Calendula, Marigold

Caltha
Me tog gur gum མེ་ཏོག་གུརགུམ་ (Tibetan Medicine)
Picture
Picture Ortus Sanitatis, Meydenbach, 1491

Picture Kreutterbuch, Matthiolus, 1586

Picture Icones Plantarum Medcio-oeconomico, Vietz, 1800

Botanical name:


Calendula officinalis

Parts used:


Flower

Temperature & Taste:


Warm, dry. Pungent
Open, discuss, astringe

Classifications:


2L. EMOLLIENT
3A. SUDORIFICS & DIAPHORETICS.   3C. ALEXIPHARMIC.   3D. CORDIALS & CARDIACS.   3E. DIURETIC.   3G. EMMENAGOGUE
4c. CARDIAC

Uses:


1. Moves the Blood, Clears Stasis, Eases Pain:
-strengthens the Heart and circulation
-Headaches or chronic Pain of a fixed nature
-promote Menstruation; painful, scanty or clotted Menstruation
-promotes Birth and Afterbirth
-poor circulation, arterial or venous: varicose veins
-chronic ulcers, chronic sores, slow-healing wounds
-Pain, inflammation and tumors with blood stagnation
-Nodes, Cysts, Scrofula, Lymphadenitis, Swellings, chronic Skin lesions, Tumors
-Cancer: Cancer
of Liver, Uterus, Breast, Stomach, Intestines, Soft Tissue (anti-cancer effects demonstrated)

2. Resists Poison, Promotes Sweat:
-Fevers; Tetanus
-promotes expression of Rashes
-boil, carbuncles, rashes, acne, especially when dark-colored
-Syphilis, Gonorrhea
-abscess of the Lungs (Tibet)

3. Clears Liver Heat, Opens Obstructions:
-Hepatitis, Liver disease, Liver congestion or hardness
-Jaundice

4. Benefits the Stomach and Bowels:
-Internal Ulcers, Gastritis, Colitis

5. Externally:
chronic Ulcers, Bed Sores, Varicose Veins, Fistulas, Phlebitis, Frost Bite, Burns, Scars and Surgical Wounds
-swellings including Lymphadenoma and Scrofula.
-wash is good for Vaginal abrasions.
-ointment or Vinegar-tincture reportedly has cured many cases of chronic Varicose Veins with constant application for 4-6 weeks.
-Calendula leaf juice in vinegar makes a good wash for hot swellings
-Calendula juice or fresh herb paste is a good application to Warts, Corns and Callouses.
-the leaf juice is also applied to Toothache
(Salmon)
-fresh Calendula flower rubbed onto a Bee or Wasp sting is said to be an ‘admirable remedy’.
-as a wash to strengthen the Sight


Dose:


INFUSION or BRIEF DECOCTION: 3–9 grams; 1 oz. decocted in 500mls of water can be taken in tablespoonful doses.
TINCTURE (1:2 fresh or 1:5 dried in 70% alcohol): 3–5 mls., up to 10–15mls. 5–20 drops as a dose in long-term use.
FRESHLY EXPRESSED JUICE diluted with equal amount of water: 1 teaspoonful
SEEDS: 7 Calendula seeds were taken in powder with wine for ‘Quartan Agues’;
Washes and Compress for externally use are made with 1 tablespoon of the flowers boiled briefly in 500 mls. of water.

Substitutes:


1. Arnica (especially for external use)
2. Safflower

Main Combinations:


