4th to the 8th centuries, there was frequent intercourse and exchange of commodities, name Cinnamon as one of the productions of the Island. The Sacred Books and other ancient records of the Singhalese are also completely silent on this point.

Cassia, under the name of Kiwi, is mentioned in the earliest Chinese herbal,— that of the emperor Shen-nung, who reigned about 2700 B.C., in the ancient Chinese Classics, and in the Rh-ya, a herbal dating from 1200 B.C. In the Hai-yau-pen-ts’ao, written in the 8th century, mention is made of Tien-chu kwei. Tien-chu is the ancient name for India: perhaps the allusion may be to the cassia bark of Malabar.

In connexion with these extremely early references to the spice, it may be stated that a bark supposed to be cassia is mentioned as imported into Egypt together with gold, ivory, frankincense, precious woods, and apes, in the 17th century B.C.

The accounts given by Dioscorides, Ptolemy and the author of the Periplus of the Erythrean Sea, indicate that cinnamon and cassia were obtained from Arabia and Eastern Africa; and we further know that the importers were Phoenicians, who traded by Egypt and the Red Sea with Arabia. Whether the spice under notice was really a production of Arabia or Africa, or whether it was imported thither from Southern China (the present source of the best sort of cassia), is a question which has excited no small amount of discussion.

We are in favour of the second alternative,— firstly, because no substance of the nature of cinnamon is known to be produced in Arabia or Africa; and secondly, because the commercial intercourse which was undoubtedly carried on by China with India and Arabia, and which also existed between Arabia, India and Africa, is amply sufficient to explain the importation of Chinese produce. That the spice was a production of the far East is moreover implied by the name Darchini (from dar, wood or bark, and Chini, Chinese) given to it by the Arabians and Persians.

If this view of the case is admissible, we must regard the ancient cinnamon to have been the substance now known as Chinese Cassia Lignea or Chinese Cinnamon, and cassia as one of the thicker and perhaps less aromatic barks of the same group, such in fact as are still found in commerce.

Of the circumstances which led to the collection of cinnamon in Ceylon, and of the period at which it was commenced, nothing is known. That the Chinese were concerned in the discovery is not an unreasonable supposition, seeing that they traded to Ceylon, and were in all probability acquainted with the cassia-yielding species of Cinnamomum of Southern China, a tree extremely like the cinnamon tree of Ceylon.

Whatever may be the facts, the early notices of cinnamon as a production of Ceylon are not prior to the 13th century. The very first, according to Yule, is a mention of the spice by Kazwini, an Arab writer of about A.D. 1275, very soon after which period it is noticed by the historian of the Egyptian Sultan Kelaoun, A.D. 1283. The prince of Ceylon is stated to have sent an ambassador, Al-Hadj-Abu-Othman, to the Sultan’s court. It was mentioned that Ceylon produced elephants, Bakam (the wood of Cassalpinia Sapan L., pearls and also cinnamon.

A still more positive evidence is due to the Minorite friar, John of Montecorvino, a missionary who visited India. This man, in a letter under date December 20th, 1292 or 1293, written at Mabar, citta dell India di sopra,”
and still extant in the Mediccan library at Florence, says that the cinnamon tree is of medium bulk, and in trunk, bark and foliage, like a laurel, and that great store of its bark is carried forth from the island which is near by Malabar.

Again, it is mentioned by the Mahomedan traveller Ibn Batuta about A.D. 1340, and a century later by the Venetian merchant Nicolo di Conti, whose description of the tree is very correct.

The circumnavigation of the Cape of Good Hope led to the real discovery of Ceylon by the Portuguese in 1505, and to their permanent occupation of the island in 1530, chiefly for the sake of the cinnamon. It is from the first of these dates that more exact accounts of the spice began to reach Europe. Thus in 1511 Barbosa distinguished the fine cinnamon of Ceylon from the inferior Canella trista of Malabar. Garcia de Orta, about the middle of the same century, stated that Ceylon cinnamon was forty times as dear as that of Malabar. Clusius, the translator of Garcia, saw branches of the cinnamon-tree as early as 1571 at Bristol and in Holland.


