Acorus, Calamus, Shi Chang Pu 石菖蒲

Sweet Flag
Vacha (Ayurveda)
Vasambu (Siddha)
Shi Chang Pu 石菖蒲 (TCM)
Shu dag  ཤུ་དག  (A. calamus, Tibetan)
Waj, Waj e Turki (Unani)
Picture
Picture Gart der Gesundheit, Cuba, 1485

Picture Ortus Sanitatis, Cube, Johann von, 1501

Picture Picture
Calamus (Acorum verum, Acorus of Dioscorides)
Krauterbuch, Lonitzer, 1578
 Pseudoacorus
New Kreuterbuch
, Matthiolus, 1563

Picture Acorus calamus
Kohler’s Medizinal Pflanzen
, 1887

Picture The ‘True’ (original) Acorus of the ancients
Museum Museorum, Valentini, 1704

Picture Calamus root
(bottom left shows underside of the root, bottom right shows upperside)
(A Manual of materia medica and pharmacology, Culbreth, 1906)

Picture  Calamus (A. calamus) used in Tibetan Medicine. (Adam, 2016)
Picture Calamus used in TCM
(Adam, 2022)

Botanical name:


Acorus calamus (syn A. vulgaris, A. aromaticus, A. odoratus; Calamus aromaticus)
TCM recognises 3 main varieties of Acorus:
  1. Acorus tatarinowii (Shi Chang Pu)
  2. Acorus calamus (Shui Chang Pu); Shu dag nag po ཤུ་དག་ནག་པོ  (Tibetan)
  3. Acorus gramineus (Jin Xian Pu); Shu dag dkar po ཤུ་དག་དཀར་པོ (Tibetan)
A. tatarinowii is regarded as best and most aromatic in TCM; A. calamus has the most pleasant scent and is generally preferable.
Due to the potential risk of toxicity of ß-asarone, the American Acorus calamus. var. americanus has been recommended.

Note that in ancient formulas of the West, ‘Acorus’ is Iris pseudoacorus, although Calamus may generally be used in its place. Many authors and herbals covered them under the same heading and treated them as one.

Parts used:


Root

Temperature & Taste:


Warm and dry in the third degree. Pungent, Bitter

Classification:


2A APERIENT MEDICINES.   2B ATTENUATERS.   2C INCIDERS.   2G. CLEANSING.   2H. CARMINATIVES.   2I. ANTISPASMODICS    2S. STRENGTHENING MEDICINES
3C. ALEXIPHARMICS.   3D. CORDIALS & CARDIACS.   3F. LITHONTRIPTIC.   3G. EMMENAGOGUE.   3K. EXPECTORANT.   3M. ARTHRITIC    3O. EMETICS
4a. CEPHALIC.   4c. CARDIAC.   4e. STOMACHIC.   4f. SPLENETIC.   4g. HEPATIC.   4i. UTERINE.   4k. ARTHRITIC
TCM:
J. Aromatics that Open the Orifices

Uses:


1. Clears Wind-Damp-Phlegm, Benefits Brain and Nerves: (TCM, West, Tibet, Ayurveda)
-Clears Wind, Damp and Phlegm and also clears Blood stagnation or bruising from head trauma
-Special medicine to restore Memory and Brain function
-Epilepsy, Headache, Vertigo, Dizziness, Paralysis
-Dullness of the Senses, Deafness, Loss of Speech, Stuttering, Head Trauma
odontalgia and heaviness of the tongue (Avicenna)
-Heart Wind affecting the Brain and Nerves (Tibet)
-promotes alertness and increases intelligence and memory (Ayurveda)
-‘Long term use makes one feel happy and vigorous, have a good Memory and Spirit and enjoy a Long Life. It invigorates Wisdom’. (Shen Nong Ben Cao)
-ameliorates harmful effects of narcotics, especially Cannabis (Ayurveda)