1. Cardiac, for Palpitations, Fainting, Melancholy etc.: Calendula with Rosemary, Elder flower, Angelica, Balm, Citron peel, Saffron
2. Myocarditis, Calendula with Hawthorn berry and Daisy (Bellis) (Wonder in Weeds, W. Smith)
3. Loss of Speech after Apoplexy, Calendula with Borage, Peony, Rosemary, Calamus, Storax
4. Paralysis, Calendula with Asparagus root, Peony root, Betony, Cowslip, Four Cold Seeds, Calendula, Rosemary (as in Tincture for Paralysis)
5. To promote Menstruation, Calendula with Pennyroyal, Balm, Sage, Mugwort
6. Tumors, Cancers, Calendula with Celandine, Nettle, Cleavers, Wormwood, St. Johns wort
7. Lymphatic Cancers: Calendula with Horsetail, Yarrow, Nettle (Treben)
8. Cancer tea: Menyanthes, Hops, Calendula, Clematis recta, Milk Thistle seed, Celandine (Wesenberg)
9. Increase strength, Calendula, Radish Seed, 4 Greater Cold Seeds, Licorice (Herbarium Horstianum, 1630)
10. To preserve from Plague and Epidemic diseases, Calendula with Rosemary, Wormwood, Balm, Blessed Thistle, Betony, Angelica, Zedoary, Licorice, Elecampane, Sage
11. To expel Small Pox and other spotted Fever, Calendula decocted in Water and Wine
12. Chicken Pox, Calendula with Pitcher plant (Sarracenia), Pennyroyal (1 oz. each), Senna (half oz.). Steep in 3 pints of boiling water and drink freely. (Family Botanic Guide, Fox, 1924)
13. Measles, Calendula, Raspberry leaf, Pennyroyal, Cleavers, Hyssop (½ oz. ea.), Boil in 1 ½ pints of water down to 1 pint. Take 2 tablespoonfuls every 3 hours. (Slacks Herbal, 1892)
14. Chronic Gastritis, Colitis, or Duodenal Ulcer:
i. Calendula with Comfrey, Licorice
ii. Calendula with Comfrey root, Marshmallow, Aniseed
iii. Calendula with Dandelion, St. Johns wort, Balm, Fennel
15. Stomach Ulcers, Calendula with Oak bark, Fumitory, Vervain, Veronica (Zimmerman)
16. Gastric bleeding and Urinary Stones, Calendula with Yarrow, Knotgrass, St. Johns wort (Fischer)
17. Hayfever, Catarrh, Calendula with Violet and Wormwood
18. Chronic Obstructive Pulmonary Disease, Calendula, Violet, Elder berry (see research below)
19. Gout, Calendula with Agrimony, Camomile, Centaury, Rhubarb
20. Amenorrhea, decoct Calendula in wine (Herbarium Horstianum, 1630)
21. Varicose Veins, Calendula with Yarrow and St. Johns wort, internally and topically
22. Bruising, Trauma, combine Calendula with St. Johns wort
23. Gingivitis, Calendula, Rosemary, Ginger as a mouthwash
24. ‘Scarless Healer’: Calendula with St. Johns wort and Comfrey as an ointment. (Treben)

Major Formulas


Decoction for Apoplexy (Countess of Kent)
Tincture for Paralysis
Powder for Cold Diseases of the Head (Renodeus)

Cautions:


1. Avoid in Pregnancy.

Toxicity


Toxicological studies on hydroalcohol extract of Calendula officinalis L.
Final report on the safety assessment of Calendula officinalis extract and Calendula officinalis.

Main Preparations used:


Distilled Water, Vinegar, Tincture, Conserve of the Flowers, Ointment

1. Conserve of the Flowers:
i. Calendula flowers (1 part), White Sugar (2 parts)

  ‘Conserve made of the flowers and sugar taken in the morning fasting, cureth the trembling of the Heart, and is also given in the time of Plague or Pestilence’. Also very good for stoppage of the urine.
Dose: 1–2 drams. (Culpeper, Salmon)

2. Distilled Water of Calendula Flowers.
  Very good for many Heat diseases of the Head, Eyes, and Stomach. It is dropped into the eyes for red, swollen and painful eyes. A cloth is soaked in the Distilled Water and applied to the temples and forehead for headaches

3. Extract of Calendula:
i. Calendula (1 part), Water (8 parts); macerate 24 hours, boil 15 minutes; strain. Boil the residue again with 4 parts of water; mix the 2 decoctions, set aside 24 hours, then evaporate to the thickness of honey.
Dose: 15–30 grains

4. Vinegar of Calendula:
i. Calendula petals (1 part), Vinegar (4 parts). Digest in the sun or a warm place, then strain.

5. Ointment of Calendula:
i. Fresh Calendula petals (4 oz.), Fresh Butter (1 lb.). Boil until the herb is dry and press. Emollient and resolvent.

GENERAL / REVIEW
Chemical, Nutritional and Sensory Characteristics of Six Ornamental Edible Flowers Species.
Characterization of Biologically Active Substances from Calendula officinalis.
Biological Activities of Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) Plant Extracts.
A review on phytochemistry and ethnopharmacological aspects of genus Calendula.