At this period cinnamon was cut from trees growing wild in the forests in the interior of Ceylon, the bark being exacted as tribute from the Singhalese kings by the Portuguese. A peculiar caste called chalias, who are said to have emigrated from India to Ceylon in the 13th century, and who in after-times became cinnamon-peelers, delivered the bark to the Portuguese. The cruel oppression of these chalias was not mitigated by the Dutch, who from the year 1656 were virtually masters of the whole seaboard, and conceded the cinnamon trade to their East India Company as a profitable monopoly, which the Company exercised with the greatest severity. The bark previous to shipment was minutely examined by special officers, to guard against frauds on the part of the chalias.

About 1770 De Koke conceived the happy idea, in opposition to the universal prejudice in favour of wild-growing cinnamon, of attempting the cultivation of the tree. This project was carried out under Governors Falck and Vander Graff with extraordinary success, so that the Dutch were able, independently of the kingdom of Kandy, to furnish about 400,000 Ib. of cinnamon annually, thereby supplying the entire European demand. In fact, they completely ruled the trade, and would even burn the cinnamon in Holland, lest its unusual abundance should reduce the price.

After Ceylon had been wrested from the Dutch by the English in 1796, the cinnamon trade became the monopoly of the English East India Company, who then obtained more cinnamon from the forests, especially after the year 1815, when the kingdom of Kandy fell under British rule. But though the chalias had much increased in numbers, the yearly production of cinnamon does not appear to have exceeded 500,000Ib. The condition of the unfortunate chalias was not ameliorated until 1833, when the monopoly granted to the Company was finally abolished, and Government, ceasing to be the sole exporters of cinnamon, permitted the merchants of Colombo and Galle to share in the trade.

Cinnamon however was still burdened with an export duty equal to a third or a half of its value; in consequence of which and of the competition with cinnamon raised in Java, and with cassia from China and other places, the cultivation in Ceylon began to suffer. This duty was not removed until 1853.

The earliest notice of cinnamon in connection with Northern Europe that we have met with, is the diploma granted by Chilperic II., king of the Franks, to the monastery of Corbie in Normandy, A.D. 716, in which provision is made for a certain supply of spices and grocery, including 5 Ib. of Cinnamon.

The extraordinary value set on cinnamon at this period is remarkably illustrated by some letters written from Italy, in which mention is here and there incidentally made of presents of spices and incense. Thus in A.D. 745, Gemmulus, a Roman deacon, sends to Boniface, archbishop of Mayence (“cum magna reverentia“), 4 ounces of Cinnamon, 4 ounces of Costus, and 2 pounds of Pepper. In A.D. 748, Theophilacias, a Roman archdeacon, presents to the same bishop similar spices and incense. Lullus, the successor of Boniface, sends to Eadburga, abbatissa Thanetensis, circa A.D. 732-751— “unum graphium argenteum, et utoracis et cinnamomi partem aliquam” ; and about the same date, another present of cinnamon to archbishop Boniface is recorded. Under date A.D. 732-742, a letter is extant of three persons to the abbess Cuneburga, to whom the writers offer— “turis et piperis et cinnamomi periodica xenia, sed omni mentis affectione destinata.”

In the 9th century, Cinnamon, pepper, costus, cloves, and several indigenous aromatic plants were used in the monastery of St. Gall in Switzerland as ingredients for seasoning fish.

