Angelica gigas, Korean Angelica

Gigantic Angelica, Korean Dang Gui
Chao Xian Dang Gui (TCM)
Picture Angelica gigas
(Photo by Emma Forsberg) (Wikimedia)

Botanical name:


Angelica gigas
Used similarly to Dang Gui, but is not synonymous.

Parts used:


Root

Temperature & Taste:


Warm, dry. Pungent

Classification:




Uses:


1. Moves the Blood, Regulates Menstruation:
-Amenorrhea, Dysmenorrhea, Irregular Menstruation
-Menopause

2. Moves the Blood, Resolves Masses:
-commonly used in Cancer therapy: Prostate, Lung, Breast, Colon, Bladder, Sarcoma, Myeloma, Leukemia
-reduces proliferation and angiogenesis, increases apoptosis
-synergistic with Chemotherapy such as Doxorubicin

2. Benefits Liver, Settles Wind:
-Joint pain
-beneficial in Memory loss and improves cognition


Dose:


Decoction: 3–9 grams (larger doses have been used for Cancer)
Powder: 1–3 grams

Substitute:


Dang Gui when used for gynecological effects.

Comment:


Angelica gigas is classed as a type of Dang Gui (Angelica sinensis) in TCM, and is commonly used in Korea. However, its red color signifies a stronger affinity for moving the blood and it is also regarded as settling Wind. More recently it has been widely used in Korea in Cancer therapy.

Main Combinations:


1. Cancer:
i. of the Prostate, Ovary or Breast, Angelica gigas (2 parts) Aconitum Fu Zi, Ginger (1 part each). This is a Korean formula found effective in a number of Cancer cell lines; see Research below)
ii. Solid Cancers (various including Prostate), Angelica gigas, Astragalus Huang Qi, Trichosanthes Gua Lou Zi (equal parts) (See research here)
2. Impotence, Male Infertility, Angelica gigas with Epimedium Yin Yang Huo
3. Memory loss:
i. Angelica gigas, Calamus, Frankincense
ii. Angelica gigas, Saururus chinensis, Schisandra Wu Wei Zi (this has been studied)
4. Gynecological use: see Dang Gui

Major Formulas:



Cautions:


None noted

Main Preparations used:




1. ANTI-INFLAMMATORY:
Anti-Inflammatory Effect of Angelica gigas via Heme Oxygenase (HO)-1 Expression
Effects of Angelica gigas Nakai as an Anti-Inflammatory Agent in In Vitro and In Vivo Atopic Dermatitis Models

2. ANTIOXIDANT:
Antioxidant and ACE Inhibitory Activity of Cultivated and Wild Angelica gigas Nakai Extracts Prepared Using Different Extraction Conditions

3. ATHEROSCLEROSIS:
An ethanolic extract of Angelica gigas improves atherosclerosis by inhibiting vascular smooth muscle cell proliferation

4. ANTI-THROMBOTIC:
Antithrombotic Effect of the Ethanol Extract of Angelica gigas Nakai (AGE 232)

5. NEUROPROTECTIVE:
Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review
Neuroprotective effect of Angelica gigas root in a mouse model of ischemic brain injury through MAPK signaling pathway regulation
Neuroprotective effect of the hairy root extract of Angelica gigas NAKAI on transient focal cerebral ischemia in rats through the regulation of angiogenesis

6. BRAIN INJURY:
Angelica gigas root ameliorates ischaemic stroke-induced brain injury in mice by activating the PI3K/AKT/mTOR and MAPK pathways

7. COGNITIVE ENHANCING:
Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review

8. MEMORY ENHANCING:
Evaluating the Memory Enhancing Effects of Angelica gigas in Mouse Models of Mild Cognitive Impairments
Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice.

9. IMMUNO-STIMULANT:
Anti-cancer activity of Angelica gigas by increasing immune response and stimulating natural killer and natural killer T cells

10. MALE INFERTILITY:
Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2/HO-1 Signaling Pathway
Restoration of Spermatogenesis Using a New Combined Herbal Formula of Epimedium koreanum Nakai and Angelica gigas Nakai in an Luteinizing Hormone-Releasing Hormone Agonist-Induced Rat Model of Male Infertility

11. REGULATES OVARIAN HORMONES
Ultrafine Angelica gigas powder normalizes ovarian hormone levels and has antiosteoporosis properties in ovariectomized rats: particle size effect.
12. CANCER:
Anti-cancer activity of Angelica gigas by increasing immune response and stimulating natural killer and natural killer T cells
Cancer Chemoprevention with Korean Angelica: Active Compounds, Pharmacokinetics, and Human Translational Considerations
In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin.
Anti-tumor activities of decursinol angelate and decursin from Angelica gigas.
Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds.
Decursin: a cytotoxic agent and protein kinase C activator from the root of Angelica gigas.
BREAST:
The Herbal Formula JI017 Induces ER Stress via Nox4 in Breast Cancer Cells
GASTRIC CANCER:
Decursin inhibits cell growth and autophagic flux in gastric cancer via suppression of cathepsin C
GLIOBLASTOMA:
Decursin induces apoptosis in glioblastoma cells, but not in glial cells via a mitochondria-related caspase pathway
LYMPHOMA:
Angelica gigas Nakai and Decursin Downregulate Myc Expression to Promote Cell Death in B-cell Lymphoma
MELANOMA:
Decursin from Angelica gigas Nakai Inhibits B16F10 Melanoma Growth Through Induction of Apoptosis
OVARIAN:
JI017, a Complex Herbal Medication, Induces Apoptosis via the Nox4–PERK–CHOP Axis in Ovarian Cancer Cells
PANCREAS:
Effect of Angelica gigas Nakai Ethanol Extract and Decursin on Human Pancreatic Cancer Cells
PROSTATE:
In vitro Anticancer Effects of JI017 on Two Prostate Cancer Cell Lines Involve Endoplasmic Reticulum Stress Mediated by Elevated Levels of Reactive Oxygen Species
Prostate Cancer Xenograft Inhibitory Activity and Pharmacokinetics of Decursinol, a Metabolite of Angelica Gigas Pyranocoumarins, in Mouse Models
SH003 induces apoptosis of DU145 prostate cancer cells by inhibiting ERK-involved pathway

13. SYNERGISTIC WITH DOXORUBICIN:
Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis

14. HAIR GROWTH:
Effects of Decursin and Angelica gigas Nakai Root Extract on Hair Growth in Mouse Dorsal Skin via Regulating Inflammatory Cytokines