2. Moves the Blood and Qi, Clears Damp, Resolves Stagnation: (TCM, West, Tibet, Ayurveda)
-Anxiety with Palpitations; Arrhythmia; old TCM herbals listed it for ‘Insufficient Heart Qi’ (TCM, West)
-promotes Menstruation, used for stoppage or painful Menstruation
-moves the Blood; internally and externally for Bruising, Trauma, Blood stagnation
-Swellings and Tumors
-“improves the complexion” (Avicenna)
-clears Damp and Melancholy (Confected root is good for Melancholy)

3. Clears Damp, Moves Qi, Benefits the Stomach: (TCM, West, Tibet, Ayurveda)
-promotes appetite and digestion; Indigestion, Colic, Diarrhea
-obstructions of the Liver and Spleen
-Cold phlegm of the Lungs; Cough, Bronchitis

4. Clears Damp, Promotes Urine, Warms the Kidneys: (West, Tibet, Ayurveda, TCM)
-Edema or obstructed Urine from Cold and Damp
-lack of Bladder control
-“According to some people it is also useful in strangury” (Avicenna)
-increases Libido and Sexual Energy; Arabs regarded it as a longevity tonic (Confected Root)
-“acts as a stimulant and increases libido” (Avicenna)
-Arthralgia, Rheumatoid Arthritis (TCM, Tibetan Medicine)

5. Resists Poison: (West, Tibet, TCM)
-classically used against various Poisons
-Snake bite, Rabies
-Worms, Parasites
-Boils, Toxic Sores, Diphtheria
-acute Cough, Whooping Cough
-Infectious and Epidemic diseases; Plague; both to preserve and cure
-root steeped in vinegar and chewed preserves from Infection during Epidemics (Herbarium Horstianum, 1630)
-expressed juice relieves toxin of Croton and Euphorbia species (TCM)


6. Emetic
-decoction has been used as an emetic

7. Externally:
-applied as a fomentation for colic and abdominal pain
-applied to Wind-Cold_damp type nerve, muscle and joint pains
-“useful for treating corneal thickness and opacity” (Avicenna)
-externally for Sores and Scabies
Pityriasis and Leukoderma (Avicenna)
-decocted in wine and gargled to clear Phlegm and Damp from the Head
-pain of the stomach or abdomen, powder, fry and apply the powder while hot (TCM)


Dose:


Decoction: 3–6 grams, added at the end of boiling;
Powder: 500mg–2 grams (up to 5 grams daily) 

Correctives
1. Cochlospermum religiosum; Tragacanth
2. Honey


Substitutes:


1. Orris, Valerian, Pyrethrum
2. Chrysanthemum indicum and Cumin (Unani)
3. Cumin with one-third part Rhubarb (as a carminative,and  for Spleen and Liver) (Avicenna)

Preparation:


1. Confected Calamus:
  In the west it was confected where it is regarded as a Brain and Kidney tonic, strengthening the Mind and Kidneys, and being aphrodisiac.
2. Stir-fried Calamus:
  The dried root can be lightly stir-fried. This reduces its pungent, dispersing nature while keeping its warming, drying nature. It is better for treating children. (TCM)
3. Carbonised Calamus:
  The root is stir-fried until scorched and blackened. This is better for Diarrhea and is used in Siddha medicine.

Main Combinations:


Calamus, Galangal
Calamus, Peony
Calamus, Rue

Mind, Brain, Nerves
1. Amnesia, to increase Memory:
i. Calamus (1 part), Lucerne seed (2 parts); powder, mix with Ghee and Honey
ii. Calamus with Frankincense, Cyperus rotundus, Black Pepper (Unani and Western)
iii. Calamus with Ginseng, Poria Fu Ling and Polygala Yuan Zhi. (TCM; proven effect)
2. Strengthen the Brain, Mental Fatigue, Stress, following Brain Injury, and during periods of Intense Study, combine Calamus with Gotu Kola (Ayurveda)
3. To enhance mental clarity, and for speech impediments, Calamus with Centella, Convolvulus Shankhapushpi (Ayurveda)
4. Wind-Heat diseases of the Head such as Epilepsy and Seizures, Calamus with Tabasheer
5. Epilepsy, Hysteria, Headache, Vertigo:
i. Calamus with Peony, Mistletoe and Sandalwood
ii. Calamus, Curcuma Yu Jin, Alum Ming Fan, Cinnabar (Zhu Sha) (TCM)
iii. Calamus, Peony, Mistletoe, Aloeswood, Juniper berry, Cinnamon, Clove, Rosemary, Sage, Calendula, Lavender
6. Tremors, Cal;amus with Stoechas, Oregano, Mild, Calamint, Ground Pine, Germander, Sage, Cowslip (as in Experienced Syrup for Tremors)
7. Mental disorders, Schizophrenia:
i. Calamus, Rauwolfia serpentina. These two medicines are often combined for various mental disorders in Ayurveda.
ii. combine equal parts of Calamus, Costus, Gotu Kola, Licorice, Rauwolfia serpentina, Withania, Nutmeg; take 1 gram three times daily (Simple Ayurvedic Remedies, Dr. Puri, India, 2002)