Of the pecuniary value of this spice in England, there are many notices from the year 1204 downwards. In the 16th century it was probably not plentiful, if we may judge from the fact that it figures among the New Year’s gifts to Philip and Mary (1556-57), and to Queen Elizabeth (1561-62). (Pharmacographia, Fluckiger & Hanbury, 1879)
GENERAL / REVIEW
Metabolomic profiling and comparison of major cinnamon species using UHPLC–HRMS
Cinnamon as a Useful Preventive Substance for the Care of Human and Plant Health
Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits
Cinnamon: A Multifaceted Medicinal Plant
Cinnamon: Mystic powers of a minute ingredient
Differentiation of the Four Major Species of Cinnamons (C. burmannii, C. verum, C. cassia, and C. loureiroi) Using a Flow Injection Mass Spectrometric (FIMS) Fingerprinting Method
Medicinal properties of ‘true’ cinnamon (Cinnamomum zeylanicum): a systematic review

ANTIBACTERIAL
Antibacterial Effects of Cinnamon: From Farm to Food, Cosmetic and Pharmaceutical Industries
Antibacterial activity of clove (Syzygium aromaticum) and cinnamon (Cinnamomum burmannii) essential oil against extended-spectrum β-lactamase-producing bacteria
Antibacterial activity of cinnamon essential oils and their synergistic potential with antibiotics
Antibacterial Activity of Ethanolic Extract of Cinnamon Bark, Honey, and Their Combination Effects against Acne-Causing Bacteria
Antibacterial and Antifungal Activities of Spices
Medicinal properties of ‘true’ cinnamon (Cinnamomum zeylanicum): a systematic review

ANTI-VIRAL
Evaluation of the effect of hydro alcoholic extract of cinnamon on herpes simplex virus-1

COVID
Cinnamon and its possible impact on COVID-19: The viewpoint of traditional and conventional medicine

ANTIFUNGAL
Determination of the effects of cinnamon bark fractions on Candida albicans and oral epithelial cells
Development and Evaluation of Clove and Cinnamon Supercritical Fluid Extracts-Loaded Emulgel for Antifungal Activity in Denture Stomatitis
Anti‐fungal bandages containing cinnamon extract
Antifungal effects of tulsi, garlic, cinnamon and lemongrass in powder and oil form on Candida albicans: An in vitro study
Antibacterial and Antifungal Activities of Spices
Antifungal Activity of Cinnamon Oil and Olive Oil against Candida Spp. Isolated from Blood Stream Infections
Investigation of the Antifungal Activity and Mode of Action of Thymus vulgaris, Citrus limonum, Pelargonium graveolens, Cinnamomum cassia, Ocimum basilicum, and Eugenia caryophyllus Essential Oils
In vitro antifungal activity of Cinnamomum zeylanicum bark and leaf essential oils against Candida albicans and Candida auris

ANTI-INFLAMMAORY
Beneficial Effects of Cinnamon on the Metabolic Syndrome, Inflammation, and Pain, and Mechanisms Underlying These Effects – A Review
A polyphenolic cinnamon fraction exhibits anti-inflammatory properties in a monocyte/macrophage model
Synergistic Anti-inflammatory and Neuroprotective Effects of Cinnamomum cassia and Zingiber officinale Alleviate Diabetes-Induced Hippocampal Changes in Male Albino Rats: Structural and Molecular Evidence
Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model
Anti-inflammatory Effects of Cinnamon Extracts on an Animal Model of Intestinal Inflammation (P06-088-19)

ANTIOXIDANT
The Hypoglycemic and Antioxidant Activity of Cress Seed and Cinnamon on Streptozotocin Induced Diabetes in Male Rats
The Anti-Oxidant Effects of Ginger and Cinnamon on Spermatogenesis Dys-function of Diabetes Rats
Antioxidant capacity of cinnamon extract for palm oil stability

HYPERLIPIDEMIA
Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High-Fat Diet-Fed Rats
Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro
Cinnamon as Dietary Supplement Caused Hyperlipidemia in Healthy Rats
Effects of Cinnamon (Cinnamomum cassia) Consumption on Serum Lipid Profiles in Albino Rats
The benefit of cinnamon ( Cinnamomum burmannii) in lowering total cholesterol levels after consumption of high-fat containing foods in white mice ( Mus musculus) models

HYPERTENSION
Cinnamon effects on blood pressure and metabolic profile: A double-blind, randomized, placebo-controlled trial in patients with stage 1 hypertension

DYSPEPSIA
Evaluation of the Effectiveness of Cinnamon Oil Soft Capsule in Patients with Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Clinical Trial

COLITIS
Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells
Anti-inflammatory Effects of Cinnamon Extracts on an Animal Model of Intestinal Inflammation (P06-088-19)

AUTOIMMUNE DISEASE
Can cinnamon spice down autoimmune diseases?