ANTI-BACTERIAL
Antimicrobial activity of Calendula officinalis petal extracts against fungi, as well as Gram-negative and Gram-positive clinical pathogens.
Antimicrobial activity of Calendula officinalis, Camellia sinensis and chlorhexidine against the adherence of microorganisms to sutures after extraction of unerupted third molars.
Antibacterial and antiparasitic activity of oleanolic acid and its glycosides isolated from marigold (Calendula officinalis).
Antibacterial activity of medicinal plant extracts against periodontopathic bacteria.

ANTI-FUNGAL
Antimicrobial activity of Calendula officinalis petal extracts against fungi, as well as Gram-negative and Gram-positive clinical pathogens.
Antifungal activity of the essential oil from Calendula officinalis L. (asteraceae) growing in Brazil.

ANTI-VIRAL
Anti-HIV activity of extracts from Calendula officinalis flowers.
[Study of antiviral properties of Calendula officinalis].

ANTIPARASITIC
Antibacterial and antiparasitic activity of oleanolic acid and its glycosides isolated from marigold (Calendula officinalis).

ANTI-INFLAMMATORY
Anti-inflammatory and antiresorptive effects of Calendula officinalis on inflammatory bone loss in rats.
Plant food supplements with anti-inflammatory properties: a systematic review (II).
Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil.
Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action.
Improved anti-inflammatory activity of three new terpenoids derived, by systematic chemical modifications, from the abundant triterpenes of the flowery plant Calendula officinalis.
Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers.
Antioxidant properties of some hydroalcoholic plant extracts with antiinflammatory activity.
Hydroalcoholic plant extracts with anti-inflammatory activity.
Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects.

ANTIOXIDANT
Concentration of Antioxidant Compounds from Calendula officinalis through Sustainable Supercritical Technologies, and Computational Study of Their Permeability in Skin for Cosmetic Use.
Antioxidant properties of some hydroalcoholic plant extracts with antiinflammatory activity.

SEDATIVE
ON THE SEDATIVE AND HYPOTENSIVE EFFECT OF PREPARATIONS FROM THE PLANT CALENDULA OFFICINALIS.

SPASMOLYTIC
Studies on spasmogenic and spasmolytic activities of Calendula officinalis flowers.

HYPOTENSIVE
ON THE SEDATIVE AND HYPOTENSIVE EFFECT OF PREPARATIONS FROM THE PLANT CALENDULA OFFICINALIS.

RENOPROTECTIVE
Hepato and reno protective action of Calendula officinalis L. flower extract.

HEPATOPROTECTIVE
Hepato and reno protective action of Calendula officinalis L. flower extract.
The hepatoprotective action of ten herbal extracts in CCl4 intoxicated liver.

GASTROPROTECTIVE
Medicinal flowers. III. Marigold. (1): hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis.

MYOCARDIAL ISCHEMIA
Amelioration of myocardial ischemic reperfusion injury with Calendula officinalis.

PROTECTIVE EFFECT AGAINST CIGARETTE SMOKE
Subacute effect of cigarette smoke exposure in rats: protection by pot marigold (Calendula officinalis L.) extract.

COPD
Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study.

FATIGUE
Antifatigue Activity and Exercise Performance of Phenolic-Rich Extracts from Calendula officinalis, Ribes nigrum, and Vaccinium myrtillus.

PANCREATITIS
Calendula officinalis ameliorates l-arginine-induced acute necrotizing pancreatitis in rats.

HYPOGLYCEMIC
Medicinal flowers. III. Marigold. (1): hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis.

GASTRODUODENAL ULCERS
[Treanntment of duodenal ulcers and gastroduodenitis with a herbal combination of Symphitum officinalis and Calendula officinalis with and without antacids].

COLITIS
Healing acceleration of acetic acid-induced colitis by marigold (Calendula officinalis) in male rats.
[Treatment of chronic colitis with an herbal combination of Taraxacum officinale, Hipericum perforatum, Melissa officinaliss, Calendula officinalis and Foeniculum vulgare].

ULCERATIVE COLITIS
The effect of calendula officinalis in therapy of acetic Acid induced ulcerative colitis in dog as an animal model.
IMMUNOLOGICAL EFFECT
A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation.
Evaluation of the immunomodulatory effects of five herbal plants.
[Immunostimulating action of polysaccharides (heteroglycans) from higher plants].