Stomach, Intestines
8. Stomach weakness, Colic, Bloating, Gastritis:
i. Cold-type Colic and Griping, Calamus decocted in Wine. (Herbarium Horstianum, 1630)
ii. Calamus with Peppermint
iii. Calamus with Swertia (or Gentian)
iv. Calamus with Balm and Fennel seed
v. Calamus with Cardamon, Fennel, Ginger (Ayurveda)
vi. Calamus, Galangal, Zedoary, Orris (Herbarium Horstianum, 1630)
vii. Calamus with Aniseed, Fennel seed, Caraway, Coriander seed, Licorice, Cinnamon, Ginger, Nutmeg (as in Species Incisa)
9. Aromatic Bitters, Calamus with Orange peel, Gentian, Rhubarb, Cinnamon, Clove
10. Stomach and Kidney weakness, Calamus with Wormwood
11. Gastritis with irritation, Colic:
i. Calamus with Marshmallow and Licorice
ii. Calamus, Balm, Fennel seed, Peppermint
iii. Calamus, Wormwood, Yarrow, Calendula, Licorice
12. Epigastric pain and distention, nausea, poor appetite:
i. from Damp-Cold-Phlegm and Qi stagnation, Calamus with Orange peel / Tangerine peel (Chen Pi).
ii. from Cold and Qi stagnation, Calamus with Evodia Wu Zhu Yu (TCM)
13. Cold diseases of the Stomach, Liver, Spleen, Chronic Disease, Edema, Calamus with Saffron, Myrrh, Cumin, Aniseed, Cinnamon, Spikenard, Mint (as in Diamorusia of Mesue)
14. Spleen disease, Calamus powdered, steeped in vinegar, then decocted to half and Honey or Sugar added is effective for the Spleen. (Herbarium Horstianum, 1630)

Urinary:
15. Obstructed Urine, Edema:
i. Calamus with Cough grass (Dioscorides)
ii. Calamus with Celery seed (Dioscorides)
iii. Calamus with Peppermint, Juniper, Senna (Meyer)
16. Gravel, Stones:
i. Calamus, Tribulus, Shilajit (Ayurveda)
ii. Calamus with Radish seed, Parsley seed, Bitter Almonds, Cyperus rotundus, Gentian, Myrrh (as in Pills to Crumble Kidney Stones)
17. Warm and strengthen the Kidneys, Brain and Nerves; for Epilepsy, Poor Memory and to increase Libido, with Sea Holly root, Pine nuts, Long Pepper and Clove (as in Diacorum)