HEPATOPROTECTIVE
Cinnamon Aqueous Extract Attenuates Diclofenac Sodium and Oxytetracycline Mediated Hepato-Renal Toxicity and Modulates Oxidative Stress, Cell Apoptosis, and Inflammation in Male Albino Rats
Hepatoprotective activity of cinnamon ethanolic extract against CCI4-induced liver injury in rats

NEUROPROTECTIVE
Cinnamon Treatment Upregulates Neuroprotective Proteins Parkin and DJ-1 and Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease
Synergistic Anti-inflammatory and Neuroprotective Effects of Cinnamomum cassia and Zingiber officinale Alleviate Diabetes-Induced Hippocampal Changes in Male Albino Rats: Structural and Molecular Evidence
Neuroprotective potentials of selected natural edible oils using enzyme inhibitory, kinetic and simulation approaches

ANTI-ANXIETY / ANTIDEPRESSANT
Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice

MEMORY / LEARNING ENHANCING
Cinnamon converts poor learning mice to good learners: Implications for memory improvement

NEURODEGENERATIVE DISORDERS
Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate: Therapeutic implications for neurodegenerative disorders

ALZHEIMER’S DISEASE
Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer’s Disease
Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer’s disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities
Cinnamon Counteracts the Negative Effects of a High Fat/High Fructose Diet on Behavior, Brain Insulin Signaling and Alzheimer-Associated Changes
Orally Administrated Cinnamon Extract Reduces β-Amyloid Oligomerization and Corrects Cognitive Impairment in Alzheimer’s Disease Animal Models
Possible Role of Common Spices as a Preventive and Therapeutic Agent for Alzheimer’s Disease
PARKINSON’S DISEASE
Cinnamon Treatment Upregulates Neuroprotective Proteins Parkin and DJ-1 and Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease
Cinnamon and its metabolite protect the nigrostriatum in a mouse model of Parkinson’s disease via astrocytic GDNF
Cinnamon and its metabolite protect the nigrostriatum in a mouse model of Parkinson’s disease via astrocytic GDNF
Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP+-Induced Apoptosis in a Cell Culture Model of Parkinson’s Disease
Bioactive constituents from cinnamon, hemp seed and polygonum cuspidatum protect against H2O2 but not rotenone toxicity in a cellular model of Parkinson’s disease
Can cinnamon bring aroma in Parkinson’s disease treatment?

MULTIPLE SCLEROSIS
Cinnamon Ameliorates Experimental Allergic Encephalomyelitis in Mice via Regulatory T Cells: Implications for Multiple Sclerosis Therapy
Prospects of Cinnamon in Multiple Sclerosis

RENOPROTECTIVE
Cinnamon Aqueous Extract Attenuates Diclofenac Sodium and Oxytetracycline Mediated Hepato-Renal Toxicity and Modulates Oxidative Stress, Cell Apoptosis, and Inflammation in Male Albino Rats
Cinnamon Extract and Probiotic Supplementation Alleviate Copper-Induced Nephrotoxicity via Modulating Oxidative Stress, Inflammation, and Apoptosis in Broiler Chickens
Renoprotective effects of cinnamon oil against APAP-Induced nephrotoxicity by ameliorating oxidative stress, apoptosis and inflammation in rats

EFFECT ON BLOOD GLUCOSE LEVELS
The Effect of Different Amounts of Cinnamon Consumption on Blood Glucose in Healthy Adult
The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials
Acute Effects of Cinnamon Spice on Post-prandial Glucose and Insulin in Normal Weight and Overweight/Obese Subjects: A Pilot Study