LEUKOPLAKIA
Comparison of effectiveness of Calendula officinalis extract gel with lycopene gel for treatment of tobacco-induced homogeneous leukoplakia: A randomized clinical trial.

CANCER
Antimelanogenic and Antimigration Properties of the Ethyl Acetate Fraction of Calendula officinalis Flowers on Melanoma Cells.
Calendula officinalis: Potential Roles in Cancer Treatment and Palliative Care.
Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts.
Evaluation of in vitro anticancer activity of Ocimum basilicum, Alhagi maurorum, Calendula officinalis and their parasite Cuscuta campestris.
Chamomile and marigold tea: chemical characterization and evaluation of anticancer activity.
Cytotoxic effect of some medicinal plants from Asteraceae family on J-45.01 leukemic cell line–pilot study.
Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers.
Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers.
A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation.
Cytotoxic and antitumoral activity of Calendula officinalis extracts.

SIDE EFFECTS OF CANCER TREATMENT
Medicinal plants used for the treatment of mucositis induced by oncotherapy: a systematic review.
Effectiveness of nursing interventions in preventing and treating radiotherapy side effects in cancer patients: a systematic review.
Traditionally Used Natural Products in Preventing Ionizing Radiation-Induced.
Effectiveness of skin protectors and calendula officinalis for prevention and treatment of radiodermatitis: an integrative review.
Efficacy of topical Calendula officinalis on prevalence of radiation-induced dermatitis: A randomised controlled trial.
[Usage of Calendula officinalis in the prevention and treatment of radiodermatitis: a randomized double-blind controlled clinical trial].
Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study.
Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer.

PERIODONTITIS / GINGIVITIS
Effects of Calendula Officinalis and Hypericum Perforatum on Antioxidant, Anti-Inflammatory, and Histopathology Indices of Induced Periodontitis in Male Rats.
The Effect of Calendula officinalis on Oxidative Stress and Bone Loss in Experimental Periodontitis.
Evaluation of the efficacy of a polyherbal mouthwash containing Zingiber officinale, Rosmarinus officinalis and Calendula officinalis extracts in patients with gingivitis: A randomized double-blind placebo-controlled trial.

DENTISTRY
[Action of Calendula officinalis essence on bone preservation after the extraction].
Antimicrobial activity of Calendula officinalis, Camellia sinensis and chlorhexidine against the adherence of microorganisms to sutures after extraction of unerupted third molars.

WOUNDS
Calendula officinalis and Wound Healing: A Systematic Review.
Treatment of acute wounds in hand with Calendula officinalis L.: A randomized trial.
A systematic review of Calendula officinalis extract for wound healing.
Use of Some Asteraceae Plants for the Treatment of Wounds: From Ethnopharmacological Studies to Scientific Evidences.
In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts.
The Water Fraction of Calendula officinalis Hydroethanol Extract Stimulates In Vitro and In Vivo Proliferation of Dermal Fibroblasts in Wound Healing.
The Impact of Aloe vera and Calendula on Perineal Healing after Episiotomy in Primiparous Women: A Randomized Clinical Trial.
Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil.
Wound healing activity of flower extract of Calendula officinalis.

ACHILLES TENDON HEALING
Effect of Calendula officinalis cream on achilles tendon healing.

SKIN ANTI-AGEING
Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.

LEG / FOOT ULCERS
Therapeutic effectiveness of a Calendula officinalis extract in venous leg ulcer healing.
Low-level laser therapy and Calendula officinalis in repairing diabetic foot ulcers.
Pressure ulcer healing with Plenusdermax Calendula officinalis L. extract.
A Prospective, Descriptive Study to Assess the Clinical Benefits of Using Calendula officinalis Hydroglycolic Extract for the Topical Treatment of Diabetic Foot Ulcers.
Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers.

VAGINOSIS
The effect of Calendula officinalis versus metronidazole on bacterial vaginosis in women: A double-blind randomized controlled trial.

CANDIDA
Comparing the effects of Calendula officinalis and clotrimazole on vaginal Candidiasis: A randomized controlled trial.

ANTI-LEISHMANIAL
In vitro anti-leishmanial activity of methanolic extracts of Calendula officinalis flowers, Datura stramonium seeds, and Salvia officinalis leaves.

EYE DISEASES
Medicinal plants used for ophthalmological problems in Navarra (Spain).

NAPPY RASH
A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children.