Other:
18. Cold-phlegm of the Lungs:
i. Calamus with Adhatoda, Licorice (Ayurveda)
ii. Calamus with Almond, Licorice, Ginger
19. Whooping Cough, Calamus powder, 2 pinches three times daily in egg white (Siddha Medicine)
20. Scrofula, Calamus with Butchers Broom, Polypody, Orris, Marshmallow, Peony root, Figwort, Squill (as in Potion for Scrofula)
21. Chronic Internal Bleeding, Calamus with Horsetail, Gentian, Houseleek (Hüttner)
22. Heart Qi Stagnation:
i. Calamus, Aloeswood
ii. Calamus, Ligusticum Chuan Xiong, Costus, Polygala Yuan Zhi, Zizyphus Suan Zao Ren, Curcuma Yu Jin, Aloeswood (Chen Xiang) (The Formulas of Dr. John H.F. Shen)
23. Chest oppression and Angina Pectoris from Qi and Blood stagnation:
i. Calamus, Cyperus rotundus (Xiang Fu), Ligusticum Chuan Xiong, Clove (Ding Xiang) (Formulas of Dr. John H.F. Shen)
ii. Calamus, Ligusticum Chuan Xiong, Costus (Mu Xiang), Polygala Yuan Zhi, Curcuma Yu Jin (Formulas of Dr. John H.F. Shen)
24. Arrhythmia:
i. Calamus, Galangal, Cinnamon, Camphor
ii. Calamus, Red Coral, Frankincense, Clove
iii. Calamus, Valerian, Sandalwood, Aloeswood
25. To move the Blood and clear stagnation, Calamus with Saffron, Myrrh, Cinnamon, Seseli, Aniseed, Spikenard, Costus (as in Diamorusia)
26. Amenorrhea, Calamus, Cyperus rotundus, Asarum, Madder
27. Hysteria, Dysmenorrhea, Calamus with Cassia Wood, Agnus Castus, Rue seed, Peony, Aniseed, Cinnamon, Sugar of Rosemary (as in Tragea Hysterica)
28. Infertility, Calamus with Seseli, Peony, Cyperus, Cinnamon, Mugwort, Spikenard, Olibanum, Mastic (as in Electuary Against Sterility)
29. Quartan Fever, Calamus with Pontic Wormwood decocted in Wine (Herbarium Horstianum, 1630)
30. Intermittent Fever, and convalescence after Fever, Calamus with Swertia
31. Syphilis, make an ointment with Withania, Calamus and Costus in Ghee to be applied. (Ayurveda)

Major Formulas:


Aromatic Bitter Decoction
Cephalic Decoction (Charras)
Decoction for Arthritis (Mynsichts)
Syrup for the Memory
Syrup of Calamus (Wirtzung)
Syrup of Mugwort (Augustana)
Wine for Catarrh
Four Thieves Vinegar
Electuary of Calamus (Mesue)
Electuary of Saffron Greater (Diacrocon Majores) (Mesue)
Orvietan Antidote
Electuary for Gastric Pain
Electuary Against Forgetfulness
Electuary for Amnesia (Unani)
The Powder of Trithemius
Powder of Galangal Compound (Diagalanga) (Mesue)
Species Incisa (Augustine Pharmacopoeia)
Powder to Strengthen the Memory (2)
Special Powder for Memory (Wirtzung)
Powder of Nutmeg for Vertigo
Powder for Incontinence (Alexander Benedictus)
Aromatic Hysteric Powder
Troches of Coral (Diacorallium) (Nicholas)
Aromatic Pills of Aloes (Sweet Pills of Aloe, Pilulae Aloephangine) (Mesue)
Pills to Increase Memory

Calamus 4 (Tibetan)
Cantharide 37 (Tibetan)
Ding Xian Wan (TCM)
Ding Zhi Wan (TCM)
Mu Xiang Liu Qi Yin (TCM)
Sang Piao Xiao San (TCM)
Garuda 5 (Khyung Lnga) (Tibetan)
Garuda 8 (Khyung lnga mchu sder can) (Tibetan)

Greater Universal Women’s Disease Conqueror (Mo nad spyi ‘joms chen mo) (Tibetan)
Increase Awareness Pills (Tibetan)
Madder Pill (Tibetan)
Medicine for Infants (Pillaru Marundu) (Siddha)
Przewalskia 11 (Thang phrom bcu gchig)
Red Coral 25 (Rin chen byur dmar nyer lnga)
Sarasvata Churna (Ayurveda)
Settle the Lungs 8 (Glo man brgyad pa) (Tibetan)
Supreme 25 (Bla med nyer lnga)
Vajra conquering Heart Wind 17 (Tibetan)