DIABETES
Beneficial Antioxidative and Antiperoxidative Effect of Cinnamaldehyde Protect Streptozotocin-Induced Pancreatic β-Cells Damage in Wistar Rats
An Overview of Indian Novel Traditional Medicinal Plants with Anti-Diabetic Potentials
Cinnamon Shows Antidiabetic Properties that Are Species-Specific: Effects on Enzyme Activity Inhibition and Starch Digestion
Cinnamon Extract Improves Insulin Sensitivity in the Brain and Lowers Liver Fat in Mouse Models of Obesity
Antidiabetic Potential of Volatile Cinnamon Oil: A Review and Exploration of Mechanisms Using In Silico Molecular Docking Simulations
The Hypoglycemic and Antioxidant Activity of Cress Seed and Cinnamon on Streptozotocin Induced Diabetes in Male Rats
Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro
Influence of Cinnamon on Glycemic Control in Individuals With Prediabetes: A Randomized Controlled Trial
Impact of Cassia Bark Consumption on Glucose and Lipid Control in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis
Effects of probiotic, cinnamon, and synbiotic supplementation on glycemic control and antioxidant status in people with type 2 diabetes; a randomized, double-blind, placebo-controlled study
Anti-diabetic and antioxidant effect of cinnamon in poorly controlled type-2 diabetic Iraqi patients: A randomized, placebo-controlled clinical trial
Effect of cinnamon supplementation on glucose, lipids levels, glomerular filtration rate, and blood pressure of subjects with type 2 diabetes mellitus
Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial
Some pharmacological effects of cinnamon and ginger herbs in obese diabetic rats
Cinnamon for diabetes mellitus

METABOLIC SYNDROME
Beneficial Effects of Cinnamon on the Metabolic Syndrome, Inflammation, and Pain, and Mechanisms Underlying These Effects – A Review
Cinnamon effects on metabolic syndrome: a review based on its mechanisms
Selected Indonesian Medicinal Plants for the Management of Metabolic Syndrome: Molecular Basis and Recent Studies

SPERMATOGENESIS
The Anti-Oxidant Effects of Ginger and Cinnamon on Spermatogenesis Dys-function of Diabetes Rats

ALLEVIATES TESTICULAR DAMAGE
Cinnamomum zeylanicum alleviate testicular damage induced by high fat diet in albino rats; histological and ultrastructural studies

DYSMENORRHEA
Comparative Effect of Cinnamon and Ibuprofen for Treatment of Primary Dysmenorrhea: A Randomized Double-Blind Clinical Trial
Efficacy of herbal medicine (cinnamon/fennel/ginger) for primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials
The Effect of Cinnamon on Menstrual Bleeding and Systemic Symptoms With Primary Dysmenorrhea

POLYCYSTIC OVARY (PCOS)
The Effects of Traditional Chinese Medicine-Associated Complementary and Alternative Medicine on Women with Polycystic Ovary Syndrome
Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review
The effect of cinnamon on polycystic ovary syndrome in a mouse model

ANTI-ANGIOGENESIS:
Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling

CANCER
Cinnamon: Mystic powers of a minute ingredient
Cinnamon in Anticancer Armamentarium: A Molecular Approach
Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer’s disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities
Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1
BREAST
Targets and Mechanism Used by Cinnamaldehyde, the Main Active Ingredient in Cinnamon, in the Treatment of Breast Cancer
Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses
CERVICAL
Aqueous Cinnamon Extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential
LEUKEMIA
The effect of aqueous cinnamon extract on the apoptotic process in acute myeloid leukemia HL-60 cells
LIVER
Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats
ORAL
Anti-Cancer Effects of Traditional Medicinal Herbs on Oral Squamous Cell Carcinoma

EFFECTS IN DENTISTRY
Effects of Cinnamon (Cinnamomum spp.) in Dentistry: A Review

STOMATITIS
Development and Evaluation of Clove and Cinnamon Supercritical Fluid Extracts-Loaded Emulgel for Antifungal Activity in Denture Stomatitis