1. Compound Tincture of Calamus:
i.  Calamus
    Coriander seed   2 oz. each
    Alcohol               24 oz. (Pharmacopoeia Generalis, 1783)
ii.  Calamus              3 oz.
    Zedoary
    Ginger                   1 oz. each
    Unripe Orange    2 oz.
    Alcohol                 3 pounds.
Digest, press and filter. (Pharmacopoeia regni Poloniae, 1817)
iii. Calamus
    Ginger
    Coriander
    Black Pepper       1 oz. each,
Alcohol (2 ½ pounds) (Niemann)

2. Stomach Tincture:
i.  Calamus
    Lesser Galangal
    Gentian
    Zedoary                 1 ½ oz. each
    Rhubarb                 6 drams
    Cochineal              2 drams
    Lesser Cardamon 3 drams
    Orange peel          1 oz.
    Blessed Thistle     1 ½ oz.
    Alcohol                   5 pounds
Dose: 60–80 drops (Pharmacopoeia Hannoverana, 1819)

Cautions:


1.  Avoid in Pregnancy and Breastfeeding
2. Very warm and dry, therefore not suitable for Yin deficiency.
3. Avoid long term use of full doses.
4. Not used in those with Liver disease.

Toxicity:


Due to the potential Liver toxicity of ß-asarone, it should not be used long-term, or in those with Liver disease. Use for a maximum of one month, then have a break in treatment. Calamus usually forms a small part of an overall formula in which case its continued use is safe. The American Acorus calamus var. americanus does not contain ß-asarone so has been recommended.
α-Asarone, β-asarone, and γ-asarone: Current status of toxicological evaluation.

Main Preparations used:


Distilled Water, Candied and Confected root, Distilled Oil, Extract

1. Conserve of Calamus:
i. Calamus root, soften by boiling; let it drain and pour upon it hot sugar syrup.
  Used for various diseases of the Head and nerves; it sharpens the wit, eases the Headache, and is good for all old sickness, especially Rheums which fall from the head to the breast. Also ‘Commended’ for Vertigo (Wirtzung); as well as Nightmares

2. Confected Calamus root:
i. Dry Calamus root (2 parts); peel and cut it, macerate it in a sufficient quantity of hot water until it becomes soft; then pound it in a marble mortar: put it, in the same water, upon the fire, strain through a sieve, add White Sugar (3 parts) to the pulp, and evaporate to the right consistency. (Pharmacopee Usuelle, Louvain, 1821)

3. Distilled Water of Calamus:
i. Calamus root (1 part), Salted Water (6 parts). Macerate for several days, then distill. (Pharmacopoeia Sardoa, 1773)
ii. Calamus (1 part), Water (12 parts), macerate 24 hours, distill over 9 parts.

Sweet Flag root has been from the earliest times a favourite medicine of the natives of India, in which country it is sold in every bazaar. Ainslie asserts that it is reckoned so valuable in the bowel complaints of children that there is a penalty incurred by any druggist who will not open his door in the middle of the night to sell it, if demanded!

The descriptions of Acoron, a plant of Colchis, Galatia, Pontus, and Crete, given by Dioscorides and Pliny, certainly refer to this drug. We think that the [?] of Dioscorides, which he states to grow in India, is the same, though Royle regards it as an Andropogon. The [?] of Theophrastus and the Calamus of the English Bible are considered by some authors to refer to the Sweet Flag.

Celsus in the first century mentioned Calamus Alexandrinus, the drug being probably then brought from India by way of the Red Sea. We know by the
testimony of Amatus Lusitanus that in the 16th century it used to be so imported into Venice. Rheede, moreover, described and figured Acorus Calamus as an Indian plant under the name Vacha, which it still bears on the Malabar Coast. But in the pharmaceutical tariff of the German town of Halberstadt of the year 1697, “Calamus aromaticus verus, Indianischer Calmus,” and “Calamus aromaticus nostras,” common Calmus, are quoted at exactly the same price, and Murray states expressly that in his time (1790) Asiatic calamus was still met with in the pharmacies of Continental Europe, but that it had mostly been replaced by the home-grown drug.

At the present time the Calamus aromaticus of commerce is European; in all essential characters it agrees with that of India, a package of which is now and then offered in the London drug sales.’
(Pharmacographia, Fluckiger & Hanbury, 1879)

Daoists texts on Calamus (from A Soup for the Qan, Hu Sihui et al. 2010)
Food for Beneficient Immortals:
Seek for sweetflag with nine joints. Dry in a cellar. After one hundred days grind into a powder. Take three times a day. If taken for a long time, it will make sensitive and bright the ear and the eye. It will increase the years and enhance longevity.’
The Baopuzi says:
Han Ju took sweetflag for 13 years. He sprouted hair on his body. He could read ten thousand words in a day. He was not cold [when] naked in winter. You should obtain sweetflag growing on rocks, with nine knots per cun. Sweetflag with purple flowers is still better.
GENERAL / REVIEW
Acorus calamus: a bio-reserve of medicinal values.
Acorus calamus (The Healing Plant): a review on its medicinal potential, micropropagation and conservation.
An overview on traditional uses and pharmacological profile of Acorus calamus Linn. (Sweet flag) and other Acorus species.
Chemical compositions, phytotoxicity, and biological activities of Acorus calamus essential oils from Nepal.
[Asarone and its biological properties].

PROCESSING
Śodhana: An Ayurvedic process for detoxification and modification of therapeutic activities of poisonous medicinal plants
Fate of β-asarone in Ayurvedic Sodhana process of Vacha.
Anticonvulsant activity of raw and classically processed Vacha (Acorus calamus Linn.) rhizomes.

ANTIBACTERIAL
Acorus calamus Linn.: phytoconstituents and bactericidal property.
Major constituents and antimicrobial activity of Korean herb Acorus calamus.
Antibacterial properties of traditionally used Indian medicinal plants.

ANTI-VIRAL
The Antiviral Effect of Indonesian Medicinal Plant Extracts Against Dengue Virus In Vitro and In Silico.
Tatanan A from the Acorus calamus L. root inhibited dengue virus proliferation and infections.

ANTI-INFLAMMATORY
Evaluation of the wound-healing activity and anti-inflammatory activity of aqueous extracts from Acorus calamus L.
Anti-inflammatory activity of a water extract of Acorus calamus L. leaves on keratinocyte HaCaT cells.

ANTIHISTAMINE
In vitro anticholinergic and antihistaminic activities of Acorus calamus Linn. leaves extracts.

BRONCHODILATORY
Bronchodilatory effect of Acorus calamus (Linn.) is mediated through multiple pathways.

HEPATOPROTECTIVE
Protective effect of Acorus calamus on kidney and liver functions in healthy mice.
Amelioration of alcohol-induced hepatotoxicity and oxidative stress in rats by Acorus calamus.

NEPHROPROTECTIVE
Protective effect of Acorus calamus on kidney and liver functions in healthy mice.

DIABETES
Effects and molecular mechanisms of the antidiabetic fraction of Acorus calamus L. on GLP-1 expression and secretion in vivo and in vitro.

CARDIOVASCULAR
Is it safe to use Acorus calamus as a source of promising bioactive compounds in prevention and treatment of cardiovascular diseases?
Aqueous-methanolic extract of sweet flag (Acorus calamus) possesses cardiac depressant and endothelial-derived hyperpolarizing factor-mediated coronary vasodilator effects.
Isoproterenol-induced cardiomyopathy in rats: influence of Acorus calamus Linn.: A. calamus attenuates cardiomyopathy.

HYPOLIPIDEMIC
Hypolipidemic activity of Acorus calamus L. in rats.

ANTI-HYPERTENSIVE
Blood pressure-lowering and vascular modulator effects of Acorus calamus extract are mediated through multiple pathways.

IMMUNOMODULATORY
The protective effect of the Vacha rhizome extract on chronic stress-induced immunodeficiency in rat.
Water-soluble polysaccharide obtained from Acorus calamus L. classically activates macrophages and stimulates Th1 response.

NEUROPROTECTIVE
Neuroprotective effect of saponin rich extract of Acorus calamus L. in rat model of chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain.
Neuroprotective effect of Acorus calamus against middle cerebral artery occlusion-induced ischaemia in rat.
Protective effect of acorus calamus against acrylamide induced neurotoxicity.

NEUROLOGICAL DISORDERS
Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study.
Molecular Mechanisms and Therapeutic Potential of α- and β-Asarone in the Treatment of Neurological Disorders.
NEUROPATHY
Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transection-induced painful neuropathy in rats.

MEMORY LOSS
The Effects of Acorus calamus L. in Preventing Memory Loss, Anxiety, and Oxidative Stress on Lipopolysaccharide-induced Neuroinflammation Rat Models.

DEPRESSION
Experimental evaluation of antidepressant effect of Vacha (Acorus calamus) in animal models of depression.

ANTISPASMODIC
Antispasmodic effect of Acorus calamus Linn. is mediated through calcium channel blockade.

ANTICONVULSANT
Preliminary Screening of a Classical Ayurvedic Formulation for Anticonvulsant Activity.
Anticonvulsant activity of raw and classically processed Vacha (Acorus calamus Linn.) rhizomes.

EPILEPSY
Herbal medicine for epilepsy seizures in Asia, Africa and Latin America: A systematic review.
Inhibitory role of Acorus calamus in ferric chloride-induced epileptogenesis in rat.

NEURODEGENERATION / ALZHEIMER’S DISEASE / DEMENTIA
Phytotherapeutics against Alzheimer’s Disease: Mechanism, Molecular Targets and Challenges for Drug Development.
Acorus calamus extract and its component α-asarone attenuate murine hippocampal neuronal cell death induced by l-glutamate and tunicamycin.
Ayurvedic Medicine for the Treatment of Dementia: Mechanistic Aspects.

STRESS-INDUCED COGNITIVE DECLINE
Effects of Acorus calamus Rhizome Extract on the Neuromodulatory System in Restraint Stress Male Rats.

AUTISM
Neurotransmitter, Antioxidant and Anti-neuroinflammatory Mechanistic Potentials of Herbal Medicines in Ameliorating Autism Spectrum Disorder.

DIURETIC
Diuretic and antiurolithiatic activities of an ethanolic extract of Acorus calamus L. rhizome in experimental animal models.

KIDNEY STONES
Diuretic and antiurolithiatic activities of an ethanolic extract of Acorus calamus L. rhizome in experimental animal models.

RADIOPROTECTIVE
Radioprotection by α-asarone: prevention of genotoxicity and hematopoietic injury in mammalian organism.
Protection of DNA and membrane from γ-radiation induced damage by the extract of Acorus calamus Linn.: An in vitro study.

CANCER
Experimental evidence for use of Acorus calamus (asarone) for cancer chemoprevention.
Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice.
Anti-carcinogenic and anti-angiogenic properties of the extracts of Acorus calamus on gastric cancer cells.
Nitro Derivatives of Naturally Occurring β -Asarone and Their Anticancer Activity.
β-Asarone induces senescence in colorectal cancer cells by inducing lamin B1 expression.

AMELIORATES CHEMOTHERAPY TOXICITY
β-Asarone increases doxorubicin sensitivity by suppressing NF-κB signaling and abolishes doxorubicin-induced enrichment of stem-like population by destabilizing Bmi1.
Amelioration of cisplatin-induced nephrotoxicity by extracts of Hemidesmus indicus and Acorus calamus.

ANTHELMINTIC
Compositional variations and anthelmentic activity of essential oils from rhizomes of different wild populations of Acorus calamus L. and its major component, beta-Asarone.
SEARCH FOR ANTHELMINTICS OF PLANT ORIGIN: ACTIVITIES OF VOLATILE PRINCIPLES OF ACORUS CALAMUS against ASCARIS LUMBRICOIDES.

WOUNDS
Evaluation of the wound-healing activity and anti-inflammatory activity of aqueous extracts from Acorus calamus L.
Evaluation of wound-healing activity of Acorus calamus Linn.